Light-scattering detection below the level of single fluorescent molecules for high-resolution characterization of functional nanoparticles

ACS Nano

Volumn 8, Issue 10, 2014, Pages 10998-11006

  Zhu, Shaobin ^a   Ma, Ling ^a   Wang, Shuo ^a   Chen, Chaoxiang ^a   Zhang, Wenqiang ^a   Yang, Lingling ^a   Hang, Wei ^a   Nolan, John P ^b   Wu, Lina ^a   Yan, Xiaomei ^a  

^a XIAMEN UNIVERSITY   (China)

^b SCINTILLON INSTITUTE   (United States)

Author keywords

flow cytometry; light scattering; nanomedicine; nanoparticle characterization; single molecule detection; single nanoparticle detection; size distribution

Indexed keywords

FLOW CYTOMETRY; FLUORESCENCE; LIGHT SCATTERING; MEDICAL NANOTECHNOLOGY; MOLECULES; NANOPARTICLES; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; SILICA; SIZE DISTRIBUTION; SUSPENSIONS (FLUIDS);

ENGINEERED NANOPARTICLES; FUNCTIONAL NANOPARTICLES; LIGHT-SCATTERING DETECTION; NANOPARTICLE SIZE DISTRIBUTION; SINGLE MOLECULE FLUORESCENCE DETECTION; SINGLE NANOPARTICLE DETECTIONS; SINGLE-MOLECULE DETECTION; ULTRASENSITIVE DETECTION;

GOLD NANOPARTICLES;

FLUORESCENT DYE; NANOPARTICLE;

CHEMISTRY; LIMIT OF DETECTION; RADIATION SCATTERING;

FLUORESCENT DYES; LIMIT OF DETECTION; NANOPARTICLES; SCATTERING, RADIATION;

EID: 84908432128     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn505162u     Document Type: Article

References (45)

