Identification of genetic loci shared between schizophrenia and the Big Five personality traits

Scientific Reports

Volumn 7, Issue 1, 2017, Pages

  Smeland, Olav B ^a   Wang, Yunpeng ^a,b   Lo, Min Tzu ^c   Li, Wen ^a   Frei, Oleksandr ^a   Witoelar, Aree ^a   Tesli, Martin ^a,d   Hinds, David A ^e   Tung, Joyce Y ^e   Djurovic, Srdjan ^f,g   Chen, Chi Hua ^c   Dale, Anders M ^b,c,h   Andreassen, Ole A ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LOVISENBERG DIAKONALE HOSPITAL   (Norway)

^e 23andMe Inc ^*  (United States)

^f OSLO UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF BERGEN   (Norway)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE LOCUS; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; HUMAN; PERSONALITY; PSYCHOLOGY; QUANTITATIVE TRAIT; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

GENETIC ASSOCIATION STUDIES; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; HUMANS; PERSONALITY; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 85019761718     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-02346-3     Document Type: Article

References (57)

1. Clark, L. A. Temperament as a unifying basis for personality and psychopathology. Journal of abnormal psychology 114, 505-521, doi: 10.1037/0021-843X.114.4.505 (2005
2. Krueger, R. F., & Tackett, J. L. Personality and psychopathology: working toward the bigger picture. J Pers Disord 17, 109-128, doi: 10.1521/pedi.17.2.109.23986 (2003
3. Widiger, T. A. Personality and psychopathology. World Psychiatry 10, 103-106, doi: 10.1002/wps.2011.10.issue-2 (2011
4. Malouff, J. M., Thorsteinsson, E. B., & Schutte, N. S. The relationship between the five-factor model of personality and symptoms of clinical disorders: a meta-analysis. Journal of Psychopathology and Behavioral Assessment 27, 101-114, doi: 10.1007/s10862-005-5384-y (2005
5. Vukasovic, T., & Bratko, D. Heritability of personality: A meta-analysis of behavior genetic studies. Psychol Bull 141, 769-785, doi: 10.1037/bul0000017 (2015
6. Lichtenstein, P., et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373, 234-239, doi: S0140-6736(09)60072-6 [pii] 10.1016/S0140-6736(09)60072-6 (2009
7. Service, S. K., et al. A genome-wide meta-analysis of association studies of Cloninger?s Temperament Scales. Transl Psychiatry 2, e116, doi: 10.1038/tp.2012.37 (2012
8. de Moor, M. H. M., et al. Meta-analysis of genome-wide association studies for personality. Molecular psychiatry 17, 337-349, doi: 10.1038/mp.2010.128 (2012
9. Genetics of Personality, C., et al. Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA psychiatry, doi: 10.1001/jamapsychiatry.2015.0554 (2015
10. Lo, M. T., et al. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat Genet, doi: 10.1038/ng.3736 (2016
11. Schizophrenia Working Group of the Psychiatric Genomics, C. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427, doi: 10.1038/nature13595 (2014
12. Smith, D. J., et al. Genome-wide analysis of over 106,000 individuals identifies 9 neuroticism-associated loci. bioRxiv (2015
13. Digman, J. M. Personality Structure-Emergence of the 5-Factor Model. Annu Rev Psychol 41, 417-440, doi: 10.1146/Annurev. Ps.41.020190.002221 (1990
14. Bouchard, T. J. Jr., & Loehlin, J. C. Genes, evolution, and personality. Behavior genetics 31, 243-273, doi: 10.1023/A: 1012294324713 (2001
15. McCrae, R. R., Terracciano, A., & Project, P. P. C. Universal features of personality traits from the observer?s perspective: Data from 50 cultures. J Pers Soc Psychol 88, 547-561, doi: 10.1037/0022-3514.88.3.547 (2005
