The fragment HMGA2-sh-3p20 from HMGA2 mRNA 3′UTR promotes the growth of hepatoma cells by Upregulating HMGA2

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Wang, Yuan ^a   Chen, Fuquan ^a   Yang, Zhe ^a   Zhao, Man ^a   Zhang, Shuqin ^a   Gao, Yuen ^a   Feng, Jinyan ^a   Yang, Guang ^a   Zhang, Weiying ^a   Ye, Lihong ^a   Zhang, Xiaodong ^a  

^a NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A2 PROTEIN; HMGA2 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CONFORMATION; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; RNA INTERFERENCE; RNA STABILITY; XENOGRAFT;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGRAFTS; HMGA2 PROTEIN; HUMANS; LIVER NEOPLASMS; MICE; MODELS, BIOLOGICAL; NUCLEIC ACID CONFORMATION; PTEN PHOSPHOHYDROLASE; RNA INTERFERENCE; RNA STABILITY; RNA, SMALL INTERFERING;

EID: 85019917085     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-02311-0     Document Type: Article

References (49)

1. Fusco, A. & Fedele, M. Roles of HMGA proteins in cancer. Nat Rev Cancer 7, 899-910 (2007).
2. Hammond, S. M. & Sharpless, N. E. HMGA2, microRNAs, and stem cell aging. Cell 135, 1013-1016 (2008).
3. Wu, J. & Wei, J. J. HMGA2 and high-grade serous ovarian carcinoma. J Mol Med (Berl) 91, 1155-1165 (2013).
4. Wu, J. et al. Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer. Cancer Letters 376, 284-292 (2016).
5. Singh, I. et al. Hmga2 is required for canonical WNT signaling during lung development. BMC Biol 12, 21 (2014).
6. Wang, X. et al. Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers. Clin Cancer Res 17, 2570-2580 (2011).
7. Wend, P. et al. WNT10B/beta-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol Med 5, 264-279 (2013).
8. Ahmed, K. M., Tsai, C. Y. & Lee, W. H. Derepression of HMGA2 via removal of ZBRK1/BRCA1/CtIP complex enhances mammary tumorigenesis. J Biol Chem 285, 4464-4471 (2010).
9. Shell, S. et al. Let-7 expression defines two differentiation stages of cancer. Proc Natl Acad Sci USA 104, 11400-11405 (2007).
10. Poliseno, L. et al. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465, 1033-1038 (2010).
11. Wachter, A. Gene regulation by structured mRNA elements. Trends Genet 30, 172-181 (2014).
12. Feng, S. & Holland, E. C. HIV-1 tat trans-activation requires the loop sequence within tar. Nature 334, 165-167 (1988).
13. Gao, Y. et al. A hairpin within YAP mRNA 3′UTR functions in regulation at post-transcription level. Biochem Biophys Res Commun 459, 306-312 (2015).
14. Gao, Y. E. et al. Post-transcriptional modulation of protein phosphatase PPP2CA and tumor suppressor PTEN by endogenous siRNA cleaved from hairpin within PTEN mRNA 3′UTR in human liver cells. Acta Pharmacol Sin 37, 898-907 (2016).
15. Cullen, B. R. Transcription and processing of human microRNA precursors. Mol Cell 16, 861-865 (2004).
16. Grishok, A. et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 106, 23-34 (2001).
17. Burger, K. & Gullerova, M. Swiss army knives: non-canonical functions of nuclear Drosha and Dicer. Nat Rev Mol Cell Biol 16, 417-430 (2015).
18. Rybak-Wolf, A. et al. A variety of dicer substrates in human and C. elegans. Cell 159, 1153-1167 (2014).
19. Karginov, F. V. et al. Diverse endonucleolytic cleavage sites in the mammalian transcriptome depend upon microRNAs, Drosha, and additional nucleases. Mol Cell 38, 781-788 (2010).
20. Cook, K. B., Kazan, H., Zuberi, K., Morris, Q. & Hughes, T. R. RBPDB: a database of RNA-binding specificities. Nucleic Acids Res 39, D301-308 (2011).
21. Hafner, M. et al. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141, 129-141 (2010).
22. Yoon, J. H. et al. PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity. Nat Commun 5, 5248 (2014).
23. Hitti, E. et al. Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins. Cancer Res, doi: 10.1158/0008-5472.CAN-15-3110 (2016).
24. Lai, W. S., Kennington, E. A. & Blackshear, P. J. Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Mol Cell Biol 23, 3798-3812 (2003).
25. Lai, W. S., Kennington, E. A. & Blackshear, P. J. Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J Biol Chem 277, 9606-9613 (2002).
26. Sanduja, S., Blanco, F. F. & Dixon, D. A. The roles of TTP and BRF proteins in regulated mRNA decay. Wiley Interdiscip Rev RNA 2, 42-57 (2011).
27. Cully, M., You, H., Levine, A. J. & Mak, T. W. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 6, 184-192 (2006).
28. Matzura, O. & Wennborg, A. RNAdraw: an integrated program for RNA secondary structure calculation and analysis under 32-bit Microsoft Windows. Comput Appl Biosci 12, 247-249 (1996).
29. Bellaousov, S., Reuter, J. S., Seetin, M. G. & Mathews, D. H. RNAstructure: Web servers for RNA secondary structure prediction and analysis. Nucleic Acids Res 41, W471-474 (2013).
30. You, X. et al. Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. Carcinogenesis 34, 1644-1652 (2013).
31. Gregory, R. I. et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235-240 (2004).
32. Barreau, C., Paillard, L. & Osborne, H. B. AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res 33, 7138-7150 (2005).
33. Ma, F. et al. MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J Immunol 184, 6053-6059 (2010).
34. Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233 (2009).
35. Kruger, J. & Rehmsmeier, M. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res 34, W451-454 (2006).
36. Milke, L. et al. Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages. Carcinogenesis 34, 850-857 (2013).
37. Zhou, H. et al. MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancer cell proliferation by directly targeting HMGA2. Int J Oncol 44, 2050-2058 (2014).
38. Yang, Y. et al. Decreased MicroRNA-26a expression causes cisplatin resistance in human non-small cell lung cancer. Cancer Biol Ther 17, 515-525 (2016).
39. Ding, K. et al. MiR-26a performs converse roles in proliferation and metastasis of different gastric cancer cells via regulating of PTEN expression. Pathol Res Pract, doi: 10.1016/j.prp.2017.01.026 (2017).
40. Al-Haj, L., Blackshear, P. J. & Khabar, K. S. Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements. Nucleic Acids Res 40, 7739-7752 (2012).
41. Zhang, H. et al. Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Acta Pharmacol Sin 29, 473-480 (2008).
42. Zhang, S. et al. MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-kappaB-inducing kinase (NIK). Oncogene 31, 3607-3620 (2012).
43. Du, Y. et al. Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18. J Biol Chem 287, 26302-26311 (2012).
44. Yang, L. et al. lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature 500, 598-602 (2013).
45. Zhang, X. et al. Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. J Med Virol 77, 374-381 (2005).
46. Gao, S. et al. MicroRNA-133a regulates insulin-like growth factor-1 receptor expression and vascular smooth muscle cell proliferation in murine atherosclerosis. Atherosclerosis 232, 171-179 (2014).
47. Hu, N. et al. miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem 286, 13714-13722 (2011).
48. Zhang, W. et al. MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1. PLoS One 7, e31450 (2012).
49. Zhang, T. et al. Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells. Hepatology 56, 2051-2059 (2012).