메뉴 건너뛰기




Volumn 17, Issue 3, 2016, Pages 161-168

The Evolving Role of Nivolumab in Non-Small-Cell Lung Cancer for Second-Line Treatment: A New Cornerstone for Our Treatment Algorithms. Results from an International Experts Panel Meeting of the Italian Association of Thoracic Oncology

Author keywords

Anti PD 1 antibody; Immunotherapy; Nivolumab; PD L1; Second line treatment

Indexed keywords

DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; NINTEDANIB; NIVOLUMAB; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; RAMUCIRUMAB; ANTINEOPLASTIC AGENT; CD274 PROTEIN, HUMAN; MONOCLONAL ANTIBODY; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84958552083     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.1016/j.cllc.2016.01.004     Document Type: Review
Times cited : (15)

References (36)
  • 2
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • R. Rosell, E. Carcereny, R. Gervais, and et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial Lancet Oncol 13 2012 239 246
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 3
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
    • C. Zhou, Y.L. Wu, G. Chen, and et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study Lancet Oncol 12 2011 735 742
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 4
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • T.S. Mok, Y.L. Wu, S. Thongprasert, and et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma N Engl J Med 361 2009 947 957
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 5
    • 84884736973 scopus 로고    scopus 로고
    • Phase III Study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • L.V. Sequist, J.C. Yang, N. Yamamoto, and et al. Phase III Study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations J Clin Oncol 31 2013 3327 3334
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 6
    • 84884605223 scopus 로고    scopus 로고
    • Symptom control and quality of life in LUX-Lung 3: A phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
    • J.C. Yang, V. Hirsh, M. Schuler, and et al. Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations J Clin Oncol 31 2013 3342 3350
    • (2013) J Clin Oncol , vol.31 , pp. 3342-3350
    • Yang, J.C.1    Hirsh, V.2    Schuler, M.3
  • 7
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • A.T. Shaw, D.W. Kim, K. Nakagawa, and et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer N Engl J Med 368 2013 2385 2394
    • (2013) N Engl J Med , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 8
    • 84896957081 scopus 로고    scopus 로고
    • Ceritinib in ALK-rearranged non-small-cell lung cancer
    • A.T. Shaw, D.W. Kim, R. Mehra, and et al. Ceritinib in ALK-rearranged non-small-cell lung cancer N Engl J Med 370 2014 1189 1197
    • (2014) N Engl J Med , vol.370 , pp. 1189-1197
    • Shaw, A.T.1    Kim, D.W.2    Mehra, R.3
  • 9
    • 84890929261 scopus 로고    scopus 로고
    • Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer
    • B. Solomon, K.D. Wilner, and A.T. Shaw Current status of targeted therapy for anaplastic lymphoma kinase-rearranged non-small cell lung cancer Clin Pharmacol Ther 95 2014 15 23
    • (2014) Clin Pharmacol Ther , vol.95 , pp. 15-23
    • Solomon, B.1    Wilner, K.D.2    Shaw, A.T.3
  • 10
    • 80054734928 scopus 로고    scopus 로고
    • Second-line treatment of non-small-cell lung cancer: Chemotherapy or tyrosine kinase inhibitors?
    • A. Passaro, E. Cortesi, and F. de Marinis Second-line treatment of non-small-cell lung cancer: chemotherapy or tyrosine kinase inhibitors? Expert Rev Anticancer Ther 11 2011 1587 1597
    • (2011) Expert Rev Anticancer Ther , vol.11 , pp. 1587-1597
    • Passaro, A.1    Cortesi, E.2    De Marinis, F.3
  • 11
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-celllung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised phase 3 trial
    • E.B. Garon, T.E. Ciuleanu, O. Arrieta, and et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-celllung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial Lancet 384 2014 665 673
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.E.2    Arrieta, O.3
  • 12
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): A phase 3, double-blind, randomised controlled trial
    • M. Reck, R. Kaiser, A. Mellemgaard, and et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial Lancet Oncol 15 2014 143 155
    • (2014) Lancet Oncol , vol.15 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 13
    • 84947966922 scopus 로고    scopus 로고
    • New antiangiogenetic therapy beyond bevacizumab in the treatment of advanced non small cell lung cancer
    • S.P. Claudia, M. Paolo, R. Antonio, and et al. New antiangiogenetic therapy beyond bevacizumab in the treatment of advanced non small cell lung cancer Curr Pharm Des 21 2015 4763 4772
    • (2015) Curr Pharm des , vol.21 , pp. 4763-4772
    • Claudia, S.P.1    Paolo, M.2    Antonio, R.3
  • 14
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • D.M. Pardoll The blockade of immune checkpoints in cancer immunotherapy Nat Rev Cancer 12 2012 252 264
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 15
    • 84937575428 scopus 로고    scopus 로고
    • PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors
    • R. Rosell, and R. Palmero PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors Cancer Biol Med 12 2015 71 73
    • (2015) Cancer Biol Med , vol.12 , pp. 71-73
    • Rosell, R.1    Palmero, R.2
  • 16
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • R.D. Schreiber, L.J. Old, and M.J. Smyth Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion Science 331 2011 1565 1570
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 17
    • 84892485531 scopus 로고    scopus 로고
    • Immune checkpoint inhibitors: Making immunotherapy a reality for the treatment of lung cancer
    • J.R. Brahmer, and D.M. Pardoll Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer Cancer Immunol Res 1 2013 85 91
    • (2013) Cancer Immunol Res , vol.1 , pp. 85-91
    • Brahmer, J.R.1    Pardoll, D.M.2
  • 18
    • 84894499071 scopus 로고    scopus 로고
    • Immune checkpoint blockade: The hope for immunotherapy as a treatment of lung cancer?
