MicroRNA profile in patients with Alzheimer's disease: Analysis of miR-9-5p and miR-598 in raw and exosome enriched cerebrospinal fluid samples

Journal of Alzheimer's Disease

Volumn 57, Issue 2, 2017, Pages 483-491

  Riancho, Javier ^a   Vázquez Higuera, José Luis ^a   Pozueta, Ana ^a   Lage, Carmen ^a   Kazimierczak, Martha ^a   Bravo, María ^a   Calero, Miguel ^b   González, Andrea ^a   Rodríguez, Eloy ^a   Lleó, Alberto ^c   Sánchez Juan, Pascual ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

Alzheimer's disease; Biomarkers; Exosomes; microRNAs

Indexed keywords

BIOLOGICAL MARKER; MAPT PROTEIN, HUMAN; MICRORNA; MIRN-598 MICRORNA, HUMAN; MIRN134 MICRORNA, HUMAN; MIRN92 MICRORNA, HUMAN; TAU PROTEIN;

AGED; ALZHEIMER DISEASE; CEREBROSPINAL FLUID; COHORT ANALYSIS; EXOSOME; FEMALE; HUMAN; MALE; METABOLISM;

AGED; ALZHEIMER DISEASE; BIOMARKERS; COHORT STUDIES; EXOSOMES; FEMALE; HUMANS; MALE; MICRORNAS; TAU PROTEINS;

EID: 85021308107     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-161179     Document Type: Article

References (35)

1. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: Prevalence estimates using the 2000 census. Arch Neurol 60, 1119-1122.
2. Miller BL, Boeve BF (2013) The Behavioral Neurology of Dementia. Cambridge University Press, Cambridge.
3. BatemanR(2015) Alzheimer's disease and other dementias: Advances in 2014. Lancet Neurol 14, 4-6.
4. Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ (2010) Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 9, 119-128.
5. Jack CR Jr, Therneau TM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ (2016) Transition rates between amyloid and neurodegeneration biomarker states and to dementia: A population-based, longitudinal cohort study. Lancet Neurol 15, 56-64.
6. Riancho J, Del Real A, Riancho JA (2016) How to interpret epigenetic association studies: A guide for clinicians. Bonekey Rep 5, 797.
7. Ha M, KimVN(2014) Regulation of microRNAbiogenesis. Nat Rev Mol Cell Biol 15, 509-524.
8. Erson AE, Petty EM (2008) MicroRNAs in development and disease. Clin Genet 74, 296-306.
9. Properzi F, Ferroni E, Poleggi A, Vinci R (2015) The regulation of exosome function in the CNS: Implications for neurodegeneration. Swiss Med Wkly 145, w14204.
10. Denk J, Boelmans K, Siegismund C, Lassner D, Arlt S, JahnH(2015) MicroRNAProfiling of CSF reveals potential biomarkers to detect Alzheimer's disease. PLoS One 10, e0126423.
11. Burgos K, Malenica I, Metpally R, Courtright A, Rakela B, Beach T (2014) Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology. PLoS One 9, e94839.
12. Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T (2014) MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease. J Alzheimers Dis 39, 253-259.
13. Cosin-Tomas M, Antonell A, Llado A, Alcolea D, Fortea J, Ezquerra M, Lleo A, Martí MJ, Pallas M, Sánchez-Valle R, Molinuevo JL, Sanfeliu C, Kaliman P (2016) Plasma miR-34a-5p and miR-545-3p as early biomarkers of Alzheimer's disease: Potential and limitations. Mol Neurobiol, doi: 10.1007/s12035-016-0088-8 [Epub ahead of print]
14. Keller A, Backes C, Haas J, Leidinger P, Maetzler W, Deuschle C, Berg D, Ruschil C, Galata V, Ruprecht K, Stähler C, Würstle M, Sickert D, Gogol M, Meder B, Meese E (2016) Validating Alzheimer's disease micro RNAs using next-generation sequencing. Alzheimers Dement 12, 565-576.
15. Kumar S, Reddy PH (2016) Are circulating microRNAs peripheral biomarkers for Alzheimer's disease? Biochim Biophys Acta 1862, 1617-1627.
16. van Harten AC, Mulders J, Scheltens P, van der Flier WM, Oudejans CB (2015) Differential expression of microRNA in cerebrospinal fluid as a potential novel biomarker for Alzheimer's disease. J Alzheimers Dis 47, 243-252.
17. Muller M, Jakel L, Bruinsma IB, Claassen JA, Kuiperij HB, Verbeek MM (2016) MicroRNA-29a is a candidate biomarker for Alzheimer's disease in cell-free cerebrospinal fluid. Mol Neurobiol 53, 2894-2899.
18. Liu CG, Song J, Zhang YQ, Wang PC (2014) MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease. Mol Med Rep 10, 2395-2400.
19. Sala FC, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe R, Wallin A, Bjerke M, Zetterberg H, Blennow K, De Strooper B (2013) Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology 81, 2103-2106.
20. Lusardi TA, Phillips JI, Wiedrick JT, Harrington CA, Lind B, Lapidus JA, Quinn JF, Saugstad JA (2017) MicroRNAs in human cerebrospinal fluid as biomarkers for Alzheimer's disease. J Alzheimers Dis 55, 1223-1233.
21. Muller M, Kuiperij HB, Versleijen AA, Chiasserini D, Farotti L, Baschieri F, Parnetti L, Struyfs H, De Roeck N, Luyckx J, Engelborghs S, Claassen JA, VerbeekMM(2016) Validation of microRNAs in cerebrospinal fluid as biomarkers for different forms of dementia in a multicenter study. J Alzheimers Dis 52, 1321-1333.
22. Dangla-Valls A, Molinuevo JL, Altirriba J, Sanchez-Valle R, Alcolea D, Fortea J Rami L, Balasa M, Muñoz-García C, Ezquerra M, Fernández-Santiago R, Lleó A, Lladó A, Antonell A (2016) CSF microRNA profiling in Alzheimer's disease: A screening and validation study. Mol Neurobiol, doi: 10.1007/s12035-016-0106-x [Epub ahead of print]
23. Kalani A, Tyagi A, Tyagi N (2014) Exosomes: Mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol 49, 590-600.
24. Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry WT Jr, Carter BS, Krichevsky AM, Breakefield XO (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10, 1470-1476.
25. Lugli G, Cohen AM, Bennett DA, Shah RC, Fields CJ, Hernandez AG, Smalheiser NR (2015) Plasma exosomal miRNAs in persons with and without Alzheimer disease: Altered expression and prospects for biomarkers. PLoS One 10, e0139233.
26. Riancho J, Gonzalo I, Ruiz-Soto M, Berciano J (2016) Why do motor neurons degenerate? Actualization in the pathogenesis of amyotrophic lateral sclerosis. Neurologia, doi: 10.1016/j.nrl.2015.12.001 [Epub ahead of print]
27. Van GiauV, An SS (2016) Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease. J Neurol Sci 360, 141-152.
28. Gui Y, Liu H, Zhang L, Lv W, Hu X (2015) Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget 6, 37043-37053.
29. Kalani A, Tyagi A, Tyagi N (2014) Exosomes: Mediators of neurodegeneration, neuroprotection and therapeutics. Mol Neurobiol 49, 590-600.
30. Alcolea D, Martinez-Lage P, Sanchez-Juan P, Olazaran J, Antunez C, Izagirre A, Ecay-Torres M, Estanga A, Clerigué M, Guisasola MC, Sánchez Ruiz D, Marín Muñoz J, Calero M, Blesa R, Clarimón J, Carmona-Iragui M, Morenas-Rodríguez E, Rodríguez-Rodríguez E, Vázquez Higuera JL, Fortea J, Lleó A (2015) Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease. Neurology 85, 626-633.
31. Lewczuk P, Kornhuber J, Wiltfang J (2006) The German Competence Net Dementias: Standard operating procedures for the neurochemical dementia diagnostics. J Neural Transm (Vienna) 113, 1075-1080.
32. Tan L, Yu JT, Tan MS, Liu QY, Wang HF, Zhang W, Jian T, Tan L (2012) Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. J Alzheimers Dis 40, 1017-1027.
33. Alexandrov PN, Dua P, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ (2012) microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). Int J Biochem Mol Biol 3, 365-373.
34. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D (2015) Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology 85, 40-47.
35. Howitt J, Hill AF (2016) Exosomes in the pathology of neurodegenerative diseases. J BiolChem291, 26589-26597.