Brain and organ uptake in the Rhesus monkey in vivo of recombinant iduronidase compared to an insulin receptor antibody-iduronidase fusion protein

Molecular Pharmaceutics

Volumn 14, Issue 4, 2017, Pages 1271-1277

  Boado, Ruben J ^a   Pardridge, William M ^a  

^a ArmaGen Inc   (United States)

Author keywords

Blood brain barrier; CSF; Drug delivery; Iduronidase; Insulin receptor; Monoclonal antibody

Indexed keywords

HYBRID PROTEIN; INSULIN RECEPTOR ANTIBODY IDURONIDASE FUSION PROTEIN; LARONIDASE; UNCLASSIFIED DRUG; BOLTON-HUNTER REAGENT; INSR PROTEIN, HUMAN; INSULIN RECEPTOR; LEUKOCYTE ANTIGEN; LEVO IDURONIDASE; MONOCLONAL ANTIBODY; SOMATOMEDIN B RECEPTOR; SUCCINIMIDE DERIVATIVE;

ADULT; ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN HOMOGENATE; CHOROID PLEXUS; CONTROLLED STUDY; DRUG CONJUGATION; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RADIOACTIVITY; RHESUS MONKEY; VOLUME OF DISTRIBUTION; WHOLE BODY AUTORADIOGRAPHY; ANIMAL; BRAIN; HUMAN; HURLER SYNDROME; METABOLISM;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; BLOOD-BRAIN BARRIER; BRAIN; HUMANS; IDURONIDASE; MACACA MULATTA; MUCOPOLYSACCHARIDOSIS I; RECEPTOR, IGF TYPE 2; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS; SUCCINIMIDES;

EID: 85019028653     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b01166     Document Type: Article

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