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Volumn 13, Issue 4, 2017, Pages 482-490

L-Glutamine in vitro Modulates some Immunomodulatory Properties of Bone Marrow Mesenchymal Stem Cells

Author keywords

Cytokines; Immunomodulation; L Glutamine; Macrophages and lymphocytes; Mesenchymal stem cells

Indexed keywords

ALPHA5 INTEGRIN; ATAXIN 1; GLUTAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MICROSOMAL AMINOPEPTIDASE; NEUROTROPHIN RECEPTOR P75; STAT PROTEIN; STAT3 PROTEIN; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; CYTOKINE; STAT3 PROTEIN, MOUSE;

EID: 85020276492     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-017-9746-0     Document Type: Article
Times cited : (23)

References (43)
  • 1
    • 0034843181 scopus 로고    scopus 로고
    • Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection?
    • COI: 1:CAS:528:DC%2BD3MXmslGls7c%3D, PID: 11533304
    • Newsholme, P. (2001). Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection? Journal of Nutrition, 131(9), 2515S–2522S.
    • (2001) Journal of Nutrition , vol.131 , Issue.9 , pp. 2515S-2522S
    • Newsholme, P.1
  • 4
    • 77953538994 scopus 로고    scopus 로고
    • Amino acid regulation of mammalian gene expression in the intestine
    • COI: 1:CAS:528:DC%2BC3cXntFShu74%3D, PID: 20188788
    • Brasse-Lagnel, C. G., Lavoinne, A. M., & Husson, A. S. (2010). Amino acid regulation of mammalian gene expression in the intestine. Biochimie, 92(7), 729–735.
    • (2010) Biochimie , vol.92 , Issue.7 , pp. 729-735
    • Brasse-Lagnel, C.G.1    Lavoinne, A.M.2    Husson, A.S.3
  • 5
    • 85001759445 scopus 로고    scopus 로고
    • Pivotal role of glutamine synthetase in ammonia detoxification
    • COI: 1:CAS:528:DC%2BC2sXisFWg, PID: 27641632
    • Hakvoort, T. B., He, Y., Kulik, W., et al. (2017). Pivotal role of glutamine synthetase in ammonia detoxification. Hepatology, 65(1), 281–293.
    • (2017) Hepatology , vol.65 , Issue.1 , pp. 281-293
    • Hakvoort, T.B.1    He, Y.2    Kulik, W.3
  • 6
    • 84964905706 scopus 로고    scopus 로고
    • Alanyl-glutamine supplementation regulates mTOR and ubiquitin proteasome proteolysis signaling pathways in piglets
    • COI: 1:CAS:528:DC%2BC28XnsFWmsbg%3D, PID: 27155955
    • Zhang, B., Lin, M., Yu, C., et al. (2016). Alanyl-glutamine supplementation regulates mTOR and ubiquitin proteasome proteolysis signaling pathways in piglets. Nutrition, 32(10), 1123–1131.
    • (2016) Nutrition , vol.32 , Issue.10 , pp. 1123-1131
    • Zhang, B.1    Lin, M.2    Yu, C.3
  • 7
    • 0033489873 scopus 로고    scopus 로고
    • Glutamine and the immune system
    • COI: 1:CAS:528:DyaK1MXnslaqtLw%3D, PID: 10582122
    • Calder, P. C., & Yaqoob, P. (1999). Glutamine and the immune system. Amino Acids, 17(3), 227–241.
    • (1999) Amino Acids , vol.17 , Issue.3 , pp. 227-241
    • Calder, P.C.1    Yaqoob, P.2
  • 8
    • 84883536378 scopus 로고    scopus 로고
    • Side effects of long-term glutamine supplementation
    • PID: 22990615
    • Holecek, M. (2013). Side effects of long-term glutamine supplementation. Journal of Parenteral and Enteral Nutrition, 37(5), 607–616.
