Effects of pomegranate (punica granatum L.) seed and peel methanolic extracts on oxidative stress and lipid profile changes induced by methotrexate in rats

Advanced Pharmaceutical Bulletin

Volumn 7, Issue 2, 2017, Pages 269-274

  Doostan, Farideh ^a   Vafafar, Roxana ^b   Zakeri Milani, Parvin ^c   Pouri, Aliasghar ^c   Afshar, Rogayeh Amini ^d   Abbasi, Mehran Mesgari ^e  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d URMIA UNIVERSITY   (Iran)

^e TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Methotrexate; Oxidative stress; Pomegranate; Rats

Indexed keywords

ANTIOXIDANT; CATALASE; CHOLESTEROL; FLAVONOID; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; METHANOL; METHOTREXATE; PLACEBO; POMEGRANATE EXTRACT; POMEGRANATE PEEL EXTRACT; POMEGRANATE SEED EXTRACT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; LIPID ANALYSIS; MALE; NONHUMAN; OXIDATIVE STRESS; PLANT SEED; PROTEIN BLOOD LEVEL; RAT;

EID: 85021420852     PISSN: 22285881     EISSN: 22517308     Source Type: Journal    
DOI: 10.15171/apb.2017.032     Document Type: Article

References (26)

1. Gouda M, Moustafa A, Hussein L, Hamza M. Three week dietary intervention using apricots, pomegranate juice or/and fermented sour sobya and impact on biomarkers of antioxidative activity, oxidative stress and erythrocytic glutathione transferase activity among adults. Nutr J 2016;15(1):52. doi: 10.1186/s12937-016-0173-x
2. Czerska M, Mikolajewska K, Zielinski M, Gromadzinska J, Wasowicz W. Today's oxidative stress markers. Med Pr 2015;66(3):393-405. doi: 10.13075/mp.5893.00137
3. Chan ES, Cronstein BN. Mechanisms of action of methotrexate. Bull Hosp Jt Dis 2013;71 Suppl 1:S5-8
4. Braun J, Rau R. An update on methotrexate. Curr Opin Rheumatol 2009;21(3):216-23. doi: 10.1097/BOR.0b013e328329c79d
5. Jahovic N, Cevik H, Sehirli AO, Yegen BC, Sener G. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. J Pineal Res 2003;34(4):282-7
6. Coomes E, Chan ES, Reiss AB. Methotrexate in atherogenesis and cholesterol metabolism. Cholesterol 2011;2011:503028. doi: 10.1155/2011/503028
7. Wang JY, Zhu C, Qian TW, Guo H, Wang DD, Zhang F, et al. Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice. Exp Ther Med 2015;9(1):43-8. doi: 10.3892/etm.2014.2040
8. Braidy N, Selvaraju S, Essa MM, Vaishnav R, AlAdawi S, Al-Asmi A, et al. Neuroprotective effects of a variety of pomegranate juice extracts against mptp-induced cytotoxicity and oxidative stress in human primary neurons. Oxid Med Cell Longev 2013;2013:685909. doi: 10.1155/2013/685909
9. Spilmont M, Leotoing L, Davicco MJ, Lebecque P, Mercier S, Miot-Noirault E, et al. Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis. Eur J Nutr 2014;53(5):1155-64. doi: 10.1007/s00394-013-0615-6
10. Mesgari Abbasi M, Heidari R, Amini afshari R, Zakeri milani P, Ghamarzad Shishavan N. Effects of pomegranate seed methanolic extract on methotrexate-induced changes in rat liver antioxidant compounds. Curr Top Nutraceutr 2015;13(3):153-9
11. Ghasemi Pirbalouti A, Siahpoosh A, Setayesh M, Craker L. Antioxidant activity, total phenolic and flavonoid contents of some medicinal and aromatic plants used as herbal teas and condiments in iran. J Med Food 2014;17(10):1151-7. doi: 10.1089/jmf.2013.0057
12. Vador N, Vador B, Hole R. Simple spectrophotometric methods for standardizing ayurvedic formulation. Indian J Pharm Sci 2012;74(2):161-3. doi: 10.4103/0250-474X.103852
