Corn silk maysin ameliorates obesity in vitro and in vivo via suppression of lipogenesis, differentiation, and function of adipocytes

Biomedicine and Pharmacotherapy

Volumn 93, Issue , 2017, Pages 267-275

  Lee, Chang Won ^a   Seo, Jeong Yeon ^a   Kim, Sun Lim ^b   Lee, Jisun ^a   Choi, Ji Won ^a   Park, Yong Il ^a  

^a The Catholic University of Korea   (South Korea)

^b National Institute of Animal Science   (South Korea)

Author keywords

Adipocytes; Anti obesity; Corn silk; High fat diet mice; Maysin

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOBESITY AGENT; ASPARTATE AMINOTRANSFERASE; CASPASE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; FLAVONOID; GLUCOSE; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAYSIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLUCOSIDE;

3T3-L1 CELL LINE; ADIPOCYTE; ADIPOSE TISSUE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY COMPOSITION; BODY WEIGHT; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; ENZYME ACTIVATION; EPIDIDYMIS FAT; FAT MASS; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; LIPID STORAGE; LIPOGENESIS; LIVER TISSUE; LOW FAT DIET; MAIZE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ADIPOGENESIS; ANIMAL; BODY WEIGHT GAIN; C57BL MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; BODY WEIGHT; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL LINE; CHOLESTEROL, LDL; DIET, HIGH-FAT; FLAVONOIDS; GLUCOSIDES; LIPOGENESIS; MICE; MICE, INBRED C57BL; OBESITY; PPAR GAMMA; TRIGLYCERIDES; WEIGHT GAIN; ZEA MAYS;

EID: 85021099878     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2017.06.039     Document Type: Article

References (35)

