-
1
-
-
0035338343
-
Risks in new drug development: approval success rates for investigational drugs
-
Dimasi JA. Risks in new drug development: approval success rates for investigational drugs. Clin Pharmacol Ther 2001;69:297-307
-
(2001)
Clin Pharmacol Ther
, vol.69
, pp. 297-307
-
-
Dimasi, J.A.1
-
2
-
-
33645675960
-
Estimating the cost of new drug development: is it really 802 million?
-
Adams CP, Brantner VV. Estimating the cost of new drug development: is it really 802 million? Health Aff 2006;25:420-8
-
(2006)
Health Aff
, vol.25
, pp. 420-428
-
-
Adams, C.P.1
Brantner, V.V.2
-
3
-
-
4344668661
-
Drug repositioning: identifying and developing new uses for existing drugs
-
Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 2004;3:673-83
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
4
-
-
62549131608
-
Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the US preventive services task force
-
Wolff T, Miller T, Ko S. Aspirin for the primary prevention of cardiovascular events: an update of the evidence for the US preventive services task force. Ann Intern Med 2009;150:405-72
-
(2009)
Ann Intern Med
, vol.150
, pp. 405-472
-
-
Wolff, T.1
Miller, T.2
Ko, S.3
-
5
-
-
84860467522
-
Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials
-
Algra AM, Rothwell PM. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol 2012;13:518-27
-
(2012)
Lancet Oncol
, vol.13
, pp. 518-527
-
-
Algra, A.M.1
Rothwell, P.M.2
-
6
-
-
0032516296
-
Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group
-
Goldstein I, Lue TF, Padma-Nathan H, et al. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 1998;338:1397-404
-
(1998)
N Engl J Med
, vol.338
, pp. 1397-1404
-
-
Goldstein, I.1
Lue, T.F.2
Padma-Nathan, H.3
-
7
-
-
0034655161
-
Thalidomide: current and potential clinical applications
-
Calabrese L, Fleischer AB. Thalidomide: current and potential clinical applications. Am J Med 2000;108:487-95
-
(2000)
Am J Med
, vol.108
, pp. 487-495
-
-
Calabrese, L.1
Fleischer, A.B.2
-
8
-
-
43249097561
-
Thalidomide for treatment of multiple myeloma: 10 years later
-
Palumbo A, Facon T, Sonneveld P, et al. Thalidomide for treatment of multiple myeloma: 10 years later. Blood 2008;111:3968-77
-
(2008)
Blood
, vol.111
, pp. 3968-3977
-
-
Palumbo, A.1
Facon, T.2
Sonneveld, P.3
-
9
-
-
84858983547
-
KEGG for integration and interpretation of large-scale molecular data sets
-
Kanehisa M, Goto S, Sato Y, et al. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 2012;40:D109-14
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D109-D114
-
-
Kanehisa, M.1
Goto, S.2
Sato, Y.3
-
11
-
-
84859267371
-
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery
-
Zhu F, Shi Z, Qin C, et al. Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res 2012;40:D1128-36
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D1128-D1136
-
-
Zhu, F.1
Shi, Z.2
Qin, C.3
-
12
-
-
84876467333
-
The comparative toxicogenomics database: update 2013
-
Davis AP, Murphy CG, Johnson R, et al. The comparative toxicogenomics database: update 2013. Nucleic Acids Res 2013;41:D1104-14
-
(2013)
Nucleic Acids Res
, vol.41
, pp. D1104-D1114
-
-
Davis, A.P.1
Murphy, C.G.2
Johnson, R.3
-
13
-
-
79960766975
-
Literature mining, ontologies and information visualization for drug repurposing
-
Andronis C, Sharma A, Virvilis V, et al. Literature mining, ontologies and information visualization for drug repurposing. Brief Bioinform 2011;12:357-68
-
(2011)
Brief Bioinform
, vol.12
, pp. 357-368
-
-
Andronis, C.1
Sharma, A.2
Virvilis, V.3
-
14
-
-
84864238297
-
Identifying novel drug indications through automated reasoning
-
Tari L, Vo N, Liang S, et al. Identifying novel drug indications through automated reasoning. PLoS One 2012;7:e40946
-
(2012)
PLoS One
, vol.7
-
-
Tari, L.1
Vo, N.2
Liang, S.3
-
15
-
-
84927558406
-
