메뉴 건너뛰기




Volumn 10, Issue 1, 2017, Pages

Role of modern immunotherapy in gastrointestinal malignancies: A review of current clinical progress Ahmed Tarhini; Timothy Burns; Rahul Parikh; Guarvel Goel; Annie im

Author keywords

Colorectal cancer; CTLA 4; Esophageal cancer; Gastric cancer; Gastrointestinal cancers; Hepatocellular carcinoma; Immune checkpoint blockade; Immunotherapy; Pancreatic cancer; PD 1; PD L1

Indexed keywords

ATEZOLIZUMAB; AVELUMAB; AZACITIDINE; CANAKINUMAB; CISPLATIN; COBIMETINIB; DOCETAXEL; DURVALUMAB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GALUNISERTIB; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; IPILIMUMAB; IRINOTECAN; MARGETUXIMAB; NINTEDANIB; NIVOLUMAB; OXALIPLATIN; PACLITAXEL; PEMBROLIZUMAB; RAMUCIRUMAB; REGORAFENIB; ROMIDEPSIN; TICILIMUMAB; TIPIRACIL PLUS TRIFLURIDINE; TRAMETINIB; UNINDEXED DRUG; CANCER VACCINE; CD274 PROTEIN, HUMAN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TUMOR PROTEIN;

EID: 85018815658     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-017-0454-7     Document Type: Review
Times cited : (64)

References (79)
  • 1
    • 0000937789 scopus 로고
    • II. Contribution to the knowledge of sarcoma
    • 1:STN:280:DC%2BD2srksVKlsg%3D%3D 17859590 1428624
    • Coley WB. II. Contribution to the knowledge of sarcoma. Ann Surg. 1891;14(3):199-220.
    • (1891) Ann Surg , vol.14 , Issue.3 , pp. 199-220
    • Coley, W.B.1
  • 2
    • 84907552524 scopus 로고    scopus 로고
    • Cancer immunotherapy in clinical practice - The past, present, and future
    • 1:CAS:528:DC%2BC2cXitFajtrjI 25189717 4190434
    • Goel G, Sun W. Cancer immunotherapy in clinical practice - the past, present, and future. Chin J Cancer. 2014;33(9):445-57.
    • (2014) Chin J Cancer , vol.33 , Issue.9 , pp. 445-457
    • Goel, G.1    Sun, W.2
  • 3
    • 45549092607 scopus 로고    scopus 로고
    • Cancer immunology
    • 1:CAS:528:DC%2BD1cXns1ajt7k%3D 18565863
    • Finn OJ. Cancer immunology. N Engl J Med. 2008;358(25):2704-15.
    • (2008) N Engl J Med , vol.358 , Issue.25 , pp. 2704-2715
    • Finn, O.J.1
  • 7
    • 85010928016 scopus 로고    scopus 로고
    • PD-1, PD-L1 (B7-H1) and tumor-site immune modulation therapy: The historical perspective
    • 28122590 5267378
    • Wang J, Yuan R, Song W, Sun J, Liu D, Li Z. PD-1, PD-L1 (B7-H1) and tumor-site immune modulation therapy: the historical perspective. J Hematol Oncol. 2017;10(1):34.
    • (2017) J Hematol Oncol , vol.10 , Issue.1 , pp. 34
    • Wang, J.1    Yuan, R.2    Song, W.3    Sun, J.4    Liu, D.5    Li, Z.6
  • 11
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513(7517):202-209.
    • (2014) Nature , vol.513 , Issue.7517 , pp. 202-209
  • 12
    • 84907487936 scopus 로고    scopus 로고
    • Four subtypes of gastric cancer identified
    • Four subtypes of gastric cancer identified. Cancer Discov. 2014;4(10):1108-1109.
