Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40

Nature Structural and Molecular Biology

Volumn 24, Issue 7, 2017, Pages 570-577

  Lu, Jun ^a   Byrne, Noel ^a   Wang, John ^a   Bricogne, Gerard ^b   Brown, Frank K ^a   Chobanian, Harry R ^a   Colletti, Steven L ^a   Di Salvo, Jerry ^a   Thomas Fowlkes, Brande ^a   Guo, Yan ^a   Hall, Dawn L ^a   Hadix, Jennifer ^a   Hastings, Nicholas B ^a   Hermes, Jeffrey D ^a   Ho, Thu ^a   Howard, Andrew D ^a   Josien, Hubert ^a   Kornienko, Maria ^a   Lumb, Kevin J ^a   Miller, Michael W ^a   Patel, Sangita B ^a   Pio, Barbara ^a   Plummer, Christopher W ^a   Sherborne, Bradley S ^a   Sheth, Payal ^a   Souza, Sarah ^a   Tummala, Srivanya ^a   Vonrhein, Clemens ^b   Webb, Maria ^a   Allen, Samantha J ^a   Johnston, Jennifer M ^a   Weinglass, Adam B ^a   Sharma, Sujata ^a   Soisson, Stephen M ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b GLOBAL PHASING LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC AGONIST; ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR 40; LIPID; MK 8666; PARTIAL AGONIST; UNCLASSIFIED DRUG; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; PRIORITY JOURNAL; AGONISTS; CHEMISTRY; HUMAN; MOLECULAR MODEL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 85022332317     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.3417     Document Type: Article

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