Blood-brain barrier molecular trojan horse enables imaging of brain uptake of radioiodinated recombinant protein in the rhesus monkey

Bioconjugate Chemistry

Volumn 24, Issue 10, 2013, Pages 1741-1749

  Boado, Ruben J ^a,b   Hui, Eric K W ^b   Lu, Jeff Zhiqiang ^b   Sumbria, Rachita K ^a   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ArmaGen Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; HALOGENATION; MONOCLONAL ANTIBODIES;

BARRIER PENETRATION; BLOOD-BRAIN BARRIER; BRAIN UPTAKE; FUSION PROTEINS; IS-ENABLED; PROTEIN THERAPEUTICS; RE-ENGINEERING; RECEPTOR-MEDIATED TRANSPORTS; RHESUS MONKEY; SULFATASES;

RECOMBINANT PROTEINS;

BOLTON HUNTER REAGENT I 125; HIRMAB IDS FUSION PROTEIN; HYBRID PROTEIN; IDURONATE 2 SULFATASE; IODINE 125; MONOCLONAL ANTIBODY; RECOMBINANT ENZYME; RECOMBINANT IDURONATE 2 SULFATASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; BLOOD SAMPLING; BRAIN; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG UPTAKE; HORSE; IMMUNOPRECIPITATION; ISOTOPE LABELING; MALE; MOLECULAR IMAGING; NEUROIMAGING; NONHUMAN; RADIOACTIVITY; RADIOIODINATION; RHESUS MONKEY; TROJAN HORSE;

EQUIDAE; MACACA MULATTA;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD-BRAIN BARRIER; BRAIN; HORSES; HUMANS; IDURONATE SULFATASE; IODINE RADIOISOTOPES; MACACA MULATTA; RECEPTOR, INSULIN; RECOMBINANT FUSION PROTEINS; SUCCINIMIDES;

EID: 84885998729     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400319d     Document Type: Article

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