1. Jain, R. K.; Stylianopoulos, T. Delivering Nanomedicine to Solid Tumors Nat. Rev. Clin. Oncol. 2010, 7, 653-664
2. Abeylath, S. C.; Ganta, S.; Iyer, A. K.; Amiji, M. Combinatorial-Designed Multifunctional Polymeric Nanosystems for Tumor-Targeted Therapeutic Delivery Acc. Chem. Res. 2011, 44, 1009-1017
3. Bourzac, K. Nanotechnology: Carrying Drugs Nature 2012, 491, S58-S60
4. Hubbell, J. A.; Langer, R. Translating Materials Design to the Clinic Nat. Mater. 2013, 12, 963-966
5. Chauhan, V. P.; Jain, R. K. Strategies for Advancing Cancer Nanomedicine Nat. Mater. 2013, 12, 958-962
6. Cressey, D. Tiny Traits Cause Big Headaches Nature 2010, 467, 264-265
7. Mullen, D. G.; Fang, M.; Desai, A.; Baker, J. R.; Orr, B. G.; Banaszak Holl, M. M. A Quantitative Assessment of Nanoparticle-Ligand Distributions: Implications for Targeted Drug and Imaging Delivery in Dendrimer Conjugates ACS Nano 2010, 4, 657-670
8. Grossman, J. H.; McNeil, S. E. Nanotechnology in Cancer Medicine Phys. Today 2012, 65, 38-42
9. Daaboul, G. G.; Yurt, A.; Zhang, X.; Hwang, G. M.; Goldberg, B. B.; Ünlü, M. S. High-Throughput Detection and Sizing of Individual Low-Index Nanoparticles and Viruses for Pathogen Identification Nano Lett. 2010, 10, 4727-4731
10. Filipe, V.; Hawe, A.; Jiskoot, W. Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by Nanosight for the Measurement of Nanoparticles and Protein Aggregates Pharm. Res. 2010, 27, 796-810
11. Gaiduk, A.; Yorulmaz, M.; Ruijgrok, P. V.; Orrit, M. Room-Temperature Detection of a Single Molecules Absorption by Photothermal Contrast Science 2010, 330, 353-356
12. Mitra, A.; Deutsch, B.; Ignatovich, F.; Dykes, C.; Novotny, L. Nano-Optofluidic Detection of Single Viruses and Nanoparticles ACS Nano 2010, 4, 1305-1312
13. Wang, S.; Shan, X.; Patel, U.; Huang, X.; Lu, J.; Li, J.; Tao, N. Label-Free Imaging, Detection, and Mass Measurement of Single Viruses by Surface Plasmon Resonance Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 16028-16032
14. Fraikin, J. L.; Teesalu, T.; McKenney, C. M.; Ruoslahti, E.; Cleland, A. N. A High-Throughput Label-Free Nanoparticle Analyser Nat. Nanotechnol. 2011, 6, 308-313
15. He, L.; Ozdemir, S. K.; Zhu, J.; Kim, W.; Yang, L. Detecting Single Viruses and Nanoparticles Using Whispering Gallery Microlasers Nat. Nanotechnol. 2011, 6, 428-432
16. Nantakomol, D.; Dondorp, A. M.; Krudsood, S.; Udomsangpetch, R.; Pattanapanyasat, K.; Combes, V.; Grau, G. E.; White, N. J.; Viriyavejakul, P.; Day, N. P. et al. Circulating Red Cell-Derived Microparticles in Human Malaria J. Infect. Dis. 2011, 203, 700-706
17. Simons, P. C.; Young, S. M.; Carter, M. B.; Waller, A.; Zhai, D.; Reed, J. C.; Edwards, B. S.; Sklar, L. A. Simultaneous In Vitro Molecular Screening of Protein-Peptide Interactions by Flow Cytometry, Using Six Bcl-2 Family Proteins as Examples Nat. Protoc. 2011, 6, 943-952
18. Gregori, G.; Patsekin, V.; Rajwa, B.; Jones, J.; Ragheb, K.; Holdman, C.; Robinson, J. P. Hyperspectral Cytometry at the Single-Cell Level Using a 32-Channel Photodetector Cytometry, Part A 2012, 81, 35-44
19. van der Pol, E.; Coumans, F. A.; Grootemaat, A. E.; Gardiner, C.; Sargent, I. L.; Harrison, P.; Sturk, A.; van Leeuwen, T. G.; Nieuwland, R. Particle Size Distribution of Exosomes and Microvesicles Determined by Transmission Electron Microscopy, Flow Cytometry, Nanoparticle Tracking Analysis, and Resistive Pulse Sensing J. Thromb. Haemostasis 2014, 12, 1182-1192
20. Hercher, M.; Mueller, W.; Shapiro, H. M. Detection and Discrimination of Individual Viruses by Flow Cytometry J. Histochem. Cytochem. 1979, 27, 350-352
21. Zarrin, F.; Risfelt, J. A.; Dovichi, N. J. Light Scatter Detection within the Sheath Flow Cuvette for Size Determination of Multicomponent Submicrometer Particle Suspensions Anal. Chem. 1987, 59, 850-854
22. Steen, H. B. Flow Cytometer for Measurement of the Light Scattering of Viral and Other Submicroscopic Particles Cytometry, Part A 2004, 57, 94-99
23. Yang, L.; Zhu, S.; Hang, W.; Wu, L.; Yan, X. Development of an Ultrasensitive Dual-Channel Flow Cytometer for the Individual Analysis of Nanosized Particles and Biomolecules Anal. Chem. 2009, 81, 2555-2563
