메뉴 건너뛰기




Volumn 12, Issue 5, 2017, Pages 563-569

Targeting the PD-1/PD-L1 Immune Checkpoint in EGFR-Mutated or ALK-Translocated Non-Small-Cell Lung Cancer

Author keywords

[No Author keywords available]

Indexed keywords

AFATINIB; ANAPLASTIC LYMPHOMA KINASE; ATEZOLIZUMAB; AVELUMAB; CRIZOTINIB; DOCETAXEL; DURVALUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; IPILIMUMAB; LORLATINIB; NIVOLUMAB; OSIMERTINIB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TICILIMUMAB; CD274 PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; PDCD1 PROTEIN, HUMAN; PROTEIN TYROSINE KINASE;

EID: 85020544350     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-017-0510-9     Document Type: Article
Times cited : (71)

References (63)
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • COI: 1:CAS:528:DC%2BC3MXjsFeqtrk%3D, PID: 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–74.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • COI: 1:CAS:528:DC%2BD3cXks1CktA%3D%3D, PID: 10647931
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57–70.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 84958552083 scopus 로고    scopus 로고
    • The evolving role of nivolumab in non-small-cell lung cancer for second-line treatment: a new cornerstone for our treatment algorithms. Results from an international experts panel meeting of the Italian Association of Thoracic Oncology
    • COI: 1:CAS:528:DC%2BC28Xitlyntrc%3D, PID: 26908078
    • Gridelli C, Besse B, Brahmer JR, Crinò L, Felip E, de Marinis F. The evolving role of nivolumab in non-small-cell lung cancer for second-line treatment: a new cornerstone for our treatment algorithms. Results from an international experts panel meeting of the Italian Association of Thoracic Oncology. Clin Lung Cancer. 2016;17(3):161–8.
    • (2016) Clin Lung Cancer. , vol.17 , Issue.3 , pp. 161-168
    • Gridelli, C.1    Besse, B.2    Brahmer, J.R.3    Crinò, L.4    Felip, E.5    de Marinis, F.6
  • 5
    • 84966405086 scopus 로고    scopus 로고
    • FDA approval summary: nivolumab for the treatment of metastatic non-small cell lung cancer with progression on or after platinum-based chemotherapy
    • COI: 1:CAS:528:DC%2BC28XhvFGntbfE, PID: 26984449
    • Kazandjian D, Suzman DL, Blumenthal G, Mushti S, He K, Libeg M, et al. FDA approval summary: nivolumab for the treatment of metastatic non-small cell lung cancer with progression on or after platinum-based chemotherapy. Oncologist. 2016;21(5):634–42.
    • (2016) Oncologist , vol.21 , Issue.5 , pp. 634-642
    • Kazandjian, D.1    Suzman, D.L.2    Blumenthal, G.3    Mushti, S.4    He, K.5    Libeg, M.6
  • 6
    • 84966341112 scopus 로고    scopus 로고
    • FDA approval summary: pembrolizumab for the treatment of patients with metastatic non-small cell lung cancer whose tumors express programmed death-ligand 1
    • COI: 1:CAS:528:DC%2BC28XhvFGnurzK, PID: 27026676
    • Sul J, Blumenthal GM, Jiang X, He K, Keegan P, Pazdur R. FDA approval summary: pembrolizumab for the treatment of patients with metastatic non-small cell lung cancer whose tumors express programmed death-ligand 1. Oncologist. 2016;21(5):643–50.
    • (2016) Oncologist , vol.21 , Issue.5 , pp. 643-650
    • Sul, J.1    Blumenthal, G.M.2    Jiang, X.3    He, K.4    Keegan, P.5    Pazdur, R.6
  • 7
    • 84918804764 scopus 로고    scopus 로고
    • First-line crizotinib versus chemotherapy in ALK-positive lung cancer
    • PID: 25470694
    • Solomon BJ, Mok T, Kim D-W, Wu Y-L, Nakagawa K, Mekhail T, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med. 2014;371(23):2167–77.
    • (2014) N Engl J Med , vol.371 , Issue.23 , pp. 2167-2177
    • Solomon, B.J.1    Mok, T.2    Kim, D.-W.3    Wu, Y.-L.4    Nakagawa, K.5    Mekhail, T.6
  • 8
    • 84863221857 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-tyrosine kinase inhibitor therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: a meta-analysis from six phase III randomized controlled trials
    • COI: 1:CAS:528:DC%2BC38Xhtl2gsb0%3D, PID: 22161771
    • Gao G, Ren S, Li A, Xu J, Xu Q, Su C, et al. Epidermal growth factor receptor-tyrosine kinase inhibitor therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: a meta-analysis from six phase III randomized controlled trials. Int J Cancer. 2012;131(5):E822–9.
