-
1
-
-
79958078455
-
Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells
-
Bess E., Fisslthaler B., Frömel T., Fleming I. Nitric oxide-induced activation of the AMP-activated protein kinase α2 subunit attenuates IκB kinase activity and inflammatory responses in endothelial cells PLoS One 6 2011 e20848
-
(2011)
PLoS One
, vol.6
, pp. e20848
-
-
Bess, E.1
Fisslthaler, B.2
Frömel, T.3
Fleming, I.4
-
2
-
-
84872672425
-
Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity
-
Friedrichsen M., Mortensen B., Pehmøller C., Birk J.B., Wojtaszewski J.F. Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity Mol. Cell. Endocrinol. 366 2013 204 214
-
(2013)
Mol. Cell. Endocrinol.
, vol.366
, pp. 204-214
-
-
Friedrichsen, M.1
Mortensen, B.2
Pehmøller, C.3
Birk, J.B.4
Wojtaszewski, J.F.5
-
3
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor κb kinase complex
-
Gao Z., Hwang D., Bataille F., Lefevre M., York D., Quon M.J., Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex J. Biol. Chem. 277 2002 48115 48121
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
Lefevre, M.4
York, D.5
Quon, M.J.6
Ye, J.7
-
4
-
-
14544271905
-
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
-
Gual P., Le Marchand-Brustel Y., Tanti J.F. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation Biochimie 87 2005 99 109
-
(2005)
Biochimie
, vol.87
, pp. 99-109
-
-
Gual, P.1
Le Marchand-Brustel, Y.2
Tanti, J.F.3
-
5
-
-
70049110010
-
Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells
-
Ha D.T., Tuan D.T., Thu N.B., Nhiem N.X., Ngoc T.M., Yim N., Bae K. Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells Bioorg. Med. Chem. Lett. 19 2009 5556 5559
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 5556-5559
-
-
Ha, D.T.1
Tuan, D.T.2
Thu, N.B.3
Nhiem, N.X.4
Ngoc, T.M.5
Yim, N.6
Bae, K.7
-
6
-
-
84861222690
-
The ancient drug salicylate directly activates AMP-activated protein kinase
-
Hawley S.A., Fullerton M.D., Ross F.A., Schertzer J.D., Chevtzoff C., Walker K.J., Peggie M.W., Zibrova D., Green K.A., Mustard K.J. The ancient drug salicylate directly activates AMP-activated protein kinase Science 336 2012 918 922
-
(2012)
Science
, vol.336
, pp. 918-922
-
-
Hawley, S.A.1
Fullerton, M.D.2
Ross, F.A.3
Schertzer, J.D.4
Chevtzoff, C.5
Walker, K.J.6
Peggie, M.W.7
Zibrova, D.8
Green, K.A.9
Mustard, K.J.10
-
7
-
-
0018689279
-
Metformin: A review of its pharmacological properties and therapeutic use
-
Hermann L. Metformin: a review of its pharmacological properties and therapeutic use Diab. Metab. 5 1979 233 245
-
(1979)
Diab. Metab.
, vol.5
, pp. 233-245
-
-
Hermann, L.1
-
8
-
-
45549104269
-
Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway
-
Higaki Y., Mikami T., Fujii N., Hirshman M.F., Koyama K., Seino T., Tanaka K., Goodyear L.J. Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway Am. J. Physiol-Endoc. M. 294 2008 E889 E897
-
(2008)
Am. J. Physiol-Endoc. M.
, vol.294
, pp. E889-E897
-
-
Higaki, Y.1
Mikami, T.2
Fujii, N.3
Hirshman, M.F.4
Koyama, K.5
Seino, T.6
Tanaka, K.7
Goodyear, L.J.8
-
9
-
-
33644695373
-
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase
-
Holmes B.F., Sparling D.P., Olson A.L., Winder W.W., Dohm G.L. Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase Am. J. Physiol-Endoc. M. 289 2005 E1071 E1076
-
(2005)
Am. J. Physiol-Endoc. M.
