메뉴 건너뛰기




Volumn 4, Issue 10, 2015, Pages 1866-1889

Nephroprotection by hypoglycemic agents: Do we have supporting data?

Author keywords

Albuminuria; Antihyperglycemic drugs; DDP4 inhibitors; Diabetes mellitus; Diabetic chronic kidney disease; Diabetic nephropathy; Glucagon like peptide agonists; Nephroprotection; SGLT2 inhibition

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; FIBROBLAST GROWTH FACTOR; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INCRETIN; METFORMIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SOMATOMEDIN C; SULFONYLUREA;

EID: 85020530779     PISSN: None     EISSN: 20770383     Source Type: Journal    
DOI: 10.3390/jcm4101866     Document Type: Review
Times cited : (23)

References (108)
  • 1
    • 77951089891 scopus 로고    scopus 로고
    • International Diabetes Federation, 6th ed. Available online:, (accessed on 1 June 2015)
    • International Diabetes Federation. IDF Diabetes Atlas, 6th ed. Available online: http://www.idf.org/diabetesatlas (accessed on 1 June 2015).
    • IDF Diabetes Atlas
  • 2
    • 79959282613 scopus 로고    scopus 로고
    • Epidemiology of diabetic nephropathy
    • Reutens, A.T.; Atkins, R.C. Epidemiology of diabetic nephropathy. Contrib Nephrol. 2011, 170, 1-7.
    • (2011) Contrib Nephrol , vol.170 , pp. 1-7
    • Reutens, A.T.1    Atkins, R.C.2
  • 3
    • 84862525384 scopus 로고    scopus 로고
    • Therapeutic modalities in diabetic nephropathy: Standard and emerging approaches
    • Abdel-Rahman, E.M.; Saadulla, L.; Reeves, W.B.; Awad, A.S. Therapeutic modalities in diabetic nephropathy: Standard and emerging approaches. J. Gen. Intern. Med. 2012, 27, 458-468.
    • (2012) J. Gen. Intern. Med , vol.27 , pp. 458-468
    • Abdel-Rahman, E.M.1    Saadulla, L.2    Reeves, W.B.3    Awad, A.S.4
  • 4
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a multifactorial intervention on mortality in type 2 diabetes
    • Gaede, P.; Lund-Andersen, H.; Parving, H.H.; Pedersen, O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N. Engl. J. Med. 2008, 355, 580-591.
    • (2008) N. Engl. J. Med , vol.355 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.H.3    Pedersen, O.4
  • 5
    • 84866744335 scopus 로고    scopus 로고
    • The emerging concept of chronic kidney disease without clinical proteinuria in diabetic patients
    • Halimi, J.M. The emerging concept of chronic kidney disease without clinical proteinuria in diabetic patients. DiabetesMeTable 2012, 38, 291-297.
    • (2012) Diabetesmetable , vol.38 , pp. 291-297
    • Halimi, J.M.1
  • 6
    • 85114281881 scopus 로고    scopus 로고
    • The Concept and the Epidemiology of Diabetic Nephropathy Have Changed in Recent Years
    • Martinez-Castelao, A.; Navarro-Gonzalez, J.F.; Gorriz, J.L.; de Alvaro, F. The Concept and the Epidemiology of Diabetic Nephropathy Have Changed in Recent Years. J. Clin. Med. 2015, 4, 1207-1216.
    • (2015) J. Clin. Med , vol.4 , pp. 1207-1216
    • Martinez-Castelao, A.1    Navarro-Gonzalez, J.F.2    Gorriz, J.L.3    De Alvaro, F.4
  • 7
    • 84908076737 scopus 로고    scopus 로고
    • K.H. Diabetic nephropathy-complications and treatment
    • Lim, A.K.H. Diabetic nephropathy-complications and treatment. Int. J. Nephrol. Renovasc. Dis. 2014, 7, 361-381.
    • (2014) Int. J. Nephrol. Renovasc. Dis , vol.7 , pp. 361-381
    • Lim, A.1
  • 8
    • 0037472879 scopus 로고    scopus 로고
    • Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
    • J. Clin. Med. 2015, 4 1882
    • Gaede, P.; Vedel, P.; Larsen, N.; Jensen, G.V.; Parving, H.H.; Pedersen, O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N. Engl. J. Med. 2003, 348, 383-393. J. Clin. Med. 2015, 4 1882
    • (2003) N. Engl. J. Med , vol.348 , pp. 383-393
    • Gaede, P.1    Vedel, P.2    Larsen, N.3    Jensen, G.V.4    Parving, H.H.5    Pedersen, O.6
  • 9
    • 29144453326 scopus 로고    scopus 로고
    • Diabetes Control and Complications Trial/Epidemiology of DiabetesInterventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan, D.M.; Cleary, P.A.; Backlund, J.Y.; Genuth, S.M.; Lachin, J.M.; Orchard, T.J. Raskin, P. Zinman, B. Diabetes Control and Complications Trial/Epidemiology of DiabetesInterventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N. Engl. J. Med. 2005, 353, 2643-2653.