    • (2012) Int J Cancer , vol.131 , Issue.5 , pp. E822-E829
    • Gao, G.1    Ren, S.2    Li, A.3    Xu, J.4    Xu, Q.5    Su, C.6
  • 9
    • 84921892043 scopus 로고    scopus 로고
    • Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-lung 3 and LUX-lung 6): analysis of overall survival data from two randomised, phase 3 trials
    • COI: 1:CAS:528:DC%2BC2MXhtVGmu78%3D, PID: 25589191
    • Yang JC-H, Wu Y-L, Schuler M, Sebastian M, Popat S, Yamamoto N, et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-lung 3 and LUX-lung 6): analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol. 2015;16(2):141–51.
    • (2015) Lancet Oncol. , vol.16 , Issue.2 , pp. 141-151
    • Yang, J.C.-H.1    Wu, Y.-L.2    Schuler, M.3    Sebastian, M.4    Popat, S.5    Yamamoto, N.6
  • 10
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2MXht12qu7%2FJ, PID: 26028407
    • Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WEE, Poddubskaya E, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373(2):123–35.
    • (2015) N Engl J Med , vol.373 , Issue.2 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3    Crinò, L.4    Eberhardt, W.E.E.5    Poddubskaya, E.6
  • 11
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC28XjsFyitL0%3D, PID: 26412456
    • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373(17):1627–39.
    • (2015) N Engl J Med , vol.373 , Issue.17 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3    Spigel, D.R.4    Steins, M.5    Ready, N.E.6
  • 12
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1–positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
    • COI: 1:CAS:528:DC%2BC2MXitVGrtLzI, PID: 26712084
    • Herbst RS, Baas P, Kim D-W, Felip E, Pérez-Gracia JL, Han J-Y, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1–positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016;387(10027):1540–50.
    • (2016) Lancet , vol.387 , Issue.10027 , pp. 1540-1550
    • Herbst, R.S.1    Baas, P.2    Kim, D.-W.3    Felip, E.4    Pérez-Gracia, J.L.5    Han, J.-Y.6
  • 14
    • 85008239423 scopus 로고    scopus 로고
    • Et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial
    • PID: 27979383
    • Rittmeyer A, Barlesi F, Waterkamp D, Park K, Ciardiello F, von Pawel J. Et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet. 2017;389(10066):255–65.
    • (2017) Lancet , vol.389 , Issue.10066 , pp. 255-265
    • Rittmeyer, A.1    Barlesi, F.2    Waterkamp, D.3    Park, K.4    Ciardiello, F.5    von Pawel, J.6
  • 15
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin–paclitaxel in pulmonary adenocarcinoma
    • COI: 1:CAS:528:DC%2BD1MXhtVygsbfK, PID: 19692680
    • Mok TS, Wu Y-L, Thongprasert S, Yang C-H, Chu D-T, Saijo N, et al. Gefitinib or carboplatin–paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361(10):947–57.
    • (2009) N Engl J Med , vol.361 , Issue.10 , pp. 947-957
    • Mok, T.S.1    Wu, Y.-L.2    Thongprasert, S.3    Yang, C.-H.4    Chu, D.-T.5    Saijo, N.6
  • 16
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC3cXhtlGgtbo%3D, PID: 20022809
    • Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11(2):121–8.
    • (2010) Lancet Oncol. , vol.11 , Issue.2 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6
  • 17
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
    • COI: 1:CAS:528:DC%2BC3cXot1Gjt7Y%3D, PID: 20573926
    • Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362(25):2380–8.
    • (2010) N Engl J Med , vol.362 , Issue.25 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3    Sugawara, S.4    Oizumi, S.5    Isobe, H.6
  • 18
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
    • COI: 1:CAS:528:DC%2BC3MXpslKhsbY%3D, PID: 21783417
    • Zhou C, Wu Y-L, Chen G, Feng J, Liu X-Q, Wang C, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011;12(8):735–42.
    • (2011) Lancet Oncol. , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.-L.2    Chen, G.3    Feng, J.4    Liu, X.-Q.5    Wang, C.6
  • 19
    • 84861976809 scopus 로고    scopus 로고
    • First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
    • COI: 1:CAS:528:DC%2BC38XntVOqtbs%3D, PID: 22370314
    • Han J-Y, Park K, Kim S-W, Lee DH, Kim HY, Kim HT, et al. First-SIGNAL: first-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol. 2012;30(10):1122–8.
