Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication

Virology

Volumn 509, Issue , 2017, Pages 222-231

  Li, Chuntian ^a   Zhu, Zixiang ^a   Du, Xiaoli ^a   Cao, Weijun ^a   Yang, Fan ^a   Zhang, Xiangle ^a   Feng, Huanhuan ^a   Li, Dan ^a   Zhang, Keshan ^a   Liu, Xiangtao ^a   Zheng, Haixue ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

3Cpro; Foot and mouth disease virus; Lysosomes; PKR

Indexed keywords

3C PROTEINASE; INITIATION FACTOR 4G; PROTEIN KINASE R; UNCLASSIFIED DRUG; VIRAL PROTEIN; 3C PROTEASES; CYSTEINE PROTEINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; HOST; HUMAN; HUMAN CELL; KIDNEY CELL; LYSOSOME; MICROBIAL DEGRADATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS REPLICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; ENZYMOLOGY; HOST PATHOGEN INTERACTION; METABOLISM; PATHOGENICITY; PIG; PROTEIN DEGRADATION;

ANIMALS; CELL LINE; CYSTEINE ENDOPEPTIDASES; EIF-2 KINASE; FOOT-AND-MOUTH DISEASE VIRUS; HOST-PATHOGEN INTERACTIONS; LYSOSOMES; PROTEOLYSIS; SWINE; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 85021098349     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2017.06.023     Document Type: Article

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