Corticosteroids in sepsis: An updated systematic review and meta-analysis (protocol)

BMJ Open

Volumn 7, Issue 6, 2017, Pages

  Rochwerg, Bram ^a   Oczkowski, Simon ^a   Siemieniuk, Reed Alexander ^a   Menon, Kusum ^b   Szczeklik, Wojciech ^a,c   English, Shane ^b,d   Agoritsas, Thomas ^a,e   Belley Cote, Emilie ^a   D'Aragon, Frédérick ^f   Alhazzani, Waleed ^a   Duan, Erick ^a   Gossack Keenan, Kira ^a   Sevransky, Jon ^g   Vandvik, Per ^a,h   Venkatesh, Bala ⁱ   Guyatt, Gordon ^j   Annane, Djillali ^a,k  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^e GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^f CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h INNLANDET HOSPITAL TRUST   (Norway)

ⁱ UNIVERSITY OF QUEENSLAND   (Australia)

^j UNIVERSITY OF SYDNEY   (Australia)

^k LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

more..

Author keywords

corticosteroids; intensive care; meta analysis; Sepsis; shock; systematic review

Indexed keywords

BETAMETHASONE; CORTICOSTEROID; CORTISONE; DEXAMETHASONE; FLUDROCORTISONE; HYDROCORTISONE; METHYLPREDNISOLONE;

CLINICAL OUTCOME; CORTICOSTEROID THERAPY; CRITICALLY ILL PATIENT; DRUG EFFICACY; DRUG SAFETY; HUMAN; LENGTH OF STAY; META ANALYSIS; MORTALITY; PATIENT PARTICIPATION; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; SEPSIS; SYSTEMATIC REVIEW; METHODOLOGY; ORGAN DYSFUNCTION SCORE; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; HUMANS; LENGTH OF STAY; ORGAN DYSFUNCTION SCORES; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; SEPSIS; TREATMENT OUTCOME;

EID: 85021724241     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2017-016847     Document Type: Review

References (45)

