Accumulation of antibody-target complexes and the pharmacodynamics of clotting after single intravenous administration of humanized anti-factor IX monoclonal antibody to rats

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 6, Issue 3, 1999, Pages 171-179

  Davis, Charles B ^a   Tobia, LeeAnn P ^a   Kwok, Deborah C ^a   Oishi, Christine M ^a   Kheterpal, Neil ^a   Hepburn, Timothy W ^a   Benincosa, Lisa J ^a   Chow, Fung Sing ^b   Jusko, William J ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Antibody Antigen Complex; Coagulation; Factor IX Mab; Pharmacokinetics Pharmacodynamics (PK PD)

Indexed keywords

BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9A; ENZYME PRECURSOR; HUMAN MONOCLONAL ANTIBODY; SB 249417; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; AREA UNDER THE CURVE; ARTICLE; BLOOD CLOTTING; DEGRADATION; DOSE RESPONSE; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

EID: 0032851674     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/107175499266922     Document Type: Article

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