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Volumn 25, Issue 1, 2011, Pages 286-293

In vitro effect of aspartame in angiogenesis induction

Author keywords

Angiogenesis; Aspartame; Genotoxicity; IL 6; ROS; VEGF

Indexed keywords

ASPARTAME; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; SYNAPTOPHYSIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2;

EID: 78650494478     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.09.002     Document Type: Article
Times cited : (51)

References (51)
  • 2
    • 77950690023 scopus 로고    scopus 로고
    • Interleukin-6 in bone metastasis and cancer progression
    • Ara T., Declerck Y.A. Interleukin-6 in bone metastasis and cancer progression. Eur. J. Cancer. 2010, 46:1223-1231.
    • (2010) Eur. J. Cancer. , vol.46 , pp. 1223-1231
    • Ara, T.1    Declerck, Y.A.2
  • 3
    • 0026608055 scopus 로고
    • Public perceptions of the role of dietary and other environmental factors in cancer causation or prevention
    • Baghurst K.I., Baghurst P.A., Record S.J. Public perceptions of the role of dietary and other environmental factors in cancer causation or prevention. J. Epidemiol. Community Health 1992, 46:120-126.
    • (1992) J. Epidemiol. Community Health , vol.46 , pp. 120-126
    • Baghurst, K.I.1    Baghurst, P.A.2    Record, S.J.3
  • 4
    • 53849145656 scopus 로고    scopus 로고
    • Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin
    • Bandyopadhyay A., Ghoshal S., Mukherjee A. Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin. Drug. Chem. Toxicol. 2008, 31:447-457.
    • (2008) Drug. Chem. Toxicol. , vol.31 , pp. 447-457
    • Bandyopadhyay, A.1    Ghoshal, S.2    Mukherjee, A.3
  • 5
    • 33845639621 scopus 로고    scopus 로고
    • Results of long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to aspartame administered in feed
    • Belpoggi F., Soffritti M., Padovani M., Degli Esposti D., Lauriola M., Minardi F. Results of long-term carcinogenicity bioassay on Sprague-Dawley rats exposed to aspartame administered in feed. Ann. N. Y. Acad. Sci. 2006, 1076:559-577.
    • (2006) Ann. N. Y. Acad. Sci. , vol.1076 , pp. 559-577
    • Belpoggi, F.1    Soffritti, M.2    Padovani, M.3    Degli Esposti, D.4    Lauriola, M.5    Minardi, F.6
  • 8
    • 0025937690 scopus 로고
    • Acceptable daily intake vs actual intake: the aspartame example
    • Butchko H.H., Kotsonis F.N. Acceptable daily intake vs actual intake: the aspartame example. J. Am. Coll. Nutr. 1991, 10:258-266.
    • (1991) J. Am. Coll. Nutr. , vol.10 , pp. 258-266
    • Butchko, H.H.1    Kotsonis, F.N.2
  • 9
    • 0036193523 scopus 로고    scopus 로고
    • American cancer society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity
    • Byers T., Nestle M., McTiernan A., Doyle C., Currie-Williams A., Gansler T., Thun M. American cancer society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2002, 52:92-119.
    • (2002) CA Cancer J Clin. , vol.52 , pp. 92-119
    • Byers, T.1    Nestle, M.2    McTiernan, A.3    Doyle, C.4    Currie-Williams, A.5    Gansler, T.6    Thun, M.7
  • 12
    • 0344988510 scopus 로고
    • Aspartame commissioner's final decision
    • FDA (food and drug administration)
    • FDA (food and drug administration) Aspartame commissioner's final decision. Fed. Reg. 1981, 46:38285-38308.
    • (1981) Fed. Reg. , vol.46 , pp. 38285-38308
  • 13
    • 0842263443 scopus 로고
    • Food additive permitted for direct addition to food for human consumption: aspartame
    • FDA (food and drug administration)
