Autism risk associated with parental age and with increasing difference in age between the parents

Molecular Psychiatry

Volumn 21, Issue 5, 2016, Pages 693-700

  Sandin, S ^a,b,c   Schendel, D ^d,e   Magnusson, P ^a   Hultman, C ^a   Suren P ^f   Susser, E ^g,h   GrOnborg T ^d   Gissler, M ^i,j,k   Gunnes, N ^f   Gross, R ^l,m   Henning, M ⁿ   Bresnahan, M ^g,h   Sourander, A ^k   Hornig, M ^g   Carter, K ^o   Francis, R ^o   Parner, E ^d   Leonard, H ^o   Rosanoff, M ^g,p   Stoltenberg, C ^f,q   Reichenberg, A ^b,c   more..

^a KAROLINSKA INSTITUTE   (Sweden)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d AARHUS UNIVERSITY   (Denmark)

^e Lundbeck Foundation Initiative for Integrative Psychiatric Research IPSYCH   (Denmark)

^f NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^g Columbia University ^*  (United States)

^h NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

ⁱ NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^j NORDIC SCHOOL OF PUBLIC HEALTH   (Sweden)

^k UNIVERSITY OF TURKU   (Finland)

^l TEL AVIV UNIVERSITY   (Israel)

^m SHEBA MEDICAL CENTER   (Israel)

ⁿ V'stra Götaland County   (Sweden)

^o UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^p Autism Speaks Inc   (United States)

^q UNIVERSITY OF BERGEN   (Norway)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUSTRALIA; AUTISM; CHILD; DENMARK; FOLLOW UP; HUMAN; ISRAEL; MAJOR CLINICAL STUDY; MATERNAL AGE; NORWAY; PARENTAL AGE; PATERNAL AGE; PRIORITY JOURNAL; PROGENY; RISK FACTOR; SWEDEN; ADOLESCENT; ADULT; AGED; AUTISTIC DISORDER; COHORT ANALYSIS; FEMALE; MALE; MIDDLE AGED; REGISTER; RISK; SEX DIFFERENCE; STATISTICAL MODEL; WESTERN AUSTRALIA; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AUTISTIC DISORDER; COHORT STUDIES; DENMARK; FEMALE; HUMANS; ISRAEL; LOGISTIC MODELS; MALE; MATERNAL AGE; MIDDLE AGED; NORWAY; PATERNAL AGE; REGISTRIES; RISK; RISK FACTORS; SEX FACTORS; SWEDEN; WESTERN AUSTRALIA; YOUNG ADULT;

EID: 84930787620     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2015.70     Document Type: Article

References (49)