13. Modaresi A, Nafar M, Sahraei Z. Oxidative stress in chronic kidney disease. Iran J Kidney Dis 2015;9(3):165-79
14. de Andrade KQ, Moura FA, dos Santos JM, de Araujo OR, de Farias Santos JC, Goulart MO. Oxidative stress and inflammation in hepatic diseases: Therapeutic possibilities of nacetylcysteine. Int J Mol Sci 2015;16(12):30269-308. doi: 10.3390/ijms161226225
15. Otunctemur A, Ozbek E, Cakir SS, Polat EC, Dursun M, Cekmen M, et al. Pomegranate extract attenuates unilateral ureteral obstruction-induced renal damage by reducing oxidative stress. Urol Ann 2015;7(2):166-71. doi: 10.4103/0974-7796.150488
16. Elango T, Dayalan H, Gnanaraj P, Malligarjunan H, Subramanian S. Impact of methotrexate on oxidative stress and apoptosis markers in psoriatic patients. Clin Exp Med 2014;14(4):431-7. doi: 10.1007/s10238-013-0252-7
17. Kumar D, Singh S, Singh AK, Rizvi SI. Pomegranate (punica granatum) peel extract provides protection against mercuric chloride-induced oxidative stress in wistar strain rats. Pharm Biol 2013;51(4):441-6. doi: 10.3109/13880209.2012.738333
18. Al-Saleh E, Al-Harmi J, Nandakumaran M, AlShammari M, Al-Jassar W. Effect of methotrexate administration on status of some essential trace elements and antioxidant enzymes in pregnant rats in late gestation. Gynecol Endocrinol 2009;25(12):816-22. doi: 10.3109/09513590903056811
19. Shema-Didi L, Kristal B, Ore L, Shapiro G, Geron R, Sela S. Pomegranate juice intake attenuates the increase in oxidative stress induced by intravenous iron during hemodialysis. Nutr Res 2013;33(6):442-6. doi: 10.1016/j.nutres.2013.04.004
20. Faria A, Monteiro R, Mateus N, Azevedo I, Calhau C. Effect of pomegranate (punica granatum) juice intake on hepatic oxidative stress. Eur J Nutr 2007;46(5):271-8. doi: 10.1007/s00394-007-0661-z
21. Kilic S, Emre S, Metin A, Isikoglu S, Erel O. Effect of the systemic use of methotrexate on the oxidative stress and paraoxonase enzyme in psoriasis patients. Arch Dermatol Res 2013;305(6):495-500. doi: 10.1007/s00403-013-1366-1
22. Chen DY, Chih HM, Lan JL, Chang HY, Chen WW, Chiang EP. Blood lipid profiles and peripheral blood mononuclear cell cholesterol metabolism gene expression in patients with and without methotrexate treatment. BMC Med 2011;9:4. doi: 10.1186/1741-7015-9-4
23. Navarro-Millan I, Charles-Schoeman C, Yang S, Bathon JM, Bridges SL, Jr., Chen L, et al. Changes in lipoproteins associated with methotrexate or combination therapy in early rheumatoid arthritis: Results from the treatment of early rheumatoid arthritis trial. Arthritis Rheum 2013;65(6):1430-8. doi: 10.1002/art.37916
24. Saiki O, Takao R, Naruse Y, Kuhara M, Imai S, Uda H. Infliximab but not methotrexate induces extrahigh levels of vldl-triglyceride in patients with rheumatoid arthritis. J Rheumatol 2007;34(10):1997-2004
25. Rom O, Volkova N, Nandi S, Jelinek R, Aviram M. Pomegranate juice polyphenols induce macrophage death via apoptosis as opposed to necrosis induced by free radical generation: A central role for oxidative stress. J Cardiovasc Pharmacol 2016;68(2):106-14. doi: 10.1097/FJC.0000000000000391
26. Tapias V, Cannon JR, Greenamyre JT. Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in parkinson's disease. Neurobiol Aging 2014;35(5):1162-76. doi: 10.1016/j.neurobiolaging.2013.10.077