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Volumn 109, Issue , 2017, Pages 9-13

EGFR T790M mutation testing within the osimertinib AURA Phase I study

Author keywords

EGFR genes; Non small cell lung cancer; Osimertinib; Protein kinase inhibitors

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; OSIMERTINIB; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; PIPERAZINE DERIVATIVE;

EID: 85018584267     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2017.04.011     Document Type: Article
Times cited : (20)

References (35)
  • 1
    • 84983373947 scopus 로고    scopus 로고
    • NCCN Clinical Practice Guidelines in Oncology NSCLC (version 7.2015)
    • (Available at, Accessed on 16 July 2015.)
    • [1] NCCN, NCCN Clinical Practice Guidelines in Oncology NSCLC (version 7.2015). 2015 (Available at http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf, Accessed on 16 July 2015.).
    • (2015)
    • Nccn1
  • 2
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • [2] Lynch, T.J., Bell, D.W., Sordella, R., Gurubhagavatula, S., Okimoto, R.A., Brannigan, B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350 (2004), 2129–2139.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 3
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • [3] Paez, J.G., Janne, P.A., Lee, J.C., Tracy, S., Greulich, H., Gabriel, S., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304 (2004), 1497–1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3    Tracy, S.4    Greulich, H.5    Gabriel, S.6
  • 4
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
    • [4] Pao, W., Miller, V., Zakowski, M., Doherty, J., Politi, K., Sarkaria, I., et al. EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc. Natl. Acad. Sci. U. S. A. 101 (2004), 13306–13311.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3    Doherty, J.4    Politi, K.5    Sarkaria, I.6
  • 6
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
    • [6] Rosell, R., Carcereny, E., Gervais, R., Vergnenegre, A., Massuti, B., Felip, E., et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 13 (2012), 239–246.
    • (2012) Lancet Oncol. , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3    Vergnenegre, A.4    Massuti, B.5    Felip, E.6
  • 7
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • [7] Sequist, L.V., Yang, J.C., Yamamoto, N., O'Byrne, K., Hirsh, V., Mok, T., et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J. Clin. Oncol. 31 (2013), 3327–3334.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3    O'Byrne, K.4    Hirsh, V.5    Mok, T.6
  • 8
    • 84911493241 scopus 로고    scopus 로고
    • Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • [8] Reck, M., Popat, S., Reinmuth, N., De Ruysscher, D., Kerr, K.M., Peters, S., Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 25:Suppl. 3 (2014), iii27–iii39.
    • (2014) Ann. Oncol. , vol.25 , pp. iii27-iii39
    • Reck, M.1    Popat, S.2    Reinmuth, N.3    De Ruysscher, D.4    Kerr, K.M.5    Peters, S.6
  • 9
    • 84945194223 scopus 로고    scopus 로고
    • Systemic therapy for Stage IV non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline update
    • [9] Masters, G.A., Temin, S., Azzoli, C.G., Giaccone, G., Baker, S. Jr., Brahmer, J.R., et al. Systemic therapy for Stage IV non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline update. J. Clin. Oncol. 33 (2015), 3488–3515.
    • (2015) J. Clin. Oncol. , vol.33 , pp. 3488-3515
    • Masters, G.A.1    Temin, S.2    Azzoli, C.G.3    Giaccone, G.4    Baker, S.5    Brahmer, J.R.6
  • 11
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • [11] Pao, W., Miller, V.A., Politi, K.A., Riely, G.J., Somwar, R., Zakowski, M.F., et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med., 2, 2005, e73.
    • (2005) PLoS Med. , vol.2 , pp. e73
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6
  • 12
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
    • [12] Yu, H.A., Arcila, M.E., Rekhtman, N., Sima, C.S., Zakowski, M.F., Pao, W., et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin. Cancer Res. 19 (2013), 2240–2247.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2240-2247
    • Yu, H.A.1    Arcila, M.E.2    Rekhtman, N.3    Sima, C.S.4    Zakowski, M.F.5    Pao, W.6
  • 13
    • 84904898065 scopus 로고    scopus 로고
    • AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
    • [13] Cross, D.A., Ashton, S.E., Ghiorghiu, S., Eberlein, C., Nebhan, C.A., Spitzler, P.J., et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 4 (2014), 1046–1061.