1. Grether JK, Anderson MC, Croen LA, Smith D, Windham GC. Risk of autism and increasing maternal and paternal age in a large north American population. Am J Epidemiol 2009; 170: 1118-1126
2. Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A. Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-Analysis of epidemiological studies. Mol Psychiatry 2011; 16: 1203-1212
3. Parner ET, Baron-Cohen S, Lauritsen MB, Jørgensen M, Schieve LA, Yeargin-Allsopp M et al. Parental age and autism spectrum disorders. Ann Epidemiol 2012; 22: 143-150
4. McGrath JJ, Petersen L, Agerbo E, Mors O, Mortensen PB, Pedersen CB. A comprehensive assessment of parental age and psychiatric disorders. JAMA Psychiatry 2014; 71: 301-309
5. D'Onofrio BM, Rickert ME, Frans E, Kuja-Halkola R, Almqvist C, Sjölander A et al. Paternal age at childbearing and offspring psychiatric and academic morbidity. JAMA Psychiatry 2014; 71: 432-438
6. Sandin S, Hultman CM, Kolevzon A, Gross R, Maccabe JH, Reichenberg A. Advancing maternal age is associated with increasing risk for autism: a review and meta-Analysis. J Am Acad Child Adolesc Psychiatry 2012; 51: 477-486.e1
7. Durkin MS, Maenner MJ, Newschaffer CJ, Lee L-C, Cunniff CM, Daniels JL et al. Advanced parental age and the risk of autism spectrum disorder. Am J Epidemiol 2008; 168: 1268-1276
8. Shelton JF, Tancredi DJ, Hertz-Picciotto I. Independent and dependent contributions of advanced maternal and paternal ages to autism risk. Autism Res 2010; 3: 30-39
9. Malaspina D, Harlap S, Fennig S, Heiman D, Nahon D, Feldman D et al. Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry 2001; 58: 361-367
10. Ek M, Wicks S, Svensson AC, Idring S, Dalman C. Advancing paternal age and schizophrenia: the impact of delayed fatherhood. Schizophr Bull 2014; 41: 708-714
11. Bourne H. Parental age difference and schizophrenia. Br J Psychiatry 2004; 184: 540-541
12. Kinzler WL, Ananth CV, Smulian JC, Vintzileos AM. Parental age difference and adverse perinatal outcomes in the United States. Paediatr Perinat Epidemiol 2002; 16: 320-327
13. Schendel DE, Bresnahan M, Carter KW, Francis RW, Gissler M, Grønborg TK et al. The International Collaboration for Autism Registry Epidemiology (iCARE): multinational registry-based investigations of autism risk factors and trends. J Autism Dev Disord 2013; 43: 2650-2663
14. Elsabbagh M, Divan G, Koh Y-J, Kim YS, Kauchali S, Marcín C et al. Global prevalence of autism and other pervasive developmental disorders. Autism Res 2012; 5: 160-179
15. Ronald A, Hoekstra RA. Autism spectrum disorders and autistic traits: a decade of new twin studies. Am J Med Genet Part B Neuropsychiatr Genet 2011; 156B: 255-274
16. Ananth CV, Chauhan SP. Epidemiology of twinning in developed countries. Semin Perinatol 2012; 36: 156-161
17. Smith PL. Splines as a useful and convenient statistical tool. Am Stat 1979; 33: 57-62
18. Hastie T, Tibshirani R, Friedman J. The Elements of Statistical Learning: Data Mining, Inference, and Prediction. 2nd Springer: 2009. Corr. 3rd printing, 5th Printing
19. Borgan O, Langholz B, Samuelsen SO, Goldstein L, Pogoda J. Exposure stratified case-cohort designs. Lifetime Data Anal 2000; 6: 39-58
20. Barlow WE. Robust variance estimation for the case-cohort design. Biometrics 1994; 50: 1064-1072
21. Wood SN. Thin plate regression splines. J R Stat Soc Ser B Stat Methodol 2003; 65: 95-114
22. Korn EL, Graubard BI, Midthune D. Time-To-event analysis of longitudinal follow-up of a survey: choice of the time-scale. Am J Epidemiol 1997; 145: 72-80
23. Wood S, Scheipl F gamm4: Generalized additive mixed models using mgcv and lme4. 2013. Available at http://cran.r-project.org/web/packages/gamm4/index. html (accessed 13 September 2013
24. Anon. Development Core Team, R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2005. Available at http://www.R-project.org (accessed 10 November 2011
25. Chakrabarti S, Fombonne E. Pervasive developmental disorders in preschool children: confirmation of high prevalence. Am J Psychiatry 2005; 162: 1133-1141
