Is elevated norepinephrine an etiological factor in some cases of epilepsy?

Seizure

Volumn 19, Issue 6, 2010, Pages 311-318

  Fitzgerald, Paul J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenoceptor; Anticonvulsant; Clonidine; Desipramine; Norepinephrine; Prazosin; Proconvulsant; Propranolol; Tricyclic antidepressant

Indexed keywords

ATOMOXETINE; CLONIDINE; DESIPRAMINE; ISONIAZID; NORADRENALIN; PENTETRAZOLE; PRAZOSIN; PROPRANOLOL; REBOXETINE; ADRENERGIC RECEPTOR AFFECTING AGENT; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ATTENTION DEFICIT DISORDER; BIPOLAR DISORDER; COMORBIDITY; DEPRESSION; DRUG EFFECT; DRUG INHIBITION; ELECTROENCEPHALOGRAM; EPILEPSY; HUMAN; HYPERTENSION; MAGNETOENCEPHALOGRAPHY; MENTAL STRESS; NONHUMAN; OBESITY; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; REVIEW; SEIZURE; ADRENAL TUMOR; ANIMAL; COMPLICATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENAL GLAND NEOPLASMS; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BIPOLAR DISORDER; EPILEPSY; HUMANS; HYPERTENSION; NOREPINEPHRINE; PHEOCHROMOCYTOMA; STRESS, PSYCHOLOGICAL;

EID: 77955326973     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2010.04.011     Document Type: Review

References (117)

1. F.S. Giorgi, C. Pizzanelli, F. Biagioni, L. Murri, and F. Fornai The role of norepinephrine in epilepsy: from the bench to the bedside Neurosci Biobehav Rev 28 2004 507 524
2. J.W. Dailey, and P.C. Jobe Anticonvulsant drugs and the genetically epilepsy-prone rat Fed Proc 44 1985 2640 2644
3. P. Szot, D. Weinshenker, S.S. White, C.A. Robbins, N.C. Rust, and P.A. Schwartzkroin Norepinephrine-deficient mice have increased susceptibility to seizure-inducing stimuli J Neurosci 19 1999 10985 10992
4. D. Weinshenker, P. Szot, N.S. Miller, and R.D. Palmiter Alpha(1) and beta(2) adrenoreceptor agonists inhibit pentylenetetrazole-induced seizures in mice lacking norepinephrine J Pharmacol Exp Ther 298 2001 1042 1048
5. P. Szot, M. Lester, M.L. Laughlin, R.D. Palmiter, L.C. Liles, and D. Weinshenker The anticonvulsant and proconvulsant effects of alpha2- adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors Neuroscience 126 2004 795 803
6. J. Martillotti, D. Weinshenker, L.C. Liles, and D.A. Eagles A ketogenic diet and knockout of the norepinephrine transporter both reduce seizure severity in mice Epilepsy Res 68 2006 207 211
7. K. Nylen, S. Likhodii, and W.M. Burnham The ketogenic diet: proposed mechanisms of action Neurotherapeutics 6 2009 402 405
8. R.M. Kaminski, T.S. Shippenberg, J.M. Witkin, and B.A. Rocha Genetic deletion of the norepinephrine transporter decreases vulnerability to seizures Neurosci Lett 382 2005 51 55
9. T.H. Ahern, M.A. Javors, D.A. Eagles, J. Martillotti, H.A. Mitchell, and L.C. Liles The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice Neuropsychopharmacology 31 2006 730 738
10. P.C. Jobe, and R.A. Browning The serotonergic and noradrenergic effects of antidepressant drugs are anticonvulsant, not proconvulsant Epilepsy Behav 7 2005 602 619
11. J.W. Dailey, and D.K. Naritoku Antidepressants and seizures: clinical anecdotes overshadow neuroscience Biochem Pharmacol 52 1996 1323 1329
12. A.P. Gibson, T.L. Bettinger, N.C. Patel, and M.L. Crismon Atomoxetine versus stimulants for treatment of attention deficit/hyperactivity disorder Ann Pharmacother 40 2006 1134 1142
13. L. Leggio, G.A. Kenna, and R.M. Swift New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications Prog Neuropsychopharmacol Biol Psychiatry 32 2008 1106 1117