    • (2014) Cancer Discov. , vol.4 , pp. 1046-1061
    • Cross, D.A.1    Ashton, S.E.2    Ghiorghiu, S.3    Eberlein, C.4    Nebhan, C.A.5    Spitzler, P.J.6
  • 14
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • [14] Zhou, W., Ercan, D., Chen, L., Yun, C.H., Li, D., Capelletti, M., et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462 (2009), 1070–1074.
    • (2009) Nature , vol.462 , pp. 1070-1074
    • Zhou, W.1    Ercan, D.2    Chen, L.3    Yun, C.H.4    Li, D.5    Capelletti, M.6
  • 16
    • 85032635803 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology NSCLC (version 4.2016)
    • (Available at, Accessed on 4 April 2016).
    • [16] National Comprehensive Cancer Network NCCN Clinical Practice Guidelines in Oncology NSCLC (version 4.2016). 2016 (Available at http://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf, Accessed on 4 April 2016).
    • (2016)
  • 18
    • 84874606355 scopus 로고    scopus 로고
    • EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples
    • [18] Ellison, G., Zhu, G., Moulis, A., Dearden, S., Speake, G., McCormack, R., EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples. J. Clin. Pathol. 66 (2013), 79–89.
    • (2013) J. Clin. Pathol. , vol.66 , pp. 79-89
    • Ellison, G.1    Zhu, G.2    Moulis, A.3    Dearden, S.4    Speake, G.5    McCormack, R.6
  • 20
    • 84913595275 scopus 로고    scopus 로고
    • Targeted treatment of mutated EGFR-expressing non-small-cell lung cancer: focus on erlotinib with companion diagnostics
    • [20] Karachaliou, N., Rosell, R., Targeted treatment of mutated EGFR-expressing non-small-cell lung cancer: focus on erlotinib with companion diagnostics. Lung Cancer (Auckl) 5 (2014), 73–79.
    • (2014) Lung Cancer (Auckl) , vol.5 , pp. 73-79
    • Karachaliou, N.1    Rosell, R.2
  • 21
    • 84874972652 scopus 로고    scopus 로고
    • Comparison of direct sequencing, PNA clamping-real time polymerase chain reaction, and pyrosequencing methods for the detection of EGFR mutations in non-small cell lung carcinoma and the correlation with clinical responses to EGFR tyrosine kinase inhibitor treatment
    • [21] Lee, H.J., Xu, X., Kim, H., Jin, Y., Sun, P., Kim, J.E., et al. Comparison of direct sequencing, PNA clamping-real time polymerase chain reaction, and pyrosequencing methods for the detection of EGFR mutations in non-small cell lung carcinoma and the correlation with clinical responses to EGFR tyrosine kinase inhibitor treatment. Korean J. Pathol. 47 (2013), 52–60.
    • (2013) Korean J. Pathol. , vol.47 , pp. 52-60
    • Lee, H.J.1    Xu, X.2    Kim, H.3    Jin, Y.4    Sun, P.5    Kim, J.E.6
  • 22
    • 84879290901 scopus 로고    scopus 로고
    • Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology
    • [22] Lindeman, N.I., Cagle, P.T., Beasley, M.B., Chitale, D.A., Dacic, S., Giaccone, G., et al. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology. J. Mol. Diagn. 15 (2013), 415–453.
    • (2013) J. Mol. Diagn. , vol.15 , pp. 415-453
    • Lindeman, N.I.1    Cagle, P.T.2    Beasley, M.B.3    Chitale, D.A.4    Dacic, S.5    Giaccone, G.6
  • 23
    • 84876695102 scopus 로고    scopus 로고
    • Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer
    • [23] O'Donnell, P., Ferguson, J., Shyu, J., Current, R., Rehage, T., Tsai, J., et al. Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer. BMC Cancer, 13, 2013, 210.
    • (2013) BMC Cancer , vol.13 , pp. 210
    • O'Donnell, P.1    Ferguson, J.2    Shyu, J.3    Current, R.4    Rehage, T.5    Tsai, J.6
  • 24
    • 85018556793 scopus 로고    scopus 로고
    • ® EGFR Mutation Test v2
    • (Available at, Accessed on 1 October 2015.)
    • ® EGFR Mutation Test v2. 2015 (Available at http://molecular.roche.com/assays/Pages/cobasEGFRMutationTest.aspx, Accessed on 1 October 2015.).
    • (2015)
  • 25
    • 85018559886 scopus 로고    scopus 로고
    • Premarket Approval (PMA) P120019, cobas EGFR Mutation Test v2
    • (Available at, Accessed on 08 July 2016.)
    • [25] FDA Summary of Safety and Effectiveness Data (SSED), Premarket Approval (PMA) P120019, cobas EGFR Mutation Test v2. 2015 (Available at http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm?id=P120019S007, Accessed on 08 July 2016.).
    • (2015)
    • Fda1
  • 26
    • 84930767348 scopus 로고    scopus 로고
    • Updated safety and efficacy from a Phase I study of AZD9291 in patients with EGFR-TKI-resistant non-small cell lung cancer (NSCLC)