    • (2013) Journal of Parenteral and Enteral Nutrition , vol.37 , Issue.5 , pp. 607-616
    • Holecek, M.1
  • 9
    • 80054984946 scopus 로고    scopus 로고
    • Glutamine as an immunonutrient
    • COI: 1:CAS:528:DC%2BC3MXhsFOisbbF, PID: 22028151
    • Kim, H. (2011). Glutamine as an immunonutrient. Yonsei Medical Journal, 52(6), 892–897.
    • (2011) Yonsei Medical Journal , vol.52 , Issue.6 , pp. 892-897
    • Kim, H.1
  • 10
    • 84896929687 scopus 로고    scopus 로고
    • Metabolic requirements for the maintenance of self-renewing stem cells
    • COI: 1:CAS:528:DC%2BC2cXks12ksL8%3D, PID: 24651542
    • Ito, K., & Suda, T. (2014). Metabolic requirements for the maintenance of self-renewing stem cells. Nature Reviews Molecular Cell Biology, 15(4), 243–256.
    • (2014) Nature Reviews Molecular Cell Biology , vol.15 , Issue.4 , pp. 243-256
    • Ito, K.1    Suda, T.2
  • 11
    • 0017119380 scopus 로고
    • Fibroblast precursors in normal and irradiated mouse hematopoietic organs
    • COI: 1:STN:280:DyaE2s%2Fis1Wktw%3D%3D, PID: 976387
    • Friedenstein, A. J., Gorskaja, J. F., & Kulagina, N. N. (1976). Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Experimental Hematology, 4(5), 267–274.
    • (1976) Experimental Hematology , vol.4 , Issue.5 , pp. 267-274
    • Friedenstein, A.J.1    Gorskaja, J.F.2    Kulagina, N.N.3
  • 12
    • 24944503491 scopus 로고    scopus 로고
    • Review: Mesenchymal stem cells: Cell-based reconstructive therapy in orthopedics
    • COI: 1:CAS:528:DC%2BD2MXpslagur0%3D, PID: 16144456
    • Caplan, A. (2005). Review: Mesenchymal stem cells: Cell-based reconstructive therapy in orthopedics. Tissue Engineering, 11(7–8), 1198–1211.
    • (2005) Tissue Engineering , vol.11 , Issue.7-8 , pp. 1198-1211
    • Caplan, A.1
  • 14
    • 84949626345 scopus 로고    scopus 로고
    • Mesenchymal stromal cells and hematopoietic stem cell transplantation
    • COI: 1:CAS:528:DC%2BC2MXhtVyht7jM, PID: 26116911
    • Bernardo, M. E., & Fibbe, W. E. (2015). Mesenchymal stromal cells and hematopoietic stem cell transplantation. Immunology Letters, 168(2), 215–221.
    • (2015) Immunology Letters , vol.168 , Issue.2 , pp. 215-221
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 15
    • 84952864927 scopus 로고    scopus 로고
    • The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy
    • Zhang, J., Huang, X., Wang, H., et al. (2015). The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy. Stem Cell Research & Therapy, 1(6), 234.
    • (2015) Stem Cell Research & Therapy , vol.1 , Issue.6 , pp. 234
    • Zhang, J.1    Huang, X.2    Wang, H.3
  • 16
    • 84943250221 scopus 로고    scopus 로고
    • Strategies to improve the immunosuppressive properties of human mesenchymal stem cells
    • Lee, M. W., Ryu, S., Kim, D. S., Sung, K. W., Koo, H. H., & Yoo, K. H. (2015). Strategies to improve the immunosuppressive properties of human mesenchymal stem cells. Stem Cell Research & Therapy, 7(6), 179.