    • (2005) N. Engl. J. Med , vol.353 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3    Genuth, S.M.4    Lachin, J.M.5    Orchard Raskin Zinman, T.J.P.B.6
  • 10
    • 0027370108 scopus 로고
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 1993, 329, 977-986.
    • (1993) N. Engl. J. Med , vol.329 , pp. 977-986
  • 11
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352, 837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 13
    • 77955585592 scopus 로고    scopus 로고
    • Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial
    • Ismail-Beigi, F.; Craven, T.; Banerji, M.A.; Basile, J.; Calles, J.; Cohen, R.M.; Cuddihy, R.; Cushman, W.C.; Genuth, S.; Grimm R.H.; et al. Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: An analysis of the ACCORD randomised trial. Lancet 2010, 376, 419-430.
    • (2010) Lancet , vol.376 , pp. 419-430
    • Ismail-Beigi, F.1    Craven, T.2    Banerji, M.A.3    Basile, J.4    Calles, J.5    Cohen, R.M.6    Cuddihy, R.7    Cushman, W.C.8    Genuth, S.9    Grimm, R.H.10
  • 16
    • 24044478791 scopus 로고    scopus 로고
    • Metformin’s contraindications should be contraindicated
    • McCormack, J.; Johns, K. Metformin’s contraindications should be contraindicated. CMAJ 2005, 173, 502-504.
    • (2005) CMAJ , vol.173 , pp. 502-504
    • McCormack, J.1    Johns, K.2
  • 17
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998, 352, 854-856.
    • (1998) Lancet , vol.352 , pp. 854-856
  • 19
    • 33746068289 scopus 로고    scopus 로고
    • Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress
    • Rosen, P.; Wiernsperger, N.F. Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress. Diabetes Metab. Res. Rev. 2006, 22, 323-330.
    • (2006) Diabetes Metab. Res. Rev , vol.22 , pp. 323-330
    • Rosen, P.1    Wiernsperger, N.F.2
  • 21
    • 84886720185 scopus 로고    scopus 로고
    • Metformin and renal injury protection
    • Rafieian-Kopaie, M. Metformin and renal injury protection. J. RenalInj. Prev. 2013, 2, 91-92.
    • (2013) J. Renalinj. Prev , vol.2 , pp. 91-92
    • Rafieian-Kopaie, M.1
  • 22
    • 84867814558 scopus 로고    scopus 로고
    • Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin
    • J. Clin. Med. 2015, 4 1883
    • Kim, J.; Shon, E.; Kim, C.S.; Kim, J.S. Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin. Exp. Diabetes Res. 2012, 2012, 210821, doi:10.1155/2012/210821. J. Clin. Med. 2015, 4 1883
    • (2012) Exp. Diabetes Res , vol.2012 , pp. 210821
    • Kim, J.1    Shon, E.2    Kim, C.S.3    Kim, J.S.4
  • 23
    • 84893109173 scopus 로고    scopus 로고
    • Gliquidone decreases urinary protein by promoting tubular reabsorption in diabetic Goto-Kakizaki rats
    • Ke, J.T.; Li, M.; Xu, S.Q.; Zhang, W.J.; Jiang, Y.W.; Cheng, L.Y.; Lou, J.N.; Wu, W. Gliquidone decreases urinary protein by promoting tubular reabsorption in diabetic Goto-Kakizaki rats. J. Endocrinol. 2014, 220, 129-141.
    • (2014) J. Endocrinol , vol.220 , pp. 129-141
    • Ke, J.T.1    Li, M.2    Xu, S.Q.3    Zhang, W.J.4    Jiang, Y.W.5    Cheng, L.Y.6    Lou, J.N.7    Wu, W.8
  • 25
    • 70449360911 scopus 로고    scopus 로고
    • Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial
    • Zoungas, S.; de Galan, B.E.; Ninomiya, T.; Grobbee, D.; Hamet, P.; Heller, S.; MacMahon, S.; Marre, M.; Neal, B.; Patel, A.; Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial. Diabetes Care 2009, 32, 2068-2074.
    • (2009) Diabetes Care , vol.32 , pp. 2068-2074
    • Zoungas, S.1    De Galan, B.E.2    Ninomiya, T.3    Grobbee, D.4    Hamet, P.5    Heller, S.6    Macmahon, S.7    Marre, M.8    Neal, B.9    Patel, A.10
  • 26
    • 84940918489 scopus 로고    scopus 로고
    • Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1
    • McCarty, M.F.; DiNicolantonio, J.J. Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1. Open Heart 2015, 2, e000205, doi:10.1136/openhrt-2014-000205.
    • (2015) Open Heart , pp. 2
    • McCarty, M.F.1    Dinicolantonio, J.J.2
  • 27
    • 0033046464 scopus 로고    scopus 로고
    • Randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44)
    • Holman, R.R.; Cull, C.A.; Turner, R.C. A randomized double-blind trial of acarbose in type 2 diabetes shows improved glycemic control over 3 years (U.K. Prospective Diabetes Study 44). Diabetes Care 1999, 22, 960-964.
