Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase

Journal of Biological Chemistry

Volumn 292, Issue 25, 2017, Pages 10398-10413

  French, Michael E ^a,b   Klosowiak, Julian L ^c   Aslanian, Aaron ^a,b   Reed, Steven I ^a   Yates, John R ^a   Hunter, Tony ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C (PROGRAMMING LANGUAGE); ENZYMES;

BRANCHED STRUCTURES; CHAIN FORMATION; NON-COVALENT; POLYUBIQUITIN; SECOND PHASE; SEQUENTIAL ADDITION; UBIQUITIN LIGASES; UBIQUITINATION;

SUBSTRATES;

LYSINE; MONOMER; PROTEASOME; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; WWP1 PROTEIN; POLYUBIQUITIN; UBIQUITIN PROTEIN LIGASE; WWP1 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DENSITOMETRY; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UBIQUITINATION; BIOSYNTHESIS; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN DOMAIN;

HUMANS; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN DOMAINS; PROTEOLYSIS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 85021679701     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M117.789479     Document Type: Article

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