14. R.M. Post Time course of clinical effects of carbamazepine: implications for mechanisms of action J Clin Psychiatry 49 Suppl. 1988 35 48
15. J.S. Meyer, and L.F. Quenzer Psychopharmacology: drugs, the brain, and behavior 136 2005 Sinauer Associates, Inc. Sunderland, MA 397
16. K. Brosen Some aspects of genetic polymorphism in the biotransformation of antidepressants Therapie 59 2004 5 12
17. S. Jordan, G.L. Kramer, P.K. Zukas, M. Moeller, and F. Petty In vivo biogenic amine efflux in medial prefrontal cortex with imipramine, fluoxetine, and fluvoxamine Synapse 18 1994 294 297
18. F. Krijzer, M. Snelder, and D. Bradford Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model Neuropsychobiology 12 1984 249 254
19. S.L. Peterson, J.P. Trzeciakowski, and J.S. St Mary Chronic but not acute treatment with antidepressants enhances the electroconvulsive seizure response in rats Neuropharmacology 24 1985 941 946
20. J.M. Warter, C. Tranchant, C. Marescaux, A. Depaulis, B. Lannes, and M. Vergnes Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures Prog Neuropsychopharmacol Biol Psychiatry 14 1990 261 270
21. J. Ago, T. Ishikawa, N. Matsumoto, M. Ashequr Rahman, and C. Kamei Mechanism of imipramine-induced seizures in amygdala-kindled rats Epilepsy Res 72 2006 1 9
22. D.B. Clifford, J.L. Rutherford, F.G. Hicks, and C.F. Zorumski Acute effects of antidepressants on hippocampal seizures Ann Neurol 18 1985 692 697
23. R. Yacobi, and W.M. Burnham The effect of tricyclic antidepressants on cortex- and amygdala-kindled seizures in the rat Can J Neurol Sci 18 1991 132 136
24. J.M. Lancaster, and J.A. Davies Desmethylimipramine potentiates NMDA responses in a mouse cortical slice preparation Neuroreport 2 1991 665 668
25. S. Arai, K. Morita, S. Kitayama, K. Kumagai, M. Kumagai, and K. Kihira Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics Brain Res 964 2003 83 90
26. Z. Kleinrok, J. Gustaw, and S.J. Czuczwar Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice J Neural Transm Suppl 34 1991 85 90
27. X.Y. Sun, L. Zhang, C.X. Wei, H.R. Piao, and Z.S. Quan Characterization of the anticonvulsant activity of doxepin in various experimental seizure models in mice Pharmacol Rep 61 2009 245 251
28. W.P. Koella, A. Glatt, K. Klebs, and T. Durst Epileptic phenomena induced in the cat by the antidepressants maprotiline, imipramine, clomipramine, and amitriptyline Biol Psychiatry 14 1979 485 497
29. M.R. Pineda, and S.C. Russell The use of a tricyclic antidepressant in epilepsy Dis Nerv Syst 35 1974 322 323
30. T.A. Petti, and M. Campbell Imipramine and seizures Am J Psychiatry 132 1975 538 540
31. S.H. Preskorn, and G.A. Fast Tricyclic antidepressant-induced seizures and plasma drug concentration J Clin Psychiatry 53 1992 160 162
32. F. Eyer, J. Stenzel, T. Schuster, N. Felgenhauer, R. Pfab, and C. von Bary Risk assessment of severe tricyclic antidepressant overdose Hum Exp Toxicol 28 2009 511 519
33. A.W. Peck, W.C. Stern, and C. Watkinson Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion J Clin Psychiatry 44 1983 197 201
34. S.A. Montgomery Antidepressants and seizures: emphasis on newer agents and clinical implications Int J Clin Pract 59 2005 1435 1440
35. K.U. Kuhn, B.B. Quednow, M. Thiel, P. Falkai, W. Maier, and C.E. Elger Antidepressive treatment in patients with temporal lobe epilepsy and major depression: a prospective study with three different antidepressants Epilepsy Behav 4 2003 674 679