    • (1999) Diabetes Care , vol.22 , pp. 960-964
    • Holman, R.R.1    Cull, C.A.2    Turner, R.3
  • 28
    • 21344466513 scopus 로고    scopus 로고
    • Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients
    • Pistrosch, F.; Herbrig, K.; Kindel, B.; Passauer, J.; Fischer, S.; Gross, P. Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients. Diabetes 2005, 54, 2206-2211.
    • (2005) Diabetes , vol.54 , pp. 2206-2211
    • Pistrosch, F.1    Herbrig, K.2    Kindel, B.3    Passauer, J.4    Fischer, S.5    Gross, P.6
  • 29
    • 0031847401 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats
    • Buckingham, R.E.; Al-Barazanji, K.A.; Toseland, C.D.; Slaughter, M.; Connor, S.C.; West, A.; Bond, B.; Turner, N.C.; Clapham, J.C. Peroxisome proliferator-activated receptor-gamma agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats. Diabetes 1998, 47, 1326-1334.
    • (1998) Diabetes , vol.47 , pp. 1326-1334
    • Buckingham, R.E.1    Al-Barazanji, K.A.2    Toseland, C.D.3    Slaughter, M.4    Connor, S.C.5    West, A.6    Bond, B.7    Turner, N.C.8    Clapham, J.C.9
  • 31
    • 84869472895 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-8 activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes. Nephrol. Dial
    • Lee, E.Y.; Kim, G.T.; Hyun, M.; Kim, S.; Seok, S.; Choi, R.; Lee, M.Y.; Chung, C.H. Peroxisome proliferator-activated receptor-8 activation ameliorates albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes. Nephrol. Dial. Transplant. 2012, 27, 4069-4079.
    • (2012) Transplant , vol.27 , pp. 4069-4079
    • Lee, E.Y.1    Kim, G.T.2    Hyun, M.3    Kim, S.4    Seok, S.5    Choi, R.6    Lee, M.Y.7    Chung, C.H.8
  • 33
    • 0033669212 scopus 로고    scopus 로고
    • Comparative effects of pioglitazone, glibenclamide, and voglibose on urinary endothelin-1 and albumin excretion in diabetes patients
    • Nakamura, T.; Ushiyama, C.; Shimada, N.; Hayashi, K.; Ebihara, I.; Koide, H. Comparative effects of pioglitazone, glibenclamide, and voglibose on urinary endothelin-1 and albumin excretion in diabetes patients. J. Diabetes Complicat. 2000, 14, 250-254.
    • (2000) J. Diabetes Complicat , vol.14 , pp. 250-254
    • Nakamura, T.1    Ushiyama, C.2    Shimada, N.3    Hayashi, K.4    Ebihara, I.5    Koide, H.6
  • 35
    • 36249006990 scopus 로고    scopus 로고
    • Rosiglitazone decreases albuminuria in type 2 diabetic patients
    • Miyazaki, Y.; Cersosimo, E.; Triplitt, C.; DeFronzo, R.A. Rosiglitazone decreases albuminuria in type 2 diabetic patients. Kidney Int. 2007, 72, 1367-1373.
    • (2007) Kidney Int , vol.72 , pp. 1367-1373
    • Miyazaki, Y.1    Cersosimo, E.2    Triplitt, C.3    Defronzo, R.A.4
  • 36
    • 24944536256 scopus 로고    scopus 로고
    • Pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy
    • J. Clin. Med. 2015, 4 1884
    • Agarwal, R.; Saha, C.; Battiwala, M.; Vasavada, N.; Curley, T.; Chase, S.D.; Sachs, N.; Semret, M.H. A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy. Kidney Int. 2005, 68, 285-292. J. Clin. Med. 2015, 4 1884
    • (2005) Kidney Int , vol.68 , pp. 285-292
    • Agarwal, R.1    Saha, C.2    Battiwala, M.3    Vasavada, N.4    Curley, T.5    Chase, S.D.6    Sachs, N.7    Semret, M.8
  • 39
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen, T.E.; Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med. 2007, 356, 2457-2471.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2457-2471
    • Nissen, T.E.1    Wolski, K.2
  • 40
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus
    • Lincoff, A.M.; Wolski, K.; Nicholls, S.J.; Nissen, S.E. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials. JAMA 2007, 298, 1180-1188.
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 43
    • 84961918944 scopus 로고    scopus 로고
    • Treatment of type 2 diabetes, lifestyle, GLP-1 agonists and DPP4 inhibitors
    • Tomkin, G.H. Treatment of type 2 diabetes, lifestyle, GLP-1 agonists and DPP4 inhibitors. World J. Diabetes 2014, 5, 636-650.
    • (2014) World J. Diabetes , vol.5 , pp. 636-650
    • Tomkin, G.H.1
  • 44
    • 0030013475 scopus 로고    scopus 로고
    • Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor
    • Bullock, B.P.; Heller, R.S.; Habener, J.F. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996, 137, 2968-2978.