    • (2014) Cancer Discov. , vol.4 , Issue.10 , pp. 1108-1109
  • 16
    • 33745491116 scopus 로고    scopus 로고
    • Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
    • 16530813
    • Wu C, Zhu Y, Jiang J, Zhao J, Zhang XG, Xu N. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem. 2006;108(1):19-24.
    • (2006) Acta Histochem , vol.108 , Issue.1 , pp. 19-24
    • Wu, C.1    Zhu, Y.2    Jiang, J.3    Zhao, J.4    Zhang, X.G.5    Xu, N.6
  • 17
    • 84875241223 scopus 로고    scopus 로고
    • Increased PD-1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer
    • 1:CAS:528:DC%2BC3sXkt1Gqsr8%3D 23129549
    • Saito H, Kuroda H, Matsunaga T, Osaki T, Ikeguchi M. Increased PD-1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer. J Surg Oncol. 2013;107(5):517-22.
    • (2013) J Surg Oncol , vol.107 , Issue.5 , pp. 517-522
    • Saito, H.1    Kuroda, H.2    Matsunaga, T.3    Osaki, T.4    Ikeguchi, M.5
  • 19
    • 85010671583 scopus 로고    scopus 로고
    • Updated results for the advanced esophageal carcinoma cohort of the phase 1b KEYNOTE-028 study of pembrolizumab
    • abstr 4046
    • Doi T, Piha-Paul SA, Jalal SI, Mai-Dang H, Saraf S, Koshiji M, Csiki I, Bennouna J. Updated results for the advanced esophageal carcinoma cohort of the phase 1b KEYNOTE-028 study of pembrolizumab. J Clin Oncol. 34;2016(suppl; abstr 4046).
    • (2016) J Clin Oncol. , vol.34
    • Doi, T.1    Piha-Paul, S.A.2    Jalal, S.I.3    Mai-Dang, H.4    Saraf, S.5    Koshiji, M.6    Csiki, I.7    Bennouna, J.8
  • 20
    • 84991198937 scopus 로고    scopus 로고
    • Preliminary safety data from KEYNOTE-059: Pembrolizumab plus 5-fluorouracil (5-FU) and cisplatin for first-line treatment of advanced gastric cancer
    • abstr 4037
    • Fuchs CS, Ohtsu A, Tabernero J, Van Cutsem E, Wang JD, Lam B, Dalal R, Koshiji M, Bang YJ. Preliminary safety data from KEYNOTE-059: pembrolizumab plus 5-fluorouracil (5-FU) and cisplatin for first-line treatment of advanced gastric cancer. J Clin Oncol. 34;2016 (suppl; abstr 4037).
    • (2016) J Clin Oncol. , vol.34
    • Fuchs, C.S.1    Ohtsu, A.2    Tabernero, J.3    Van Cutsem, E.4    Wang, J.D.5    Lam, B.6    Dalal, R.7    Koshiji, M.8    Bang, Y.J.9
  • 22
    • 85010012510 scopus 로고    scopus 로고
    • A randomized, open-label, two-arm phase II trial comparing the efficacy of sequential ipilimumab (ipi) versus best supportive care (BSC) following first-line (1 L) chemotherapy in patients with unresectable, locally advanced/metastatic (A/M) gastric or gastro-esophageal junction (G/GEJ) cancer
    • abstr 4011
    • Moehler MH, Cho JY, Kim YH, Kim JW, Bartolomeo MD, Ajani JA, Yamaguchi K, Balogh A, Kong-Sanchez MT, Bang YJ. A randomized, open-label, two-arm phase II trial comparing the efficacy of sequential ipilimumab (ipi) versus best supportive care (BSC) following first-line (1 L) chemotherapy in patients with unresectable, locally advanced/metastatic (A/M) gastric or gastro-esophageal junction (G/GEJ) cancer. J Clin Oncol. 34;2016 (suppl; abstr 4011).
