Identifying lineage effects when controlling for population structure improves power in bacterial association studies

Nature Microbiology

Volumn 1, Issue 5, 2016, Pages

  Earle, Sarah G ^a   Wu, Chieh Hsi ^a   Charlesworth, Jane ^a   Stoesser, Nicole ^a   Gordon, N Claire ^a   Walker, Timothy M ^a   Spencer, Chris C A ^b   Iqbal, Zamin ^b   Clifton, David A ^c   Hopkins, Katie L ^d   Woodford, Neil ^d   Smith, E Grace ^e   Ismail, Nazir ^f,g   Llewelyn, Martin J ^h   Peto, Tim E ^a   Crook, Derrick W ^a   McVean, Gil ^a,b   Walker, A Sarah ^a   Wilson, Daniel J ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d PUBLIC HEALTH ENGLAND   (United Kingdom)

^e BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^f NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

^g UNIVERSITY OF PRETORIA   (South Africa)

^h ROYAL SUSSEX COUNTY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CEFAZOLIN; CEFUROXIME; CIPROFLOXACIN; ERYTHROMYCIN; ETHAMBUTOL; FUSIDIC ACID; GENTAMICIN; ISONIAZID; METICILLIN; PENICILLIN DERIVATIVE; PORIN; PYRAZINAMIDE; RIFAMPICIN; TETRACYCLINE; TOBRAMYCIN; TRIMETHOPRIM;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CLONAL SPECIES; ESCHERICHIA COLI; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC RECOMBINATION; GENETIC SELECTION; GENETIC VARIATION; KLEBSIELLA PNEUMONIAE; MATHEMATICAL ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PENETRANCE; PHENOTYPIC VARIATION; PHYLOGENY; POPULATION STRUCTURE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STATISTICAL MODEL; STRAIN DIFFERENCE; TAXONOMY; DRUG EFFECTS; GENETICS; GENOME-WIDE ASSOCIATION STUDY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; PHYSIOLOGY; PROCEDURES;

DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; PENETRANCE; RECOMBINATION, GENETIC; SELECTION, GENETIC;

EID: 85019567721     PISSN: None     EISSN: 20585276     Source Type: Journal    
DOI: 10.1038/nmicrobiol.2016.41     Document Type: Article

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