    • (2012) J Clin Oncol , vol.30 , Issue.10 , pp. 1122-1128
    • Han, J.-Y.1    Park, K.2    Kim, S.-W.3    Lee, D.H.4    Kim, H.Y.5    Kim, H.T.6
  • 20
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC38XjsVCgsbk%3D, PID: 22285168
    • Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13(3):239–46.
    • (2012) Lancet Oncol. , vol.13 , Issue.3 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 21
    • 84892997539 scopus 로고    scopus 로고
    • Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-lung 6): an open-label, randomised phase 3 trial
    • COI: 1:CAS:528:DC%2BC2cXhtF2gu78%3D, PID: 24439929
    • Wu Y-L, Zhou C, Hu C-P, Feng J, Lu S, Huang Y, et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-lung 6): an open-label, randomised phase 3 trial. Lancet Oncol. 2014;15(2):213–22.
    • (2014) Lancet Oncol. , vol.15 , Issue.2 , pp. 213-222
    • Wu, Y.-L.1    Zhou, C.2    Hu, C.-P.3    Feng, J.4    Lu, S.5    Huang, Y.6
  • 22
    • 84871597401 scopus 로고    scopus 로고
    • Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin–paclitaxel for chemo-naïve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002)
    • COI: 1:STN:280:DC%2BC38bmtFCqsQ%3D%3D, PID: 22967997
    • Inoue A, Kobayashi K, Maemondo M, Sugawara S, Oizumi S, Isobe H, et al. Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin–paclitaxel for chemo-naïve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002). Ann Oncol. 2013;24(1):54–9.
    • (2013) Ann Oncol , vol.24 , Issue.1 , pp. 54-59
    • Inoue, A.1    Kobayashi, K.2    Maemondo, M.3    Sugawara, S.4    Oizumi, S.5    Isobe, H.6
  • 23
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • COI: 1:CAS:528:DC%2BC3sXhs1KrsrzP, PID: 23816960
    • Sequist LV, Yang JC-H, Yamamoto N, O’Byrne K, Hirsh V, Mok T, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3327–34.
    • (2013) J Clin Oncol , vol.31 , Issue.27 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.-H.2    Yamamoto, N.3    O’Byrne, K.4    Hirsh, V.5    Mok, T.6
  • 24
    • 84964389363 scopus 로고    scopus 로고
    • Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-lung 7): a phase 2B, open-label, randomised controlled trial
    • COI: 1:CAS:528:DC%2BC28XmtFaqtbY%3D, PID: 27083334
    • Park K, Tan E-H, O’Byrne K, Zhang L, Boyer M, Mok T, et al. Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-lung 7): a phase 2B, open-label, randomised controlled trial. Lancet Oncol. 2016;17(5):577–89.
    • (2016) Lancet Oncol. , vol.17 , Issue.5 , pp. 577-589
    • Park, K.1    Tan, E.-H.2    O’Byrne, K.3    Zhang, L.4    Boyer, M.5    Mok, T.6
  • 25
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • COI: 1:CAS:528:DC%2BD2MXhsFCiurk%3D, PID: 15728811
    • Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005;352(8):786–92.
    • (2005) N Engl J Med , vol.352 , Issue.8 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3    Jänne, P.A.4    Kocher, O.5    Meyerson, M.6
  • 26
    • 79953118839 scopus 로고    scopus 로고
    • Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
    • PID: 21430269
    • Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3(75):75ra26.
    • (2011) Sci Transl Med , vol.3 , Issue.75 , pp. 75ra26
    • Sequist, L.V.1    Waltman, B.A.2    Dias-Santagata, D.3    Digumarthy, S.4    Turke, A.B.5    Fidias, P.6
  • 28
    • 85013382512 scopus 로고    scopus 로고
    • Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer
    • COI: 1:CAS:528:DC%2BC2sXhtlyktbvI, PID: 27959700
    • Mok TS, Wu Y-L, Ahn M-J, Garassino MC, Kim HR, Ramalingam SS, et al. Osimertinib or platinum-pemetrexed in EGFR T790M-positive lung cancer. N Engl J Med. 2017;376(7):629–40.
    • (2017) N Engl J Med , vol.376 , Issue.7 , pp. 629-640
    • Mok, T.S.1    Wu, Y.-L.2    Ahn, M.-J.3    Garassino, M.C.4    Kim, H.R.5    Ramalingam, S.S.6
  • 29
    • 84959324643 scopus 로고    scopus 로고
    • Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial
    • COI: 1:CAS:528:DC%2BC2MXitVGrtLzL, PID: 26708155
    • Shaw AT, Gandhi L, Gadgeel S, Riely GJ, Cetnar J, West H, et al. Alectinib in ALK-positive, crizotinib-resistant, non-small-cell lung cancer: a single-group, multicentre, phase 2 trial. Lancet Oncol. 2016;17(2):234–42.