    • FDA (food and drug administration) Food additive permitted for direct addition to food for human consumption: aspartame. Fed. Reg. 1983, 48:31376-31382.
    • (1983) Fed. Reg. , vol.48 , pp. 31376-31382
  • 14
    • 0022648938 scopus 로고
    • How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture
    • Folkman J. How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture. Cancer Res. 1986, 46:467-473.
    • (1986) Cancer Res. , vol.46 , pp. 467-473
    • Folkman, J.1
  • 15
    • 0022821867 scopus 로고
    • Growth control in capillary endothelium
    • (N Y 1985)
    • Folkman J. Growth control in capillary endothelium. Dev. Biol. 1986, 3:101-110. (N Y 1985).
    • (1986) Dev. Biol. , vol.3 , pp. 101-110
    • Folkman, J.1
  • 16
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1995, 1:27-31.
    • (1995) Nat. Med. , vol.1 , pp. 27-31
    • Folkman, J.1
  • 17
    • 0021150803 scopus 로고
    • Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine
    • Hagiwara A., Fukushima S., Kitaori M., Shibata M., Ito N. Effects of three sweeteners on rat urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine. Gann 1984, 75:763-768.
    • (1984) Gann , vol.75 , pp. 763-768
    • Hagiwara, A.1    Fukushima, S.2    Kitaori, M.3    Shibata, M.4    Ito, N.5
  • 18
    • 72449152949 scopus 로고    scopus 로고
    • Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: results from large scale efficacy trials
    • Horton E.S. Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: results from large scale efficacy trials. Obesity (Silver Spring) 2009, 1:S43-48.
    • (2009) Obesity (Silver Spring) , vol.1
    • Horton, E.S.1
  • 20
    • 0019460728 scopus 로고
    • Incidence of brain tumors in rats fed aspartame
    • Ishii H. Incidence of brain tumors in rats fed aspartame. Toxicol. Lett. 1981, 7:433-437.
    • (1981) Toxicol. Lett. , vol.7 , pp. 433-437
    • Ishii, H.1
  • 21
    • 72449195818 scopus 로고    scopus 로고
    • The utility of physical activity in the management of global cardiometabolic risk
    • Janiszewski P.M., Ross R. The utility of physical activity in the management of global cardiometabolic risk. Obesity (Silver Spring) 2009, 17:S3-S14.
    • (2009) Obesity (Silver Spring) , vol.17
    • Janiszewski, P.M.1    Ross, R.2
  • 22
    • 0034112873 scopus 로고    scopus 로고
    • Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay
    • Jeffrey A.M., Williams G.M. Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay. Food. Chem. Toxicol. 2000, 38:335-338.
    • (2000) Food. Chem. Toxicol. , vol.38 , pp. 335-338
    • Jeffrey, A.M.1    Williams, G.M.2
  • 23
  • 24
    • 77951686858 scopus 로고    scopus 로고
    • Angiogenesis and lymphangiogenesis of gastric cancer
    • Kitadai Y. Angiogenesis and lymphangiogenesis of gastric cancer. J. Oncol. 2010, 468725.
    • (2010) J. Oncol. , pp. 468725
    • Kitadai, Y.1
  • 25
  • 26
    • 0035254648 scopus 로고    scopus 로고
    • Angiogenesis: regulators and clinical applications
    • Liekens S., De Clercq E., Neyts J. Angiogenesis: regulators and clinical applications. Biochem. Pharmacol. 2001, 61:253-270.
    • (2001) Biochem. Pharmacol. , vol.61 , pp. 253-270
    • Liekens, S.1    De Clercq, E.2    Neyts, J.3
  • 27
    • 78650474831 scopus 로고    scopus 로고
    • Estimated intake of the sweeteners, acesulfame-K and aspartame, from soft drinks, soft drinks based on mineral waters and nectars for a group of Portuguese teenage students
    • Lino C.M., Costa I.M., Pena A., Ferriera R., Cardoso S.M. Estimated intake of the sweeteners, acesulfame-K and aspartame, from soft drinks, soft drinks based on mineral waters and nectars for a group of Portuguese teenage students. Food. Addit. Contam. 2008, 20:1-6.