24. Zhu, S.; Wang, S.; Yang, L.; Huang, T.; Yan, X. Progress in the Development of Techniques Based on Light Scattering for Single Nanoparticle Detection Sci. China: Chem. 2011, 54, 1244-1253
25. Bohren, C. F.; Huffman, D. R. Absorption and Scattering of Light by Small Particles; John Wiley & Sons: New York, 1983.
26. Keller, R. A.; Ambrose, W. P.; Goodwin, P. M.; Jett, J. H.; Martin, J. C.; Wu, M. Single-Molecule Fluorescence Analysis in Solution Appl. Spectrosc. 1996, 50, 12A-32A
27. Kukura, P.; Ewers, H.; Muller, C.; Renn, A.; Helenius, A.; Sandoghdar, V. High-Speed Nanoscopic Tracking of the Position and Orientation of a Single Virus Nat. Methods 2009, 6, 923-927
28. Lindfors, K.; Kalkbrenner, T.; Stoller, P.; Sandoghdar, V. Detection and Spectroscopy of Gold Nanoparticles Using Supercontinuum White Light Confocal Microscopy Phys. Rev. Lett. 2004, 93, 037401
29. Ignatovich, F. V.; Novotny, L. Real-Time and Background-Free Detection of Nanoscale Particles Phys. Rev. Lett. 2006, 96, 013901
30. Ambrose, W. P.; Goodwin, P. M.; Jett, J. H.; Van Orden, A.; Werner, J. H.; Keller, R. A. Single Molecule Fluorescence Spectroscopy at Ambient Temperature Chem. Rev. 1999, 99, 2929-2956
31. Chandler, W. L.; Yeung, W.; Tait, J. F. A New Microparticle Size Calibration Standard for Use in Measuring Smaller Microparticles Using a New Flow Cytometer J. Thromb. Haemostasis 2011, 9, 1216-1224
32. Anker, J. N.; Hall, W. P.; Lyandres, O.; Shah, N. C.; Zhao, J.; Van Duyne, R. P. Biosensing with Plasmonic Nanosensors Nat. Mater. 2008, 7, 442-453
33. Lengyel, J. S.; Milne, J. L.; Subramaniam, S. Electron Tomography in Nanoparticle Imaging and Analysis Nanomedicine 2008, 3, 125-131
34. Barenholz, Y. Doxil(R): The First FDA-Approved Nano-Drug: Lessons Learned J. Controlled Release 2012, 160, 117-134
35. http://www.liposomeexpert.com/categories/drug-loaded-liposomes/.
36. Zhao, Y.; Alakhova, D. Y.; Kim, J. O.; Bronich, T. K.; Kabanov, A. V. A Simple Way To Enhance Doxil(R) Therapy: Drug Release from Liposomes at the Tumor Site by Amphiphilic Block Copolymer J. Controlled Release 2013, 168, 61-69
37. Matsuzaki, K.; Murase, O.; Sugishita, K.; Yoneyama, S.; Akada, K.; Ueha, M.; Nakamura, A.; Kobayashi, S. Optical Characterization of Liposomes by Right Angle Light Scattering and Turbidity Measurement Biochim. Biophys. Acta 2000, 1467, 219-226
38. van der Pol, E.; van Gemert, M. J.; Sturk, A.; Nieuwland, R.; van Leeuwen, T. G. Single vs. Swarm Detection of Microparticles and Exosomes by Flow Cytometry J. Thromb. Haemostasis 2012, 10, 919-930
39. Seymour, L. W.; Thrasher, A. J. Gene Therapy Matures in the Clinic Nat. Biotechnol. 2012, 30, 588-593
40. Zimmermann, T. S.; Lee, A. C.; Akinc, A.; Bramlage, B.; Bumcrot, D.; Fedoruk, M. N.; Harborth, J.; Heyes, J. A.; Jeffs, L. B.; John, M. et al. RNAi-Mediated Gene Silencing in Non-human Primates Nature 2006, 441, 111-114
41. Whitehead, K. A.; Langer, R.; Anderson, D. G. Knocking down Barriers: Advances in SiRNA Delivery Nat. Rev. Drug Discovery 2009, 8, 129-138
42. Semple, S. C.; Akinc, A.; Chen, J.; Sandhu, A. P.; Mui, B. L.; Cho, C. K.; Sah, D. W.; Stebbing, D.; Crosley, E. J.; Yaworski, E. et al. Rational Design of Cationic Lipids for SiRNA Delivery Nat. Biotechnol. 2010, 28, 172-176
43. Leung, A. K.; Hafez, I. M.; Baoukina, S.; Belliveau, N. M.; Zhigaltsev, I. V.; Afshinmanesh, E.; Tieleman, D. P.; Hansen, C. L.; Hope, M. J.; Cullis, P. R. Lipid Nanoparticles Containing SiRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core J. Phys. Chem. C 2012, 116, 18440-18450
44. Jayaraman, M.; Ansell, S. M.; Mui, B. L.; Tam, Y. K.; Chen, J.; Du, X.; Butler, D.; Eltepu, L.; Matsuda, S.; Narayanannair, J. K. et al. Maximizing the Potency of SiRNA Lipid Nanoparticles for Hepatic Gene Silencing in Vivo Angew. Chem., Int. Ed. 2012, 51, 8529-8533
45. Zhu, S.; Yang, L.; Long, Y.; Gao, M.; Huang, T.; Hang, W.; Yan, X. Size Differentiation and Absolute Quantification of Gold Nanoparticles via Single Particle Detection with a Laboratory-Built High-Sensitivity Flow Cytometer J. Am. Chem. Soc. 2010, 132, 12176-12178