    • (2015) Stem Cell Research & Therapy , vol.7 , Issue.6 , pp. 179
    • Lee, M.W.1    Ryu, S.2    Kim, D.S.3    Sung, K.W.4    Koo, H.H.5    Yoo, K.H.6
  • 17
    • 85022166206 scopus 로고    scopus 로고
    • The influence of protein malnutrition on biological and immunomodulatory aspects of bone marrow mesenchymal stem cells
    • Dos Santos, G. G., Batool, S., Hastreiter, A., et al. (2016). The influence of protein malnutrition on biological and immunomodulatory aspects of bone marrow mesenchymal stem cells. Clinical Nutrition, S0261-5614(16), 30202–30203.
    • (2016) Clinical Nutrition , vol.S0261-5614 , Issue.16 , pp. 30202-30203
    • Dos Santos, G.G.1    Batool, S.2    Hastreiter, A.3
  • 18
    • 0000045991 scopus 로고
    • The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid
    • COI: 1:CAS:528:DyaG28Xjt12hsg%3D%3D, PID: 13295214
    • Eagle, H., Oyama, V. I., Levy, M., Horton, C. L., & Fleischman, R. (1956). The growth response of mammalian cells in tissue culture to L-glutamine and L-glutamic acid. Journal of Biological Chemistry, 218, 607–616.
    • (1956) Journal of Biological Chemistry , vol.218 , pp. 607-616
    • Eagle, H.1    Oyama, V.I.2    Levy, M.3    Horton, C.L.4    Fleischman, R.5
  • 19
    • 0037221363 scopus 로고    scopus 로고
    • Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells
    • COI: 1:CAS:528:DC%2BD38XpvVahsrc%3D, PID: 12507630
    • Wischmeyer, P. E., Riehm, J., Singleton, K. D., et al. (2003). Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. Nutrition, 19, 1–6.
    • (2003) Nutrition , vol.19 , pp. 1-6
    • Wischmeyer, P.E.1    Riehm, J.2    Singleton, K.D.3
  • 20
    • 85022133437 scopus 로고
    • Nutrition and immunity: Practical applications of Research findings
    • COI: 1:STN:280:DC%2BC3M7ktFWnug%3D%3D, PID: 21263876
    • Chandra, R. K. (1987). Nutrition and immunity: Practical applications of Research findings. Canadian Family Physician, 33, 1417–1420.
    • (1987) Canadian Family Physician , vol.33 , pp. 1417-1420
    • Chandra, R.K.1
  • 21
    • 84857814973 scopus 로고    scopus 로고
    • Patterns of amino acid metabolism by proliferating human mesenchymal stem cells
    • COI: 1:CAS:528:DC%2BC38Xjt1Whs70%3D, PID: 21943055
    • Higuera, G. A., Schop, D., Spitters, T. W., et al. (2012). Patterns of amino acid metabolism by proliferating human mesenchymal stem cells. Tissue Engineering Part a, 18(5–6), 654–664.
    • (2012) Tissue Engineering Part a , vol.18 , Issue.5-6 , pp. 654-664
    • Higuera, G.A.1    Schop, D.2    Spitters, T.W.3
  • 23
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
    • COI: 1:CAS:528:DC%2BC3cXivFKgsrs%3D
    • Grivennikov, S. I., & Karin, M. (2010). Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine & Growth Factor Reviews, 21(1), 11–19.
    • (2010) Cytokine & Growth Factor Reviews , vol.21 , Issue.1 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 24
    • 84860990117 scopus 로고    scopus 로고
    • Immunosuppressive properties of mesenchymal stem cells: Advances and applications
    • PID: 22515979
    • De Miguel, M. P., Fuentes-Julián, S., & Blázquez-Martínez, A. (2012). Immunosuppressive properties of mesenchymal stem cells: Advances and applications. Current Molecular Medicine, 12(5), 574–591.
    • (2012) Current Molecular Medicine , vol.12 , Issue.5 , pp. 574-591
    • De Miguel, M.P.1    Fuentes-Julián, S.2    Blázquez-Martínez, A.3
  • 25
    • 84922876934 scopus 로고    scopus 로고
    • Secretion of immunoregulatory cytokines by mesenchymal stem cells
    • PID: 25426252
    • Kyurkchiev, D., Bochev, I., Ivanova-Todorova, E., et al. (2014). Secretion of immunoregulatory cytokines by mesenchymal stem cells. World J Stem Cells, 6(5), 552–570.