    • (2008) Food. Addit. Contam. , vol.20 , pp. 1-6
    • Lino, C.M.1    Costa, I.M.2    Pena, A.3    Ferriera, R.4    Cardoso, S.M.5
  • 29
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld G., Cohen T., Gengrinovitch S., Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999, 13:9-22.
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 30
    • 28244475975 scopus 로고    scopus 로고
    • Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine
    • Nilsson M.B., Langley R.R., Fidler I.J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res. 2005, 65:10794-10800.
    • (2005) Cancer Res. , vol.65 , pp. 10794-10800
    • Nilsson, M.B.1    Langley, R.R.2    Fidler, I.J.3
  • 32
    • 0034051223 scopus 로고    scopus 로고
    • The biology of tumor invasion, angiogenesis and lymph node metastasis
    • Petruzzelli G.J. The biology of tumor invasion, angiogenesis and lymph node metastasis. ORL J. Otorhinolaryngol. Relat. Spec. 2000, 62:178-185.
    • (2000) ORL J. Otorhinolaryngol. Relat. Spec. , vol.62 , pp. 178-185
    • Petruzzelli, G.J.1
  • 33
    • 0018647092 scopus 로고
    • A review of the metabolism of the aspartyl moiety of aspartame in experimental animals and man
    • Ranney R.E., Oppermann J.A. A review of the metabolism of the aspartyl moiety of aspartame in experimental animals and man. J. Environ. Pathol. Toxicol. 1979, 2:979-985.
    • (1979) J. Environ. Pathol. Toxicol. , vol.2 , pp. 979-985
    • Ranney, R.E.1    Oppermann, J.A.2
  • 35
    • 33644771206 scopus 로고    scopus 로고
    • First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats
    • Soffritti M., Belpoggi F., Degli Esposti D., Lambertini L., Ribaldi E., Rigano A. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ. Health. Perspect. 2006, 114:379-385.
    • (2006) Environ. Health. Perspect. , vol.114 , pp. 379-385
    • Soffritti, M.1    Belpoggi, F.2    Degli Esposti, D.3    Lambertini, L.4    Ribaldi, E.5    Rigano, A.6
  • 36
    • 34748884376 scopus 로고    scopus 로고
    • Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats
    • Soffritti M., Belpoggi F., Ribaldi E., Degli Esposti D., Lauriola M. Life-span exposure to low doses of aspartame beginning during prenatal life increases cancer effects in rats. Environ. Health. Perspect. 2007, 115:1293-1297.
    • (2007) Environ. Health. Perspect. , vol.115 , pp. 1293-1297
    • Soffritti, M.1    Belpoggi, F.2    Ribaldi, E.3    Degli Esposti, D.4    Lauriola, M.5
  • 37
    • 0036910386 scopus 로고    scopus 로고
    • The role of hydrogen peroxide in endothelial proliferative responses
    • Stone J.R., Collins T. The role of hydrogen peroxide in endothelial proliferative responses. Endothelium 2002, 9:231-238.
    • (2002) Endothelium , vol.9 , pp. 231-238
    • Stone, J.R.1    Collins, T.2
  • 39
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • Takahashi H., Shibuya M. The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions. Clin. Sci. 2005, 109:227-241.
    • (2005) Clin. Sci. , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 40
    • 0033588435 scopus 로고    scopus 로고
    • Comments on the purported generation of formaldehyde and adduct formation from the sweetener aspartame
    • Tephly T.R. Comments on the purported generation of formaldehyde and adduct formation from the sweetener aspartame. Life Sci. 1999, 65:157-160.
    • (1999) Life Sci. , vol.65 , pp. 157-160
    • Tephly, T.R.1
  • 41
    • 70249146570 scopus 로고    scopus 로고
    • Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals
    • Tosetti F., Noonan D.M., Albini A. Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals. Int. J. Cancer 2009, 125:1997-2003.
    • (2009) Int. J. Cancer , vol.125 , pp. 1997-2003
    • Tosetti, F.1    Noonan, D.M.2    Albini, A.3
  • 42
    • 0028299617 scopus 로고
    • Neuropsychological and biochemical investigations in heterozygotes for phenylketonuria during ingestion of high dose aspartame (a sweetener containing phenylalanine)
    • Trefz F., de Sonneville L., Matthis P., Benninger C., Lanz-Englert B., Bickel H. Neuropsychological and biochemical investigations in heterozygotes for phenylketonuria during ingestion of high dose aspartame (a sweetener containing phenylalanine). Hum. Genet. 1994, 93:369-374.
    • (1994) Hum. Genet. , vol.93 , pp. 369-374
    • Trefz, F.1    de Sonneville, L.2    Matthis, P.3    Benninger, C.4    Lanz-Englert, B.5    Bickel, H.6
  • 44
    • 33745217132 scopus 로고    scopus 로고
    • Redox signaling in angiogenesis: role of NADPH oxidase
    • Ushio-Fukai M. Redox signaling in angiogenesis: role of NADPH oxidase. Cardiovasc. Res. 2006, 71:226-235.
    • (2006) Cardiovasc. Res. , vol.71 , pp. 226-235
    • Ushio-Fukai, M.1
  • 45
    • 44949084501 scopus 로고    scopus 로고
    • Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for neurovascular age-related macular degeneration
    • Vedula S.S., Krzystolikm M.G. Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for neurovascular age-related macular degeneration. Cochrane Database Syst. Rev. 2008, 16:CD005139.
    • (2008) Cochrane Database Syst. Rev. , vol.16
    • Vedula, S.S.1    Krzystolikm, M.G.2
  • 46
    • 70450174366 scopus 로고    scopus 로고
    • VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus
    • Waltenberger J. VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus. Biochem. Soc. Trans. 2009, 37:1167-1170.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 1167-1170
    • Waltenberger, J.1
  • 47
    • 6944239873 scopus 로고    scopus 로고
    • Artificial sweeteners-do they bear a carcinogenic risk?
    • Weihrauch M.R., Diehl V. Artificial sweeteners-do they bear a carcinogenic risk?. Ann. Oncology 2004, 15:1460-1465.
    • (2004) Ann. Oncology , vol.15 , pp. 1460-1465
    • Weihrauch, M.R.1    Diehl, V.2
  • 49
    • 77952593669 scopus 로고    scopus 로고
    • A systems biology perspective on sVEGF1: its biological function, pathogenic role and therapeutic use
    • Wu F.T.H., Stefanini M.O., Gabhann F.M., Kontos C.D., Annex B.H., Popel A.S. A systems biology perspective on sVEGF1: its biological function, pathogenic role and therapeutic use. J. Cell. Mol. Med. 2010, 14:528-552.
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 528-552
    • Wu, F.T.H.1    Stefanini, M.O.2    Gabhann, F.M.3    Kontos, C.D.4    Annex, B.H.5    Popel, A.S.6
  • 50
    • 69449095475 scopus 로고    scopus 로고
    • Stroma-epithelium crosstalk in prostate cancer
    • Yi-Nong N., Shu-Jie X. Stroma-epithelium crosstalk in prostate cancer. Asian. J. Andrology 2009, 11:28-35.
    • (2009) Asian. J. Andrology , vol.11 , pp. 28-35
    • Yi-Nong, N.1    Shu-Jie, X.2
  • 51
    • 0348049834 scopus 로고    scopus 로고
    • VEGF signalling: integration and multi-tasking in endothelial cell biology
    • Zachary I. VEGF signalling: integration and multi-tasking in endothelial cell biology. Biochem. Soc. Trans. 2003, 31:1171-1177.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 1171-1177
    • Zachary, I.1


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