    • (1996) Endocrinology , vol.137 , pp. 2968-2978
    • Bullock, B.P.1    Heller, R.S.2    Habener, J.F.3
  • 45
    • 0030187992 scopus 로고    scopus 로고
    • Distribution of GLP-1 and PACAP receptors in human tissues
    • Wei, Y.; Mojsov, S. Distribution of GLP-1 and PACAP receptors in human tissues. Acta Physiol. Scand. 1996, 157, 355-357.
    • (1996) Acta Physiol. Scand , vol.157 , pp. 355-357
    • Wei, Y.1    Mojsov, S.2
  • 46
    • 84895072279 scopus 로고    scopus 로고
    • The gut-renal axis: Do ncretin-based agents confer renoprotection in diabetes? Nat
    • Muskiet, M.H.; Smits, M.M.; Morsink, L.M.; Diamant, M. The gut-renal axis: Do ncretin-based agents confer renoprotection in diabetes? Nat. Rev. Nephrol. 2014, 10, 88-103.
    • (2014) Rev. Nephrol , vol.10 , pp. 88-103
    • Muskiet, M.H.1    Smits, M.M.2    Morsink, L.M.3    Diamant, M.4
  • 47
    • 84926197236 scopus 로고    scopus 로고
    • The potential for renoprotection with incretin-based drugs
    • Tanaka, T.; Higashijima, Y.; Wada, Y.; Nangaku, M. The potential for renoprotection with incretin-based drugs. Kidney Int. 2014, 86, 701-711
    • (2014) Kidney Int , vol.86 , pp. 701-711
    • Tanaka, T.1    Higashijima, Y.2    Wada, Y.3    Nangaku, M.4
  • 48
    • 34250635159 scopus 로고    scopus 로고
    • GLP-1 receptor expression in human tumors and human normal tissues: Potential for in vivo targeting
    • Kórner, M.; Stóckli, M.; Waser, B.; Reubi, J.C. GLP-1 receptor expression in human tumors and human normal tissues: Potential for in vivo targeting. J. Nucl. Med. 2007, 48, 736-743.
    • (2007) J. Nucl. Med , vol.48 , pp. 736-743
    • Kórner, M.1    Stóckli, M.2    Waser, B.3    Reubi, J.C.4
  • 50
    • 84865576863 scopus 로고    scopus 로고
    • Renal and cardiac effects of DPP4 inhibitors-from preclinical development to clinical research
    • Hocher, B.; Reichetzeder, C.; Alter, M.L. Renal and cardiac effects of DPP4 inhibitors-from preclinical development to clinical research. Kidney Blood Press. Res. 2012, 36, 65-84.
    • (2012) Kidney Blood Press. Res , vol.36 , pp. 65-84
    • Hocher, B.1    Reichetzeder, C.2    Alter, M.L.3
  • 52
    • 33947584619 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells
    • Schlatter, P.; Beglinger, C.; Drewe, J.; Gutmann, H. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul. Pept. 2007, 141, 120-128.
    • (2007) Regul. Pept , vol.141 , pp. 120-128
    • Schlatter, P.1    Beglinger, C.2    Drewe, J.3    Gutmann, H.4
  • 53
    • 0026703489 scopus 로고
    • Ultrastructural localization of dipeptidylpeptidase IV in the glomerulum of the rat kidney
    • Kettmann, U.; Humbel, B.; Holzhausen, H.J. Ultrastructural localization of dipeptidylpeptidase IV in the glomerulum of the rat kidney. Acta Histochem. 1992, 92, 225-227.
    • (1992) Acta Histochem , vol.92 , pp. 225-227
    • Kettmann, U.1    Humbel, B.2    Holzhausen, H.J.3
  • 54
    • 84855611505 scopus 로고    scopus 로고
    • Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat)
    • Mega, C.; de Lemos, E.T.; Vala, H.; Fernandes, R.; Oliveira, J.; Mascarenhas-Melo, F.; Teixeira, F.; Reis, F. Diabetic nephropathy amelioration by a low-dose sitagliptin in an animal model of type 2 diabetes (Zucker diabetic fatty rat). Exp. Diabetes Res. 2011, 2011, 162092, doi:10.1155/2011/162092.
    • (2011) Exp. Diabetes Res , vol.2011 , pp. 162092
    • Mega, C.1    De Lemos, E.T.2    Vala, H.3    Fernandes, R.4    Oliveira, J.5    Mascarenhas-Melo, F.6    Teixeira, F.7    Reis, F.8
  • 57
    • 0023894405 scopus 로고
    • Adenosine deaminase-complexing protein from bovine kidney. Isolation of two distinct subunits
    • Weisman, M.I.; Caiolfa, V.R.; Parola, A.H. Adenosine deaminase-complexing protein from bovine kidney. Isolation of two distinct subunits. J. Biol. Chem. 1988, 263, 5266-5270.