Systematic drug repurposing through text mining
-
Tari LB, Patel JH. Systematic drug repurposing through text mining. Methods Mol Biol 2014;1159:253-67
-
(2014)
Methods Mol Biol
, vol.1159
, pp. 253-267
-
-
Tari, L.B.1
Patel, J.H.2
-
16
-
-
36749097784
-
Automated acquisition of disease-drug knowledge from biomedical and clinical documents: an initial study
-
Chen ES, Hripcsak G, Xu H, et al. Automated acquisition of disease-drug knowledge from biomedical and clinical documents: an initial study. J Am Med Inform Assoc 2008;15:87-98
-
(2008)
J Am Med Inform Assoc
, vol.15
, pp. 87-98
-
-
Chen, E.S.1
Hripcsak, G.2
Xu, H.3
-
17
-
-
84878514642
-
Large-scale extraction of accurate drug-disease treatment pairs from biomedical literature for drug repurposing
-
Xu R, Wang Q. Large-scale extraction of accurate drug-disease treatment pairs from biomedical literature for drug repurposing. BMC Bioinformatics 2013;14:181
-
(2013)
BMC Bioinformatics
, vol.14
, pp. 181
-
-
Xu, R.1
Wang, Q.2
-
19
-
-
85037338954
-
Generating typed dependency parses from phrase structure parses
-
Genoa, Italy
-
De Marneffe M-C, MacCartney B, Manning CD. Generating typed dependency parses from phrase structure parses. In: Proceedings of LREC. 2006, Genoa, Italy, pp. 449-54
-
(2006)
Proceedings of LREC
, pp. 449-454
-
-
De Marneffe, M.-C.1
MacCartney, B.2
Manning, C.D.3
-
20
-
-
85144480129
-
Dependency tree kernels for relation extraction
-
Association for Computational Linguistics, 2004, Barcelona, Spain
-
Culotta A, Sorensen J. Dependency tree kernels for relation extraction. In: Proceedings of the 42nd Annual Meeting on Association for Computational Linguistics. Association for Computational Linguistics, 2004, Barcelona, Spain, pp. 423
-
Proceedings of the 42nd Annual Meeting on Association for Computational Linguistics
, pp. 423
-
-
Culotta, A.1
Sorensen, J.2
-
21
-
-
80053262847
-
A shortest path dependency kernel for relation extraction. In: Proceedings of the conference on Human Language Technology and Empirical Methods in Natural Language Processing
-
Vancouver, Canada
-
Bunescu RC, Mooney RJ. A shortest path dependency kernel for relation extraction. In: Proceedings of the conference on Human Language Technology and Empirical Methods in Natural Language Processing. Association for Computational Linguistics, 2005, Vancouver, Canada, pp. 724-31
-
(2005)
Association for Computational Linguistics
, pp. 724-731
-
-
Bunescu, R.C.1
Mooney, R.J.2
-
22
-
-
13244275598
-
Using predicate-argument structures for information extraction. In: Proceedings of the 41st Annual Meeting on Association for Computational Linguistics
-
Sapporo, Japan
-
Surdeanu M, Harabagiu S, Williams J, et al. Using predicate-argument structures for information extraction. In: Proceedings of the 41st Annual Meeting on Association for Computational Linguistics-Volume 1. Association for Computational Linguistics, 2003, Sapporo, Japan, pp. 8-15
-
(2003)
Association for Computational Linguistics
, vol.1
, pp. 8-15
-
-
Surdeanu, M.1
Harabagiu, S.2
Williams, J.3
-
23
-
-
79954510351
-
Condensing biomedical journal texts through paragraph ranking
-
Chiang JH, Liu HH, Huang YT. Condensing biomedical journal texts through paragraph ranking. Bioinformatics 2011;27:1143-9
-
(2011)
Bioinformatics
, vol.27
, pp. 1143-1149
-
-
Chiang, J.H.1
Liu, H.H.2
Huang, Y.T.3
-
24
-
-
85084287330
-
A study on dependency tree kernels for automatic extraction of protein-protein interaction. In: Proceedings of BioNLP 2011 Workshop
-
Portland, Oregon, USA
-
Chowdhury FM, Lavelli A, Moschitti A. A study on dependency tree kernels for automatic extraction of protein-protein interaction. In: Proceedings of BioNLP 2011 Workshop. Association for Computational Linguistics, 2011, Portland, Oregon, USA, pp. 124-133
-
(2011)
Association for Computational Linguistics
, pp. 124-133
