Monoclonal antibodies against the staphylococcus aureus bicomponent leukotoxin AB isolated following invasive human infection reveal diverse binding and modes of action

Journal of Infectious Diseases

Volumn 215, Issue 7, 2017, Pages 1124-1131

  Thomsen, Isaac P ^a   Sapparapu, Gopal ^a   James, David B A ^c   Cassat, James E ^a,b   Nagarsheth, Meera ^a   Kose, Nurgun ^a   Putnam, Nicole ^b   Boguslawski, Kristina M ^c   Jones, Lauren S ^a   Wood, James B ^a   Creech, Clarence B ^a   Torres, Victor J ^c   Crowe, James E ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hybridoma; Leukocidin; LukAB; Monoclonal; Staphylococcus aureus; Toxins

Indexed keywords

LEUKOTOXIN; LEUKOTOXIN AB; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; LEUKOCIDIN; LEUKOCIDIN AB, STAPHYLOCOCCUS AUREUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; B LYMPHOCYTE; BACTERIUM COLONY; CASE REPORT; CELL SURFACE; CHILD; CONFERENCE PAPER; CYTOTOXICITY; EFFICACY PARAMETERS; FEMALE; HEART; HUMAN; HUMAN CELL; HYBRIDOMA; IN VIVO STUDY; KIDNEY; LIVER; MALE; MOUSE; NEUTROPHIL; NONHUMAN; OSTEOMYELITIS; PRIORITY JOURNAL; SCHOOL CHILD; SERODIAGNOSIS; STAPHYLOCOCCAL BACTEREMIA; STAPHYLOCOCCUS AUREUS; ANIMAL; BAGG ALBINO MOUSE; BLOOD; IMMUNOLOGY; MICROBIOLOGY; REGRESSION ANALYSIS; STAPHYLOCOCCUS INFECTION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; BACTERIAL PROTEINS; CHILD; FEMALE; HUMANS; HYBRIDOMAS; LEUKOCIDINS; MALE; MICE; MICE, INBRED BALB C; NEUTROPHILS; REGRESSION ANALYSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 85020217122     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jix071     Document Type: Conference Paper

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