    • (1988) J. Biol. Chem , vol.263 , pp. 5266-5270
    • Weisman, M.I.1    Caiolfa, V.R.2    Parola, A.H.3
  • 58
    • 84908199242 scopus 로고    scopus 로고
    • The effects of dipeptidyl peptidase-4 inhibition on microvascular diabetes complications
    • Avogaro, A.; Fadini, G.P. The effects of dipeptidyl peptidase-4 inhibition on microvascular diabetes complications. Diabetes Care 2014, 37, 2884-2894.
    • (2014) Diabetes Care , vol.37 , pp. 2884-2894
    • Avogaro, A.1    Fadini, G.P.2
  • 59
    • 84903386097 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor sitagliptin protects against dyslipidemia-related kidney injury in Apolipoprotein
    • Li, J.; Guan, M.; Li, C.; Lyv, F.; Zeng, Y.; Zheng, Z.; Wang, C.; Xue, Y. The dipeptidyl peptidase-4 inhibitor sitagliptin protects against dyslipidemia-related kidney injury in Apolipoprotein E knockout mice. Int. J. Mol. Sci. 2014, 15, 11416-11434.
    • (2014) E Knockout Mice. Int. J. Mol. Sci , vol.15 , pp. 11416-11434
    • Li, J.1    Guan, M.2    Li, C.3    Lyv, F.4    Zeng, Y.5    Zheng, Z.6    Wang, C.7    Xue, Y.8
  • 61
    • 78650175802 scopus 로고    scopus 로고
    • Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes
    • Vaghasiya, J.; Sheth, N.; Bhalodia, Y.; Manek, R. Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regul. Pept. 2011, 166, 48-54.
    • (2011) Regul. Pept , vol.166 , pp. 48-54
    • Vaghasiya, J.1    Sheth, N.2    Bhalodia, Y.3    Manek, R.4
  • 62
    • 84929469873 scopus 로고    scopus 로고
    • Linagliptin blocks renal damage in type 1 diabetic rats by suppressing advanced glycation end products-receptor axis
    • Nakashima, S.; Matsui, T.; Takeuchi, M.; Yamagishi, S.I. Linagliptin blocks renal damage in type 1 diabetic rats by suppressing advanced glycation end products-receptor axis. Horm. Metab. Res. 2014, 46, 717-721.
    • (2014) Horm. Metab. Res. , vol.46 , pp. 717-721
    • Nakashima, S.1    Matsui, T.2    Takeuchi, M.3    Yamagishi, S.I.4
  • 63
    • 84926297509 scopus 로고    scopus 로고
    • Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker diabetic fatty rat
    • Vavrinec, P.; Henning, R.H.; Landheer, S.W.; Wang, Y.; Deelman, L.E.; Dokkum, R.P.; Buikema, H. Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker diabetic fatty rat. Curr. Vasc. Pharmacol. 2014, 12, 836-844.
    • (2014) Curr. Vasc. Pharmacol , vol.12 , pp. 836-844
    • Vavrinec, P.1    Henning, R.H.2    Landheer, S.W.3    Wang, Y.4    Deelman, L.E.5    Dokkum, R.P.6    Buikema, H.7
  • 64
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)—Role in the inactivation of regulatory peptides
    • Mentlein, R. Dipeptidyl-peptidase IV (CD26)—Role in the inactivation of regulatory peptides. Regul. Pept. 1999, 85, 9-24.
    • (1999) Regul. Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 65
    • 79251604529 scopus 로고    scopus 로고
    • Sitagliptin reduces albuminuria in patients with type 2 diabetes
    • Hattori, S. Sitagliptin reduces albuminuria in patients with type 2 diabetes. Endocr. J. 2011, 58, 69-73.
    • (2011) Endocr. J , vol.58 , pp. 69-73
    • Hattori, S.1
  • 66
    • 84883560410 scopus 로고    scopus 로고
    • Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product receptor for advanced glycation end product axis, and albuminuria in Japanese type 2 diabetes
    • J. Clin. Med. 2015, 4 1886
    • Sakata, K.; Hayakawa, M.; Yano, Y.; Tamaki, N.; Yokota, N.; Eto, T.; Watanabe, R.; Hirayama, N.; Matsuo, T.; Kuroki, K.; et al. Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product receptor for advanced glycation end product axis, and albuminuria in Japanese type 2 diabetes. Diabetes Metab. Res. Rev. 2013, 29, 624-630. J. Clin. Med. 2015, 4 1886
    • (2013) Diabetes Metab. Res. Rev , vol.29 , pp. 624-630
    • Sakata, K.1    Hayakawa, M.2    Yano, Y.3    Tamaki, N.4    Yokota, N.5    Eto, T.6    Watanabe, R.7    Hirayama, N.8    Matsuo, T.9    Kuroki, K.10
  • 67
    • 84890476805 scopus 로고    scopus 로고
    • Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction
    • Groop, P.-H.; Cooper, M.E.; Perkovic, V.; Emser, A.; Woerle, H.J.; von Eynatten, M. Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction. Diabetes Care 2013, 36, 3460-3468.