-
-
Chowdhury, F.M.1
Lavelli, A.2
Moschitti, A.3
-
25
-
-
0022786956
-
Fish oil, Raynaud's syndrome, and undiscovered public knowledge
-
Swanson DR. Fish oil, Raynaud's syndrome, and undiscovered public knowledge. Perspect Biol Med 1986;30:7-18
-
(1986)
Perspect Biol Med
, vol.30
, pp. 7-18
-
-
Swanson, D.R.1
-
26
-
-
0024031265
-
Migraine and magnesium: eleven neglected connections
-
Swanson DR. Migraine and magnesium: eleven neglected connections. Perspect Biol Med 1988;31:526-57
-
(1988)
Perspect Biol Med
, vol.31
, pp. 526-557
-
-
Swanson, D.R.1
-
27
-
-
77957044703
-
Discovery of drug mode of action and drug repositioning from transcriptional responses
-
Iorio F, Bosotti R, Scacheri E, et al. Discovery of drug mode of action and drug repositioning from transcriptional responses. Proc Natl Acad Sci USA 2010;107:14621-26
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14621-14626
-
-
Iorio, F.1
Bosotti, R.2
Scacheri, E.3
-
29
-
-
84876541616
-
Prediction of polypharmacological profiles of drugs by the integration of chemical, side effect, and therapeutic space
-
Cheng F, Li W, Wu Z, et al. Prediction of polypharmacological profiles of drugs by the integration of chemical, side effect, and therapeutic space. J Chem Inf Model 2013;53:753-62
-
(2013)
J Chem Inf Model
, vol.53
, pp. 753-762
-
-
Cheng, F.1
Li, W.2
Wu, Z.3
-
30
-
-
78049427383
-
Literature mining for the discovery of hidden connections between drugs, genes and diseases
-
Frijters R, van Vugt M, Smeets R, et al. Literature mining for the discovery of hidden connections between drugs, genes and diseases. PLoS Comput Biol 2010;6:e1000943
-
(2010)
PLoS Comput Biol
, vol.6
-
-
Frijters, R.1
van Vugt, M.2
Smeets, R.3
-
31
-
-
84893959920
-
Synergistic effect of COX-2 inhibitor on paclitaxel-induced apoptosis in the human ovarian cancer cell line OVCAR-3
-
Kim HJ, Yim GW, Nam EJ, et al. Synergistic effect of COX-2 inhibitor on paclitaxel-induced apoptosis in the human ovarian cancer cell line OVCAR-3. Cancer Res Treat 2014;46:81-92
-
(2014)
Cancer Res Treat
, vol.46
, pp. 81-92
-
-
Kim, H.J.1
Yim, G.W.2
Nam, E.J.3
-
32
-
-
84896837299
-
A novel role for raloxifene nanomicelles in management of castrate resistant prostate cancer
-
Taurin S, Nehoff H, van Aswegen T, et al. A novel role for raloxifene nanomicelles in management of castrate resistant prostate cancer. Biomed Res Int 2014;2014;323594
-
(2014)
Biomed Res Int
, vol.2014
-
-
Taurin, S.1
Nehoff, H.2
van Aswegen, T.3
-
33
-
-
84861553131
-
Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells
-
Li B, Gao S, Wei F, et al. Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells. Oncol Rep 2012;28:15-20
-
(2012)
Oncol Rep
, vol.28
, pp. 15-20
-
-
Li, B.1
Gao, S.2
Wei, F.3
-
34
-
-
84905036566
-
Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway
-
Li J, Xue LY, Hao HL, et al. Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway. Tumor Biol 2014;35:6467-74
-
(2014)
Tumor Biol
, vol.35
, pp. 6467-6474
-
-
Li, J.1
Xue, L.Y.2
Hao, H.L.3
-
35
-
-
84878376817
-
Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling
-
Kumar BN, Rajput S, Dey KK, et al. Celecoxib alleviates tamoxifen-instigated angiogenic effects by ROS-dependent VEGF/VEGFR2 autocrine signaling. BMC Cancer 2013;13:273
-
(2013)
BMC Cancer
, vol.13
, pp. 273
-
-
Kumar, B.N.1
Rajput, S.2
Dey, K.K.3
-
36
-
-
84920767626
-
Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of the literature
-
Yoshino T, Ohara S, Moriyama H. Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of the literature. BMC Res Notes 2014;7:779
-
(2014)
BMC Res Notes
, vol.7
, pp. 779
-
-
Yoshino, T.1
Ohara, S.2
Moriyama, H.3
-
37
-
-
70449715476
-
Effects of tamoxifen and raloxifene on memory and other cognitive abilities: cognition in the study of tamoxifen and raloxifene
-
