Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages

Colloids and Surfaces B: Biointerfaces

Volumn 155, Issue , 2017, Pages 459-465

  Nogueira, Eugénia ^a   Freitas, Jaime ^b,c   Loureiro, Ana ^a   Nogueira, Patrícia ^b,c   Gomes, Andreia C ^a   Preto, Ana ^a   Carmo, Alexandre M ^b,c,d   Moreira, Alexandra ^b,c   Cavaco Paulo, Artur ^a  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

Activated macrophages; Folate; Liposomes; Neutral; PEGylated; RNA interference

Indexed keywords

CELL DEATH; DISEASES; EFFICIENCY; GENE EXPRESSION; GENE THERAPY; GENES; LIPOSOMES; MAMMALS; RNA; TOXICITY;

ACTIVATED MACROPHAGES; FOLATE; NEUTRAL; PEGYLATED; RNA INTERFERENCE;

MACROPHAGES;

1,2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; FOLATE RECEPTOR 2; FOLIC ACID; LIPOSOME; LOCKED NUCLEIC ACID; MACROGOL; PHOSPHOETHANOLAMINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; 1,2-DIELAIDOYLPHOSPHATIDYLETHANOLAMINE; DRUG CARRIER; MACROGOL DERIVATIVE; MCL1 PROTEIN, HUMAN; PHOSPHATIDYLETHANOLAMINE; PROTEIN MCL 1;

APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOSOMAL GENE DELIVERY SYSTEM; MACROPHAGE ACTIVATION; MCL1 GENE; NANOENCAPSULATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SURFACE CHARGE; ANIMAL; CELL CULTURE; CELL LINE; CHEMISTRY; GENETIC TRANSFECTION; GENETICS; MACROPHAGE; METABOLISM; MOUSE; PROCEDURES; RNA INTERFERENCE;

ANIMALS; CELL LINE; CELLS, CULTURED; DRUG CARRIERS; FOLATE RECEPTOR 2; FOLIC ACID; HUMANS; LIPOSOMES; MACROPHAGES; MICE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 85019046361     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2017.04.023     Document Type: Article

References (28)

1. [1] Mello, C.C., Conte, D. Jr., Revealing the world of RNA interference. Nature 431 (2004), 338–342.
2. [2] Whitehead, K.A., Langer, R., Anderson, D.G., Knocking down barriers: advances in siRNA delivery. Nat. Rev. Drug Discov. 8 (2009), 129–138.
3. [3] Kumar, K., Maiti, B., Kondaiah, P., Bhattacharya, S., Efficacious gene silencing in serum and significant apoptotic activity induction by survivin downregulation mediated by new cationic gemini tocopheryl lipids. Mol. Pharm., 1, 2014, 1.
4. [4] Simões, S., Filipe, A., Faneca, H., et al. Cationic liposomes for gene delivery. Expert Opin. Drug Deliv. 2 (2005), 237–254.
5. [5] Kostarelos, K., Miller, A.D., Synthetic, self-assembly ABCD nanoparticles; a structural paradigm for viable synthetic non-viral vectors. Chem. Soc. Rev. 34 (2005), 970–994.
6. [6] Buyens, K., Lucas, B., Raemdonck, K., et al. A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum. J. Controll. Release 126 (2008), 67–76.
7. [7] Sanmarti, R., Ruiz-Esquide, V., Hernandez, M.V., Rheumatoid arthritis: a clinical overview of new diagnostic and treatment approaches. Curr. Top. Med. Chem. 13 (2013), 698–704.
8. [8] Shrivastava, A.K., Pandey, A., Inflammation and rheumatoid arthritis. J. Physiol. Biochem. 69 (2013), 335–347.
9. [9] Maruotti, N., Cantatore, F.P., Crivellato, E., Vacca, A., Ribatti, D., Macrophages in rheumatoid arthritis. Histol. Histopathol. 22 (2007), 581–586.
10. [10] Pope, R.M., Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat. Rev. Immunol. 2 (2002), 527–535.
11. [11] Nakashima-Matsushita, N., Homma, T., Yu, S., et al. Selective expression of folate receptor β and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. Arthritis Rheum. 42 (1999), 1609–1616.
12. [12] Schiffelers, R.M., Xu, J., Storm, G., Woodle, M.C., Scaria, P.V., Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. Arthritis Rheum. 52 (2005), 1314–1318.
13. [13] Khoury, M., Escriou, V., Courties, G., et al. Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes. Arthritis Rheum. 58 (2008), 2356–2367.
14. [14] Liu, H., Eksarko, P., Temkin, V., et al. Mcl-1 is essential for the survival of synovial fibroblasts in rheumatoid arthritis. J. Immunol. 175 (2005), 8337–8345.
15. [15] Liu, H., Huang, Q., Shi, B., et al. Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophages. Arthritis Rheum. 54 (2006), 3174–3181.
16. [16] Mook, O., Vreijling, J., Wengel, S.L., et al. In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts. Artif. DNA PNA XNA 1 (2010), 36–44.
17. [17] Buyens, K., Demeester, J., De Smedt, S.S., Sanders, N.N., Elucidating the encapsulation of short interfering RNA in PEGylated cationic liposomes. Langmuir 25 (2009), 4886–4891.
18. [18] Nogueira, E., Lager, F., Le Roux, D., et al. Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice. J. Biomed. Nanotechnol. 11 (2015), 2243–2252.
19. [19] Landen, C.N. Jr., Chavez-Reyes, A., Bucana, C., et al. Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res. 65 (2005), 6910–6918.
20. [20] Halder, J., Kamat, A.A., Landen, C.N. Jr., et al. Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin. Cancer Res. 12 (2006), 4916–4924.
21. [21] Nogueira, E., Mangialavori, I.C., Loureiro, A., et al. Peptide anchor for folate-targeted liposomal delivery. Biomacromolecules 16 (2015), 2904–2910.
22. [22] Li, J., Hsu, H.C., Mountz, J.D., Managing macrophages in rheumatoid arthritis by reform or removal. Curr. Rheumatol. Rep. 14 (2012), 445–454.
23. [23] Puig-Kroger, A., Sierra-Filardi, E., Dominguez-Soto, A., et al. Folate receptor beta is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Cancer Res. 69 (2009), 9395–9403.
24. [24] Hattori, Y., Sakaguchi, M., Maitani, Y., Folate-linked lipid-based nanoparticles deliver a NFkappaB decoy into activated murine macrophage-like RAW264.7 cells. Biol. Pharm. Bull. 29 (2006), 1516–1520.
25. [25] Thomas, T.P., Goonewardena, S.N., Majoros, I.J., et al. Folate-targeted nanoparticles show efficacy in the treatment of inflammatory arthritis. Arthritis Rheum. 63 (2011), 2671–2680.
26. [26] Maurer, U., Charvet, C., Wagman, A.S., Dejardin, E., Green, D.R., Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 (2006), 749–760.
27. [27] Brumatti, G., Ekert, P.G., Seeking a MCL-1 inhibitor. Cell Death Differ. 20 (2013), 1440–1441.
28. [28] Varadarajan, S., Vogler, M., Butterworth, M., et al. Evaluation and critical assessment of putative MCL-1 inhibitors. Cell Death Differ. 20 (2013), 1475–1484.