    • (2013) Diabetes Care , vol.36 , pp. 3460-3468
    • Groop, P.-H.1    Cooper, M.E.2    Perkovic, V.3    Emser, A.4    Woerle, H.J.5    Von Eynatten, M.6
  • 68
    • 84861972909 scopus 로고    scopus 로고
    • Exenatide reduces urinary transforming growth factor-P1 and type IV collagen excretion in patients with type 2 diabetes and microalbuminuria
    • Zhang, H.; Zhang, X.; Hu, C.; Lu, W. Exenatide reduces urinary transforming growth factor-P1 and type IV collagen excretion in patients with type 2 diabetes and microalbuminuria. Kidney Blood Press. Res. 2012, 35, 483-488.
    • (2012) Kidney Blood Press. Res , vol.35 , pp. 483-488
    • Zhang, H.1    Zhang, X.2    Hu, C.3    Lu, W.4
  • 70
    • 84939565970 scopus 로고    scopus 로고
    • Kidney Disease End Points in a Pooled Analysis of Individual Patient-Level Data from a Large Clinical Trials Program of the Dipeptidyl Peptidase 4 Inhibitor Linagliptin in Type 2 Diabetes
    • in press
    • Cooper, M.E.; Perkovic, V.; McGill, J.B.; Groop, P.H.; Wanner, C.; Rosenstock, J.; Hehnke, U.; Woerle, H.J.; Eynatten, M. Kidney Disease End Points in a Pooled Analysis of Individual Patient-Level Data from a Large Clinical Trials Program of the Dipeptidyl Peptidase 4 Inhibitor Linagliptin in Type 2 Diabetes. Am. J. Kidney Dis. 2015, in press.
    • (2015) Am. J. Kidney Dis
    • Cooper, M.E.1    Perkovic, V.2    McGill, J.B.3    Groop, P.H.4    Wanner, C.5    Rosenstock, J.6    Hehnke, U.7    Woerle, H.J.8    Eynatten, M.9
  • 73
    • 79953826349 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
    • Kodera, R.; Shikata, K.; Kataoka, H.U.; Takatsuka, T.; Miyamoto, S.; Sasaki, M.; Kajitani, N.; Nishishita, S.; Sarai, K.; Hirota, D.;. Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes. Diabetologia 2011, 54, 965-978.
    • (2011) Diabetologia , vol.54 , pp. 965-978
    • Kodera, R.1    Shikata, K.2    Kataoka, H.U.3    Takatsuka, T.4    Miyamoto, S.5    Sasaki, M.6    Kajitani, N.7    Nishishita, S.8    Sarai, K.9    Hirota, D.10
  • 74
    • 34047205064 scopus 로고    scopus 로고
    • Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice
    • Park, C.W.; Kim, H.W.; Ko, S.H.; Lim, J.H.; Ryu, G.R.; Chung, H.W.; Han, S.W.; Shin, S.J.; Bang, B.K.; Breyer, M.D.;. Long-term treatment of glucagon-like peptide-1 analog exendin-4 ameliorates diabetic nephropathy through improving metabolic anomalies in db/db mice. J. Am. Soc. Nephrol. 2007, 18, 1227-1238.
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 1227-1238
    • Park, C.W.1    Kim, H.W.2    Ko, S.H.3    Lim, J.H.4    Ryu, G.R.5    Chung, H.W.6    Han, S.W.7    Shin, S.J.8    Bang, B.K.9    Breyer, M.D.10
  • 75
  • 78
    • 85114276395 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men
    • et al.Gutmann, H.; Drewe, J.; Henzen, C.; Goeke, B.; Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men. J. Clin. Endocrinol. Metab. 2004, 89, 30553061.
    • (2004) J. Clin. Endocrinol. Metab , vol.89
    • Gutmann, H.1    Drewe, J.2    Henzen, C.3    Goeke, B.4
  • 79
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss: Systematic review and meta-analyses of randomised controlled trials
    • J. Clin. Med. 2015, 4 1887
    • Vilsb0ll, T.; Christensen, M.; Junker, A.E.; Knop, F.K.; Gluud, L.L. Effects of glucagon-like peptide-1 receptor agonists on weight loss: Systematic review and meta-analyses of randomised controlled trials. BMJ 2012, 344, d7771, doi:10.1136/bmj.d7771. J. Clin. Med. 2015, 4 1887
    • (2012) BMJ , vol.344
    • Vilsb0ll, T.1    Christensen, M.2    Junker, A.E.3    Knop, F.K.4    Gluud, L.L.5
  • 80
    • 84877317750 scopus 로고    scopus 로고
    • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
    • Kim, M.; Platt, M.J.; Shibasaki, T.; Quaggin, S.E.; Backx, P.H.; Seino, S.; Simpson, J.A.; Drucker, D.J. GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat. Med. 2013, 19, 67-575.
    • (2013) Nat. Med , vol.19 , pp. 67-575
    • Kim, M.1    Platt, M.J.2    Shibasaki, T.3    Quaggin, S.E.4    Backx, P.H.5    Seino, S.6    Simpson, J.A.7    Drucker, D.J.8
  • 81
    • 84899467577 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-KB Activation
    • Dai, Y.; Mehta, J.L.; Chen, M. Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-KB Activation. Cardiovasc. Drugs Ther. 2013, 27, 371-380.