36. J.F. Wernicke, K.C. Holdridge, L. Jin, T. Edison, S. Zhang, and M.E. Bangs Seizure risk in patients with attention-deficit-hyperactivity disorder treated with atomoxetine Dev Med Child Neurol 49 2007 498 502
37. A.T. McAfee, K.C. Holdridge, C.B. Johannes, K. Hornbuckle, and A.M. Walker The effect of pharmacotherapy for attention deficit hyperactivity disorder on risk of seizures in pediatric patients as assessed in an insurance claims database Curr Drug Saf 3 2008 123 131
38. J. Kashani, and A.M. Ruha Isolated atomoxetine overdose resulting in seizure J Emerg Med 32 2007 175 178
39. D.E. Golan, A.H. Tashjian Jr., E.J. Armstrong, J.M. Galanter, A.W. Armstrong, and R.A. Arnaout Principles of pharmacology: the pathophysiologic basis of drug therapy; 2005 Lippincott Williams & Wilkins Baltimore, MD p. 110
40. U. Tacke, and S. Kolonen The effect of clonidine and yohimbine on audiogenic seizures (AGS) in rats Pharmacol Res Commun 16 1984 1019 1030
41. H. Kleinlogel Spontaneous EEG paroxysms in the rat: effects of psychotropic and alpha-adrenergic agents Neuropsychobiology 13 1985 206 213
42. H.Q. Wu, M. Tullii, R. Samanin, and A. Vezzani Norepinephrine modulates seizures induced by quinolinic acid in rats: selective and distinct roles of alpha-adrenoceptor subtypes Eur J Pharmacol 138 1987 309 318
43. D. Ashton, and A. Wauquier Alpha-noradrenaline modulation of d,l-allylgycine seizures Eur J Pharmacol 75 1981 71 74
44. J. Papanicolaou, R.J. Summers, F.J. Vajda, and W.J. Louis The relationship between alpha 2-adrenoceptor selectivity and anticonvulsant effect in a series of clonidine-like drugs Brain Res 241 1982 393 397
45. M. Lazarova, C. Bendotti, and R. Samanin The role of different types of adrenergic receptors in pentylenetetrazol-induced seizures and the effect of di-n-propylacetate in the rat Psychopharmacology 81 1983 177 182
46. A.L. Mueller, and T.V. Dunwiddie Anticonvulsant and proconvulsant actions of alpha- and beta-noradrenergic agonists on epileptiform activity in rat hippocampus in vitro Epilepsia 24 1983 57 64
47. H. Baran, H. Hortnagl, and O. Hornykiewicz Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine Brain Res 495 1989 253 260
48. R. Chermat, L. Doare, F. Lachapelle, and P. Simon Effects of drugs affecting the noradrenergic system on convulsions in the quaking mouse Naunyn Schmiedebergs Arch Pharmacol 318 1981 94 99
49. R. Horton, G. Anlezark, and B. Meldrum Noradrenergic influences on sound-induced seizures J Pharmacol Exp Ther 214 1980 437 442
50. A.M. Homeida, and R.G. Cooke Anti-convulsant activity of diazepam and clonidine on metaldehyde-induced seizures in mice: effects on brain gamma-amino butyric acid concentrations and monoamine oxidase activity J Vet Pharmacol Ther 5 1982 187 190
51. G.J. Amabeoku The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice Experientia 49 1993 859 864
52. G. Amabeoku, and R. Chandomba Strychnine-induced seizures in mice: the role of noradrenaline Prog Neuropsychopharmacol Biol Psychiatry 18 1994 753 763
53. K. Kirchberger, H. Schmitt, C. Hummel, A. Peinemann, E. Pauli, and B. Kettenmann Clonidine and methohexital-induced epileptic magnetoencephalographic discharges in patients with focal epilepsies Epilepsia 39 1998 841 849
54. B. Kettenmann, M. Feichtinger, C. Tilz, M. Kaltenhauser, C. Hummel, and H. Stefan Comparison of clonidine to sleep deprivation in the potential to induce spike or sharp-wave activity Clin Neurophysiol 116 2005 905 912
55. R.S. Neuman Suppression of penicillin-induced focal epileptiform activity by locus ceruleus stimulation: mediation by an alpha 1-adrenoceptor Epilepsia 27 1986 359 366