    • (2016) J Clin Oncol. , vol.34
    • Moehler, M.H.1    Cho, J.Y.2    Kim, Y.H.3    Kim, J.W.4    Bartolomeo, M.D.5    Ajani, J.A.6    Yamaguchi, K.7    Balogh, A.8    Kong-Sanchez, M.T.9    Bang, Y.J.10
  • 24
    • 84938321273 scopus 로고    scopus 로고
    • Ramucirumab, another anti-angiogenic agent for metastatic colorectal cancer in second-line setting - Its impact on clinical practice
    • 26215324 4517427
    • Goel G, Sun W. Ramucirumab, another anti-angiogenic agent for metastatic colorectal cancer in second-line setting - its impact on clinical practice. J Hematol Oncol. 2015;8:92.
    • (2015) J Hematol Oncol , vol.8 , pp. 92
    • Goel, G.1    Sun, W.2
  • 28
    • 84982816995 scopus 로고    scopus 로고
    • Ramucirumab: A novel antiangiogenic agent in the treatment of metastatic colorectal cancer
    • Goel G, Chauhan A, Hosein PJ. Ramucirumab: a novel antiangiogenic agent in the treatment of metastatic colorectal cancer. Curr Colorectal Cancer Rep. 2016;12(5):232-40.
    • (2016) Curr Colorectal Cancer Rep , vol.12 , Issue.5 , pp. 232-240
    • Goel, G.1    Chauhan, A.2    Hosein, P.J.3
  • 33
    • 84964398060 scopus 로고    scopus 로고
    • Microsatellite instability as a biomarker for PD-1 blockade
    • 1:CAS:528:DC%2BC28XivFGmsbY%3D 26880610
    • Dudley JC, Lin MT, Le DT, Eshleman JR. Microsatellite instability as a biomarker for PD-1 blockade. Clin Cancer Res. 2016;22(4):813-20.
    • (2016) Clin Cancer Res , vol.22 , Issue.4 , pp. 813-820
    • Dudley, J.C.1    Lin, M.T.2    Le, D.T.3    Eshleman, J.R.4
  • 41
    • 84857242852 scopus 로고    scopus 로고
    • Relevance, pathogenesis, and testing algorithm for mismatch repair-defective colorectal carcinomas: A report of the association for molecular pathology
    • 1:CAS:528:DC%2BC38Xms1Srtb8%3D 22260991
    • Funkhouser Jr WK, Lubin IM, Monzon FA, Zehnbauer BA, Evans JP, Ogino S, Nowak JA. Relevance, pathogenesis, and testing algorithm for mismatch repair-defective colorectal carcinomas: a report of the association for molecular pathology. J Mol Diagn. 2012;14(2):91-103.
    • (2012) J Mol Diagn , vol.14 , Issue.2 , pp. 91-103
    • Funkhouser, W.K.1    Lubin, I.M.2    Monzon, F.A.3    Zehnbauer, B.A.4    Evans, J.P.5    Ogino, S.6    Nowak, J.A.7
  • 42
    • 77955292303 scopus 로고    scopus 로고
    • Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer
    • 1:CAS:528:DC%2BC3cXhtVGis7fE 20498386
    • Chung KY, Gore I, Fong L, Venook A, Beck SB, Dorazio P, Criscitiello PJ, Healey DI, Huang B, Gomez-Navarro J, Saltz LB. Phase II study of the anti-cytotoxic T-lymphocyte-associated antigen 4 monoclonal antibody, tremelimumab, in patients with refractory metastatic colorectal cancer. J Clin Oncol. 2010;28(21):3485-90.
    • (2010) J Clin Oncol , vol.28 , Issue.21 , pp. 3485-3490
    • Chung, K.Y.1    Gore, I.2    Fong, L.3    Venook, A.4    Beck, S.B.5    Dorazio, P.6    Criscitiello, P.J.7    Healey, D.I.8    Huang, B.9    Gomez-Navarro, J.10    Saltz, L.B.11
  • 43
    • 84962431681 scopus 로고    scopus 로고
    • Case report: Mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance
    • 27012666 4806434
    • Chen KH, Yuan CT, Tseng LH, Shun CT, Yeh KH. Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance. J Hematol Oncol. 2016;9:29.
