Ultrasound-induced opening of the blood-brain barrier to enhance temozolomide and irinotecan delivery: An experimental study in rabbits

Journal of Neurosurgery

Volumn 124, Issue 6, 2016, Pages 1602-1610

  Beccaria, Kevin ^a,b   Canney, Michael ^a   Goldwirt, Lauriane ^c   Fernandez, Christine ^c   Piquet, Julie ^d   Perier, Marie Cécile ^e   Lafon, Cyril ^f   Chapelon, Jean Yves ^f   Carpentier, Alexandre ^g  

^a INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^f INSERM   (France)

^g SORBONNE UNIVERSITÉ   (France)

Author keywords

Blood brain barrier; Brain tumors; Drug delivery; Irinotecan; Oncology; Temozolomide; Ultrasound

Indexed keywords

IRINOTECAN; SONOVUE; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DACARBAZINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TUMOR; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG PENETRATION; HEMISPHERE; MALE; NEW ZEALAND RABBIT; NONHUMAN; PRIORITY JOURNAL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRASOUND; ULTRASOUND TRANSDUCER; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD ANALYSIS; BRAIN; DRUG EFFECTS; ECHOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MICROBUBBLE; PROCEDURES; RABBIT; REPRODUCIBILITY;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD CHEMICAL ANALYSIS; BLOOD-BRAIN BARRIER; BRAIN; CAMPTOTHECIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DACARBAZINE; MALE; MICROBUBBLES; RABBITS; REPRODUCIBILITY OF RESULTS; ULTRASONOGRAPHY;

EID: 84975275232     PISSN: 00223085     EISSN: 19330693     Source Type: Journal    
DOI: 10.3171/2015.4.JNS142893     Document Type: Article

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