, vol.289
, pp. E1071-E1076
-
-
Holmes, B.F.1
Sparling, D.P.2
Olson, A.L.3
Winder, W.W.4
Dohm, G.L.5
-
10
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil G.S. Inflammation and metabolic disorders Nature 444 2006 860 867
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
11
-
-
84898814284
-
Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice
-
Jiang C., Yao N., Wang Q., Zhang J., Sun Y., Xiao N., Liu K., Huang F., Fang S., Shang X. Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice J. Ethnopharmacol. 153 2014 344 351
-
(2014)
J. Ethnopharmacol.
, vol.153
, pp. 344-351
-
-
Jiang, C.1
Yao, N.2
Wang, Q.3
Zhang, J.4
Sun, Y.5
Xiao, N.6
Liu, K.7
Huang, F.8
Fang, S.9
Shang, X.10
-
12
-
-
84874045511
-
The origins and drivers of insulin resistance
-
Johnson A.M., Olefsky J.M. The origins and drivers of insulin resistance Cell 152 2013 673 684
-
(2013)
Cell
, vol.152
, pp. 673-684
-
-
Johnson, A.M.1
Olefsky, J.M.2
-
13
-
-
0028825748
-
Tumor Necrosis Factor-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1
-
Kanety H., Feinstein R., Papa M.Z., Hemi R., Karasik A. Tumor Necrosis Factor-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1) Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1 J. Biol. Chem. 270 1995 23780 23784
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 23780-23784
-
-
Kanety, H.1
Feinstein, R.2
Papa, M.Z.3
Hemi, R.4
Karasik, A.5
-
14
-
-
0642287562
-
Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice
-
Kurihara H., Asami S., Shibata H., Fukami H., Tanaka T. Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice Biol. Pharm. Bull. 26 2003 383 385
-
(2003)
Biol. Pharm. Bull.
, vol.26
, pp. 383-385
-
-
Kurihara, H.1
Asami, S.2
Shibata, H.3
Fukami, H.4
Tanaka, T.5
-
15
-
-
0042821560
-
Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice
-
Kurihara H., Fukami H., Kusumoto A., Toyoda Y., Shibata H., Matsui Y., Asami S., Tanaka T. Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice Biosci. Biotechnol. Biochem. 67 2003 877 880
-
(2003)
Biosci. Biotechnol. Biochem.
, vol.67
, pp. 877-880
-
-
Kurihara, H.1
Fukami, H.2
Kusumoto, A.3
Toyoda, Y.4
Shibata, H.5
Matsui, Y.6
Asami, S.7
Tanaka, T.8
-
16
-
-
9444249257
-
AMP-activated protein kinase: A new beta-cell glucose sensor? Regulation by amino acids and calcium ions
-
Leclerc I., Rutter G.A. AMP-activated protein kinase: a new beta-cell glucose sensor? Regulation by amino acids and calcium ions Diabetes 53 2004 S67 S74
-
(2004)
Diabetes
, vol.53
, pp. S67-S74
-
-
Leclerc, I.1
Rutter, G.A.2
-
17
-
-
78149466792
-
Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice
-
Lee J., Yee S.T., Kim J.J., Choi M.S., Kwon E.Y., Seo K.I., Lee M.K. Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice Chem. Biol. Interact. 188 2010 635 642
-
(2010)
Chem. Biol. Interact.
, vol.188
, pp. 635-642
-
-
Lee, J.1
Yee, S.T.2
Kim, J.J.3
Choi, M.S.4
Kwon, E.Y.5
Seo, K.I.6
Lee, M.K.7
-
18
-
-
76149144996
-
Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism
-
Lee M.S., Hwang J.T., Kim S.H., Yoon S., Kim M.S., Yang H.J., Kwon D.Y. Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism J. Ethnopharmacol. 127 2010 771 776
-
(2010)
J. Ethnopharmacol.
, vol.127
, pp. 771-776
-
-
Lee, M.S.1
Hwang, J.T.2
Kim, S.H.3
Yoon, S.4
Kim, M.S.5
Yang, H.J.6
Kwon, D.Y.7
-
19
-
-
84871717518
-
Phytochemicals and their impact on adipose tissue inflammation and diabetes
-
Leiherer A., Mündlein A., Drexel H. Phytochemicals and their impact on adipose tissue inflammation and diabetes Vascul. Pharmacol. 58 2013 3 20
-
(2013)
Vascul. Pharmacol.
