Pharmacological analysis of the anti-epileptic mechanisms of fenfluramine in scn1a mutant zebrafish

Frontiers in Pharmacology

Volumn 8, Issue APR, 2017, Pages

  Sourbron, Jo ^a   Smolders, Ilse ^b   de Witte, Peter ^a   Lagae, Lieven ^b  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Dravet syndrome; Epilepsy; GABA; Glutamate; Monoamines; Pharmacological modulation; Sigma; Zebrafish

Indexed keywords

4 AMINOBUTYRIC ACID; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; DOPAMINE; FENFLURAMINE; GLUTAMIC ACID; KETANSERIN; NORADRENALIN; SEROTONIN 1D RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SODIUM CHANNEL NAV1.1;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; EMBRYO; GENE MUTATION; LOCOMOTION; NEUROTRANSMISSION; NONHUMAN; SCN1A GENE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; ZEBRA FISH;

EID: 85018742308     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2017.00191     Document Type: Article

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