Obesity Induces Artery-Specific Alterations: Evaluation of Vascular Function and Inflammatory and Smooth Muscle Phenotypic Markers

BioMed Research International

Volumn 2017, Issue , 2017, Pages

  Soares, Antonio Garcia ^a   Carvalho, Maria Helena Catelli De ^a   Akamine, Eliana ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ; CALDESMON; CHOLESTEROL; COLLAGEN TYPE 3; CYCLOOXYGENASE 2; CYCLOPHILIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MYOSIN LIGHT CHAIN KINASE; NOTCH3 RECEPTOR; TROPOMYOSIN; TUMOR NECROSIS FACTOR; COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; GENE EXPRESSION; INFLAMMATION; LIPID DIET; MALE; MESENTERIC ARTERY; MOUSE; NONHUMAN; OBESITY; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CELL; THORACIC AORTA; WEIGHT GAIN; ANIMAL; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SMOOTH MUSCLE; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA, THORACIC; COLLAGEN; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; MESENTERIC ARTERIES; MICE; MUSCLE, SMOOTH; OBESITY; RNA, MESSENGER;

EID: 85018640840     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2017/5038602     Document Type: Article

References (46)

1. World Health Organization, 2016, http://www.who. int/mediacentre/factsheets/fs311/en/.
2. N. Abate, "Insulin resistance and obesity: the role of fat distribution pattern, " Diabetes Care, vol. 19, no. 3, pp. 292-294, 1996.
3. A. Avogaro and S. V. De Kreutzenberg, "Mechanisms of endothelial dysfunction in obesity, " Clinica Chimica Acta, vol. 360, no. 1-2, pp. 9-26, 2005.
4. M. Bastien, P. Poirier, I. Lemieux, and J.-P. Després, "Overview of epidemiology and contribution of obesity to cardiovascular disease, " Progress in Cardiovascular Diseases, vol. 56, no. 4, pp. 369-381, 2014.
5. L. Ghibaudi, J. Cook, C. Farley, M. Van Heek, and J. J. Hwa, "Fat intake affects adiposity, comorbidity factors, and energy metabolism of Sprague-Dawley rats, " Obesity Research, vol. 10, no. 9, pp. 956-963, 2002.
6. C. K. Roberts, R. J. Barnard, R. K. Sindhu, M. Jurczak, A. Ehdaie, and N. D. Vaziri, "Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome, " Metabolism: Clinical and Experimental, vol. 55, no. 7, pp. 928-934, 2006.
7. G. Michas, R. Micha, and A. Zampelas, "Dietary fats and cardiovascular disease: putting together the pieces of a complicated puzzle, " Atherosclerosis, vol. 234, no. 2, pp. 320-328, 2014.
8. H. O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel, and A. D. Baron, "Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance, " Journal of Clinical Investigation, vol. 97, no. 11, pp. 2601-2610, 1996.
9. A. P. Davel, C. F. Wenceslau, E. H. Akamine et al., "Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update, " Brazilian Journal of Medical and Biological Research, vol. 44, no. 9, pp. 920-932, 2011.
10. G. K. Owens, M. S. Kumar, and B. R. Wamhoff, "Molecular regulation of vascular smooth muscle cell differentiation in development and disease, " Physiological Reviews, vol. 84, no. 3, pp. 767-801, 2004.
11. J.-B. Michel, Z. Li, and P. Lacolley, "Smooth muscle cells and vascular diseases, " Cardiovascular Research, vol. 95, no. 2, pp. 135-137, 2012.
12. V. Z. Wall and K. E. Bornfeldt, "Arterial smooth muscle, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 10, pp. 2175-2179, 2014.
13. P. A. Stapleton, M. E. James, A. G. Goodwill, and J. C. Frisbee, "Obesity and vascular dysfunction, " Pathophysiology, vol. 15, no. 2, pp. 79-89, 2008.
14. M. A. Alpert, C. J. Lavie, H. Agrawal, K. B. Aggarwal, and S. A. Kumar, "Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management, " Translational Research, vol. 164, no. 4, pp. 345-356, 2014.
15. V. Z. Rocha and P. Libby, "Obesity, inflammation, and atherosclerosis, " Nature Reviews Cardiology, vol. 6, no. 6, pp. 399-409, 2009.
16. R. Sotornik, P. Brassard, E. Martin, P. Yale, A. C. Carpentier, and J.-L. Ardilouze, "Update on adipose tissue blood flow regulation, "American Journal of Physiology-Endocrinology and Metabolism, vol. 302, no. 10, pp. E1157-E1170, 2012.
17. D. Rizzoni, C. De Ciuceis, E. Porteri, F. Semeraro, and E. A. Rosei, "Structural alterations in small resistance arteries in obesity, " Basic and Clinical Pharmacology and Toxicology, vol. 110, no. 1, pp. 56-62, 2012.
18. W. C. Aird, "Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms, " Circulation Research, vol. 100, no. 2, pp. 158-173, 2007.
19. M. W. Majesky, "Developmental basis of vascular smooth muscle diversity, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 6, pp. 1248-1258, 2007.
20. G. Wang, L. Jacquet, E. Karamariti, and Q. Xu, "Origin and differentiation of vascular smooth muscle cells, " Journal of Physiology, vol. 593, no. 14, pp. 3013-3030, 2015.
21. M. J. Mulvany and W. Halpern, "Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats, " Circulation Research, vol. 41, no. 1, pp. 19-26, 1977.