    • (2016) Lancet Oncol. , vol.17 , Issue.2 , pp. 234-242
    • Shaw, A.T.1    Gandhi, L.2    Gadgeel, S.3    Riely, G.J.4    Cetnar, J.5    West, H.6
  • 30
    • 84896957081 scopus 로고    scopus 로고
    • Ceritinib in ALK-rearranged non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2cXlvVCitL0%3D, PID: 24670165
    • Shaw AT, Kim D-W, Mehra R, Tan DSW, Felip E, Chow LQM, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med. 2014;370(13):1189–97.
    • (2014) N Engl J Med , vol.370 , Issue.13 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.-W.2    Mehra, R.3    Tan, D.S.W.4    Felip, E.5    Chow, L.Q.M.6
  • 31
    • 84994207040 scopus 로고    scopus 로고
    • FDA approval: alectinib for the treatment of metastatic ALK-positive non-small cell lung cancer following crizotinib
    • PID: 27413075
    • Larkins E, Blumenthal GM, Chen H, He K, Agarwal R, Gieser G, et al. FDA approval: alectinib for the treatment of metastatic ALK-positive non-small cell lung cancer following crizotinib. Clin Cancer Res. 2016;22(21):5171–6.
    • (2016) Clin Cancer Res , vol.22 , Issue.21 , pp. 5171-5176
    • Larkins, E.1    Blumenthal, G.M.2    Chen, H.3    He, K.4    Agarwal, R.5    Gieser, G.6
  • 32
    • 84962038946 scopus 로고    scopus 로고
    • Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial
    • COI: 1:CAS:528:DC%2BC28XktVOltrs%3D, PID: 26970723
    • Fehrenbacher L, Spira A, Ballinger M, Kowanetz M, Vansteenkiste J, Mazières J, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet. 2016;387(10030):1837–46.
    • (2016) Lancet , vol.387 , Issue.10030 , pp. 1837-1846
    • Fehrenbacher, L.1    Spira, A.2    Ballinger, M.3    Kowanetz, M.4    Vansteenkiste, J.5    Mazières, J.6
  • 33
    • 85015330057 scopus 로고    scopus 로고
    • Checkpoint inhibitors in metastatic EGFR-mutated non-small cell lung cancer-a meta-analysis
    • PID: 27765535
    • Lee CK, Man J, Lord S, Links M, Gebski V, Mok T, et al. Checkpoint inhibitors in metastatic EGFR-mutated non-small cell lung cancer-a meta-analysis. J Thorac Oncol. 2017;12(2):403–7.
    • (2017) J Thorac Oncol , vol.12 , Issue.2 , pp. 403-407
    • Lee, C.K.1    Man, J.2    Lord, S.3    Links, M.4    Gebski, V.5    Mok, T.6
  • 34
    • 84990938506 scopus 로고    scopus 로고
    • EGFR mutations and ALK rearrangements are associated with low response rates to PD-1 pathway blockade in non-small cell lung cancer (NSCLC): a retrospective analysis
    • COI: 1:CAS:528:DC%2BC28XhsFCkurrI, PID: 27225694
    • Gainor JF, Shaw AT, Sequist LV, Fu X, Azzoli CG, Piotrowska Z, et al. EGFR mutations and ALK rearrangements are associated with low response rates to PD-1 pathway blockade in non-small cell lung cancer (NSCLC): a retrospective analysis. Clin Cancer Res. 2016;22(18):4585–93.
    • (2016) Clin Cancer Res , vol.22 , Issue.18 , pp. 4585-4593
    • Gainor, J.F.1    Shaw, A.T.2    Sequist, L.V.3    Fu, X.4    Azzoli, C.G.5    Piotrowska, Z.6
  • 35
    • 84960498096 scopus 로고    scopus 로고
    • Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study
    • COI: 1:CAS:528:DC%2BC28XitlCntro%3D, PID: 26858122
    • Antonia S, Goldberg SB, Balmanoukian A, Chaft JE, Sanborn RE, Gupta A, et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study. Lancet Oncol. 2016;17(3):299–308.
    • (2016) Lancet Oncol , vol.17 , Issue.3 , pp. 299-308
    • Antonia, S.1    Goldberg, S.B.2    Balmanoukian, A.3    Chaft, J.E.4    Sanborn, R.E.5    Gupta, A.6
  • 36
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study
    • COI: 1:CAS:528:DC%2BC38XhtVynsbvP, PID: 22547592
    • Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30(17):2046–54.