56. H.C. Jackson, S.L. Dickinson, and D.J. Nutt Exploring the pharmacology of the pro-convulsant effects of alpha 2-adrenoceptor antagonists in mice Psychopharmacology 105 1991 558 562
57. W. Loscher, and S.J. Czuczwar Comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy Epilepsy Res 1 1987 165 172
58. F. Nicoletti, M.L. Barbaccia, M.J. Iadarola, O. Pozzi, and H.E. Laird II Abnormality of alpha 1-adrenergic receptors in the frontal cortex of epileptic rats J Neurochem 46 1986 270 273
59. S.P. Jazrawi, and R.W. Horton Brain adrenoceptor binding sites in mice susceptible(DBA/2J) and resistant (C57 Bl/6) to audiogenic seizures J Neurochem 47 1986 173 177
60. T. Kunieda, M.J. Zuscik, A. Boongird, D.M. Perez, H.O. Luders, and I.M. Najm Systemic overexpression of the alpha 1B-adrenergic receptor in mice: an animal model of epilepsy Epilepsia 43 2002 1324 1329
61. C. Pizzanelli, G. Lazzeri, F. Fulceri, F.S. Giorgi, L. Pasquali, and G. Cifelli Lack of alpha 1b-adrenergic receptor protects against epileptic seizures Epilepsia 50 Suppl 1 2009 59 64
62. R. Briere, A.L. Sherwin, Y. Robitaille, A. Olivier, L.F. Quesney, and T.A. Reader Alpha-1 adrenoceptors are decreased in human epileptic foci Ann Neurol 19 1986 26 30
63. G. Ferraro, P. Sardo, M. Sabatino, G. Caravaglios, and V. La Grutta Anticonvulsant activity of the noradrenergic locus coeruleus system: role of beta mediation Neurosci Lett 169 1994 93 96
64. W.J. Louis, J. Papanicolaou, R.J. Summers, and F.J. Vajda Role of central beta-adrenoceptors in the control of pentylenetetrazol-induced convulsions in rats Br J Pharmacol 75 1982 441 446
65. V. Paul, and M.S. Krishnamoorthy The effect of beta-adrenoceptor antagonists alone and in combination with a GABA-elevating agent on isoniazid-induced convulsions in rats Indian J Physiol Pharmacol 33 1989 175 178
66. T. Nakamura, Y. Oda, R. Takahashi, K. Tanaka, I. Hase, and A. Asada Propranolol increases the threshold for lidocaine-induced convulsions in awake rats: a direct effect on the brain Anesth Analg 106 2008 1450 1455
67. R.A. Gross, and J.A. Ferrendelli Relationships between norepinephrine and cyclic nucleotides in brain and seizure activity Neuropharmacology 21 1982 655 661
68. C. Wambebe, G. Osuide, and K. Gamaniel Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice Gen Pharmacol 15 1984 243 245
69. C.E. Lints, and C. Nyquist-Battie A possible role for beta-adrenergic receptors in the expression of audiogenic seizures Pharmacol Biochem Behav 22 1985 711 716
70. N. Khanna, A. Ray, M. Alkondon, and P. Sen Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice Indian J Exp Biol 27 1989 128 130
71. S.S. Raju, H.N. Gopalakrishna, and N. Venkatadri Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice: individually and in combination Pharmacol Res 38 1998 449 452
72. G. De Sarro, E.D. Di Paola, G. Ferreri, A. De Sarro, and W. Fischer Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice Eur J Pharmacol 442 2002 205 213
73. W. Fischer Anticonvulsant profile and mechanism of action of propranolol and its two enantiomers Seizure 11 2002 285 302
74. G.W. Fowler Propanolol treatment of infantile polymyoclonia Neuropadiatrie 7 1976 443 449
75. G.G. de Oliveira, and M.A. Borges Propranolol action in chronically unstable generalized epilepsy Am J Ther 1 1994 38 41
76. P. Levitt, and J.L. Noebels Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation Proc Natl Acad Sci USA 78 1981 4630 4634