1. Pérez, M.R., Medina-Gómez, G., Obesity, adipogenesis and insulin resistance. Endocrinol. Nutr. 58 (2011), 360–369.
2. Sethi, J.K., Vidal-Puig, A.J., Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J. Lipid Res. 48 (2007), 1253–1262.
3. Sorisky, A., Magun, R., Gagnon, A.M., Adipose cell apoptosis: death in the energy depot. Int. J. Obes. Relat. Metab. Disord. 24:Suppl. 4 (2000), S3–S7.
4. Hasanudin, K., Hashim, P., Mustafa, S., Corn silk (Stigma maydis) in healthcare: a phytochemical and pharmacological review. Molecules 17 (2012), 9697–9715.
5. Zhao, W., Yin, Y., Yu, Z., Liu, J., et al. Comparison of anti-diabetic effects of polysaccharides from corn silk on normal and hyperglycemia rats. Int. J. Biol. Macromol. 50 (2012), 1133–1137.
6. Snook, M.E., Gueldner, R.C., Widstrom, N.W., Wiseman, B.R., et al. Levels of maysin and maysin analogs in silks of maize germplasm. J. Agric. Food Chem. 41 (1993), 1481–1485.
7. Lee, E.A., Byrne, P.F., McMullen, M.D., Snook, M.E., et al. Genetic mechanisms underlying apimaysin and maysin synthesis and corn earworm antibiosis in maize (Zea mays L.). Genetics 149 (1998), 1997–2006.
8. Lee, J., Lee, S., Kim, S.L., Choi, J.W., et al. Corn silk maysin induces apoptotic cell death in PC-3 prostate cancer cells via mitochondria-dependent pathway. Life Sci. 119 (2014), 47–55.
9. Choi, D.J., Kim, S.L., Choi, J.W., Park, Y.I., Neuroprotective effects of corn silk maysin via inhibition of H2O2-induced apoptotic cell death in SK-N-MC cells. Life Sci. 109 (2014), 57–64.
10. Lee, J., Kim, S.L., Lee, S., Chung, M.J., Park, Y.I., Immunostimulating activity of maysin isolated from corn silk in murine RAW 264.7 macrophages. BMB Rep. 47 (2014), 382–387.
11. Park, H.J., Chung, B.Y., Lee, M.K., Song, Y., et al. Centipede grass exerts anti-adipogenic activity through inhibition of C/EBPbeta, C/EBPalpha, and PPARgamma expression and the AKT signaling pathway in 3T3-L1 adipocytes. BMC Complement. Altern. Med., 12, 2012, 230.
12. Lee, E.M., Lee, S.S., Chung, B.Y., Cho, J.Y., et al. Pancreatic lipase inhibition by C-glycosidic flavonoids isolated from Eremochloa ophiuroides. Molecules 15 (2010), 8251–8259.
13. Bai, H.W., Lee, E.M., Lee, S.S., Hong, S.H., et al. Drastic enhancement of maysin and maysin derivatives contents in the centipedegrass extracts by different stresses. 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB), IEEE, 2012, 187–189.
14. Kim, J., Lee, I., Seo, J., Jung, M., et al. Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells. Phytother. Res. 24 (2010), 1543–1548.
15. Kim, S.L., Kim, M.J., Lee, Y.Y., Jung, G.H., et al. Isolation and identification of flavonoids from corn silk. Korean J. Crop Sci. 59 (2014), 435–444.
16. Hemati, N., Ross, S.E., Erickson, R.L., Groblewski, G.E., MacDougald, O.A., Signaling pathways through which insulin regulates CCAAT/enhancer binding protein alpha (C/EBPalpha) phosphorylation and gene expression in 3T3-L1 adipocytes. J. Biol. Chem. 272 (1997), 25913–25919.
17. Quan, X., Wang, Y., Ma, X., Liang, Y., et al. Á-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1Cells via inhibiting fatty acid synthase. PLoS One, 7, 2012, e33376.
18. Choi, J.W., Lee, C.W., Lee, J., Choi, D.J., et al. 7,8-Dihydroxyflavone inhibits adipocyte differentiation via antioxidant activity and induces apoptosis in 3T3-L1 preadipocyte cells. Life Sci. 144 (2016), 103–112.
19. Wang, C., Zhang, T., Liu, J., Lu, S., et al. Subchronic toxicity study of corn silk with rats. J. Ethnopharmacol. 137 (2011), 36–43.
20. Antonsson, B., Martinou, J.-C., The bcl-2 protein family. Exp. Cell Res. 256 (2000), 50–57.
21. Kuwana, T., Newmeyer, D.D., Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr. Opin. Cell Biol. 15 (2003), 691–699.
22. Porter, A.G., Janicke, R.U., Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6 (1999), 99–104.
23. Earnshaw, W.C., Martins, L.M., Kaufmann, S.H., Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68 (1999), 383–424.
24. Choi, J.W., Synytsya, A., Capek, P., Bleha, R., et al. Structural analysis and anti-obesity effect of a pectic polysaccharide isolated from Korean mulberry fruit Oddi (Morus alba L.). Carbohydr. Polym. 146 (2016), 187–196.
25. Di Carlo, G., Mascolo, N., Izzo, A.A., Capasso, F., Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci. 65 (1999), 337–353.
26. Wang, I.K., Lin-Shiau, S.Y., Lin, J.K., Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur. J. Cancer 35 (1999), 1517–1525.
27. McNamara, D.J., Dietary cholesterol and atherosclerosis. Biochim. Biophys. Acta 1529 (2000), 310–320.
28. Kao, Y.H., Hiipakka, R.A., Liao, S., Modulation of endocrine systems and Rfood intake by green tea epigallocatechin gallate. Endocrinology 141 (2000), 980–987.
29. Farmer, S.R., Transcriptional control of adipocyte formation. Cell Metab. 4 (2006), 263–273.
30. Picard, F., Kurtev, M., Chung, N., Topark-Ngarm, A., et al. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 (2004), 716–717.
31. Yang, J.Y., Della-Fera, M.A., Rayalam, S., Ambati, S., et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci. 82 (2008), 1032–1039.
32. de Melo, C.L., Queiroz, M.G., Fonseca, S.G., Bizerra, A.M., et al. Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. Chem. Biol. Interact. 185 (2010), 59–65.
33. Fan, S., Zhang, Y., Sun, Q., Yu, L., et al. Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice. J. Nutr. Biochem. 25 (2014), 702–709.
34. Lee, Y.S., Cha, B.Y., Saito, K., Choi, S.S., et al. Effects of a Citrus depressa Hayata (shiikuwasa) extract on obesity in high-fat diet-induced obese mice. Phytomedicine 18 (2011), 648–654.
35. Danforth, E. Jr, Failure of adipocyte differentiation causes type II diabetes mellitus?. Nat. Genet., 26, 2000, 13.