    • (2016) J Hematol Oncol , vol.9 , pp. 29
    • Chen, K.H.1    Yuan, C.T.2    Tseng, L.H.3    Shun, C.T.4    Yeh, K.H.5
  • 46
    • 37349014037 scopus 로고    scopus 로고
    • Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis
    • 1:CAS:528:DC%2BD1cXhtF2ltg%3D%3D 17920123
    • Zhang P, Su DM, Liang M, Fu J. Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis. Mol Immunol. 2008;45(5):1470-6.
    • (2008) Mol Immunol , vol.45 , Issue.5 , pp. 1470-1476
    • Zhang, P.1    Su, D.M.2    Liang, M.3    Fu, J.4
  • 49
    • 18344375283 scopus 로고    scopus 로고
    • Immunotherapy and chemotherapy - A practical partnership
    • 1:CAS:528:DC%2BD2MXjslertbk%3D 15864281
    • Lake RA, Robinson BW. Immunotherapy and chemotherapy - a practical partnership. Nat Rev Cancer. 2005;5(5):397-405.
    • (2005) Nat Rev Cancer , vol.5 , Issue.5 , pp. 397-405
    • Lake, R.A.1    Robinson, B.W.2
  • 50
    • 37549032137 scopus 로고    scopus 로고
    • Immunological aspects of cancer chemotherapy
    • 1:CAS:528:DC%2BD2sXhsVKrsLnP 18097448
    • Zitvogel L, Apetoh L, Ghiringhelli F, Kroemer G. Immunological aspects of cancer chemotherapy. Nat Rev Immunol. 2008;8(1):59-73.
    • (2008) Nat Rev Immunol , vol.8 , Issue.1 , pp. 59-73
    • Zitvogel, L.1    Apetoh, L.2    Ghiringhelli, F.3    Kroemer, G.4
  • 51
    • 1542719818 scopus 로고    scopus 로고
    • Drug- and cell-mediated antitumor cytotoxicities modulate cross-presentation of tumor antigens by myeloid dendritic cells
    • 1:CAS:528:DC%2BD3sXos1WgtL8%3D 14597879
    • Galetto A, Buttiglieri S, Forno S, Moro F, Mussa A, Matera L. Drug- and cell-mediated antitumor cytotoxicities modulate cross-presentation of tumor antigens by myeloid dendritic cells. Anticancer Drugs. 2003;14(10):833-43.
    • (2003) Anticancer Drugs , vol.14 , Issue.10 , pp. 833-843
    • Galetto, A.1    Buttiglieri, S.2    Forno, S.3    Moro, F.4    Mussa, A.5    Matera, L.6
  • 53
    • 84929318458 scopus 로고    scopus 로고
    • Novel approaches in the management of pancreatic ductal adenocarcinoma: Potential promises for the future
    • 25935754 4431030
    • Goel G, Sun W. Novel approaches in the management of pancreatic ductal adenocarcinoma: potential promises for the future. J Hematol Oncol. 2015;8:44.
    • (2015) J Hematol Oncol , vol.8 , pp. 44
    • Goel, G.1    Sun, W.2
  • 56
    • 33845247353 scopus 로고    scopus 로고
    • Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study
    • 1:CAS:528:DC%2BD28Xht1CntrzJ 17060934 2360729
    • Bernhardt SL, Gjertsen MK, Trachsel S, Moller M, Eriksen JA, Meo M, Buanes T, Gaudernack G. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study. Br J Cancer. 2006;95(11):1474-82.