77. P. Levitt Normal pharmacological and morphometric parameters in the noradrenergic hyperinnervated mutant mouse, "tottering" Cell Tissue Res 252 1988 175 180
78. J.L. Noebels A single gene error of noradrenergic axon growth synchronizes central neurones Nature 310 1984 409 411
79. J.E. Hardebo, and C. Owman Barrier mechanisms for neurotransmitter monoamines and their precursors at the blood-brain interface Ann Neurol 8 1980 1 31
80. O. Devinsky, B.H. Price, and S.I. Cohen Cardiac manifestations of complex partial seizures Am J Med 80 1986 195 202
81. C. Stoba, B. Skoczylas-Stoba, and P. Czauderna Clinical course and treatment of pheochromocytomas in children. Analysis of five cases Eur J Pediatr Surg 3 1993 154 156
82. P. Reichardt, T.W. Apel, M. Domula, R.B. Trobs, I. Krause, and U. Bierbach Recurrent polytopic chromaffin paragangliomas in a 9-year-old boy resulting from a novel germline mutation in the von Hippel-Lindau gene J Pediatr Hematol Oncol 24 2002 145 148
83. A. Leiba, Y. Bar-Dayan, R.R. Leker, S. Apter, and E. Grossman Seizures as a presenting symptom of phaeochromocytoma in a young soldier J Hum Hypertens 17 2003 73 75
84. J.J. Schildkraut The catecholamine hypothesis of affective disorders: a review of supporting evidence Am J Psychiatry 122 1965 509 522
85. D.C. Jimerson, J.I. Nurnberger Jr., R.M. Post, E.S. Gershon, and I.J. Kopin Plasma MHPG in rapid cyclers and healthy twins Arch Gen Psychiatry 38 1981 1287 1290
86. J.J. Barry The recognition and management of mood disorders as a comorbidity of epilepsy Epilepsia 44 2003 30 40
87. A.B. Ettinger, M.L. Reed, J.F. Goldberg, and R.M. Hirschfeld Prevalence of bipolar symptoms in epilepsy vs other chronic health disorders Neurology 65 2005 535 540
88. M. Mula, B. Schmitz, R. Jauch, A. Cavanna, R. Cantello, and F. Monaco On the prevalence of bipolar disorder in epilepsy Epilepsy Behav 13 2008 658 661
89. M. Mula, R. Jauch, A. Cavanna, L. Collimedaglia, D. Barbagli, and V. Gaus Manic/hypomanic symptoms and quality of life measures in patients with epilepsy Seizure 18 2009 530 532
90. M.G. Roxanas, A.J. Corbett, and W.G. Reid A patient with mania and photoconvulsive epilepsy Aust N Z J Psychiatry 30 1996 867 870
91. M. Mula, A.E. Marotta, and F. Monaco Epilepsy and bipolar disorders Expert Rev Neurother 10 2010 13 23
92. J.A. Salpekar, J.A. Conry, W. Doss, S. Cushner-Weinstein, P.L. Pearl, and S.L. Weinstein Clinical experience with anticonvulsant medication in pediatric epilepsy and comorbid bipolar spectrum disorder Epilepsy Behav 9 2006 327 334
93. K.N. Fountoulakis, and E. Vieta Treatment of bipolar disorder: a systematic review of available data and clinical perspectives Int J Neuropsychopharmacol 11 2008 999 1029
94. V.B. Solt, M.R. Brown, B. Kennedy, O.G. Kolterman, and M.G. Ziegler Elevated insulin, norepinephrine, and neuropeptide Y in hypertension Am J Hypertens 3 1990 823 828
95. D.A. Sica Centrally acting antihypertensive agents: an update J Clin Hypertens (Greenwich) 9 2007 399 405
96. I. Eide, R. Kolloch, V. DeQuattro, L. Miano, R. Dugger, and J. Van der Meulen Raised cerebrospinal fluid norepinephrine in some patients with primary hypertension Hypertension 1 1979 255 260
97. V. DeQuattro, P. Sullivan, R. Minagawa, I. Kopin, J. Bornheimer, and A. Foti Central and peripheral noradrenergic tone in primary hypertension Fed Proc 43 1984 47 51
98. Y. Kawano, K. Fukiyama, Y. Takeya, I. Abe, and T. Omae Catecholamines, angiotensin II and sodium concentrations in cerebrospinal fluid in young men with borderline hypertension Clin Exp Hypertens A 6 1984 1131 1145
