Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments

Journal of Virology

Volumn 91, Issue 12, 2017, Pages

  Wu, Ren Huang ^a   Tsai, Ming Han ^a   Tsai, Kuen Nan ^a   Tian, Jia Ni ^a,b   Wu, Jian Sung ^a   Wu, Su Ying ^a   Chern, Jyh Haur ^a   Chen, Chun Hong ^a   Yueh, Andrew ^a,b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CENTRAL UNIVERSITY   (Taiwan)

Author keywords

Cytopathic effect; Dengue virus; Intermolecular interaction; RNA replication; Scanning mutagenesis; Transmembrane segment

Indexed keywords

ALANINE; ISOLEUCINE; LACTATE DEHYDROGENASE; LEUCINE; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2A; NONSTRUCTURAL PROTEIN 2B; PHENYLALANINE; THREONINE; UNCLASSIFIED DRUG; NS2A PROTEIN, DENGUE VIRUS TYPE 2; VIRAL PROTEIN; VIRUS RNA;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CODON; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DENGUE VIRUS; ENZYME RELEASE; HEK293 CELL LINE; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; REPLICON; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS MUTATION; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; PHYSIOLOGY; SECRETION (PROCESS); SEQUENCE ANALYSIS; VIRUS ASSEMBLY; VIRUS REPLICATION;

ALANINE; AMINO ACID SUBSTITUTION; CELL PROLIFERATION; CYTOPATHOGENIC EFFECT, VIRAL; DENGUE VIRUS; HEK293 CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LEUCINE; MUTAGENESIS; MUTATION; PHENYLALANINE; RNA, VIRAL; SEQUENCE ANALYSIS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS ASSEMBLY; VIRUS REPLICATION;

EID: 85019770807     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01836-16     Document Type: Article

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