메뉴 건너뛰기




Volumn 37, Issue 6, 2017, Pages 3405-3414

Nifuroxazide prompts antitumor immune response of TCL-loaded DC in mice with orthotopically-implanted hepatocarcinoma

Author keywords

Antitumor immune response; HCC; Nifuroxazide; STAT3; TCL loaded DC

Indexed keywords

NIFUROXAZIDE; STAT3 PROTEIN; ANTINEOPLASTIC AGENT; CANCER VACCINE; HYDROXYBENZOIC ACID DERIVATIVE; NITROFURAN DERIVATIVE;

EID: 85019622453     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2017.5629     Document Type: Article
Times cited : (25)

References (44)
  • 2
  • 3
    • 84962793735 scopus 로고    scopus 로고
    • Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma
    • Bruix J, Reig M and Sherman M: Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma. Gastroenterology 150: 835-853, 2016.
    • (2016) Gastroenterology , vol.150 , pp. 835-853
    • Bruix, J.1    Reig, M.2    Sherman, M.3
  • 4
    • 84868136614 scopus 로고    scopus 로고
    • Cellular immune suppressor mechanisms in patients with hepatocellular carcinoma
    • Zhao F, Korangy F and Greten TF: Cellular immune suppressor mechanisms in patients with hepatocellular carcinoma. Dig Dis 30: 477-482, 2012.
    • (2012) Dig Dis , vol.30 , pp. 477-482
    • Zhao, F.1    Korangy, F.2    Greten, T.F.3
  • 5
    • 84948783235 scopus 로고    scopus 로고
    • Immunotherapy in hepatocellular carcinoma: Primed to make a difference?
    • Harding JJ, El Dika I and Abou-Alfa GK: Immunotherapy in hepatocellular carcinoma: Primed to make a difference? Cancer 122: 367-377, 2016.
    • (2016) Cancer , vol.122 , pp. 367-377
    • Harding, J.J.1    El Dika, I.2    Abou-Alfa, G.K.3
  • 6
    • 39049185232 scopus 로고    scopus 로고
    • Pillars Article: Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med.1973. 137: 1142-1162
    • Steinman RM and Cohn ZA: Pillars Article: Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J. Exp. Med.1973. 137: 1142-1162. J Immunol 178: 5-25, 2007.
    • (2007) J Immunol , vol.178 , pp. 5-25
    • Steinman, R.M.1    Cohn, Z.A.2
  • 7
    • 38349160872 scopus 로고    scopus 로고
    • Dendritic cell as therapeutic vaccines against tumors and its role in therapy for hepatocellular carcinoma
    • Sun K, Wang L and Zhang Y: Dendritic cell as therapeutic vaccines against tumors and its role in therapy for hepatocellular carcinoma. Cell Mol Immunol 3: 197-203, 2006.
    • (2006) Cell Mol Immunol , vol.3 , pp. 197-203
    • Sun, K.1    Wang, L.2    Zhang, Y.3
  • 8
    • 81855204935 scopus 로고    scopus 로고
    • Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432
    • Ge C, Xing Y, Wang Q, Xiao W, Lu Y, Hu X, Gao Z, Xu M, Ma Y, Cao R, et al: Improved efficacy of therapeutic vaccination with dendritic cells pulsed with tumor cell lysate against hepatocellular carcinoma by introduction of 2 tandem repeats of microbial HSP70 peptide epitope 407-426 and OK-432. Int Immunopharmacol 11: 2200-2207, 2011.
    • (2011) Int Immunopharmacol , vol.11 , pp. 2200-2207
    • Ge, C.1    Xing, Y.2    Wang, Q.3    Xiao, W.4    Lu, Y.5    Hu, X.6    Gao, Z.7    Xu, M.8    Ma, Y.9    Cao, R.10
  • 9
    • 24144433435 scopus 로고    scopus 로고
    • Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: A clinical trial
    • Lee WC, Wang HC, Hung CF, Huang PF, Lia CR and Chen MF: Vaccination of advanced hepatocellular carcinoma patients with tumor lysate-pulsed dendritic cells: A clinical trial. J Immunother 28: 496-504, 2005.
    • (2005) J Immunother , vol.28 , pp. 496-504
    • Lee, W.C.1    Wang, H.C.2    Hung, C.F.3    Huang, P.F.4    Lia, C.R.5    Chen, M.F.6
  • 10
    • 84952639822 scopus 로고    scopus 로고
    • A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma
    • Lee JH, Lee Y, Lee M, Heo MK, Song JS, Kim KH, Lee H, Yi NJ, Lee KW, Suh KS, et al: A phase I/IIa study of adjuvant immunotherapy with tumour antigen-pulsed dendritic cells in patients with hepatocellular carcinoma. Br J Cancer 113: 1666-1676, 2015.
    • (2015) Br J Cancer , vol.113 , pp. 1666-1676
    • Lee, J.H.1    Lee, Y.2    Lee, M.3    Heo, M.K.4    Song, J.S.5    Kim, K.H.6    Lee, H.7    Yi, N.J.8    Lee, K.W.9    Suh, K.S.10
  • 11
    • 40649087829 scopus 로고    scopus 로고
    • Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN
    • Sun X, Zhang J, Wang L and Tian Z: Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN. Cancer Lett 262: 201-213, 2008.
    • (2008) Cancer Lett , vol.262 , pp. 201-213
    • Sun, X.1    Zhang, J.2    Wang, L.3    Tian, Z.4
  • 12
    • 84905989027 scopus 로고    scopus 로고
    • NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma
    • Sui Q, Zhang J, Sun X, Zhang C, Han Q and Tian Z: NK cells are the crucial antitumor mediators when STAT3-mediated immunosuppression is blocked in hepatocellular carcinoma. J Immunol 193: 2016-2023, 2014.
    • (2014) J Immunol , vol.193 , pp. 2016-2023
    • Sui, Q.1    Zhang, J.2    Sun, X.3    Zhang, C.4    Han, Q.5    Tian, Z.6
  • 15
    • 33845865825 scopus 로고    scopus 로고
    • Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
    • Yu H, Kortylewski M and Pardoll D: Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment. Nat Rev Immunol 7: 41-51, 2007.
    • (2007) Nat Rev Immunol , vol.7 , pp. 41-51
    • Yu, H.1    Kortylewski, M.2    Pardoll, D.3
  • 19
    • 79960847915 scopus 로고    scopus 로고
    • Interleukin-4 enhances trafficking and functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage
    • Yin SY, Wang CY and Yang NS: Interleukin-4 enhances trafficking and functional activities of GM-CSF-stimulated mouse myeloid-derived dendritic cells at late differentiation stage. Exp Cell Res 317: 2210-2221, 2011.
    • (2011) Exp Cell Res , vol.317 , pp. 2210-2221
    • Yin, S.Y.1    Wang, C.Y.2    Yang, N.S.3
  • 21
    • 79952038728 scopus 로고    scopus 로고
    • The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets
    • Yang JD, Nakamura I and Roberts LR: The tumor microenvironment in hepatocellular carcinoma: Current status and therapeutic targets. Semin Cancer Biol 21: 35-43, 2011.
    • (2011) Semin Cancer Biol , vol.21 , pp. 35-43
    • Yang, J.D.1    Nakamura, I.2    Roberts, L.R.3
  • 22
    • 67650650986 scopus 로고    scopus 로고
    • Dendritic cells in immunotherapy of established cancer: Roles of signals 1, 2, 3 and 4
    • Kalinski P: Dendritic cells in immunotherapy of established cancer: Roles of signals 1, 2, 3 and 4. Curr Opin Investig Drugs 10: 526-535, 2009.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 526-535
    • Kalinski, P.1
  • 24
    • 84966783578 scopus 로고    scopus 로고
    • Regulation of natural killer cell function by STAT3
    • Cacalano NA: Regulation of natural killer cell function by STAT3. Front Immunol 7: 128, 2016.
    • (2016) Front Immunol , vol.7 , pp. 128
    • Cacalano, N.A.1
  • 25
    • 84977522809 scopus 로고    scopus 로고
    • Renalase expression by melanoma and tumor-associated macrophages promotes tumor growth through a STAT3-mediated mechanism
    • Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C and Desir GV: Renalase expression by melanoma and tumor-associated macrophages promotes tumor growth through a STAT3-mediated mechanism. Cancer Res 76: 3884-3894, 2016.
    • (2016) Cancer Res , vol.76 , pp. 3884-3894
    • Hollander, L.1    Guo, X.2    Velazquez, H.3    Chang, J.4    Safirstein, R.5    Kluger, H.6    Cha, C.7    Desir, G.V.8