99. D.C. Hesdorffer, W.A. Hauser, J.F. Annegers, and W.A. Rocca Severe, uncontrolled hypertension and adult-onset seizures: a case-control study in Rochester, Minnesota Epilepsia 37 1996 736 741
100. X. Li, M.M. Breteler, M.C. de Bruyne, H. Meinardi, W.A. Hauser, and A. Hofman Vascular determinants of epilepsy: the Rotterdam Study Epilepsia 38 1997 1216 1220
101. K. Masuo, T. Katsuya, Y. Fu, H. Rakugi, T. Ogihara, and M.L. Tuck Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years Circulation 111 2005 3429 3434
102. G.A. Oltmans, J.F. Lorden, and D.L. Margules Effects of food restriction and mutation on central catecholamine levels in genetically obese mice Pharmacol Biochem Behav 5 1976 617 620
103. G.A. Oltmans Norepinephrine and dopamine levels in hypothalamic nuclei of the genetically obese mouse (ob/ob) Brain Res 273 1983 369 373
104. T. Shimazu, M. Noma, and M. Saito Chronic infusion of norepinephrine into the ventromedial hypothalamus induces obesity in rats Brain Res 369 1986 215 223
105. R. Kobau, C.A. DiIorio, P.H. Price, D.J. Thurman, L.M. Martin, and D.L. Ridings Prevalence of epilepsy and health status of adults with epilepsy in Georgia and Tennessee: Behavioral Risk Factor Surveillance System, 2002 Epilepsy Behav 5 2004 358 366
106. Z.S. Daniels, T.G. Nick, C. Liu, A. Cassedy, and T.A. Glauser Obesity is a common comorbidity for pediatric patients with untreated, newly diagnosed epilepsy Neurology 73 2009 658 664
107. F.G. Gilliam, A. Mendiratta, A.M. Pack, and C.W. Bazil Epilepsy and common comorbidities: improving the outpatient epilepsy encounter Epileptic Disord 7 Suppl. 1 2005 S27 S33
108. J. Wong, and E. Wirrell Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy Epilepsia 47 2006 631 639
109. H. Homayoun, S. Khavandgar, and A.R. Dehpour The role of alpha2-adrenoceptors in the modulatory effects of morphine on seizure susceptibility in mice Epilepsia 43 2002 797 804
110. K. Tabb, K.A. Boss-Williams, J.M. Weiss, and D. Weinshenker Rats bred for susceptibility to depression-like phenotypes have higher kainic acid-induced seizure mortality than their depression-resistant counterparts Epilepsy Res 74 2007 140 146
111. W.A. Swinkels, M. Engelsman, D.G. Kasteleijn-Nolst Trenite, M.G. Baal, G.J. de Haan, and J. Oosting Influence of an evacuation in February 1995 in The Netherlands on the seizure frequency in patients with epilepsy: a controlled study Epilepsia 39 1998 1203 1207
112. A.W. Yuen, P.J. Thompson, D. Flugel, G.S. Bell, and J.W. Sander Mortality and morbidity rates are increased in people with epilepsy: is stress part of the equation? Epilepsy Behav 10 2007 1 7
113. J. Layne Moore, J.O. Elliot, B. Lu, E.T. Klatte, and C. Charyton Serious psychological distress among persons with epilepsy based on the 2005 California Health Interview Survey Epilepsia 50 2009 1077 1084
114. M. Hiramatsu, N. Fujimoto, and A. Mori Catecholamine level in cerebrospinal fluid of epileptics Neurochem Res 7 1982 1299 1305
115. K.D. Laxer, T.L. Sourkes, T.Y. Fang, S.N. Young, S.G. Gauthier, and K. Missala Monoamine metabolites in the CSF of epileptic patients Neurology 29 1979 1157 1161
116. O. Devinsky, S. Emoto, D.S. Goldstein, R. Stull, R.J. Porter, and W.H. Theodore Cerebrospinal fluid and serum levels of dopa, catechols, and monoamine metabolites in patients with epilepsy Epilepsia 33 1992 263 270
117. H.S. Nelson, S.T. Weiss, E.R. Bleecker, S.W. Yancey, P.M. Dorinsky SMART Study Group The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol Chest 129 2006 15 26