, vol.58
, pp. 3-20
-
-
Leiherer, A.1
Mündlein, A.2
Drexel, H.3
-
20
-
-
84857232727
-
New triterpenoids from the leaves of Cyclocarya paliurus
-
Li S., Cui B., Liu Q., Tang L., Yang Y., Jin X., Shen Z. New triterpenoids from the leaves of Cyclocarya paliurus Planta Med. 78 2012 290 296
-
(2012)
Planta Med.
, vol.78
, pp. 290-296
-
-
Li, S.1
Cui, B.2
Liu, Q.3
Tang, L.4
Yang, Y.5
Jin, X.6
Shen, Z.7
-
21
-
-
80052167163
-
Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase
-
Li S., Li J., Guan X.L., Li J., Deng S.P., Li L.Q., Tang M.T., Huang J.G., Chen Z.Z., Yang R.Y. Hypoglycemic effects and constituents of the barks of Cyclocarya paliurus and their inhibiting activities to glucosidase and glycogen phosphorylase Fitoterapia 82 2011 1081 1085
-
(2011)
Fitoterapia
, vol.82
, pp. 1081-1085
-
-
Li, S.1
Li, J.2
Guan, X.L.3
Li, J.4
Deng, S.P.5
Li, L.Q.6
Tang, M.T.7
Huang, J.G.8
Chen, Z.Z.9
Yang, R.Y.10
-
22
-
-
84899157465
-
Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats
-
Li Y., Wang J., Gu T., Yamahara J., Li Y. Oleanolic acid supplement attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt signaling pathway in rats Toxicol. Appl. Pharmacol. 277 2014 155 163
-
(2014)
Toxicol. Appl. Pharmacol.
, vol.277
, pp. 155-163
-
-
Li, Y.1
Wang, J.2
Gu, T.3
Yamahara, J.4
Li, Y.5
-
23
-
-
79960318828
-
Modified Si-Miao-San extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKKβ/IRS-1/Akt-dependent pathway
-
Liu K., Luo T., Zhang Z., Wang T., Kou J., Liu B., Huang F. Modified Si-Miao-San extract inhibits inflammatory response and modulates insulin sensitivity in hepatocytes through an IKKβ/IRS-1/Akt-dependent pathway J. Ethnopharmacol. 136 2011 473 479
-
(2011)
J. Ethnopharmacol.
, vol.136
, pp. 473-479
-
-
Liu, K.1
Luo, T.2
Zhang, Z.3
Wang, T.4
Kou, J.5
Liu, B.6
Huang, F.7
-
24
-
-
77952700957
-
Berberine suppresses neuroinflammatory responses through AMPactivated protein kinase activation in BV-2 microglia
-
Lu D.Y., Tang C.H., Chen Y.H., Wei I.H. Berberine suppresses neuroinflammatory responses through AMPactivated protein kinase activation in BV-2 microglia J. Cell. Biochem. 110 2010 697 705
-
(2010)
J. Cell. Biochem.
, vol.110
, pp. 697-705
-
-
Lu, D.Y.1
Tang, C.H.2
Chen, Y.H.3
Wei, I.H.4
-
25
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
Lumeng C.N., Saltiel A.R. Inflammatory links between obesity and metabolic disease J. Clin. Invest. 121 2011 2111 2117
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
26
-
-
0024160877
-
Role of insulin resistance in human disease
-
Reaven G.M. Role of insulin resistance in human disease Diabetes 37 1988 1595 1607
-
(1988)
Diabetes
, vol.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
27
-
-
74949121815
-
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC
-
Sajan M.P., Bandyopadhyay G., Miura A., Standaert M., Nimal S., Longnus S.L., Van Obberghen E., Hainault I., Foufelle F., Kahn R. AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC Am. J. Physiol-Endoc. M. 298 2010 E179 E192
-
(2010)
Am. J. Physiol-Endoc. M.