    • (2013) Cardiovasc. Drugs Ther , vol.27 , pp. 371-380
    • Dai, Y.1    Mehta, J.L.2    Chen, M.3
  • 83
    • 84872400225 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat
    • Thomson, S.C.; Kashkouli, A.; Singh, P. Glucagon-like peptide-1 receptor stimulation increases GFR and suppresses proximal reabsorption in the rat. Am. J. Physiol. Renal Physiol. 2013, 304, F137-F144.
    • (2013) Am. J. Physiol. Renal Physiol , vol.304 , pp. F137-F144
    • Thomson, S.C.1    Kashkouli, A.2    Singh, P.3
  • 84
    • 79951702236 scopus 로고    scopus 로고
    • Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: A retrospective analysis of the LifeLink database
    • Best, J.H.; Hoogwerf, B.J.; Herman, W.H.; Pelletier, E.M.; Smith, D.B.; Wenten, M. Hussein, M.A. Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: A retrospective analysis of the LifeLink database. Diabetes Care 2011, 34, 90-95.
    • (2011) Diabetes Care , vol.34 , pp. 90-95
    • Best, J.H.1    Hoogwerf, B.J.2    Herman, W.H.3    Pelletier, E.M.4    Smith, D.B.5    Wenten Hussein, M.M.A.6
  • 86
    • 84871706890 scopus 로고    scopus 로고
    • Role of GLP-1 and DPP-4 in diabetic nephropathy and cardiovascular disease
    • Panchapakesan, U.; Mather, A.; Pollock, C. Role of GLP-1 and DPP-4 in diabetic nephropathy and cardiovascular disease. Clin. Sci. (Lond.) 2013, 124, 17-26.
    • (2013) Clin. Sci. (Lond.) , vol.124 , pp. 17-26
    • Panchapakesan, U.1    Mather, A.2    Pollock, C.3
  • 87
    • 84905996272 scopus 로고    scopus 로고
    • Renal effects of dapagliflozin in patients with type 2 diabetes
    • Thomas, M.C. Renal effects of dapagliflozin in patients with type 2 diabetes. Ther. Adv. Endocrinol. Metab. 2014, 5, 53-61.
    • (2014) Ther. Adv. Endocrinol. Metab , vol.5 , pp. 53-61
    • Thomas, M.C.1
  • 88
    • 0042422126 scopus 로고    scopus 로고
    • Tubuloglomerular feedback and the control of glomerular filtration rate
    • Vallon, V. Tubuloglomerular feedback and the control of glomerular filtration rate. News Physiol. Sci. 2003, 18, 169-174.
    • (2003) News Physiol. Sci , vol.18 , pp. 169-174
    • Vallon, V.1
  • 89
    • 84908503059 scopus 로고    scopus 로고
    • Sodium-glucose linked transporter-2 inhibitors: Potential for renoprotection beyond blood glucose lowering?
    • Gilbert, R.E. Sodium-glucose linked transporter-2 inhibitors: Potential for renoprotection beyond blood glucose lowering? Kidney Int. 2014, 86, 693-700.
    • (2014) Kidney Int , vol.86 , pp. 693-700
    • Gilbert, R.E.1
  • 90
    • 84903266061 scopus 로고    scopus 로고
    • Sodium/glucose cotransporter 2 inhibitors and prevention of diabetic nephropathy: Targeting the renal tubule in diabetes
    • De Nicola, L.; Gabbai, F.B.; Liberti, M.E.; Sagliocca, A.; Conte, G.; Minutolo, R. Sodium/glucose cotransporter 2 inhibitors and prevention of diabetic nephropathy: Targeting the renal tubule in diabetes. Am. J. Kidney Dis. 2014, 64, 16-24.
    • (2014) Am. J. Kidney Dis , vol.64 , pp. 16-24
    • De Nicola, L.1    Gabbai, F.B.2    Liberti, M.E.3    Sagliocca, A.4    Conte, G.5    Minutolo, R.6
  • 91
    • 84898434447 scopus 로고    scopus 로고
    • Evaluating SGLT2 inhibitors for type 2 diabetes: Pharmacokinetic and toxicological considerations. Expert Opin
    • Scheen, A. Evaluating SGLT2 inhibitors for type 2 diabetes: Pharmacokinetic and toxicological considerations. Expert Opin. Drug Metab. Toxicol. 2014, 10, 647-663.