26. Carlsson LH, Norrelgen F, Kjellmer L, Westerlund J, Gillberg C, Fernell E. Coexisting disorders and problems in preschool children with autism spectrum disorders. Sci World J 2013; 2013: 213979
27. Idring S, Magnusson C, Lundberg M, Ek M, Rai D, Svensson AC et al. Parental age and the risk of autism spectrum disorders: findings from a Swedish populationbased cohort. Int J Epidemiol 2014; 43: 107-115
28. Sandin S, Nygren K-G, Iliadou A, Hultman CM, Reichenberg A. Autism and mental retardation among offspring born after in vitro fertilization. JAMA 2013; 310: 75-84
29. Kong A, Frigge ML, Masson G, Besenbacher S, Sulem P, Magnusson G et al. Rate of de novo mutations and the importance of father's age to disease risk. Nature 2012; 488: 471-475
30. Reichenberg A, Gross R, Weiser M, Bresnahan M, Silverman J, Harlap S et al. Advancing paternal age and autism. Arch Gen Psychiatry 2006; 63: 1026-1032
31. Flatscher-Bader T, Foldi CJ, Chong S, Whitelaw E, Moser RJ, Burne THJ et al. Increased de novo copy number variants in the offspring of older males. Transl Psychiatry 2011; 1: e34
32. Martin RH. Meiotic errors in human oogenesis and spermatogenesis. Reprod Biomed Online 2008; 16: 523-531
33. Ginsburg C, Fokstuen S, Schinzel A. The contribution of uniparental disomy to congenital development defects in children born to mothers at advanced childbearing age. Am J Med Genet 2000; 95: 454-460
34. Kaytor MD, Burright EN, Duvick LA, Zoghbi HY, Orr HT. Increased trinucleotide repeat instability with advanced maternal age. Hum Mol Genet 1997; 6: 2135-2139
35. Bill BR, Geschwind DH. Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr Opin Genet Dev 2009; 19: 271-278
36. Larsson HJ, Eaton WW, Madsen KM, Vestergaard M, Olesen AV, Agerbo E et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol 2005; 161: 916-925, discussion 926-928
37. Piven J, Palmer P, Jacobi D, Childress D, Arndt S. Broader autism phenotype: evidence from a family history study of multiple-incidence autism families. Am J Psychiatry 1997; 154: 185-190
38. Piven J, Palmer P. Psychiatric disorder and the broad autism phenotype: evidence from a family study of multiple-incidence autism families. Am J Psychiatry 1999; 156: 557-563
39. Mascie-Taylor CG, Boldsen JL. Assortative mating, differential fertility and abnormal pregnancy outcome. Ann Hum Biol 1988; 15: 223-228
40. Fieder M, Huber S. Parental age difference and offspring count in humans. Biol Lett 2007; 3: 689-691
41. Kolevzon A, Gross R, Reichenberg A. Prenatal and perinatal risk factors for autism: a review and integration of findings. Arch Pediatr Adolesc Med 2007; 161: 326-333
42. Abel EL, Kruger M, Burd L. Effects of maternal and paternal age on Caucasian and native American preterm births and birth weights. Am J Perinatol 2002; 19: 49-54
43. Fombonne E. Epidemiological surveys of autism and other pervasive developmental disorders: an update. J Autism Dev Disord 2003; 33: 365-382
44. Frans EM, Sandin S, Reichenberg A, Långström N, Lichtenstein P, McGrath JJ et al. Autism risk across generations: a population-based study of advancing grandpaternal and paternal age. JAMA Psychiatry Chic Ill 2013; 70: 516-521
45. Sasanfar R, Haddad SA, Tolouei A, Ghadami M, Yu D, Santangelo SL. Paternal age increases the risk for autism in an Iranian population sample. Mol Autism 2010; 1: 2
46. Idring S, Rai D, Dal H, Dalman C, Sturm H, Zander E et al. Autism spectrum disorders in the Stockholm Youth Cohort: design, prevalence and validity. PloS One 2012; 7: e41280
47. Lauritsen MB, Jørgensen M, Madsen KM, Lemcke S, Toft S, Grove J et al. Validity of childhood autism in the Danish Psychiatric Central Register: findings from a cohort sample born 1990-1999. J Autism Dev Disord 2010; 40: 139-148
48. Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders-Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. Morb Mortal Wkly Rep Surveill Summ 2012; 61: 1-19
49. Kim YS, Leventhal BL, Koh Y-J, Fombonne E, Laska E, Lim E-C et al. Prevalence of autism spectrum disorders in a total population sample. Am J Psychiatry 2011; 168: 904-912