Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages 11714-11719

  Chen, Alan C ^a   Donovan, Adriana ^b   Ned Sykes, Renee ^c   Andrews, Nancy C ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Scholar Rock   (United States)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

Epithelial mesenchymal transition; Homeostasis; Intestinal epithelium; Stem cell; Transferrin receptor

Indexed keywords

CD34 ANTIGEN; CD71 ANTIGEN; CHYLOMICRON; DCLK1 PROTEIN; FABP7 PROTEIN; FOXO4 PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HERMES ANTIGEN; IRON DEXTRAN; KI 67 ANTIGEN; KIT PROTEIN; LY6A PROTEIN; LYMPHOID ENHANCER FACTOR 1; MAZ PROTEIN; MESSENGER RNA; NDN PROTEIN; NOTCH RECEPTOR; OSTEOGENIC PROTEIN 1; PROM1 PROTEIN; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SONIC HEDGEHOG PROTEIN; TAMOXIFEN; THY1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR PLAGL2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN; IRON; TFRC PROTEIN, MOUSE; TRANSFERRIN RECEPTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FATE; CELL PROLIFERATION; CONTROLLED STUDY; DIARRHEA; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION PROFILING; HOMEOSTASIS; INTESTINAL HOMEOSTASIS; INTESTINE EPITHELIUM CELL; INTESTINE FUNCTION; IRON OVERLOAD; LAMINA PROPRIA; LIPID STORAGE; MALE; MISSENSE MUTATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STOMACH DISTENSION; UPREGULATION; WEIGHT REDUCTION; ALLELE; ANIMAL; BRAIN; CYTOLOGY; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; GENOTYPE; INTESTINE; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; MUTATION; PHYSIOLOGY; STEM CELL;

ALLELES; ANIMALS; BRAIN; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; HOMEOSTASIS; INTESTINAL MUCOSA; INTESTINES; IRON; MALE; MICE; MICE, KNOCKOUT; MUTATION; PHENOTYPE; RECEPTORS, TRANSFERRIN; RECOMBINATION, GENETIC; STEM CELLS;

EID: 84941687366     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1511701112     Document Type: Article

References (42)

1. Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: Molecular control of mammalian iron metabolism. Cell 117(3):285-297.
2. Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC (1999) Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21(4):396-399.
3. Ned RM, Swat W, Andrews NC (2003) Transferrin receptor 1 is differentially required in lymphocyte development. Blood 102(10):3711-3718.
4. Trenor CC, 3rd, Campagna DR, Sellers VM, Andrews NC, Fleming MD (2000) The molecular defect in hypotransferrinemic mice. Blood 96(3):1113-1118.
5. Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC (2008) The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab 7(3):205-214.
6. Matysiak-Budnik T, et al. (2008) Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J Exp Med 205(1): 143-154.
7. Cao H, Chen J, Krueger EW, McNiven MA (2010) SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Mol Cell Biol 30(3):781-792.
8. Collawn JF, et al. (1993) YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis. J Biol Chem 268(29):21686-21692.
9. Ferrando IM, et al. (2012) Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. Mol Cell Proteomics 11(8):355-369.
10. Clevers H (2013) The intestinal crypt, a prototype stem cell compartment. Cell 154(2): 274-284.
11. Levine DS, Woods JW (1990) Immunolocalization of transferrin and transferrin receptor in mouse small intestinal absorptive cells. J Histochem Cytochem 38(6):851-858.
12. Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341(26):1986-1995.
13. el Marjou F, et al. (2004) Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis 39(3):186-193.
14. McKie AT, et al. (2001) An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291(5509):1755-1759.
15. Sanchez M, et al. (2006) Iron regulation and the cell cycle: Identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem 281(32): 22865-22874.
16. Subramanian A, et al. (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545-15550.
17. Mootha VK, et al. (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34(3): 267-273.
18. Eastman Q, Grosschedl R (1999) Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol 11(2):233-240.
19. Essers MA, et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308(5725):1181-1184.
20. Ross DA, Kadesch T (2001) The notch intracellular domain can function as a co-activator for LEF-1. Mol Cell Biol 21(22):7537-7544.
21. Katoh M (2007) Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cell Rev 3(1):30-38.
22. Perez-Pinera P, Alcantara S, Dimitrov T, Vega JA, Deuel TF (2006) Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesen-chymal transition. Proc Natl Acad Sci USA 103(47):17795-17800.
23. Cicchini C, et al. (2015) Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte. Liver Int 35(2):302-310.
24. Dong C, et al. (2013) Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell 23(3):316-331.
25. Anastassiou D, et al. (2011) Human cancer cells express Slug-based epithelial-mes-enchymal transition gene expression signature obtained in vivo. BMC Cancer 11:529.
26. Van Dyck F, et al. (2007) Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab 6(5):406-413.
27. Mattia E, Rao K, Shapiro DS, Sussman HH, Klausner RD (1984) Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells. J Biol Chem 259(5):2689-2692.
28. Chen Z, et al. (2012) The iron chelators Dp44mT and DFO inhibit TGF-β-induced epi-thelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). J Biol Chem 287(21):17016-17028.
29. Zheng H, et al. (2010) PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509.
30. Der Vartanian A, et al. (2015) Protein O-fucosyltransferase 1 expression impacts myogenic C2C12 cell commitment via the Notch signaling pathway. Mol Cell Biol 35(2):391-405.
31. Lamouille S, Xu J, Derynck R (2014) Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol 15(3):178-196.
32. Batista A, Millán J, Mittelbrunn M, Sánchez-Madrid F, Alonso MA (2004) Recruitment of transferrin receptor to immunological synapse in response to TCR engagement. J Immunol 172(11):6709-6714.
33. Salmerón A, et al. (1995) Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain. J Immunol 154(4):1675-1683.
34. Kenneth NS, Mudie S, Naron S, Rocha S (2013) TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling. Biochem J 449(1):275-284.
35. Pham DH, et al. (2014) Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1. Oncogene 33(48):5559-5568.
36. Kasibhatla S, et al. (2005) A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci USA 102(34):12095-12100.
37. Jian J, Yang Q, Huang X (2011) Src regulates Tyr(20) phosphorylation of transferrin re-ceptor-1 and potentiates breast cancer cell survival. J Biol Chem 286(41):35708-35715.
38. Senyilmaz D, et al. (2015) Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature, 10.1038/nature14601.
39. Sancho R, et al. (2009) JNK signalling modulates intestinal homeostasis and tu-mourigenesis in mice. EMBO J 28(13):1843-1854.
40. Gonzalez DM, Medici D (2014) Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal 7(344):re8.
41. McDevitt MA, Fujiwara Y, Shivdasani RA, Orkin SH (1997) An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice. Proc Natl Acad Sci USA 94(15): 7976-7981.
42. Torrance JD, Bothwell TH (1968) A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci 33(1):9-11.