    • (2014) World J Stem Cells , vol.6 , Issue.5 , pp. 552-570
    • Kyurkchiev, D.1    Bochev, I.2    Ivanova-Todorova, E.3
  • 26
    • 20844434815 scopus 로고    scopus 로고
    • The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription
    • COI: 1:CAS:528:DC%2BD2MXlsFCgtLo%3D, PID: 15937121
    • Murray, P. J. (2005). The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proceedings of the National Academy of Sciences of the United States of America, 102(24), 8686–8691.
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.24 , pp. 8686-8691
    • Murray, P.J.1
  • 27
    • 0036256644 scopus 로고    scopus 로고
    • What does Stat3 do?
    • COI: 1:CAS:528:DC%2BD38XjsFalsLw%3D, PID: 11994402
    • Levy, D. E., & Lee, C. K. (2002). What does Stat3 do? Journal of Clinical Investigation, 109(9), 1143–1148.
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.9 , pp. 1143-1148
    • Levy, D.E.1    Lee, C.K.2
  • 28
    • 0033523019 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action
    • COI: 1:CAS:528:DyaK1MXjs1Ont7Y%3D, PID: 10347215
    • Riley, J. K., Takeda, K., Akira, S., & Schreiber, R. D. (1999). Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for anti-inflammatory action. Journal of Biological Chemistry, 274(23), 16513–16521.
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.23 , pp. 16513-16521
    • Riley, J.K.1    Takeda, K.2    Akira, S.3    Schreiber, R.D.4
  • 29
    • 11144358194 scopus 로고    scopus 로고
    • Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis
    • COI: 1:CAS:528:DC%2BD2cXjslajtrs%3D, PID: 15102771
    • Bonecini-Almeida, M. G., Ho, J. L., Boechat, N., et al. (2004). Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis. Infection and Immunity, 72(5), 2628–2634.
    • (2004) Infection and Immunity , vol.72 , Issue.5 , pp. 2628-2634
    • Bonecini-Almeida, M.G.1    Ho, J.L.2    Boechat, N.3
  • 30
    • 77958467862 scopus 로고    scopus 로고
    • Immunosuppression by mesenchymal stem cells: Mechanisms and clinical applications
    • Ghannam, S., Bouffi, C., Djouad, F., Jorgensen, C., & Noël, D. (2010). Immunosuppression by mesenchymal stem cells: Mechanisms and clinical applications. Stem Cell Research & Therapy, 1(1), 2.
    • (2010) Stem Cell Research & Therapy , vol.1 , Issue.1 , pp. 2
    • Ghannam, S.1    Bouffi, C.2    Djouad, F.3    Jorgensen, C.4    Noël, D.5
  • 31
    • 15944376184 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells
    • COI: 1:CAS:528:DC%2BD2MXivFGmt7k%3D, PID: 15591115
    • Glennie, S., Soeiro, I., Dyson, P. J., Lam, E. W., & Dazzi, F. (2005). Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells. Blood, 105(7), 2821–2827.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2821-2827
    • Glennie, S.1    Soeiro, I.2    Dyson, P.J.3    Lam, E.W.4    Dazzi, F.5
  • 32
    • 0038617545 scopus 로고    scopus 로고
    • The complex role of interleukin-10 in autoimmunity
    • COI: 1:CAS:528:DC%2BD3sXkt1Gltbc%3D, PID: 12791313
    • Groux, H., & Cottrez, F. (2003). The complex role of interleukin-10 in autoimmunity. Journal of Autoimmunity, 20(4), 281–285.
