Inhibition of autophagy promotes salinomycin-induced apoptosis via reactive oxygen species-mediated PI3K/AKT/mTOR and ERK/p38 MAPK-dependent signaling in human prostate cancer cells

International Journal of Molecular Sciences

Volumn 18, Issue 5, 2017, Pages

  Kim, Kwang Youn ^a,b   Park, Kwang Il ^c   Kim, Sang Hun ^b   Yu, Sun Nyoung ^b   Park, Sul Gi ^b   Kim, Young Woo ^a   Seo, Young Kyo ^d   Ma, Jin Yeul ^c   Ahn, Soon Cheol ^b,e  

^a Daegu Haany University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^d Ulsan National Institute of Science and Technology   (South Korea)

^e Pusan National University   (South Korea)

Author keywords

Apoptosis; Autophagy; Prostate cancer cells; Reactive oxygen species; Salinomycin

Indexed keywords

3 METHYLADENINE; ACETYLCYSTEINE; BECLIN 1; CASPASE 3; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SALINOMYCIN; 2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FLAVONOID; IMIDAZOLE DERIVATIVE; MTOR PROTEIN, HUMAN; PYRAN DERIVATIVE; PYRIDINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CELL VIABILITY ASSAY; COLORIMETRY; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; MITOCHONDRIAL MEMBRANE POTENTIAL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROPIDIUM IODIDE ASSAY; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; MALE; MAPK SIGNALING; METABOLISM;

APOPTOSIS; AUTOPHAGY; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; IMIDAZOLES; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRANS; PYRIDINES; REACTIVE OXYGEN SPECIES; TOR SERINE-THREONINE KINASES;

EID: 85019959228     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18051088     Document Type: Article

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