SCARA5 plays a critical role in the progression and metastasis of breast cancer by inactivating the ERK1/2, STAT3, and AKT signaling pathways

Molecular and Cellular Biochemistry

Volumn 435, Issue 1-2, 2017, Pages 47-58

  You, Kai ^a   Su, Fei ^a   Liu, Lihua ^a   Lv, Xiaohong ^a   Zhang, Jianguo ^a   Zhang, Yafang ^a   Liu, Baoquan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Metastasis; SCARA5; VEGF A; VEGF C

Indexed keywords

CASPASE 3; CYCLIN B1; CYCLIN D1; CYCLIN E; CYCLIN E1; GELATINASE A; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SCAVENGER RECEPTOR A; SCAVENGER RECEPTOR A MEMBER 5; STAT3 PROTEIN; STROMELYSIN; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN A; VASCULOTROPIN C; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 3; SCARA5 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ADULT; AGED; AKT SIGNALING; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER GROWTH; CAPILLARY DENSITY; CELL INVASION; CELL MIGRATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME INACTIVATION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL; MAJOR CLINICAL STUDY; MDA-MB-231 CELL LINE; MIDDLE AGED; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUPPRESSOR GENE; TUNEL ASSAY; WESTERN BLOTTING; ZR-75-30 CELL LINE; BREAST TUMOR; FEMALE; HEK293 CELL LINE; MAPK SIGNALING; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; HEK293 CELLS; HUMANS; LYMPHATIC METASTASIS; MAP KINASE SIGNALING SYSTEM; MCF-7 CELLS; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTO-ONCOGENE PROTEINS C-AKT; SCAVENGER RECEPTORS, CLASS A; STAT3 TRANSCRIPTION FACTOR;

EID: 85018721527     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-017-3055-4     Document Type: Article

References (39)

1. Parrella P (2010) Epigenetic signatures in breast cancer: clinical perspective. Breast Care 5:66–73
2. Saad ED, Katz A, Buyse M (2010) Overall survival and post-progression survival in advanced breast cancer: a review of recent randomized clinical trials. J Clin Oncol 28:1958–1962
3. Gotay CC, Kawamoto CT, Bottomley A, Efficace F (2008) The prognostic significance of patient-reported outcomes in cancer clinical trials. J Clin Oncol 26:1355–1363
4. Armengol C, Bartolí R, Sanjurjo L et al (2013) Role of scavenger receptors in the pathophysiology of chronic liver diseases. Crit Rev Immunol 33:57–96
5. Peiser L, Gordon S (2002) The function of scavenger receptors expressed by macrophages and their role in the regulation of inflammation. Microbes Infect 3:149–159
6. Whelan FJ, Meehan CJ, Golding GB, McConkey BJ, Bowdish DM (2012) The evolution of the class A scavenger receptors. BMC Evol Biol 12:227
7. Brown MS, Goldstein JL (1983) Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 52:223–261
8. Li JY, Paragas N, Ned RM et al (2009) Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell 16:35–46
9. Huang J, Zheng DL, Qin FS et al (2010) Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest 120:223–241
10. Yan N, Zhang S, Yang Y et al (2012) Therapeutic upregulation of Class A scavenger receptor member 5 inhibits tumor growth and metastasis. Cancer Sci 103:1631–1639
11. Wen X, Wang N, Zhang F, Dong C (2016) Overexpression of SCARA5 inhibits tumor proliferation and invasion in osteosarcoma via suppression of the FAK signaling pathway. Mol Med Rep 13:2885–2891
12. Hu J, Cheng Y, Li Y et al (2014) microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C. Eur J Cancer 50:2336–2350
13. Park YL, Myung E, Park SY et al (2015) Impact of prospero homeobox-1 on tumor cell behavior and prognosis in colorectal cancer. Am J Cancer Res 5:3286–3300
14. Hwang A, McKenna WG, Muschel RJ (1998) Cell cycle-dependent usage of transcriptional start sites. A novel mechanism for regulation of cyclin B1. J Biol Chem 273:31505–31509
15. Quelle DE, Ashmun RA (1993) Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev 7:1559–1571
16. Ewen ME, Lamb J (2004) The activities of cyclin D1 that drive tumorigenesis. Trends Mol Med 10:158–162
17. Arnold A, Papanikolaou A (2005) Cyclin D1 in breast cancer pathogenesis. J Clin Oncol 23:4215–4224
18. Nahta R, Esteva FJ (2003) Bcl-2 antisense oligonucleotides: a potential novel strategy for the treatment of breast cancer. Semin Oncol 30:143–149
19. Ghobrial IM, Witzig TE, Adjei AA (2005) Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin 55:178–194
20. Kymionis GD, Dimitrakakis CE, Konstadoulakis MM et al (2001) Can expression of apoptosis genes, bcl-2 and bax, predict survival and responsiveness to chemotherapy in node-negative breast cancer patients? J Surg Res 99:161–168
21. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1–16
22. Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312–1316
23. Salvesen GS (2002) Caspases opening the boxes and interpreting the arrows. Cell Death Differ 9:3–5
24. Ghavami S, Hashemi M, Ande SR et al (2009) Apoptosis and cancer: mutations within caspase genes. J Med Genet 46:497–510
25. Chambers AF, Matrisian LM (1997) Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89:1260–1270
26. Bussemakers MJ, van Moorselaar RJ, Giroldi LA et al (1992) Decreased expression of E-cadherin in the progression of rat prostatic cancer. Cancer Res 52:2916–2922
27. Mittal K, Ebos J, Rini B (2014) Angiogenesis and the tumor microenvironment: vascular endothelial growth factor and beyond. Semin Oncol 41:235–251
28. Gomes FG, Nedel F, Alves AM, Nör JE, Tarquinio SB (2013) Tumor angiogenesis and lymphangiogenesis: tumor endothelial crosstalk and cellular/microenvironmental signaling mechanisms. Life Sci 92:101–107
29. Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG (2014) Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer 14:159–172
30. Teng Y, Ross JL, Cowell JK (2014) The involvement of JAK-STAT3 in cell motility, invasion, and metastasis. JAKSTAT 3:e28086
31. Zhang P, Guo X, Li J et al (2015) Immunoglobulin-like transcript 4 promotes tumor progression and metastasis and up-regulates VEGF-C expression via ERK signaling pathway in non-small cell lung cancer. Oncotarget 6:13550–13563
32. Chen H, Guan R, Lei Y et al (2015) Lymphangiogenesis in Gastric Cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis. BMC Cancer 15:103
33. Gong W, Wang L, Yao JC et al (2005) Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin Cancer Res 11:1386–1393
34. Groner B, Lucks P, Borghouts C (2008) The function of Stat3 in tumor cells and their microenvironment. Semin Cell Dev Biol 19:341–350
35. Xie TX, Huang FJ, Aldape KD et al (2006) Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 66:3188–3196
36. Niu G, Wright KL, Huang M et al (2002) Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21:2000–2008
37. Wei D, Le X, Zheng L et al (2003) Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 22:319–329
38. Yahata Y, Shirakata Y, Tokumaru S et al (2003) Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formation. J Biol Chem 278:40026–40031
39. Hu D, Fukuhara A, Miyata Y et al (2013) Adiponectin regulates vascular endothelial growth factor-C expression in macrophages via Syk-ERK pathway. PLoS ONE 8:e56071