Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice

Applied Physiology, Nutrition and Metabolism

Volumn 42, Issue 1, 2017, Pages 77-83

  Gul, Sarah S ^a   Hamilton, A Rebecca L ^a   Munoz, Alexander R ^a   Phupitakphol, Tanit ^a   Liu, Wei ^a   Hyoju, Sanjiv K ^a   Economopoulos, Konstantinos P ^a   Morrison, Sara ^a   Hu, Dong ^a   Zhang, Weifeng ^a   Gharedaghi, Mohammad Hadi ^a   Huo, Haizhong ^a   Hamarneh, Sulaiman R ^a   Hodin, Richard A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aspartame; Diet induced insulin resistance; Insulin resistance; Intestinal alkaline phosphatase; Non nutritive sweeteners; Noncaloric sweeteners; Obesity

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTAME; BIOLOGICAL MARKER; ENZYME INHIBITOR; GLUCOSE BLOOD LEVEL; NONNUTRITIVE SWEETENER; PHENYLALANINE; TUMOR NECROSIS FACTOR;

ADVERSE EFFECTS; ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOTRANSFORMATION; BLOOD; C57BL MOUSE; ENZYMOLOGY; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; INTESTINE MUCOSA; LIPID DIET; MALE; METABOLIC SYNDROME X; METABOLISM; OBESITY; SMALL INTESTINE; WEIGHT GAIN;

ALKALINE PHOSPHATASE; ANIMALS; ASPARTAME; BIOMARKERS; BIOTRANSFORMATION; BLOOD GLUCOSE; DIET, HIGH-FAT; ENZYME INHIBITORS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; METABOLIC SYNDROME X; MICE, INBRED C57BL; NON-NUTRITIVE SWEETENERS; OBESITY; PHENYLALANINE; TUMOR NECROSIS FACTOR-ALPHA; WEIGHT GAIN;

EID: 85019247493     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2016-0346     Document Type: Article

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