    • (2014) Drug Metab. Toxicol , vol.10 , pp. 647-663
    • Scheen, A.1
  • 93
    • 84903528312 scopus 로고    scopus 로고
    • Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice
    • J. Clin. Med. 2015, 4 1888
    • Terami, N.; Ogawa, D.; Tachibana, H.; Hatanaka, T.; Wada, J.; Nakatsuka, A.; Eguchi, J.; Horiguchi, C.S.; Nishii, N.; Yamada, H. Long-term treatment with the sodium glucose cotransporter 2 inhibitor, dapagliflozin, ameliorates glucose homeostasis and diabetic nephropathy in db/db mice. PLoS ONE 2014, 9, e100777. J. Clin. Med. 2015, 4 1888
    • (2014) Plos ONE , vol.9
    • Terami, N.1    Ogawa, D.2    Tachibana, H.3    Hatanaka, T.4    Wada, J.5    Nakatsuka, A.6    Eguchi, J.7    Horiguchi, C.S.8    Nishii, N.9    Yamada, H.10
  • 96
    • 84878060305 scopus 로고    scopus 로고
    • Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats
    • Kojima, N.; Williams, J.; Takahashi, T.; Miyata, N.; Roman, R.J. Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats. J. Pharmacol. Exp. Ther. 2013, 345, 464-472.
    • (2013) J. Pharmacol. Exp. Ther , vol.345 , pp. 464-472
    • Kojima, N.1    Williams, J.2    Takahashi, T.3    Miyata, N.4    Roman, R.J.5
  • 97
    • 56149087069 scopus 로고    scopus 로고
    • Phlorizin prevents glomerular hyperfiltration but not hypertrophy in diabetic rats
    • Malatiali, S.; Francis, I.; Barac-Nieto, M. Phlorizin prevents glomerular hyperfiltration but not hypertrophy in diabetic rats. Exp. Diabetes Res. 2008, 2008, 305403, doi:10.1155/2008/305403.
    • (2008) Exp. Diabetes Res , vol.2008
    • Malatiali, S.1    Francis, I.2    Barac-Nieto, M.3
  • 98
    • 84892588641 scopus 로고    scopus 로고
    • SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic akita mice
    • Vallon, V.; Gerasimova, M.; Rose, M.; Masuda, T.; Satriano, J.; Mayoux, E.; Koepsell, H.; Thomson, S.C.; Rieg, T. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic akita mice. Am. J. Physiol. Renal Physiol. 2014, 306, F194-F204.
    • (2014) Am. J. Physiol. Renal Physiol , vol.306
    • Vallon, V.1    Gerasimova, M.2    Rose, M.3    Masuda, T.4    Satriano, J.5    Mayoux, E.6    Koepsell, H.7    Thomson, S.C.8    Rieg, T.9
  • 99
    • 84905238756 scopus 로고    scopus 로고
    • The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension
    • Gembardt, F.; Bartaun, C.; Jarzebska, N.; Mayoux, E.; Todorov, V.T.; Hohenstein, B.; Hugo, C. The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension. Am. J. Physiol. Renal Physiol. 2014, 307, F317-F325.
    • (2014) Am. J. Physiol. Renal Physiol , vol.307
    • Gembardt, F.1    Bartaun, C.2    Jarzebska, N.3    Mayoux, E.4    Todorov, V.T.5    Hohenstein, B.6    Hugo, C.7
  • 100
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan, D.E.; Fioretto, P.; Tang, W.; List, F. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int. 2014, 85, 962-971.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3    List, F.4
  • 103
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin vs. Glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, doubleblind, phase 3 noninferiority trial
    • Cefalu, W.T.; Leiter, L.A.; Yoon, K.H.; Arias, P.; Niskanen, L.; Xie, J.; Balis, D.A.; Canovatchel, W.; Meininger, G. Efficacy and safety of canagliflozin vs. glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, doubleblind, phase 3 noninferiority trial. Lancet 2013, 382, 941-950.
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3    Arias, P.4    Niskanen, L.5    Xie, J.6    Balis, D.A.7    Canovatchel, W.8    Meininger, G.9
  • 104
    • 65349196064 scopus 로고    scopus 로고
    • Sodium glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List, J.F.; Woo, V.; Morales, E.; Tang, W.; Fiedorek, F.T. Sodium glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care 2009, 32, 650-657.
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 105
    • 84858323889 scopus 로고    scopus 로고
    • Dapagliflozin 006 Study Group. Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin
    • Wilding, J.; Woo, V.; Soler, N.G.; Pahor, A.; Sugg, J.; Rohwedder, K.; Parikh, S.; Dapagliflozin 006 Study Group. Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin. Ann. Intern. Med. 2012, 156, 405-415.
    • (2012) Ann. Intern. Med , vol.156 , pp. 405-415
    • Wilding, J.1    Woo, V.2    Soler, N.G.3    Pahor, A.4    Sugg, J.5    Rohwedder, K.6    Parikh, S.7
  • 106
    • 84899904943 scopus 로고    scopus 로고
    • Renal sodium glucose cotransporter 2 inhibitors as a novel therapeutic approach to treatment of type 2 diabetes: Clinical data and mechanism of action
    • J. Clin. Med. 2015, 4 1889
    • Fujita, Y.; Inagaki, N. Renal sodium glucose cotransporter 2 inhibitors as a novel therapeutic approach to treatment of type 2 diabetes: Clinical data and mechanism of action. J. Diabetes Investig. 2014, 5, 265-275. J. Clin. Med. 2015, 4 1889
    • (2014) J. Diabetes Investig , vol.5 , pp. 265-275
    • Fujita, Y.1    Inagaki, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.