    • (2012) J Clin Oncol , vol.30 , Issue.17 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6
  • 37
    • 84971637115 scopus 로고    scopus 로고
    • A phase III study of durvalumab (MEDI4736) with or without tremelimumab for previously treated patients with advanced NSCLC: rationale and protocol design of the ARCTIC study
    • COI: 1:CAS:528:DC%2BC28XltlWju70%3D, PID: 27265743
    • Planchard D, Yokoi T, McCleod MJ, Fischer JR, Kim Y-C, Ballas M, et al. A phase III study of durvalumab (MEDI4736) with or without tremelimumab for previously treated patients with advanced NSCLC: rationale and protocol design of the ARCTIC study. Clin Lung Cancer. 2016;17(3):232–6.
    • (2016) Clin Lung Cancer. , vol.17 , Issue.3 , pp. 232-236
    • Planchard, D.1    Yokoi, T.2    McCleod, M.J.3    Fischer, J.R.4    Kim, Y.-C.5    Ballas, M.6
  • 38
    • 84907651085 scopus 로고    scopus 로고
    • Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. ASCO 2014
    • Rizvi NA, Chow LQM, Borghaei H, Shen Y, Harbison C, Alaparthy S, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. ASCO 2014. J Clin Oncol. 2014;32(Suppl 5s):8022.
    • (2014) J Clin Oncol , vol.32 , pp. 8022
    • Rizvi, N.A.1    Chow, L.Q.M.2    Borghaei, H.3    Shen, Y.4    Harbison, C.5    Alaparthy, S.6
  • 39
    • 85040257501 scopus 로고    scopus 로고
    • Goto K, et al. 136O: Osimertinib combined with durvalumab in EGFR-mutant non-small cell lung cancer: results from the TATTON phase Ib trial
    • Ahn MJ, Yang J, Yu H, Saka H, Ramalingam S, Goto K, et al. 136O: Osimertinib combined with durvalumab in EGFR-mutant non-small cell lung cancer: results from the TATTON phase Ib trial. J Thorac Oncol. 2016;11(4):S115.
    • (2016) J Thorac Oncol , vol.11 , Issue.4 , pp. S115
    • Ahn, M.J.1    Yang, J.2    Yu, H.3    Saka, H.4    Ramalingam, S.5
  • 40
    • 85043626285 scopus 로고    scopus 로고
    • Poster 57O: efficacy, safety and tolerability of MEDI4736 (durvalumab [D]), a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib (G): a phase I expansion in TKI-naïve patients (pts) with EGFR mutant NSCLC
    • COI: 1:STN:280:DC%2BC2s%2FhsVeltQ%3D%3D, PID: 27198414
    • Gibbons DL, Chow LQ, Kim D-W, Kim S-W, Yeh T, Song X, et al. Poster 57O: efficacy, safety and tolerability of MEDI4736 (durvalumab [D]), a human IgG1 anti-programmed cell death-ligand-1 (PD-L1) antibody, combined with gefitinib (G): a phase I expansion in TKI-naïve patients (pts) with EGFR mutant NSCLC. J Thorac Oncol. 2016;11(4):S79.
    • (2016) J Thorac Oncol , vol.11 , Issue.4 , pp. S79
    • Gibbons, D.L.1    Chow, L.Q.2    Kim, D.-W.3    Kim, S.-W.4    Yeh, T.5    Song, X.6
  • 41
    • 85026365178 scopus 로고    scopus 로고
    • 60PD inhibition of pEGFR in paired tumour biopsies from TKI treatment-naïve EGFR mutant NSCLC patients treated with gefitinib (EGFR inhibitor) or gefitinib in combination with durvalumab (anti-PD-L1)
    • COI: 1:STN:280:DC%2BC2s%2FhsVeluw%3D%3D, PID: 27198416
    • Yeh T, Jacobs V, Angell H, Geradts J, Hou J, Karakunnel J, et al. 60PD inhibition of pEGFR in paired tumour biopsies from TKI treatment-naïve EGFR mutant NSCLC patients treated with gefitinib (EGFR inhibitor) or gefitinib in combination with durvalumab (anti-PD-L1). J Thorac Oncol. 2016;11(4):S80–1.
