Factor VIIIA-mimetic cofactor activity of a bispecific antibody to factors IX/IXA and X/XA, emicizumab, depends on its ability to bridge the antigens

Thrombosis and Haemostasis

Volumn 117, Issue 7, 2017, Pages 1348-1357

  Kitazawa, Takehisa ^a   Esaki, Keiko ^a   Tachibana, Tatsuhiko ^a   Ishii, Shinya ^a   Soeda, Tetsuhiro ^a   Muto, Atsushi ^a   Kawabe, Yoshiki ^a   Igawa, Tomoyuki ^a   Tsunoda, Hiroyuki ^a   Nogami, Keiji ^b   Shima, Midori ^b   Hattori, Kunihiro ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Coagulation factors; Drug design; Factor VIII; Haemophilia therapy

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9 COMPLEX; BLOOD CLOTTING FACTOR 9A; EMICIZUMAB; BIOMIMETIC MATERIAL; BISPECIFIC ANTIBODY; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 8A; MONOCLONAL ANTIBODY;

ANTIGEN BINDING; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; MATHEMATICAL MODEL; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; THROMBIN TIME; ANTAGONISTS AND INHIBITORS; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; BINDING SITE; BIOLOGICAL MODEL; BLOOD; COMPUTER SIMULATION; IMMUNOLOGY;

ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES; BIOMIMETIC MATERIALS; COMPUTER SIMULATION; FACTOR IX; FACTOR IXA; FACTOR VIIIA; FACTOR X; FACTOR XA; FACTOR XA INHIBITORS; HUMANS; MODELS, IMMUNOLOGICAL;

EID: 85021675727     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH17-01-0030     Document Type: Article

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