    • (2003) Journal of Autoimmunity , vol.20 , Issue.4 , pp. 281-285
    • Groux, H.1    Cottrez, F.2
  • 35
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • PID: 11986244
    • Di Nicola, M., Carlo-Stella, C., Magni, M., et al. (2002). Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood, 99(10), 3838–3843.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 36
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • COI: 1:CAS:528:DC%2BD2MXhsVGjt7Y%3D, PID: 15494428
    • Aggarwal, S., & Pittenger, M. F. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood, 105(4), 1815–1822.
    • (2005) Blood , vol.105 , Issue.4 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 37
    • 67649604299 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans
    • COI: 1:CAS:528:DC%2BD1MXovFarurk%3D, PID: 19489103
    • Sun, L., Akiyama, K., Zhang, H., et al. (2009). Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans. Stem Cells, 27(6), 1421–1432.
    • (2009) Stem Cells , vol.27 , Issue.6 , pp. 1421-1432
    • Sun, L.1    Akiyama, K.2    Zhang, H.3
  • 38
    • 70849116391 scopus 로고    scopus 로고
    • Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6
    • COI: 1:CAS:528:DC%2BD1MXhtVOrtrbF, PID: 19565371
    • Najar, M., Rouas, R., & Raicevic, G. (2009). Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6. Cytotherapy, 11(5), 570–583.
    • (2009) Cytotherapy , vol.11 , Issue.5 , pp. 570-583
    • Najar, M.1    Rouas, R.2    Raicevic, G.3
  • 39
    • 69949166907 scopus 로고    scopus 로고
    • Reciprocal effect of mesenchymal stem cell on experimental autoimmune encephalomyelitis is mediated by transforming growth factor-beta and interleukin-6
    • COI: 1:CAS:528:DC%2BD1MXht1Cqt7zF
    • Liu, X. J., Zhang, J. F., & Sun, B. (2009). Reciprocal effect of mesenchymal stem cell on experimental autoimmune encephalomyelitis is mediated by transforming growth factor-beta and interleukin-6. Clinical & Experimental Immunology, 158(1), 37–44.
    • (2009) Clinical & Experimental Immunology , vol.158 , Issue.1 , pp. 37-44
    • Liu, X.J.1    Zhang, J.F.2    Sun, B.3
  • 40
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • COI: 1:CAS:528:DC%2BD2sXhtV2is7%2FI, PID: 17898760
    • Steinman, R. M., & Banchereau, J. (2007). Taking dendritic cells into medicine. Nature, 449(7161), 419–426.
    • (2007) Nature , vol.449 , Issue.7161 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 41
    • 77949537626 scopus 로고    scopus 로고
    • Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile
    • PID: 20169081
    • Maggini, J., Mirkin, G., Bognanni, I., et al. (2010). Mouse bone marrow-derived mesenchymal stromal cells turn activated macrophages into a regulatory-like profile. PloS One, 5, e9252.
    • (2010) PloS One , vol.5
    • Maggini, J.1    Mirkin, G.2    Bognanni, I.3
  • 42
    • 78149335954 scopus 로고    scopus 로고
    • Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing
    • COI: 1:CAS:528:DC%2BC3cXhsFKntbrI, PID: 20734355
    • Zhang, Q. Z., Su, W. R., Shi, S. H., et al. (2010). Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing. Stem Cells, 28(10), 1856–1868.
    • (2010) Stem Cells , vol.28 , Issue.10 , pp. 1856-1868
    • Zhang, Q.Z.1    Su, W.R.2    Shi, S.H.3
  • 43
    • 69049104333 scopus 로고    scopus 로고
    • From IL-10 to IL-12: How pathogens and their products stimulate APCs to induce T(H)1 development
    • PID: 19692989
    • O'Garra, A., & Murphy, K. M. (2009). From IL-10 to IL-12: How pathogens and their products stimulate APCs to induce T(H)1 development. Nature Immunology, 10(9), 929–932.
    • (2009) Nature Immunology , vol.10 , Issue.9 , pp. 929-932
    • O'Garra, A.1    Murphy, K.M.2


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