Multiparameter Quantification of Liposomal Nanomedicines at the Single-Particle Level by High-Sensitivity Flow Cytometry

ACS Applied Materials and Interfaces

Volumn 9, Issue 16, 2017, Pages 13913-13919

  Chen, Chaoxiang ^a   Zhu, Shaobin ^a   Wang, Shuo ^a   Zhang, Wenqiang ^a   Cheng, Yu ^a   Yan, Xiaomei ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

doxorubicin encapsulated liposomes; flow cytometry; nanomedicine; nanoparticle characterization; single particle detection

Indexed keywords

CHARACTERIZATION; DRUG PRODUCTS; ENCAPSULATION; FLOW CYTOMETRY; FLUORESCENCE; LIPOSOMES; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; PARTICLE SIZE; REFRACTIVE INDEX;

ABSOLUTE QUANTIFICATION; CALIBRATION STANDARD; DOXORUBICIN; FLUORESCENCE SIGNALS; HIGH-THROUGHPUT METHOD; PARTICLE CONCENTRATIONS; QUANTITATIVE CHARACTERIZATION; SINGLE PARTICLE DETECTION;

DRUG DELIVERY;

LIPOSOME;

DRUG DELIVERY SYSTEM; FLOW CYTOMETRY; NANOMEDICINE; PARTICLE SIZE;

DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; LIPOSOMES; NANOMEDICINE; PARTICLE SIZE;

EID: 85018843609     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.7b01867     Document Type: Article

References (41)

