Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Kar, Gozde ^a   Kim, Jong Kyoung ^a,b   Kolodziejczyk, Aleksandra A ^a   Natarajan, Kedar Nath ^a   Triglia, Elena Torlai ^c   Mifsud, Borbala ^d,e,f   Elderkin, Sarah ^g   Marioni, John C ^a,h   Pombo, Ana ^c   Teichmann, Sarah A ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g BABRAHAM INSTITUTE   (United Kingdom)

^h UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HIGH MOBILITY GROUP A2 PROTEIN; HISTONE; HISTONE DEACETYLASE 2; KRUPPEL LIKE FACTOR 4; LEUKEMIA INHIBITORY FACTOR; POLYCOMB GROUP PROTEIN; RNA; TAMOXIFEN; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; BMI1 PROTEIN; GENETIC MARKER; MESSENGER RNA; RING1 PROTEIN, MOUSE; RNF2 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

CELLS AND CELL COMPONENTS; CHROMOSOME; GENE EXPRESSION; GENETIC ANALYSIS; POLYMERASE CHAIN REACTION; PROTEIN; RNA;

ALLELE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; ENHANCER REGION; GENE DELETION; GENE EXPRESSION; GENE REPRESSION; GENETIC HETEROGENEITY; GENETIC TRANSCRIPTION; GENETIC VARIATION; HISTONE MODIFICATION; MOUSE; MOUSE EMBRYONIC STEM CELL; NOISE; NONHUMAN; POSITION EFFECT VARIEGATION; PROMOTER REGION; RNA SEQUENCE; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; STABLE EXPRESSION; UPREGULATION; ANIMAL; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; KNOCKOUT MOUSE; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENETIC MARKERS; MICE; MICE, KNOCKOUT; POLYCOMB REPRESSIVE COMPLEX 1; POLYCOMB-GROUP PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UBIQUITIN-PROTEIN LIGASES;

EID: 85021663714     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-00052-2     Document Type: Article

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