Legault C, Maki PM, Resnick SM, et al. Effects of tamoxifen and raloxifene on memory and other cognitive abilities: cognition in the study of tamoxifen and raloxifene. J Clin Oncol 2009;27:5144-52
-
(2009)
J Clin Oncol
, vol.27
, pp. 5144-5152
-
-
Legault, C.1
Maki, P.M.2
Resnick, S.M.3
-
38
-
-
84955132162
-
Memory enhancement by tamoxifen on amyloidosis mouse model
-
Pandey D, Banerjee S, Basu M, et al. Memory enhancement by tamoxifen on amyloidosis mouse model. Horm Behav 2016;79:70-3
-
(2016)
Horm Behav
, vol.79
, pp. 70-73
-
-
Pandey, D.1
Banerjee, S.2
Basu, M.3
-
39
-
-
84883776568
-
Cancer drug discovery by repurposing: teaching new tricks to old dogs
-
Gupta SC, Sung B, Prasad S, et al. Cancer drug discovery by repurposing: teaching new tricks to old dogs. Trends Pharmacol Sci 2013;34:508-517
-
(2013)
Trends Pharmacol Sci
, vol.34
, pp. 508-517
-
-
Gupta, S.C.1
Sung, B.2
Prasad, S.3
-
40
-
-
79953325924
-
GeneTUKit: a software for documentlevel gene normalization
-
Huang M, Liu J, Zhu X. GeneTUKit: a software for documentlevel gene normalization. Bioinformatics 2011;27:1032-33
-
(2011)
Bioinformatics
, vol.27
, pp. 1032-1033
-
-
Huang, M.1
Liu, J.2
Zhu, X.3
-
41
-
-
80053432627
-
Cross-species gene normalization by species inference
-
Wei CH, Kao HY. Cross-species gene normalization by species inference. BMC bioinformatics 2011;12 (Suppl 8):S5
-
(2011)
BMC bioinformatics
, vol.12
, pp. S5
-
-
Wei, C.H.1
Kao, H.Y.2
-
42
-
-
84890064920
-
DNorm: disease name normalization with pairwise learning to rank
-
Leaman R, Islamaj Dogan R, Lu Z. DNorm: disease name normalization with pairwise learning to rank. Bioinformatics 2013;29:2909-2917
-
(2013)
Bioinformatics
, vol.29
, pp. 2909-2917
-
-
Leaman, R.1
Islamaj Dogan, R.2
Lu, Z.3
-
43
-
-
84889655691
-
Computational drug repositioning through heterogeneous network clustering
-
Wu C, Gudivada RC, Aronow BJ, et al. Computational drug repositioning through heterogeneous network clustering. BMC Systems Biology 2013;7:S6
-
(2013)
BMC Systems Biology
, vol.7
, pp. S6
-
-
Wu, C.1
Gudivada, R.C.2
Aronow, B.J.3
-
44
-
-
84901604202
-
Connections of nicotine to cancer
-
Grando SA. Connections of nicotine to cancer. Nat Rev Cancer 2014;14:419-429
-
(2014)
Nat Rev Cancer
, vol.14
, pp. 419-429
-
-
Grando, S.A.1
-
45
-
-
85104042765
-
Overview of BioNLP'09 shared task on event extraction
-
Association for Computational Linguistics, Boulder, Colorado
-
Kim J-D, Ohta T, Pyysalo S, et al. Overview of BioNLP'09 shared task on event extraction. In: Proceedings of the Workshop on Current Trends in Biomedical Natural Language Processing: Shared Task. Association for Computational Linguistics, 2009, Boulder, Colorado, pp. 1-9
-
(2009)
Proceedings of the Workshop on Current Trends in Biomedical Natural Language Processing: Shared Task
, pp. 1-9
-
-
Kim, J.-D.1
Ohta, T.2
Pyysalo, S.3
-
46
-
-
79960052396
-
Using SVMs with the command relation features to identify negated events in biomedical literature
-
Association for Computational Linguistics, Uppsala, Sweden
-
Sarafraz F, Nenadic G. Using SVMs with the command relation features to identify negated events in biomedical literature. In: Proceedings of the Workshop on Negation and Speculation in Natural Language Processing. Association for Computational Linguistics, 2010, Uppsala, Sweden, pp. 78-85
-
(2010)
Proceedings of the Workshop on Negation and Speculation in Natural Language Processing
, pp. 78-85
-
-
Sarafraz, F.1
Nenadic, G.2
-
47
-
-
84862299931
-
A machinelearning approach to negation and speculation detection in clinical texts
-
Cruz Díaz NP, Maña López MJ, Vázquez JM, et al. A machinelearning approach to negation and speculation detection in clinical texts. J Am Soc Inf Sci Technol 2012;63:1398-1410
-
(2012)
J Am Soc Inf Sci Technol
, vol.63
, pp. 1398-1410
-
-
Cruz Díaz, N.P.1
Maña López, M.J.2
Vázquez, J.M.3
|