    • J.R. Brahmer Immune checkpoint blockade: the hope for immunotherapy as a treatment of lung cancer? Semin Oncol 41 2014 126 132
    • (2014) Semin Oncol , vol.41 , pp. 126-132
    • Brahmer, J.R.1
  • 19
    • 84929251102 scopus 로고    scopus 로고
    • Nivolumab: Targeting PD-1 to bolster antitumor immunity
    • J.R. Brahmer, H. Hammers, and E.J. Lipson Nivolumab: targeting PD-1 to bolster antitumor immunity Future Oncol 11 2015 1307 1326
    • (2015) Future Oncol , vol.11 , pp. 1307-1326
    • Brahmer, J.R.1    Hammers, H.2    Lipson, E.J.3
  • 20
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • R.S. Herbst, J.C. Soria, M. Kowanetz, and et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients Nature 515 2014 563 567
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3
  • 21
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • E.B. Garon, N.A. Rizvi, R. Hui, and et al. Pembrolizumab for the treatment of non-small-cell lung cancer N Engl J Med 372 2015 2018 2028
    • (2015) N Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 22
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • J. Brahmer, K.L. Reckamp, P. Baas, and et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer N Engl J Med 373 2015 123 135
    • (2015) N Engl J Med , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 23
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • J.R. Brahmer, S.S. Tykodi, L.Q. Chow, and et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer N Engl J Med 366 2012 2455 2465
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 24
    • 77954899030 scopus 로고    scopus 로고
    • Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
    • J.R. Brahmer, C.G. Drake, I. Wollner, and et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates J Clin Oncol 28 2010 3167 3175
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3
  • 25
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • S.L. Topalian, F.S. Hodi, J.R. Brahmer, and et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer N Engl J Med 366 2012 2443 2454
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 26
    • 84936749833 scopus 로고    scopus 로고
    • Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer
    • S.N. Gettinger, L. Horn, L. Gandhi, and et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced non-small-cell lung cancer J Clin Oncol 33 2015 2004 2012
    • (2015) J Clin Oncol , vol.33 , pp. 2004-2012
    • Gettinger, S.N.1    Horn, L.2    Gandhi, L.3
  • 27
    • 84924809260 scopus 로고    scopus 로고
    • Nivolumab in NSCLC: Latest evidence and clinical potential
    • R. Sundar, B.C. Cho, J.R. Brahmer, and et al. Nivolumab in NSCLC: latest evidence and clinical potential Ther Adv Med Oncol 7 2015 85 96
    • (2015) Ther Adv Med Oncol , vol.7 , pp. 85-96
    • Sundar, R.1    Cho, B.C.2    Brahmer, J.R.3
  • 28
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • H. Borghaei, L. Paz-Ares, L. Horn, and et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer N Engl J Med 373 2015 1627 1639
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 29
    • 84935474357 scopus 로고    scopus 로고
    • PD-L1 expression as a predictive biomarker in cancer immunotherapy
    • S.P. Patel, and R. Kurzrock PD-L1 expression as a predictive biomarker in cancer immunotherapy Mol Cancer Ther 14 2015 847 856
    • (2015) Mol Cancer Ther , vol.14 , pp. 847-856
    • Patel, S.P.1    Kurzrock, R.2
  • 30
    • 84937568661 scopus 로고    scopus 로고
    • Efficacy of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with previously treated advanced non-small cell lung cancer (NSCLC): Subpopulation response analysis in a phase 1 trial
    • P2.11-038
    • S. Gettinger, L. Horn, S.J. Antonia, and et al. Efficacy of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with previously treated advanced non-small cell lung cancer (NSCLC): subpopulation response analysis in a phase 1 trial J Thorac Oncol 8 2013 P2.11-038
    • (2013) J Thorac Oncol , vol.8
    • Gettinger, S.1    Horn, L.2    Antonia, S.J.3
  • 31
    • 84890020587 scopus 로고    scopus 로고
    • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
    • E.A. Akbay, S. Koyama, J. Carretero, and et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors Cancer Discov 3 2013 1355 1363
    • (2013) Cancer Discov , vol.3 , pp. 1355-1363
    • Akbay, E.A.1    Koyama, S.2    Carretero, J.3
  • 32
    • 84920655625 scopus 로고    scopus 로고
    • PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients
    • A. D'Incecco, M. Andreozzi, V. Ludovini, and et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients Br J Cancer 112 2015 95 102
    • (2015) Br J Cancer , vol.112 , pp. 95-102
    • D'Incecco, A.1    Andreozzi, M.2    Ludovini, V.3
  • 33
    • 84937563758 scopus 로고    scopus 로고
    • PD-1/PD-L1 pathway in non-small-cell lung cancer and its relation with EGFR mutation
    • M. Ji, Y. Liu, Q. Li, and et al. PD-1/PD-L1 pathway in non-small-cell lung cancer and its relation with EGFR mutation J Transl Med 13 2015 5
    • (2015) J Transl Med , vol.13 , pp. 5
    • Ji, M.1    Liu, Y.2    Li, Q.3
  • 34
    • 84892967581 scopus 로고    scopus 로고
    • Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): A phase 3, double-blind, randomised controlled trial
    • M. Reck, R. Kaiser, A. Mellemgaard, and et al. Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial Lancet 15 2014 143 155
    • (2014) Lancet , vol.15 , pp. 143-155
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 35
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised phase 3 trial
    • E.B. Garon, T.E. Ciuleanu, O. Arrieta, and et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial Lancet 384 2014 665 673
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.E.2    Arrieta, O.3
  • 36
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
    • [Epub ahead of print]
    • R.S. Herbst, P. Baas, D.W. Kim, and et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial Lancet 2015 10.1016/S0140-6736(15)01281-7 [Epub ahead of print]
    • (2015) Lancet
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.