, vol.298
, pp. E179-E192
-
-
Sajan, M.P.1
Bandyopadhyay, G.2
Miura, A.3
Standaert, M.4
Nimal, S.5
Longnus, S.L.6
Van Obberghen, E.7
Hainault, I.8
Foufelle, F.9
Kahn, R.10
-
28
-
-
50349099779
-
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
-
Sakamoto K., Holman G.D. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic Am. J. Physiol-Endoc. M. 295 2008 E29 E37
-
(2008)
Am. J. Physiol-Endoc. M.
, vol.295
, pp. E29-E37
-
-
Sakamoto, K.1
Holman, G.D.2
-
29
-
-
84872925482
-
Opposite effects of quercetin, luteolin, and epigallocatechin gallate on insulin sensitivity under normal and inflammatory conditions in mice
-
Shao L., Liu K., Huang F., Guo X., Wang M., Liu B. Opposite effects of quercetin, luteolin, and epigallocatechin gallate on insulin sensitivity under normal and inflammatory conditions in mice Inflammation 36 2013 1 14
-
(2013)
Inflammation
, vol.36
, pp. 1-14
-
-
Shao, L.1
Liu, K.2
Huang, F.3
Guo, X.4
Wang, M.5
Liu, B.6
-
30
-
-
78149412574
-
Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells
-
Takada K., Nakane T., Masuda K., Ishii H. Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells Phytomedicine 17 2010 1114 1119
-
(2010)
Phytomedicine
, vol.17
, pp. 1114-1119
-
-
Takada, K.1
Nakane, T.2
Masuda, K.3
Ishii, H.4
-
31
-
-
40749137409
-
Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway
-
Tan M.J., Ye J.M., Turner N., Hohnen-Behrens C., Ke C.Q., Tang C.P., Chen T., Weiss H.C., Gesing E.R., Rowland A. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway Chem. Biol. 15 2008 263 273
-
(2008)
Chem. Biol.
, vol.15
, pp. 263-273
-
-
Tan, M.J.1
Ye, J.M.2
Turner, N.3
Hohnen-Behrens, C.4
Ke, C.Q.5
Tang, C.P.6
Chen, T.7
Weiss, H.C.8
Gesing, E.R.9
Rowland, A.10
-
32
-
-
0026063181
-
Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes
-
Vincent M.F., Marangos P.J., Gruber H.E., Van den Berghe G. Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes Diabetes 40 1991 1259 1266
-
(1991)
Diabetes
, vol.40
, pp. 1259-1266
-
-
Vincent, M.F.1
Marangos, P.J.2
Gruber, H.E.3
Van Den Berghe, G.4
-
33
-
-
84883206493
-
Opposite effects of genistein on the regulation of insulinmediated glucose homeostasis in adipose tissue
-
Wang M., Gao X., Zhao W., Zhao W., Jiang C., Huang F., Kou J., Liu B., Liu K. Opposite effects of genistein on the regulation of insulinmediated glucose homeostasis in adipose tissue Br. J. Pharmacol. 170 2013 328 340
-
(2013)
Br. J. Pharmacol.
, vol.170
, pp. 328-340
-
-
Wang, M.1
Gao, X.2
Zhao, W.3
Zhao, W.4
Jiang, C.5
Huang, F.6
Kou, J.7
Liu, B.8
Liu, K.9
-
34
-
-
84889097879
-
Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats
-
Wang Q., Jiang C., Fang S., Wang J., Ji Y., Shang X., Ni Y., Yin Z., Zhang J. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats J. Ethnopharmacol. 150k 2013 1119 1127
-
(2013)
J. Ethnopharmacol.
, vol.150 K
, pp. 1119-1127
-
-
Wang, Q.1
Jiang, C.2
Fang, S.3
Wang, J.4
Ji, Y.5
Shang, X.6
Ni, Y.7
Yin, Z.8
Zhang, J.9
-
35
-
-
0035979775
-
Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ
-
Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., Shoelson S.E. Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ Science 293 2001 1673 1677
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
36
-
-
33845762340
-
Multi-target therapeutics: When the whole is greater than the sum of the parts
-
Zimmermann G.R., Lehar J., Keith C.T. Multi-target therapeutics: when the whole is greater than the sum of the parts Drug Discov. Today 12 2007 34 42
-
(2007)
Drug Discov. Today
, vol.12
, pp. 34-42
-
-
Zimmermann, G.R.1
Lehar, J.2
Keith, C.T.3
|