Foot-and-mouth disease virus leader proteinase: Structural insights into the mechanism of intermolecular cleavage

Virology

Volumn 468, Issue , 2014, Pages 397-408

  Steinberger, Jutta ^a   Grishkovskaya, Irina ^a   Cencic, Regina ^a,c   Juliano, Luiz ^b   Juliano, Maria A ^b   Skern, Tim ^a  

^a MAX F PERUTZ LABORATORIES   (Austria)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Active site; Host cell shut off; Initiation of protein synthesis; Papain like cysteine proteinase; Polyprotein processing; Substrate binding

Indexed keywords

ARGININE; CATHEPSIN B; GLYCINE; INITIATION FACTOR 4G; LYSINE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS LEADER PROTEINASE; LEADER PROTEINASE, FOOT-AND-MOUTH DISEASE VIRUS; VIRUS RNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FOOT AND MOUTH DISEASE VIRUS; MUTATIONAL ANALYSIS; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RESIDUE ANALYSIS; STRUCTURE ANALYSIS; VIRUS REPLICATION; VIRUS VIRULENCE; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION;

FOOT-AND-MOUTH DISEASE VIRUS;

BINDING SITES; CATHEPSIN B; ENDOPEPTIDASES; FOOT-AND-MOUTH DISEASE VIRUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, VIRAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; RNA, VIRAL;

EID: 84907466617     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.08.023     Document Type: Article

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