22. L. F. Van Gaal, I. L. Mertens, and C. E. De Block, "Mechanisms linking obesity with cardiovascular disease, " Nature, vol. 444, no. 7121, pp. 875-880, 2006.
23. R. Kobayasi, E. H. Akamine, A. P. Davel, M. A. M. Rodrigues, C. R. O. Carvalho, and L. V. Rossoni, "Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice, " Journal of Hypertension, vol. 28, no. 10, pp. 2111-2119, 2010.
24. C. A. Gunnett, D. D. Heistad, D. J. Berg, and F. M. Faraci, "IL-10 deficiency increases superoxide and endothelial dysfunction during inflammation, " American Journal of Physiology-Heart and Circulatory Physiology, vol. 279, no. 4, pp. H1555-H1562, 2000.
25. C. A. Gunnett, D. D. Heistad, and F. M. Faraci, "Interleukin-10 protects nitric oxide-dependent relaxation during diabetes, " Diabetes, vol. 51, no. 6, pp. 1931-1937, 2002.
26. L.-H. Fan, H.-Y. Tian, M.-L. Yang et al., "High-fat diet may impair KATP channels in vascular smooth muscle cells, " Biomedicine and Pharmacotherapy, vol. 63, no. 2, pp. 165-170, 2009.
27. S. Fatani, L. C. Pickavance, C. J. Sadler et al., "Differential vascular dysfunction in response to diets of differing macronutrient composition: a phenomenonological study, " Nutrition and Metabolism, vol. 4, article 15, 2007.
28. C. Gallou-Kabani, A. Vigé, M.-S. Gross et al., "C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndrome, " Obesity, vol. 15, no. 8, pp. 1996-2005, 2007.
29. A. G. Goodwill, S. J. Frisbee, P. A. Stapleton, M. E. James, and J. C. Frisbee, "Impact of chronic anticholesterol therapy on development of microvascular rarefaction in the metabolic syndrome, " Microcirculation, vol. 16, no. 8, pp. 667-684, 2009.
30. J. Ketonen, J. Shi, E. Martonen, and E. Mervaala, "Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57BL/6 mice, " Circulation Journal, vol. 74, no. 7, pp. 1479-1487, 2010.
31. K. L. Sweazea and B. R. Walker, "Impaired myogenic tone in mesenteric arteries from overweight rats, " Nutrition and Metabolism, vol. 9, article 18, 2012.
32. X. Y. Tian, W. T. Wong, A. Xu et al., "Uncoupling protein-2 protects endothelial function in diet-induced obese mice, " Circulation Research, vol. 110, no. 9, pp. 1211-1216, 2012.
33. L. Ma, S. Ma, H. He et al., "Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats, " Hypertension Research, vol. 33, no. 5, pp. 446-453, 2010.
34. J. Molnar, S. Yu, N. Mzhavia, C. Pau, I. Chereshnev, and H. M. Dansky, "Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice, " Circulation Research, vol. 96, no. 11, pp. 1178-1184, 2005.
35. M. Kaneki, N. Shimizu, D. Yamada, and K. Chang, "Nitrosative stress and pathogenesis of insulin resistance, " Antioxidants and Redox Signaling, vol. 9, no. 3, pp. 319-329, 2007.
36. B. T. Noronha, J.-M. Li, S. B. Wheatcroft, A. M. Shall, and M. T. Kearney, "Inducible nitric oxide synthase has divergent effects on vascular andmetabolic function in obesity, " Diabetes, vol. 54, no. 4, pp. 1082-1089, 2005.
37. L. Yang, E. S. Calay, J. Fan et al., "S-nitrosylation links obesityassociated inflammation to endoplasmic reticulum dysfunction, " Science, vol. 349, no. 6247, pp. 500-506, 2015.
38. J. F. Silva, I. C. Correa, T. F. Diniz et al., "Obesity, inflammation, and exercise training: relative contribution of iNOS and eNOS in the modulation of vascular function in the mouse aorta, " Frontiers in Physiology, vol. 7, article 386, 2016.
39. E. A. Hallinan, S. Tsymbalov, C. R. Dorn et al., "Synthesis and biological characterization of L-N6-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor, " Journal of Medicinal Chemistry, vol. 45, no. 8, pp. 1686-1689, 2002.
40. L. B. R. Zocrato, L. S. A. Capettini, B. A. Rezende et al., "Increased expression of endothelial iNOS accounts for hyporesponsiveness of pulmonary artery to vasoconstrictors after paraquat poisoning, " Toxicology in Vitro, vol. 24, no. 3, pp. 1019-1025, 2010.
41. J. A. Beamish, P. He, K. Kottke-Marchant, and R. E. Marchant, "Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering, " Tissue Engineering Part B: Reviews, vol. 16, no. 5, pp. 467-491, 2010.
42. R. A. Fernandez, J. Wan, S. Song et al., "Upregulated expression of STIM2, TRPC6, and orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype, " American Journal of Physiology-Cell Physiology, vol. 308, no. 8, pp. C581-C593, 2015.
43. S. A. Fisher, "Vascular smooth muscle phenotypic diversity and function, " Physiological Genomics, vol. 42, no. 3, pp. 169-187, 2010.
44. S. Basu, D. K. Srinivasan, K. Yang et al., "Notch transcriptional control of vascular smooth muscle regulatory gene expression and function, " Journal of Biological Chemistry, vol. 288, no. 16, pp. 11191-11202, 2013.
45. E. J. Belin De Chantemèle, K. Retailleau, F. Pinaud et al., "Notch3 is amajor regulator of vascular tone in cerebral and tail resistance arteries, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 12, pp. 2216-2224, 2008.
46. C.-H. Lin and B. Lilly, "Notch signaling governs phenotypic modulation of smooth muscle cells, " Vascular Pharmacology, vol. 63, no. 2, pp. 88-96, 2014.