    • (2016) J Thorac Oncol , vol.11 , Issue.4 , pp. S80-S81
    • Yeh, T.1    Jacobs, V.2    Angell, H.3    Geradts, J.4    Hou, J.5    Karakunnel, J.6
  • 42
    • 85029884729 scopus 로고    scopus 로고
    • Poster 441O: Preliminary safety and clinical activity of erlotinib plus atezolizumab from a phase Ib study in advanced NSCLC
    • Ma BBY, Rudin CM, Cervantes A, Dowlati A, Costa D, Schmid P, et al. ;27(suppl 9)
    • Ma BBY, Rudin CM, Cervantes A, Dowlati A, Costa D, Schmid P, et al. Poster 441O: Preliminary safety and clinical activity of erlotinib plus atezolizumab from a phase Ib study in advanced NSCLC. Ann Oncol. 2016;27(suppl 9).
    • (2016) Ann Oncol
  • 43
    • 84923072443 scopus 로고    scopus 로고
    • Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small-cell lung cancer
    • COI: 1:STN:280:DC%2BC2cbhtVChsQ%3D%3D, PID: 25009014
    • Azuma K, Ota K, Kawahara A, Hattori S, Iwama E, Harada T, et al. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small-cell lung cancer. Ann Oncol. 2014;25(10):1935–40.
    • (2014) Ann Oncol , vol.25 , Issue.10 , pp. 1935-1940
    • Azuma, K.1    Ota, K.2    Kawahara, A.3    Hattori, S.4    Iwama, E.5    Harada, T.6
  • 44
    • 84920655625 scopus 로고    scopus 로고
    • PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients
    • PID: 25349974
    • D’Incecco A, Andreozzi M, Ludovini V, Rossi E, Capodanno A, Landi L, et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. Br J Cancer. 2015;112(1):95–102.
    • (2015) Br J Cancer , vol.112 , Issue.1 , pp. 95-102
    • D’Incecco, A.1    Andreozzi, M.2    Ludovini, V.3    Rossi, E.4    Capodanno, A.5    Landi, L.6
  • 45
    • 84890020587 scopus 로고    scopus 로고
    • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
    • COI: 1:CAS:528:DC%2BC3sXhvV2rtL3J, PID: 24078774
    • Akbay EA, Koyama S, Carretero J, Altabef A, Tchaicha JH, Christensen CL, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013;3(12):1355–63.
    • (2013) Cancer Discov , vol.3 , Issue.12 , pp. 1355-1363
    • Akbay, E.A.1    Koyama, S.2    Carretero, J.3    Altabef, A.4    Tchaicha, J.H.5    Christensen, C.L.6
  • 46
    • 84931054440 scopus 로고    scopus 로고
    • The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
    • PID: 25895031
    • Tang Y, Fang W, Zhang Y, Hong S, Kang S, Yan Y, et al. The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs. Oncotarget. 2015;6(16):14209–19.
    • (2015) Oncotarget , vol.6 , Issue.16 , pp. 14209-14219
    • Tang, Y.1    Fang, W.2    Zhang, Y.3    Hong, S.4    Kang, S.5    Yan, Y.6
  • 47
    • 84938491216 scopus 로고    scopus 로고
    • Programmed death-ligand 1 expression predicts tyrosine kinase inhibitor response and better prognosis in a cohort of patients with epidermal growth factor receptor mutation-positive lung adenocarcinoma
    • COI: 1:CAS:528:DC%2BC2MXjvFCjsLs%3D, PID: 25801750
    • Lin C, Chen X, Li M, Liu J, Qi X, Yang W, et al. Programmed death-ligand 1 expression predicts tyrosine kinase inhibitor response and better prognosis in a cohort of patients with epidermal growth factor receptor mutation-positive lung adenocarcinoma. Clin Lung Cancer. 2015;16(5):e25–35.
    • (2015) Clin Lung Cancer. , vol.16 , Issue.5 , pp. e25-e35
    • Lin, C.1    Chen, X.2    Li, M.3    Liu, J.4    Qi, X.5    Yang, W.6
  • 48
    • 85009921566 scopus 로고    scopus 로고
    • Significance of immune checkpoint proteins in EGFR-mutant non-small cell lung cancer
    • PID: 28236980
    • Soo RA, Kim HR, Asuncion BR, Fazreen Z, Omar MF, Herrera MC, et al. Significance of immune checkpoint proteins in EGFR-mutant non-small cell lung cancer. Lung Cancer. 2017;105:17–22.
    • (2017) Lung Cancer , vol.105 , pp. 17-22
    • Soo, R.A.1    Kim, H.R.2    Asuncion, B.R.3    Fazreen, Z.4    Omar, M.F.5    Herrera, M.C.6
  • 49
    • 84935004492 scopus 로고    scopus 로고
    • EGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-κB
    • COI: 1:CAS:528:DC%2BC2MXovV2qsr8%3D, PID: 25998384
    • Lin K, Cheng J, Yang T, Li Y, Zhu B. EGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-κB. Biochem Biophys Res Commun. 2015;463(1–2):95–101.