16. Berenbaum, H., & Fujita, F. Schizophrenia and personality: exploring the boundaries and connections between vulnerability and outcome. Journal of abnormal psychology 103, 148-158, doi: 10.1037/0021-843X.103.1.148 (1994
17. Bagby, R. M., et al. Relationship between the five-factor model of personality and unipolar, bipolar and schizophrenic patients. Psychiatry Res 70, 83-94, doi: 10.1016/S0165-1781(97)03096-5 (1997
18. Camisa, K. M., et al. Personality traits in schizophrenia and related personality disorders. Psychiatry Res 133, 23-33, doi: 10.1016/j. psychres.2004.09.002 (2005
19. Gurrera, R. J., Nestor, P. G., & O?Donnell, B. F. Personality traits in schizophrenia: comparison with a community sample. The Journal of nervous and mental disease 188, 31-35, doi: 10.1097/00005053-200001000-00006 (2000
20. Herran, A., Sierra-Biddle, D., Cuesta, M. J., Sandoya, M., & Vazquez-Barquero, J. L. Can personality traits help us explain disability in chronic schizophrenia? Psychiatry Clin Neurosci 60, 538-545, doi: 10.1111/j.1440-1819.2006.01577.x (2006
21. Pillmann, F., Bloink, R., Balzuweit, S., Haring, A., & Marneros, A. Personality and social interactions in patients with acute brief psychoses. The Journal of nervous and mental disease 191, 503-508, doi: 10.1097/01.nmd.0000082211.05819.02 (2003
22. Reno, R. M. Personality characterizations of outpatients with schizophrenia, schizophrenia with substance abuse, and primary substance abuse. The Journal of nervous and mental disease 192, 672-681, doi: 10.1097/01.nmd.0000142030.44203.63 (2004
23. Lysaker, P. H., Wilt, M. A., Plascak-Hallberg, C. D., Brenner, C. A., & Clements, C. A. Personality dimensions in schizophrenia: associations with symptoms and coping. The Journal of nervous and mental disease 191, 80-86, doi: 10.1097/01. NMD.0000050936.81128.5B (2003
24. Kentros, M., et al. Stability of personality traits in schizophrenia and schizoaffective disorder: a pilot project. The Journal of nervous and mental disease 185, 549-555, doi: 10.1097/00005053-199709000-00003 (1997
25. Van Os, J., & Jones, P. B. Neuroticism as a risk factor for schizophrenia. Psychological medicine 31, 1129-1134 (2001
26. Lonnqvist, J. E., et al. Premorbid personality factors in schizophrenia and bipolar disorder: results from a large cohort study of male conscripts. Journal of abnormal psychology 118, 418-423, doi: 10.1037/a0015127 (2009
27. Lee, S. H., et al. Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet 44, 247-250, doi: 10.1038/ng.1108 (2012
28. Schork, A. J., Wang, Y., Thompson, W. K., Dale, A. M., & Andreassen, O. A. New statistical approaches exploit the polygenic architecture of schizophrenia-implications for the underlying neurobiology. Curr Opin Neurobiol 36, 89-98, doi: 10.1016/j. conb.2015.10.008 (2016
29. Liu, J. Z., et al. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis. Nat Genet 45, 670-675, doi: 10.1038/ng.2616 (2013
30. Andreassen, O. A., Thompson, W. K., & Dale, A. M. Boosting the power of schizophrenia genetics by leveraging new statistical tools. Schizophrenia bulletin 40, 13-17, doi: 10.1093/schbul/sbt168 (2014
31. Andreassen, O. A., et al. Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate. PLoS genetics 9, e1003455, doi: 10.1371/journal.pgen.1003455 (2013
32. Andreassen, O. A., et al. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. American journal of human genetics 92, 197-209, doi: 10.1016/j.ajhg.2013.01.001 (2013
33. Andreassen, O. A., et al. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: implications for immune related disease mechanisms. Molecular psychiatry (2014
34. Andreassen, O. A., et al. Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms. PloS one 10, e0123057, doi: 10.1371/journal.pone.0123057 (2015