    • Abstract 6874 (and Poster 449PD presented at ESMO)
    • [26] Yang, J.C.-H., Kim, D.W., Planchard, D., Ohe, Y., Ramalingam, S.S., Ahn, M.-J., et al. Updated safety and efficacy from a Phase I study of AZD9291 in patients with EGFR-TKI-resistant non-small cell lung cancer (NSCLC). Ann. Oncol., 25(Suppl), 2014 Abstract 6874 (and Poster 449PD presented at ESMO).
    • (2014) Ann. Oncol. , vol.25
    • Yang, J.C.-H.1    Kim, D.W.2    Planchard, D.3    Ohe, Y.4    Ramalingam, S.S.5    Ahn, M.-J.6
  • 27
    • 84896075412 scopus 로고    scopus 로고
    • Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial
    • [27] Benlloch, S., Botero, M.L., Beltran-Alamillo, J., Mayo, C., Gimenez-Capitan, A., de Aguirre, I., et al. Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial. PLoS One, 9, 2014, e89518.
    • (2014) PLoS One , vol.9 , pp. e89518
    • Benlloch, S.1    Botero, M.L.2    Beltran-Alamillo, J.3    Mayo, C.4    Gimenez-Capitan, A.5    de Aguirre, I.6
  • 28
    • 85018615682 scopus 로고    scopus 로고
    • ® System
    • (Available at, Accessed on 1 October 2015.)
    • ® System. 2010 (Available at http://www.nature.com/app_notes/nmeth/2010/101304/full/an7545.html, Accessed on 1 October 2015.).
    • (2010)
    • Pearce, M.1    Ehrich, M.2
  • 29
    • 84865432696 scopus 로고    scopus 로고
    • A comparison of EGFR mutation testing methods in lung carcinoma: direct sequencing, real-time PCR and immunohistochemistry
    • [29] Angulo, B., Conde, E., Suarez-Gauthier, A., Plaza, C., Martinez, R., Redondo, P., et al. A comparison of EGFR mutation testing methods in lung carcinoma: direct sequencing, real-time PCR and immunohistochemistry. PLoS One, 7, 2012, e43842.
    • (2012) PLoS One , vol.7 , pp. e43842
    • Angulo, B.1    Conde, E.2    Suarez-Gauthier, A.3    Plaza, C.4    Martinez, R.5    Redondo, P.6
  • 30
    • 85018606144 scopus 로고    scopus 로고
    • ® EGFR RGQ PCR kit instructions for use (handbook)
    • (Available at, Accessed on 1 October 2015.)
    • ® EGFR RGQ PCR kit instructions for use (handbook). 2013 (Available at http://www.accessdata.fda.gov/cdrh_docs/pdf12/P120022c.pdf, Accessed on 1 October 2015.).
    • (2013)
    • Qiagen1
  • 31
    • 84907855592 scopus 로고    scopus 로고
    • Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
    • [31] de Bruin, E.C., McGranahan, N., Mitter, R., Salm, M., Wedge, D.C., Yates, L., et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 346 (2014), 251–256.
    • (2014) Science , vol.346 , pp. 251-256
    • de Bruin, E.C.1    McGranahan, N.2    Mitter, R.3    Salm, M.4    Wedge, D.C.5    Yates, L.6
  • 33
    • 57349141411 scopus 로고    scopus 로고
    • EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance
    • [33] Jiang, S.X., Yamashita, K., Yamamoto, M., Piao, C.J., Umezawa, A., Saegusa, M., et al. EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance. Int. J. Cancer 123 (2008), 2480–2486.
    • (2008) Int. J. Cancer , vol.123 , pp. 2480-2486
    • Jiang, S.X.1    Yamashita, K.2    Yamamoto, M.3    Piao, C.J.4    Umezawa, A.5    Saegusa, M.6
  • 34
    • 84937414146 scopus 로고    scopus 로고
    • Heterogeneity underlies the emergence of EGFRT790 wild-type clones following treatment of T790M-positive cancers with a third-generation EGFR inhibitor
    • [34] Piotrowska, Z., Niederst, M.J., Karlovich, C.A., Wakelee, H.A., Neal, J.W., Mino-Kenudson, M., et al. Heterogeneity underlies the emergence of EGFRT790 wild-type clones following treatment of T790M-positive cancers with a third-generation EGFR inhibitor. Cancer Discov. 5 (2015), 713–722.
    • (2015) Cancer Discov. , vol.5 , pp. 713-722
    • Piotrowska, Z.1    Niederst, M.J.2    Karlovich, C.A.3    Wakelee, H.A.4    Neal, J.W.5    Mino-Kenudson, M.6
  • 35
    • 84949205332 scopus 로고    scopus 로고
    • EGFR mutation detection in ctDNA from NSCLC patient plasma: a cross-platform comparison of leading technologies to support the clinical development of AZD9291
    • [35] Thress, K.S., Brant, R., Carr, T.H., Dearden, S., Jenkins, S., Brown, H., et al. EGFR mutation detection in ctDNA from NSCLC patient plasma: a cross-platform comparison of leading technologies to support the clinical development of AZD9291. Lung Cancer 90 (2015), 509–515.
    • (2015) Lung Cancer , vol.90 , pp. 509-515
    • Thress, K.S.1    Brant, R.2    Carr, T.H.3    Dearden, S.4    Jenkins, S.5    Brown, H.6


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