1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic shock (Sepsis-3). JAMA 2016;315:801-10.
2. Vincent JL, De Backer D. Circulatory shock. N Engl J Med 2014;370:583.
3. Gaieski DF, Edwards JM, Kallan MJ, et al. Benchmarking the incidence and mortality of severe Sepsis in the United States. Crit Care Med 2013;41:1167-74.
4. Rhee C, Murphy MV, Li L, et al. Improving documentation and coding for acute organ dysfunction biases estimates of changing Sepsis severity and burden: a retrospective study. Crit Care 2015;19:338.
5. Weiss SL, Fitzgerald JC, Pappachan J, et al. Global epidemiology of pediatric severe Sepsis: the Sepsis prevalence, outcomes, and therapies study. Am J Respir Crit Care Med 2015;191:1147-57.
6. Stevenson EK, Rubenstein AR, Radin GT, et al. Two decades of mortality trends among patients with severe Sepsis: a comparative meta-analysis. Crit Care Med 2014;42:625-31.
7. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-71.
8. Annane D, Maxime V, Ibrahim F, et al. Diagnosis of adrenal insufficiency in severe Sepsis and septic shock. Am J Respir Crit Care Med 2006;174:1319-26.
9. Arabi YM, Aljumah A, Dabbagh O, et al. Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial. CMAJ 2010;182:1971-7.
10. Bollaert PE, Charpentier C, Levy B, et al. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998;26:645-50.
11. Briegel J, Forst H, Haller M, et al. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 1999;27:723-32.
12. Confalonieri M, Urbino R, Potena A, et al. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 2005;171:242-8.
13. El-Nawawy A, Khater D, Omar H, et al. Evaluation of Early Corticosteroid Therapy in Management of Pediatric Septic Shock in Pediatric Intensive Care Patients: A Randomized Clinical Study. Pediatr Infect Dis J 2017;36:155-9.
14. Gordon AC, Mason AJ, Perkins GD, et al. The interaction of vasopressin and corticosteroids in septic shock: a pilot randomized controlled trial. Crit Care Med 2014;42:1325-33.
15. Oppert M, Schindler R, Husung C, et al. Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005;33:2457-64.
16. Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111-24.
17. Bone RC, Fisher CJ, Clemmer TP, et al. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe Sepsis and septic shock. N Engl J Med 1987;317:653-8.
18. Luce JM, Montgomery AB, Marks JD, et al. Ineffectiveness of highdose methylprednisolone in preventing parenchymal lung injury and improving mortality in patients with septic shock. Am Rev Respir Dis 1988;138:62-8.
19. Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest 2007;131:954-63.
20. Sprung CL, Caralis PV, Marcial EH, et al. The effects of highdose corticosteroids in patients with septic shock. A prospective, controlled study. N Engl J Med 1984;311:1137-43.
21. Snijders D, Daniels JM, de Graaff CS, et al. Efficacy of corticosteroids in community-acquired pneumonia: a randomized double-blinded clinical trial. Am J Respir Crit Care Med 2010;181:975-82.
22. Yildiz O, Doganay M, Aygen B, et al. Physiological-dose steroid therapy in Sepsis [ISRCTN36253388]. Crit Care 2002;6:251-9.
23. Marik PE, Pastores SM, Annane D, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of critical Care Medicine. Crit Care Med 2008;36:1937-49.
24. Bruno JJ, Dee BM, Anderegg BA, et al. US practitioner opinions and prescribing practices regarding corticosteroid therapy for severe Sepsis and septic shock. J Crit Care 2012;27:351-61.
25. Menon K, McNally JD, Choong K, et al. A survey of stated physician practices and beliefs on the use of steroids in pediatric fluid and/or vasoactive infusion-dependent shock. Pediatr Crit Care Med 2013;14:462-6.
26. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids for treating sepsis. Cochrane Database Syst Rev 2015;12:CD002243.
27. Keh D, Trips E, Marx G, et al. Effect of hydrocortisone on development of shock among patients with severe Sepsis: the HYPRESS Randomized clinical trial. JAMA 2016;316:1775-85.
28. Annane D, Buisson CB, Cariou A, et al. Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial. Ann Intensive Care 2016;6:43.
29. Siemieniuk RA, Agoritsas T, Macdonald H, et al. Introduction to BMJ Rapid Recommendations. BMJ 2016;354:i5191.
30. Annane D, Buisson CB, Cariou A, et al. Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial. Ann Intensive Care 2016;6:43.
31. Korte C, Styne D, Merritt TA, et al. Adrenocortical function in the very low birth weight infant: improved testing sensitivity and association with neonatal outcome. J Pediatr 1996;128:257-63.
32. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31:1250-6.
33. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644-55.
34. Siemieniuk RA, Agoritsas T, Macdonald H, et al. Introduction to BMJ Rapid Recommendations. BMJ 2016;354:i5191.
35. Annane D, Bellissant E, Bollaert PE, et al. Corticosteroids for treating sepsis. Cochrane Database Syst Rev 2015:CD002243.
36. Bond CM, Djogovic D, Villa-Roel C, et al. Pilot study comparing Sepsis management with and without electronic clinical practice guidelines in an academic emergency department. J Emerg Med 2013;44:698-708.
37. Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. Wiley Online Library, 2008.
38. Akl EA, Johnston BC, Alonso-Coello P, et al. Addressing dichotomous data for participants excluded from trial analysis: a guide for systematic reviewers. PLoS One 2013;8:e57132.
39. Higgins JP, Altman DG, G?tzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.
40. Sun X, Briel M, Busse JW, et al. Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ 2012;344:e1553.
41. Guyatt GH, Oxman AD, Kunz R, et al. GRADE guidelines: 7. Rating the quality of evidence-inconsistency. J Clin Epidemiol 2011;64:1294-302.
42. Guyatt GH, Oxman AD, Vist GE, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008;336:924-6.
43. Vandvik PO, Otto CM, Siemieniuk RA, et al. Transcatheter or surgical aortic valve replacement for patients with severe, symptomatic, aortic Stenosis at low to intermediate surgical risk: a clinical practice guideline. BMJ 2016;354:i5085.
44. Poolman RW, Agoritsas T, Siemieniuk RA, et al. Low intensity pulsed ultrasound (LIPUS) for bone healing: a clinical practice guideline. BMJ 2017;356:j576.
45. Siemieniuk RAC, Harris IA, Agoritsas T, et al. Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline. BMJ 2017;357:j1982.