Metal transporter Zip14 (Slc39a14) deletion in mice increases manganese deposition and produces neurotoxic signatures and diminished motor activity

Journal of Neuroscience

Volumn 37, Issue 25, 2017, Pages 5996-6006

  Aydemir, Tolunay Beker ^a   Kim, Min Hyun ^a   Kim, Jinhee ^a   Colon Perez, Luis M ^b,c   Banan, Guita ^c   Mareci, Thomas H ^b,c   Febo, Marcelo ^b,c   Cousins, Robert J ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Dystonia; Neurodegeneration; Neuroinflammation; Parkinson s; Transport; Zinc

Indexed keywords

MANGANESE; ZINC; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; SLC39A14 PROTEIN, MOUSE;

ABLATION THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; EXPERIMENTAL LOCOMOTOR ACTIVITY TEST; FEMALE; GASTROINTESTINAL TRACT FUNCTION; GENE DELETION; GENE INACTIVATION; GENE MUTATION; MALE; MANGANESE METABOLISM; METAL METABOLISM; MINERAL SUPPLEMENTATION; MOTOR ACTIVITY; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; WESTERN BLOTTING; ZINC HOMEOSTASIS; ZINC METABOLISM; ANIMAL; BRAIN CHEMISTRY; C57BL MOUSE; GASTROINTESTINAL MOTILITY; GENETICS; INTOXICATION; KNOCKOUT MOUSE; LIVER; METABOLISM; TISSUE DISTRIBUTION;

ANIMALS; BRAIN CHEMISTRY; CATION TRANSPORT PROTEINS; FEMALE; GASTROINTESTINAL MOTILITY; LIVER; MALE; MANGANESE; MANGANESE POISONING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; TISSUE DISTRIBUTION; ZINC;

EID: 85021160153     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0285-17.2017     Document Type: Article

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