Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

Microbial Cell Factories

Volumn 16, Issue 1, 2017, Pages

  Yap, Hui Yeng Yeannie ^a,c   Muria Gonzalez, Mariano Jordi ^b,e   Kong, Boon Hong ^a   Stubbs, Keith A ^c   Tan, Chon Seng ^d   Ng, Szu Ting ^d   Tan, Nget Hong ^a   Solomon, Peter S ^b   Fung, Shin Yee ^a   Chooi, Yit Heng ^b,c  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d Taman Perindustrian Balakong Jaya 2   (Malaysia)

^e CURTIN UNIVERSITY   (Australia)

Author keywords

(+) Torreyol; Heterologous expression; Lignosus rhinocerotis; Saccharomyces cerevisiae; Sesquiterpene synthase; Sesquiterpenoid; Tiger milk mushroom; Cadinol

Indexed keywords

ALPHA CARDINOL; BETA CUBEBENE; BETA ELEMENE; CARDINOL DERIVATIVE; CEDRENE; GERMACRENE DEXTRO 4 OL; PLANT MEDICINAL PRODUCT; SELINA 6 EN 4 OL; SESQUITERPENOID; TORREYOL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; SESQUITERPENE; TRANSFERASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG PURIFICATION; DRUG STRUCTURE; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; IC50; LIGNOSUS RHINOCEROTIS; MASS FRAGMENTOGRAPHY; MUSHROOM; PHYLOGENY; PROTON NUCLEAR MAGNETIC RESONANCE; AGARICALES; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENETICS; METABOLISM; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AGARICALES; ALKYL AND ARYL TRANSFERASES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; SACCHAROMYCES CEREVISIAE; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85020387800     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-017-0713-x     Document Type: Article

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