Autism risk following antidepressant medication during pregnancy

Psychological Medicine

Volumn 47, Issue 16, 2017, Pages 2787-2796

  Viktorin, A ^a,b,c   Uher, R ^d   Reichenberg, A ^a,b   Levine, S Z ^e   Sandin, S ^a,b,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Research and Treatment at Mount Sinai   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d DALHOUSIE UNIVERSITY   (Canada)

^e UNIVERSITY OF HAIFA   (Israel)

Author keywords

Antidepressant; autism; depression; pregnancy; SSRI

Indexed keywords

ANTIDEPRESSANT AGENT;

ANXIETY; AUTISM; CHEMICALLY INDUCED; CHILD; DEPRESSION; FEMALE; HUMAN; MALE; PREGNANCY; PRENATAL EXPOSURE; UNITED STATES;

ANTIDEPRESSIVE AGENTS; ANXIETY; AUTISM SPECTRUM DISORDER; CHILD; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; UNITED STATES;

EID: 85021064034     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291717001301     Document Type: Article

References (34)

1. Andrade SE, Raebel MA, Brown J, Lane K, Livingston J, Boudreau D, Rolnick SJ, Roblin D, Smith DH, Willy ME, Staffa JA, Platt R (2008). Use of antidepressant medications during pregnancy: a multisite study. American Journal of Obstetrics & Gynecology 198, 194e1-194e5.
2. Bakker MK, Kolling P, van den Berg PB, deWalle HE, de Jong van den Berg LT (2008). Increase in use of selective serotonin reuptake inhibitors in pregnancy during the last decade, a population-based cohort study from the Netherlands. British Journal of Clinical Pharmacology 65, 600-606.
3. Boukhris T, Sheehy O, Mottron L, Bérard A (2016). Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatrics 170, 117-124.
4. Castro V, Kong S, Clements C, Brady R, Kaimal A, Doyle A, Robinson E, Churchill S, Kohane I, Perlis R (2016). Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study. Translational Psychiatry 6, e708.
5. Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R,Watanabe N, Nakagawa A, Omori IM, McGuire H, Tansella M, Barbui C (2009). Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 373, 746-758.
6. Clements CC, Castro VM, Blumenthal SR, Rosenfield HR, Murphy SN, Fava M, Erb JL, Churchill SE, Kaimal AJ, Doyle AE (2015). Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system. Molecular Psychiatry 20, 727-734.
7. Cnattingius S, Ericson A, Gunnarskog J, Kallen B (1990). A quality study of a medical birth registry. Scandinavian Journal of Social Medicine 18, 143-148.
8. Croen LA, Grether JK, Yoshida CK, Odouli R, Hendrick V (2011). Antidepressant use during pregnancy and childhood autism spectrum disorders. Archives of General Psychiatry 68, 1104-1112.
9. Efron B, Tibshirani RJ (1994). An Introduction to the Bootstrap. Chapman and Hall/CRC Press: London.
10. Ekbom A (2011). The Swedish multi-generation register. Methods in Molecular Biology 675, 215-220.
11. Gidaya NB, Lee BK, Burstyn I, Yudell M, Mortensen EL, Newschaffer CJ (2014). In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder. Journal of Autism and Developmental Disorders 44, 2558-2567.
12. Grambsch PM, Therneau TM (1994). Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81, 515-526.
13. Harrington RA, Lee L-C, Crum RM, Zimmerman AW, Hertz-Picciotto I (2014). Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay. Pediatrics 133, e1241-e1248.
14. Hogberg U, Larsson N (1997). Early dating by ultrasound and perinatal outcome. A cohort study. Acta Obstetricia et Gynecologica Scandinavica 76, 907-912.
15. Holm S (1979). A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 6, 65-70.
16. Hviid A, Melbye M, Pasternak B (2013). Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. New England Journal of Medicine 369, 2406-2415.
17. Idring S, Rai D, Dal H, Dalman C, Sturm H, Zander E, Lee BK, Serlachius E, Magnusson C (2012). Autism spectrum disorders in the Stockholm Youth Cohort: design, prevalence and validity. PLoS ONE 7, e41280.
18. International Schizophrenia Consortium, Purcell SM,Wray NR, Stone JL, Visscher PM, O'DonovanMC, Sullivan PF, SklarP(2009).Commonpolygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748-752.
19. Jokiranta E, Brown AS, Heinimaa M, Cheslack-Postava K, Suominen A, Sourander A (2013). Parental psychiatric disorders and autism spectrum disorders. Psychiatry Research 207, 203-211.
20. Lecrubier Y (2001). The burden of depression and anxiety in general medicine. Journal of Clinical Psychiatry 62(Suppl. 8), 4-9; discussion 10-1.
21. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM (2009). Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373, 234-239.
22. Ludvigsson JF, Andersson E, Ekbom A, Feychting M, Kim JL, Reuterwall C, Heurgren M, Olausson PO (2011). External review and validation of the Swedish national inpatient register. BMC Public Health 11, 450.
23. Ludvigsson JF, Otterblad-Olausson P, Pettersson BU, Ekbom A (2009). The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research. European Journal of Epidemiology 24, 659-667.
24. Malm H, Brown AS, Gissler M, Gyllenberg D, Hinkka-Yli-Salomaki S, McKeague IW, Weissman M, Wickramaratne P, Artama M, Gingrich JA, Sourander A (2016). Gestational exposure to selective serotonin reuptake inhibitors and offspring psychiatric disorders: a national register-based study. Journal of the American Academy of Child and Adolescent Psychiatry 55, 359-366.
25. Marmorstein NR, Malone SM, Iacono WG (2004). Psychiatric disorders among offspring of depressed mothers: associations with paternal psychopathology. American Journal of Psychiatry 161, 1588-1594.
26. Meltzer-Brody S, Stuebe A (2014). The long-term psychiatric and medical prognosis of perinatal mental illness. Best Practice & Research Clinical Obstetrics & Gynaecology 28, 49-60.
27. O'Hara MW, McCabe JE (2013). Postpartum depression: current status and future directions. Annual Review of Clinical Psychology 9, 379-407.
28. Olfson M, Marcus SC (2009). National patterns in antidepressant medication treatment. Archives of General Psychiatry 66, 848-856.
29. Rai D, Lee BK, Dalman C, Golding J, Lewis G, Magnusson C (2013). Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 346, f2059.
30. Sandin S, Schendel D, Magnusson P, Hultman C, Suren P, Susser E, Gronborg T, Gissler M, Gunnes N, Gross R, Henning M, Bresnahan M, Sourander A, Hornig M, Carter K, Francis R, Parner E, Leonard H, Rosanoff M, Stoltenberg C, Reichenberg A (2016). Autism risk associated with parental age and with increasing difference in age between the parents. Molecular Psychiatry 21, 693-700.
31. Sorensen MJ, Gronborg TK, Christensen J, Parner ET, Vestergaard M, Schendel D, Pedersen LH (2013). Antidepressant exposure in pregnancy and risk of autism spectrum disorders. Clinical Epidemiology 5, 449-459.
32. Sullivan PF, Daly MJ, O'Donovan M (2012). Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nature Reviews Genetics 13, 537-551.
33. Wettermark B, Hammar N, Fored CM, Leimanis A, Otterblad Olausson P, Bergman U, Persson I, Sundstrom A, Westerholm B, Rosen M (2007). The new Swedish Prescribed Drug Register-opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiology and Drug Safety 16, 726-735.
34. WHO (2006). The Anatomical Therapeutic Chemical Classification System with Defined Daily Doses (ATC/DDD). WHO: Oslo.