35. Schork, A. J., et al. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS genetics 9, e1003449, doi: 10.1371/journal.pgen.1003449 (2013
36. Benjamini, Y., & Hochberg, Y. In Journal of the Royal Statistical Society. Series B (Methodological) Vol. 57, 289-300 (Blackwell Publishing, 1995
37. Davies, G., et al. Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N = 112 151). Molecular psychiatry 21, 758-767, doi: 10.1038/mp.2016.45 (2016
38. Bulik-Sullivan, B. K., et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet 47, 291-295, doi: 10.1038/ng.3211 (2015
39. Sun, L., Craiu, R. V., Paterson, A. D., & Bull, S. B. Stratified false discovery control for large-scale hypothesis testing with application to genome-wide association studies. Genetic epidemiology 30, 519-530, doi: 10.1002/gepi.20164 (2006
40. Price, A. L., et al. Long-range LD can confound genome scans in admixed populations. American journal of human genetics 83, 132-135; author reply 135-139, 10.1016/j.ajhg.2008.06.005 (2008
41. Nichols, T., Brett, M., Andersson, J., Wager, T., & Poline, J. B. Valid conjunction inference with the minimum statistic. Neuroimage 25, 653-660, doi: 10.1016/j.neuroimage.2004.12.005 (2005
42. Insel, T. R. The NIMH Research Domain Criteria (RDoC) Project: precision medicine for psychiatry. The American journal of psychiatry 171, 395-397, doi: 10.1176/appi.ajp.2014.14020138 (2014
43. Smoller, J. W. Disorders and borders: psychiatric genetics and nosology. Am J Med Genet B Neuropsychiatr Genet 162B, 559-578, doi: 10.1002/ajmg.b.32174 (2013
44. Hamshere, M. L., et al. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Molecular psychiatry 18, 708-712, doi: 10.1038/mp.2012.67 (2013
45. Moskvina, V., et al. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Molecular psychiatry 14, 252-260, doi: 10.1038/mp.2008.133 (2009
46. Costa, P. T. Jr., & McCrae, R. R. Personality disorders and the five-factor model of personality. Journal of personality disorders 4, 362-371, doi: 10.1521/pedi.1990.4.4.362 (1990
47. Deyoung, C. G. The neuromodulator of exploration: A unifying theory of the role of dopamine in personality. Front Hum Neurosci 7, 762, doi: 10.3389/fnhum.2013.00762 (2013
48. Kahn, R. S., et al. Schizophrenia. Nat Rev Dis Primers 1, 15067, doi: 10.1038/nrdp.2015.67 (2015
49. Batey, M., & Furnham, A. Creativity, intelligence, and personality: a critical review of the scattered literature. Genet Soc Gen Psychol Monogr 132, 355-429, doi: 10.3200/MONO.132.4.355-430 (2006
50. Feist, G. J. A meta-analysis of personality in scientific and artistic creativity. Pers Soc Psychol Rev 2, 290-309, doi: 10.1207/s15327957pspr0204-5 (1998
51. Karksson, J. L. Genetic association of giftedness and creativity with schizophrenia. Hereditas 66, 177-182, doi: 10.1111/j.1601-5223.1970.tb02343.x (1970
52. Power, R. A., et al. Polygenic risk scores for schizophrenia and bipolar disorder predict creativity. Nat Neurosci 18, 953-955, doi: 10.1038/nn.4040 (2015
53. Fromer, M., et al. De novo mutations in schizophrenia implicate synaptic networks. Nature 506, 179-184, doi: 10.1038/nature12929 (2014
54. Purcell, S. M., et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185-190, doi: 10.1038/nature12975 (2014
55. Solovieff, N., Cotsapas, C., Lee, P. H., Purcell, S. M., & Smoller, J. W. Pleiotropy in complex traits: challenges and strategies. Nature reviews. Genetics 14, 483-495, doi: 10.1038/nrg3461 (2013
56. Tabares-Seisdedos, R., & Rubenstein, J. L. Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer. Molecular psychiatry 14, 563-589, doi: 10.1038/mp.2009.2 (2009
57. Ripke, S., et al. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet, doi: 10.1038/ng.2742 (2013