  • 26
    • 84962033748 scopus 로고    scopus 로고
    • STAT3 in CD8+ T cells inhibits their tumor accumulation by downregulating CXCR3/CXCL10 axis
    • Yue C, Shen S, Deng J, Priceman SJ, Li W, Huang A and Yu H: STAT3 in CD8+ T cells inhibits their tumor accumulation by downregulating CXCR3/CXCL10 axis. Cancer Immunol Res 3: 864-870, 2015.
    • (2015) Cancer Immunol Res , vol.3 , pp. 864-870
    • Yue, C.1    Shen, S.2    Deng, J.3    Priceman, S.J.4    Li, W.5    Huang, A.6    Yu, H.7
  • 27
    • 85006011883 scopus 로고    scopus 로고
    • STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC
    • Ghoshal S, Fuchs BC and Tanabe KK: STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC. Hepatobiliary Surg Nutr 5: 201-203, 2016.
    • (2016) Hepatobiliary Surg Nutr , vol.5 , pp. 201-203
    • Ghoshal, S.1    Fuchs, B.C.2    Tanabe, K.K.3
  • 28
    • 84973928851 scopus 로고    scopus 로고
    • IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment
    • Zheng X, Xu M, Yao B, Wang C, Jia Y and Liu Q: IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment. Cell Signal 28: 1314-1324, 2016.
    • (2016) Cell Signal , vol.28 , pp. 1314-1324
    • Zheng, X.1    Xu, M.2    Yao, B.3    Wang, C.4    Jia, Y.5    Liu, Q.6
  • 29
    • 84946488091 scopus 로고    scopus 로고
    • CCR5 blockade suppresses melanoma development through inhibition of IL-6-Stat3 pathway via upregulation of SOCS3
    • Tang Q, Jiang J and Liu J: CCR5 blockade suppresses melanoma development through inhibition of IL-6-Stat3 pathway via upregulation of SOCS3. Inflammation 38: 2049-2056, 2015.
    • (2015) Inflammation , vol.38 , pp. 2049-2056
    • Tang, Q.1    Jiang, J.2    Liu, J.3
  • 30
    • 65049090192 scopus 로고    scopus 로고
    • Autologous dendritic cells loaded with apoptotic tumor cells induce T cell-mediated immune responses against breast cancer in vitro
    • Delirezh N, Moazzeni SM, Shokri F, Shokrgozar MA, Atri M and Kokhaei P: Autologous dendritic cells loaded with apoptotic tumor cells induce T cell-mediated immune responses against breast cancer in vitro. Cell Immunol 257: 23-31, 2009.
    • (2009) Cell Immunol , vol.257 , pp. 23-31
    • Delirezh, N.1    Moazzeni, S.M.2    Shokri, F.3    Shokrgozar, M.A.4    Atri, M.5    Kokhaei, P.6
  • 31
    • 61649125595 scopus 로고    scopus 로고
    • The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma
    • Yang DH, Park JS, Jin CJ, Kang HK, Nam JH, Rhee JH, Kim YK, Chung SY, Choi SJ, Kim HJ, et al: The dysfunction and abnormal signaling pathway of dendritic cells loaded by tumor antigen can be overcome by neutralizing VEGF in multiple myeloma. Leuk Res 33: 665-670, 2009.
    • (2009) Leuk Res , vol.33 , pp. 665-670
    • Yang, D.H.1    Park, J.S.2    Jin, C.J.3    Kang, H.K.4    Nam, J.H.5    Rhee, J.H.6    Kim, Y.K.7    Chung, S.Y.8    Choi, S.J.9    Kim, H.J.10
  • 32
    • 84871012952 scopus 로고    scopus 로고
    • Antitumor effects of Stat3-siRNA and endostatin combined therapies, delivered by attenuated Salmonella, on orthotopically implanted hepatocarcinoma
    • Jia H, Li Y, Zhao T, Li X, Hu J, Yin D, Guo B, Kopecko DJ, Zhao X, Zhang L, et al: Antitumor effects of Stat3-siRNA and endostatin combined therapies, delivered by attenuated Salmonella, on orthotopically implanted hepatocarcinoma. Cancer Immunol Immunother 61: 1977-1987, 2012.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1977-1987
    • Jia, H.1    Li, Y.2    Zhao, T.3    Li, X.4    Hu, J.5    Yin, D.6    Guo, B.7    Kopecko, D.J.8    Zhao, X.9    Zhang, L.10
  • 35
    • 84979209218 scopus 로고    scopus 로고
    • Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells
    • Kozlowska AK, Tseng HC, Kaur K, Topchyan P, Inagaki A, Bui VT, Kasahara N, Cacalano N and Jewett A: Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. Cancer Immunol Immunother 65: 1085-1097, 2016.
    • (2016) Cancer Immunol Immunother , vol.65 , pp. 1085-1097
    • Kozlowska, A.K.1    Tseng, H.C.2    Kaur, K.3    Topchyan, P.4    Inagaki, A.5    Bui, V.T.6    Kasahara, N.7    Cacalano, N.8    Jewett, A.9
  • 36
    • 84921366701 scopus 로고    scopus 로고
    • YLT192, a novel, orally active bioavailable inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy in preclinical models
    • Xia Y, Song X, Li D, Ye T, Xu Y, Lin H, Meng N, Li G, Deng S, Zhang S, et al: YLT192, a novel, orally active bioavailable inhibitor of VEGFR2 signaling with potent antiangiogenic activity and antitumor efficacy in preclinical models. Sci Rep 4: 6031, 2014.
    • (2014) Sci Rep , vol.4 , pp. 6031
    • Xia, Y.1    Song, X.2    Li, D.3    Ye, T.4    Xu, Y.5    Lin, H.6    Meng, N.7    Li, G.8    Deng, S.9    Zhang, S.10
  • 37
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara N: VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2: 795-803, 2002.
    • (2002) Nat Rev Cancer , vol.2 , pp. 795-803
    • Ferrara, N.1
  • 39
    • 20444446371 scopus 로고    scopus 로고
    • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors
    • Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A and Frank DA: Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res 65: 5054-5062, 2005.
    • (2005) Cancer Res , vol.65 , pp. 5054-5062
    • Alvarez, J.V.1    Febbo, P.G.2    Ramaswamy, S.3    Loda, M.4    Richardson, A.5    Frank, D.A.6
  • 40
    • 23744481633 scopus 로고    scopus 로고
    • Evaluation of potential Stat3-regulated genes in human breast cancer
    • Hsieh FC, Cheng G and Lin J: Evaluation of potential Stat3-regulated genes in human breast cancer. Biochem Biophys Res Commun 335: 292-299, 2005.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 292-299
    • Hsieh, F.C.1    Cheng, G.2    Lin, J.3
  • 41
    • 84881267595 scopus 로고    scopus 로고
    • Therapeutic modulators of STAT signalling for human diseases
    • Miklossy G, Hilliard TS and Turkson J: Therapeutic modulators of STAT signalling for human diseases. Nat Rev Drug Discov 12: 611-629, 2013.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 611-629
    • Miklossy, G.1    Hilliard, T.S.2    Turkson, J.3
  • 42
    • 84888302680 scopus 로고    scopus 로고
    • Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer
    • Walker SR, Xiang M and Frank DA: Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer. Mol Cell Endocrinol 382: 616-621, 2014.
    • (2014) Mol Cell Endocrinol , vol.382 , pp. 616-621
    • Walker, S.R.1    Xiang, M.2    Frank, D.A.3
  • 43
    • 0036318098 scopus 로고    scopus 로고
    • Apotosis-related proteins in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix
    • Cheung TH, Chung TK, Lo KW, Yu MY, Krajewski S, Reed JC and Wong YF: Apotosis-related proteins in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix. Gynecol Oncol 86: 14-18, 2002.
    • (2002) Gynecol Oncol , vol.86 , pp. 14-18
    • Cheung, T.H.1    Chung, T.K.2    Lo, K.W.3    Yu, M.Y.4    Krajewski, S.5    Reed, J.C.6    Wong, Y.F.7
  • 44
    • 34547126428 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) as cancer targets
    • Hunter AM, LaCasse EC and Korneluk RG: The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12: 1543-1568, 2007.
    • (2007) Apoptosis , vol.12 , pp. 1543-1568
    • Hunter, A.M.1    LaCasse, E.C.2    Korneluk, R.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.