    • (2006) Br J Cancer , vol.95 , Issue.11 , pp. 1474-1482
    • Bernhardt, S.L.1    Gjertsen, M.K.2    Trachsel, S.3    Moller, M.4    Eriksen, J.A.5    Meo, M.6    Buanes, T.7    Gaudernack, G.8
  • 60
    • 84942830712 scopus 로고    scopus 로고
    • Analysis of the immunomodulatory properties of two heat-killed mycobacterial preparations in a human whole blood model
    • 1:CAS:528:DC%2BC2MXht1ygtbfI 26253276
    • Bazzi S, Modjtahedi H, Mudan S, Akle C, Bahr GM. Analysis of the immunomodulatory properties of two heat-killed mycobacterial preparations in a human whole blood model. Immunobiology. 2015;220(12):1293-304.
    • (2015) Immunobiology , vol.220 , Issue.12 , pp. 1293-1304
    • Bazzi, S.1    Modjtahedi, H.2    Mudan, S.3    Akle, C.4    Bahr, G.M.5
  • 64
    • 85013979872 scopus 로고    scopus 로고
    • Systemic treatment with anti-PD-1 antibody nivolumab in combination with vaccine therapy in advanced pancreatic cancer
    • abstr 3092
    • Nesselhut J, Marx D, Lange H, Regalo G, Cillien N, Chang RY, Nesselhut T. Systemic treatment with anti-PD-1 antibody nivolumab in combination with vaccine therapy in advanced pancreatic cancer. J Clin Oncol. 34;2016(suppl; abstr 3092).
    • (2016) J Clin Oncol. , vol.34
    • Nesselhut, J.1    Marx, D.2    Lange, H.3    Regalo, G.4    Cillien, N.5    Chang, R.Y.6    Nesselhut, T.7
  • 67
    • 84986893023 scopus 로고    scopus 로고
    • Emerging role of epithelial-mesenchymal transition in hepatic cancer
    • 27619936 5020508
    • Yoshida GJ. Emerging role of epithelial-mesenchymal transition in hepatic cancer. J Exp Clin Cancer Res. 2016;35(1):141.
    • (2016) J Exp Clin Cancer Res , vol.35 , Issue.1 , pp. 141
    • Yoshida, G.J.1
  • 71
  • 74
    • 84931292174 scopus 로고    scopus 로고
    • A phase 2, open-label, randomized study of Pexa-Vec (JX-594) administered by jntratumoral injection in patients with unresectable primary hepatocellular carcinoma
    • Breitbach CJ, Moon A, Burke J, Hwang TH, Kirn DH. A phase 2, open-label, randomized study of Pexa-Vec (JX-594) administered by jntratumoral injection in patients with unresectable primary hepatocellular carcinoma. Methods Mol Biol (Clifton, NJ). 2015;1317:343-57.
    • (2015) Methods Mol Biol (Clifton, NJ) , vol.1317 , pp. 343-357
    • Breitbach, C.J.1    Moon, A.2    Burke, J.3    Hwang, T.H.4    Kirn, D.H.5
  • 76
    • 84960105388 scopus 로고    scopus 로고
    • Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors?
    • 26542241 4636069
    • Lin AY, Lin E. Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors? J Hematol Oncol. 2015;8:124.
    • (2015) J Hematol Oncol , vol.8 , pp. 124
    • Lin, A.Y.1    Lin, E.2
  • 77
    • 84997637224 scopus 로고    scopus 로고
    • Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma
    • 25901283 4404586
    • Laubli H, Balmelli C, Bossard M, Pfister O, Glatz K, Zippelius A. Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. J Immunother cancer. 2015;3:11.
    • (2015) J Immunother Cancer , vol.3 , pp. 11
    • Laubli, H.1    Balmelli, C.2    Bossard, M.3    Pfister, O.4    Glatz, K.5    Zippelius, A.6
  • 79
    • 84971280558 scopus 로고    scopus 로고
    • Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy
    • 27234522 4884396
    • Ma W, Gilligan BM, Yuan J, Li T. Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy. J Hematol Oncol. 2016;9(1):47.
    • (2016) J Hematol Oncol , vol.9 , Issue.1 , pp. 47
    • Ma, W.1    Gilligan, B.M.2    Yuan, J.3    Li, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.