    • (2015) Biochem Biophys Res Commun , vol.463 , Issue.1-2 , pp. 95-101
    • Lin, K.1    Cheng, J.2    Yang, T.3    Li, Y.4    Zhu, B.5
  • 50
    • 84942849158 scopus 로고    scopus 로고
    • Induction of PD-L1 expression by the EML4–ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC2MXhsVCrsb7E, PID: 26019170
    • Ota K, Azuma K, Kawahara A, Hattori S, Iwama E, Tanizaki J, et al. Induction of PD-L1 expression by the EML4–ALK oncoprotein and downstream signaling pathways in non-small cell lung cancer. Clin Cancer Res. 2015;21(17):4014–21.
    • (2015) Clin Cancer Res , vol.21 , Issue.17 , pp. 4014-4021
    • Ota, K.1    Azuma, K.2    Kawahara, A.3    Hattori, S.4    Iwama, E.5    Tanizaki, J.6
  • 51
    • 84961564399 scopus 로고    scopus 로고
    • Upregulation of PD-L1 by EML4–ALK fusion protein mediates the immune escape in ALK positive NSCLC: implication for optional anti-PD-1/PD-L1 immune therapy for ALK-TKIs sensitive and resistant NSCLC patients
    • PID: 27141355
    • Hong S, Chen N, Fang W, Zhan J, Liu Q, Kang S, et al. Upregulation of PD-L1 by EML4–ALK fusion protein mediates the immune escape in ALK positive NSCLC: implication for optional anti-PD-1/PD-L1 immune therapy for ALK-TKIs sensitive and resistant NSCLC patients. Oncoimmunology. 2016;5(3):e1094598.
    • (2016) Oncoimmunology , vol.5 , Issue.3
    • Hong, S.1    Chen, N.2    Fang, W.3    Zhan, J.4    Liu, Q.5    Kang, S.6
  • 52
    • 84940722192 scopus 로고    scopus 로고
    • Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status
    • COI: 1:CAS:528:DC%2BC2MXht1WrtbzI, PID: 26183759
    • Koh J, Go H, Keam B, Kim M-Y, Nam SJ, Kim TM, et al. Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status. Mod Pathol. 2015;28(9):1154–66.
    • (2015) Mod Pathol , vol.28 , Issue.9 , pp. 1154-1166
    • Koh, J.1    Go, H.2    Keam, B.3    Kim, M.-Y.4    Nam, S.J.5    Kim, T.M.6
  • 53
    • 84994275582 scopus 로고    scopus 로고
    • Recent advances and future strategies for immune-checkpoint inhibition in small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC28Xht1ymsrrK, PID: 27520630
    • Chae YK, Pan A, Davis AA, Mohindra N, Matsangou M, Villaflor V, et al. Recent advances and future strategies for immune-checkpoint inhibition in small-cell lung cancer. Clin Lung Cancer. 2017;18(2):132–40.
    • (2017) Clin Lung Cancer. , vol.18 , Issue.2 , pp. 132-140
    • Chae, Y.K.1    Pan, A.2    Davis, A.A.3    Mohindra, N.4    Matsangou, M.5    Villaflor, V.6
  • 54
    • 85027586380 scopus 로고    scopus 로고
    • Tumor Immune Microenvironment and Nivolumab Efficacy in EGFR Mutation-Positive Non-Small Cell Lung Cancer Based on T790M Status after Disease Progression During EGFR-TKI Treatment
    • Haratani K, Hayashi H, Tanaka T, Kaneda H, Togashi Y, Sakai K et al. in press
    • Haratani K, Hayashi H, Tanaka T, Kaneda H, Togashi Y, Sakai K et al. Tumor Immune Microenvironment and Nivolumab Efficacy in EGFR Mutation-Positive Non-Small Cell Lung Cancer Based on T790M Status after Disease Progression During EGFR-TKI Treatment. Ann Oncol. 2017 in press.
    • (2017) Ann Oncol
  • 55
    • 84950127361 scopus 로고    scopus 로고
    • Change in PD-L1 expression after acquiring resistance to Gefitinib in EGFR-mutant non-small-cell lung cancer
    • COI: 1:CAS:528:DC%2BC2MXitVejurvP, PID: 26707383
    • Han JJ, Kim D-W, Koh J, Keam B, Kim TM, Jeon YK, et al. Change in PD-L1 expression after acquiring resistance to Gefitinib in EGFR-mutant non-small-cell lung cancer. Clin Lung Cancer. 2016;17(4):263–70.
