Safe long-term repeated disruption of the blood-brain barrier using an implantable ultrasound device: A multiparametric study in a primate model

Journal of Neurosurgery

Volumn 126, Issue 4, 2017, Pages 1351-1361

  Horodyckid, Catherine ^a,b   Canney, Michael ^a   Vignot, Alexandre ^a   Boisgard, Raphael ^c   Drier, Aurélie ^d   Huberfeld, Gilles ^b,c,f,g   François, Chantal ^b   Prigent, Annick ^b   Santin, Mathieu D ^b,h   Adam, Clovis ⁱ   Willer, Jean Claude ^b,e   Lafon, Cyril ^f   Chapelon, Jean Yves ^f   Carpentier, Alexandre ^b  

^a INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c DIF   (France)

^d Center of Radiology Réseau d'Imagerie Parisien   (France)

^e PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^f INSERM   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h Centre de NeuroImagerie de Recherche (CENIR)   (France)

ⁱ BICÊTRE HOSPITAL   (France)

Author keywords

Blood brain barrier; Brain tumor; Drug delivery system; Magnetic resonance imaging; Primate; Ultrasound; Ultrasound contrast agent

Indexed keywords

FLUORODEOXYGLUCOSE F 18; SULFUR HEXAFLUORIDE; CENTRAL NERVOUS SYSTEM AGENTS; RADIOPHARMACEUTICAL AGENT;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTROENCEPHALOGRAPHY; FEMALE; GLUCOSE METABOLISM; HISTOPATHOLOGY; IMAGE ANALYSIS; IMPLANTATION; MACACA FASCICULARIS; MALE; MICROBUBBLE; MULTIPARAMETRIC MAGNETIC RESONANCE IMAGING; NEUROLOGICAL IMPLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PAPIO ANUBIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SKULL; SOMATOSENSORY EVOKED POTENTIAL; ULTRASOUND; ULTRASOUND TRANSDUCER; ANIMAL; ANIMAL MODEL; CAPILLARY PERMEABILITY; DEVICES; DRUG EFFECT; EQUIPMENT DESIGN; INTRAVENOUS DRUG ADMINISTRATION; LONGITUDINAL STUDY; METABOLISM; PATHOLOGY; ULTRASOUND THERAPY;

ADMINISTRATION, INTRAVENOUS; ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CENTRAL NERVOUS SYSTEM AGENTS; ELECTROENCEPHALOGRAPHY; EQUIPMENT DESIGN; EVOKED POTENTIALS, SOMATOSENSORY; FEMALE; FLUORODEOXYGLUCOSE F18; LONGITUDINAL STUDIES; MACACA FASCICULARIS; MAGNETIC RESONANCE IMAGING; MALE; MICROBUBBLES; MODELS, ANIMAL; PAPIO ANUBIS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; SULFUR HEXAFLUORIDE; ULTRASONIC THERAPY;

EID: 85020057399     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2016.3.JNS151635     Document Type: Article

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