1. Allen, T. M.; Cullis, P. R. Drug Delivery Systems: Entering the Mainstream Science 2004, 303, 1818-1822 10.1126/science.1095833
2. Torchilin, V. P. Recent Advances with Liposomes as Pharmaceutical Carriers Nat. Rev. Drug Discovery 2005, 4, 145-160 10.1038/nrd1632
3. Shi, J.; Votruba, A. R.; Farokhzad, O. C.; Langer, R. Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications Nano Lett. 2010, 10, 3223-3230 10.1021/nl102184c
4. Allen, T. M.; Cullis, P. R. Liposomal Drug Delivery Systems: From Concept to Clinical Applications Adv. Drug Delivery Rev. 2013, 65, 36-48 10.1016/j.addr.2012.09.037
5. Kraft, J. C.; Freeling, J. P.; Wang, Z.; Ho, R. J. Emerging Research and Clinical Development Trends of Liposome and Lipid Nanoparticle Drug Delivery Systems J. Pharm. Sci. 2014, 103, 29-52 10.1002/jps.23773
6. Barenholz, Y. Doxil(R)-the First FDA-Approved Nano-Drug: Lessons Learned J. Controlled Release 2012, 160, 117-134 10.1016/j.jconrel.2012.03.020
7. Moghimi, S. M.; Hunter, A. C.; Andresen, T. L. Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective Annu. Rev. Pharmacol. Toxicol. 2012, 52, 481-503 10.1146/annurev-pharmtox-010611-134623
8. Bozzuto, G.; Molinari, A. Liposomes as Nanomedical Devices Int. J. Nanomed. 2015, 10, 975-999 10.2147/IJN.S68861
9. Mühlebach, S.; Borchard, G.; Yildiz, S. Regulatory Challenges and Approaches to Characterize Nanomedicines and Their Follow-on Similars Nanomedicine 2015, 10, 659-674 10.2217/nnm.14.189
10. Chen, C. X.; Zhu, S. B.; Huang, T. X.; Wang, S.; Yan, X. M. Analytical Techniques for Single-Liposome Characterization Anal. Methods 2013, 5, 2150-2157 10.1039/c3ay40219c
11. 2-Expanded Solvents Nano Lett. 2013, 13, 3766-3774 10.1021/nl4017072
12. Sur, S.; Fries, A. C.; Kinzler, K. W.; Zhou, S.; Vogelstein, B. Remote Loading of Preencapsulated Drugs into Stealth Liposomes Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 2283-2288 10.1073/pnas.1324135111
13. Yang, Y.; Wang, J.; Shigematsu, H.; Xu, W.; Shih, W. M.; Rothman, J. E.; Lin, C. Self-Assembly of Size-Controlled Liposomes on DNA Nanotemplates Nat. Chem. 2016, 8, 476-483 10.1038/nchem.2472
14. Lengyel, J. S.; Milne, J. L.; Subramaniam, S. Electron Tomography in Nanoparticle Imaging and Analysis Nanomedicine 2008, 3, 125-131 10.2217/17435889.3.1.125
15. Chin, D. L.; Lum, B. L.; Sikic, B. I. Rapid Determination of Pegylated Liposomal Doxorubicin and Its Major Metabolite in Human Plasma by Ultraviolet-Visible High-Performance Liquid Chromatography J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2002, 779, 259-269 10.1016/S1570-0232(02)00395-1
16. Zhang, X. M.; Patel, A. B.; de Graaf, R. A.; Behar, K. L. Determination of Liposomal Encapsulation Efficiency Using Proton NMR Spectroscopy Chem. Phys. Lipids 2004, 127, 113-120 10.1016/j.chemphyslip.2003.09.013
17. Hupfeld, S.; Holsaeter, A. M.; Skar, M.; Frantzen, C. B.; Brandl, M. Liposome Size Analysis by Dynamic/Static Light Scattering Upon Size Exclusion-/Field Flow-Fractionation J. Nanosci. Nanotechnol. 2006, 6, 3025-3031 10.1166/jnn.2006.454
18. Carter, K. A.; Shao, S.; Hoopes, M. I.; Luo, D.; Ahsan, B.; Grigoryants, V. M.; Song, W.; Huang, H.; Zhang, G.; Pandey, R. K.; Geng, J.; Pfeifer, B. A.; Scholes, C. P.; Ortega, J.; Karttunen, M.; Lovell, J. F. Porphyrin-Phospholipid Liposomes Permeabilized by near-Infrared Light Nat. Commun. 2014, 5 3546 10.1038/ncomms4546
19. Cressey, D. Tiny Traits Cause Big Headaches Nature 2010, 467, 264-265 10.1038/467264b
20. Wang, R. B.; Billone, P. S.; Mullett, W. M. Nanomedicine in Action: An Overview of Cancer Nanomedicine on the Market and in Clinical Trials J. Nanomater. 2013, 2013 629681 10.1155/2013/629681
21. Filipe, V.; Hawe, A.; Jiskoot, W. Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by Nanosight for the Measurement of Nanoparticles and Protein Aggregates Pharm. Res. 2010, 27, 796-810 10.1007/s11095-010-0073-2
22. Nolte-'t Hoen, E. N.; van der Vlist, E. J.; Aalberts, M.; Mertens, H. C.; Bosch, B. J.; Bartelink, W.; Mastrobattista, E.; van Gaal, E. V.; Stoorvogel, W.; Arkesteijn, G. J.; Wauben, M. H. Quantitative and Qualitative Flow Cytometric Analysis of Nanosized Cell-Derived Membrane Vesicles Nanomedicine 2012, 8, 712-720 10.1016/j.nano.2011.09.006
23. Cheng, W.; Compton, R. G. Investigation of Single-Drug-Encapsulating Liposomes Using the Nano-Impact Method Angew. Chem., Int. Ed. Engl. 2014, 53, 13928-13930 10.1002/anie.201408934
