Collateral damage during dengue virus infection: Making sense of DNA by cGAS

Journal of Virology

Volumn 91, Issue 14, 2017, Pages

  Aguirre, Sebastian ^a   Fernandez Sesma, Ana ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

CGAS; Damage; Dengue virus; DNA sensing; Innate immunity; Interferon; Mitochondria; MtDNA; STING

Indexed keywords

CYCLIC GMP AMP; CYCLIC GMP AMP SYNTHASE; CYCLIC NUCLEOTIDE; DNA; MITOCHONDRIAL DNA; SYNTHETASE; TRANSFER RNA; UNCLASSIFIED DRUG; MB21D1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MPYS PROTEIN, HUMAN; NUCLEOTIDYLTRANSFERASE;

ARTICLE; CELL DAMAGE; CGAMP PATHWAY; CYTOKINE PRODUCTION; DENGUE; DNA RNA HYBRIDIZATION; DNA SENSING PATHWAY; GLOBAL DISEASE BURDEN; HUMAN; IMMUNE EVASION; INNATE IMMUNITY; MOLECULAR RECOGNITION; NONHUMAN; PLACENTAL TRANSFER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; SIGNAL TRANSDUCTION; STING PATHWAY; VIRUS REPLICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DENGUE VIRUS; HOST PATHOGEN INTERACTION; PATHOGENICITY; PATHOLOGY;

ANIMALS; DENGUE; DENGUE VIRUS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; MEMBRANE PROTEINS; NUCLEOTIDYLTRANSFERASES;

EID: 85020923671     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01081-16     Document Type: Article

References (20)

1. Mayer SV, Tesh RB, Vasilakis N. 2017. The emergence of arthropod-borne viral diseases: A global prospective on dengue, chikungunya and zika fevers. Acta Trop 166:155-163. https://doi.org/10.1016/j.actatropica .2016.11.020
2. Morrison J, Aguirre S, Fernandez-Sesma A. 2012. Innate immunity evasion by Dengue virus. Viruses 4:397-413. https://doi.org/10.3390/v4030397
3. Uchida L, Espada-Murao LA, Takamatsu Y, Okamoto K, Hayasaka D, Yu F, Nabeshima T, Buerano CC, Morita K. 2014. The dengue virus conceals double-stranded RNA in the intracellular membrane to escape from an interferon response. Sci Rep 4:7395. https://doi.org/10.1038/srep07395
4. Aguirre S, Luthra P, Sanchez-Aparicio MT, Maestre AM, Patel J, Lamothe F, Fredericks AC, Tripathi S, Zhu T, Pintado-Silva J, Webb LG, Bernal-Rubio D, Solovyov A, Greenbaum B, Simon V, Basler CF, Mulder LC, Garcia-Sastre A, Fernandez-Sesma A. 2017. Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection. Nat Microbiol 2:17037. https://doi.org/10.1038/nmicrobiol.2017.37
5. Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM. 2014. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 505:691-695. https://doi.org/10.1038/nature12862
6. Aguirre S, Maestre AM, Pagni S, Patel JR, Savage T, Gutman D, Maringer K, Bernal-Rubio D, Shabman RS, Simon V, Rodriguez-Madoz JR, Mulder LC, Barber GN, Fernandez-Sesma A. 2012. DENV inhibits type I IFN production in infected cells by cleaving human STING. PLoS Pathog 8:e1002934. https://doi.org/10.1371/journal.ppat.1002934
7. Ishikawa H, Barber GN. 2008. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 455:674-678. https://doi.org/10.1038/nature07317
8. Mankan AK, Schmidt T, Chauhan D, Goldeck M, Honing K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V. 2014. Cytosolic RNA:DNA hybrids activate the cGAS-STING axis. EMBO J 33:2937-2946. https://doi.org/10.15252/embj.201488726
9. Burdette D. 2011. STING is a direct innate immune sensor of cyclic di-GMP. Nature 478:515-518. https://doi.org/10.1038/nature10429
10. Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. 2013. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339:826-830. https://doi.org/10.1126/science.1229963
11. Ablasser A, Schmid-Burgk JL, Hemmerling I, Horvath GL, Schmidt T, Latz E, Hornung V. 2013. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature 503:530-534. https://doi.org/10.1038/nature12640
12. Civril F, Deimling T, de Oliveira Mann CC, Ablasser A, Moldt M, Witte G, Hornung V, Hopfner KP. 2013. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 498:332-337. https://doi.org/10.1038/nature12305
13. West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS. 2015. Mitochondrial DNA stress primes the antiviral innate immune response. Nature 520:553-557. https://doi .org/10.1038/nature14156
14. Wiens KE, Ernst JD. 2016. The mechanism for type I interferon induction by Mycobacterium tuberculosis is bacterial strain-dependent. PLoS Pathog 12:e1005809. https://doi.org/10.1371/journal.ppat.1005809
15. Catteau A, Roue G, Yuste VJ, Susin SA, Despres P. 2003. Expression of dengue ApoptoM sequence results in disruption of mitochondrial potential and caspase activation. Biochimie 85:789-793. https://doi.org/10 .1016/S0300-9084(03)00139-1
16. He Z, Zhu X, Wen W, Yuan J, Hu Y, Chen J, An S, Dong X, Lin C, Yu J, Wu J, Yang Y, Cai J, Li J, Li M. 2016. Dengue virus subverts host innate immunity by targeting adaptor protein MAVS. J Virol 90:7219-7230. https://doi.org/10.1128/JVI.00221-16
17. Yu CY, Liang JJ, Li J K, Lee YL, Chang BL, Su CI, Huang WJ, Lai MM, Lin YL. 2015. Dengue virus impairs mitochondrial fusion by cleaving mitofusins. PLoS Pathog 11:e1005350. https://doi.org/10.1371/journal.ppat .1005350
18. Chatel-Chaix L, Cortese M, Romero-Brey I, Bender S, Neufeldt CJ, Fischl W, Scaturro P, Schieber N, Schwab Y, Fischer B, Ruggieri A, Bartenschlager R. 2016. Dengue virus perturbs mitochondrial morphodynamics to dampen innate immune responses. Cell Host Microbe 20:342-356. https://doi.org/10.1016/j.chom.2016.07.008
19. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A. 2004. Neutrophil extracellular traps kill bacteria. Science 303:1532-1535. https://doi.org/10.1126/science.1092385
20. Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, Woodward JJ, Pardoll DM, Dubensky TW, Jr, Kim Y. 2015. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. Sci Transl Med 7:283ra52. https://doi.org/10 .1126/scitranslmed.aaa4306