    • (2016) Clin Lung Cancer. , vol.17 , Issue.4 , pp. 263-270
    • Han, J.J.1    Kim, D.-W.2    Koh, J.3    Keam, B.4    Kim, T.M.5    Jeon, Y.K.6
  • 56
    • 84987732853 scopus 로고    scopus 로고
    • Anti-PD-1/PD-L1 antibody therapy for pretreated advanced nonsmall-cell lung cancer: a meta-analysis of randomized clinical trials
    • COI: 1:CAS:528:DC%2BC28XhsVKrtb7F, PID: 27583876
    • Zhou G-W, Xiong Y, Chen S, Xia F, Li Q, Hu J. Anti-PD-1/PD-L1 antibody therapy for pretreated advanced nonsmall-cell lung cancer: a meta-analysis of randomized clinical trials. Medicine. 2016;95(35):e4611.
    • (2016) Medicine , vol.95 , Issue.35
    • Zhou, G.-W.1    Xiong, Y.2    Chen, S.3    Xia, F.4    Li, Q.5    Hu, J.6
  • 57
    • 84964677982 scopus 로고    scopus 로고
    • Biomarkers for PD-1/PD-L1 blockade therapy in non-small-cell lung cancer: is PD-L1 expression a good marker for patient selection?
    • COI: 1:CAS:528:DC%2BC28Xms1Krt7s%3D, PID: 27137346
    • Chae YK, Pan A, Davis AA, Raparia K, Mohindra NA, Matsangou M, et al. Biomarkers for PD-1/PD-L1 blockade therapy in non-small-cell lung cancer: is PD-L1 expression a good marker for patient selection? Clin Lung Cancer. 2016;17(5):350–61.
    • (2016) Clin Lung Cancer , vol.17 , Issue.5 , pp. 350-361
    • Chae, Y.K.1    Pan, A.2    Davis, A.A.3    Raparia, K.4    Mohindra, N.A.5    Matsangou, M.6
  • 58
    • 84957536816 scopus 로고    scopus 로고
    • PD-1/PD-L1 blockades in non-small-cell lung cancer therapy
    • PID: 26889087
    • Jing W, Li M, Zhang Y, Teng F, Han A, Kong L, et al. PD-1/PD-L1 blockades in non-small-cell lung cancer therapy. Onco Targets Ther. 2016;9:489–502.
    • (2016) Onco Targets Ther , vol.9 , pp. 489-502
    • Jing, W.1    Li, M.2    Zhang, Y.3    Teng, F.4    Han, A.5    Kong, L.6
  • 59
    • 84977274739 scopus 로고    scopus 로고
    • Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer
    • PID: 27565919
    • Shien K, Papadimitrakopoulou VA, Wistuba II. Predictive biomarkers of response to PD-1/PD-L1 immune checkpoint inhibitors in non-small cell lung cancer. Lung Cancer. 2016;99:79–87.
    • (2016) Lung Cancer , vol.99 , pp. 79-87
    • Shien, K.1    Papadimitrakopoulou, V.A.2    Wistuba, I.I.3
  • 60
    • 84995747147 scopus 로고    scopus 로고
    • The efficacy and potential predictive factors of PD-1/PD-L1 blockades in epithelial carcinoma patients: a systematic review and meta analysis
    • PID: 27542277
    • Yang Y, Pang Z, Ding N, Dong W, Ma W, Li Y, et al. The efficacy and potential predictive factors of PD-1/PD-L1 blockades in epithelial carcinoma patients: a systematic review and meta analysis. Oncotarget. 2016;7(45):74350–61.
    • (2016) Oncotarget , vol.7 , Issue.45 , pp. 74350-74361
    • Yang, Y.1    Pang, Z.2    Ding, N.3    Dong, W.4    Ma, W.5    Li, Y.6
  • 61
    • 84998854597 scopus 로고    scopus 로고
    • PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?
    • PID: 27532023
    • Grigg C, Rizvi NA. PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction? J Immunother Cancer. 2016;4:48.
    • (2016) J Immunother Cancer , vol.4 , pp. 48
    • Grigg, C.1    Rizvi, N.A.2
  • 62
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC2MXls1Wmtbg%3D, PID: 25765070
    • Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348(6230):124–8.
    • (2015) Science , vol.348 , Issue.6230 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6
  • 63
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and never-smokers
    • COI: 1:CAS:528:DC%2BC38XhtlKrtr7I, PID: 22980976
    • Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, Kanchi KL, et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell. 2012;150(6):1121–34.
    • (2012) Cell , vol.150 , Issue.6 , pp. 1121-1134
    • Govindan, R.1    Ding, L.2    Griffith, M.3    Subramanian, J.4    Dees, N.D.5    Kanchi, K.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.