24. Lane, R. E.; Korbie, D.; Anderson, W.; Vaidyanathan, R.; Trau, M. Analysis of Exosome Purification Methods Using a Model Liposome System and Tunable-Resistive Pulse Sensing Sci. Rep. 2015, 5 7639 10.1038/srep07639
25. Maas, S. L.; de Vrij, J.; van der Vlist, E. J.; Geragousian, B.; van Bloois, L.; Mastrobattista, E.; Schiffelers, R. M.; Wauben, M. H.; Broekman, M. L.; Nolte-'t Hoen, E. N. Possibilities and Limitations of Current Technologies for Quantification of Biological Extracellular Vesicles and Synthetic Mimics J. Controlled Release 2015, 200, 87-96 10.1016/j.jconrel.2014.12.041
26. Wibroe, P. P.; Ahmadvand, D.; Oghabian, M. A.; Yaghmur, A.; Moghimi, S. M. An Integrated Assessment of Morphology, Size, and Complement Activation of the Pegylated Liposomal Doxorubicin Products Doxil(R), Caelyx(R), Doxorubicin, and Sinadoxosome J. Controlled Release 2016, 221, 1-8 10.1016/j.jconrel.2015.11.021
27. Friedrich, R.; Block, S.; Alizadehheidari, M.; Heider, S.; Fritzsche, J.; Esbjorner, E. K.; Westerlund, F.; Bally, M. A Nano Flow Cytometer for Single Lipid Vesicle Analysis Lab Chip 2017, 17, 830-841 10.1039/C6LC01302C
28. Lohse, B.; Bolinger, P. Y.; Stamou, D. Encapsulation Efficiency Measured on Single Small Unilamellar Vesicles J. Am. Chem. Soc. 2008, 130, 14372-14373 10.1021/ja805030w
29. Braeckmans, K.; Buyens, K.; Bouquet, W.; Vervaet, C.; Joye, P.; De Vos, F.; Plawinski, L.; Doeuvre, L.; Angles-Cano, E.; Sanders, N. N.; Demeester, J.; De Smedt, S. C. Sizing Nanomatter in Biological Fluids by Fluorescence Single Particle Tracking Nano Lett. 2010, 10, 4435-4442 10.1021/nl103264u
30. Larsen, J.; Hatzakis, N. S.; Stamou, D. Observation of Inhomogeneity in the Lipid Composition of Individual Nanoscale Liposomes J. Am. Chem. Soc. 2011, 133, 10685-10687 10.1021/ja203984j
31. Ruozi, B.; Belletti, D.; Tombesi, A.; Tosi, G.; Bondioli, L.; Forni, F.; Vandelli, M. A. AFM, ESEM, TEM, and CLSM in Liposomal Characterization: A Comparative Study Int. J. Nanomed. 2011, 6, 557-563 10.2147/IJN.S14615
32. Zollmann, T.; Moiset, G.; Tumulka, F.; Tampe, R.; Poolman, B.; Abele, R. Single Liposome Analysis of Peptide Translocation by the Abc Transporter Tapl Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 2046-2051 10.1073/pnas.1418100112
33. Yang, L.; Zhu, S. B.; Hang, W.; Wu, L. N.; Yan, X. M. Development of an Ultrasensitive Dual-Channel Flow Cytometer for the Individual Analysis of Nanosized Particles and Biomolecules Anal. Chem. 2009, 81, 2555-2563 10.1021/ac802464a
34. Zhu, S.; Yang, L. L.; Long, Y.; Gao, M.; Huang, T. X.; Hang, W.; Yan, X. M. Size Differentiation and Absolute Quantification of Gold Nanoparticles Via Single Particle Detection with a Laboratory-Built High-Sensitivity Flow Cytometer J. Am. Chem. Soc. 2010, 132, 12176-12178 10.1021/ja104052c
35. Zhu, S. B.; Ma, L.; Wang, S.; Chen, C. X.; Zhang, W. Q.; Yang, L. L.; Hang, W.; Nolan, J. P.; Wu, L. N.; Yan, X. M. Light-Scattering Detection Below the Level of Single Fluorescent Molecules for High-Resolution Characterization of Functional Nanoparticles ACS Nano 2014, 8, 10998-11006 10.1021/nn505162u
36. Ma, L.; Zhu, S. B.; Tian, Y.; Zhang, W. Q.; Wang, S.; Chen, C. X.; Wu, L. N.; Yan, X. M. Label-Free Analysis of Single Viruses with a Resolution Comparable to That of Electron Microscopy and the Throughput of Flow Cytometry Angew. Chem., Int. Ed. Engl. 2016, 55, 10239-10243 10.1002/anie.201603007
37. Akbarzadeh, A.; Rezaei-Sadabady, R.; Davaran, S.; Joo, S. W.; Zarghami, N.; Hanifehpour, Y.; Samiei, M.; Kouhi, M.; Nejati-Koshki, K. Liposome: Classification, Preparation, and Applications Nanoscale Res. Lett. 2013, 8, 102 10.1186/1556-276X-8-102
38. Yoshikawa, W.; Akutsu, H.; Kyogoku, Y. Light-Scattering Properties of Osmotically Active Liposomes Biochim. Biophys. Acta 1983, 735, 397-406 10.1016/0005-2736(83)90154-2
39. Matsuzaki, K.; Murase, O.; Sugishita, K.; Yoneyama, S.; Akada, K.; Ueha, M.; Nakamura, A.; Kobayashi, S. Optical Characterization of Liposomes by Right Angle Light Scattering and Turbidity Measurement Biochim. Biophys. Acta, Biomembr. 2000, 1467, 219-226 10.1016/S0005-2736(00)00223-6
40. Chong, C. S.; Colbow, K. Light Scattering and Turbidity Measurements on Lipid Vesicles Biochim. Biophys. Acta 1976, 436, 260-282 10.1016/0005-2736(76)90192-9
41. Jiang, W.; Lionberger, R.; Yu, L. X. In Vitro and in Vivo Characterizations of Pegylated Liposomal Doxorubicin Bioanalysis 2011, 3, 333-344 10.4155/bio.10.204