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Volumn 28, Issue 4, 2017, Pages 323-327

AAV Infection: Protection from Cancer

Author keywords

DNA integration; liver cancer; recombinant AAV vectors; wild type AAV2

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR; VIRUS DNA;

EID: 85018513551     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2016.147     Document Type: Article
Times cited : (27)

References (70)
  • 1
    • 84942905508 scopus 로고    scopus 로고
    • Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
    • Nault JC, Datta S, Imbeaud S, et al. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet 2015;47: 1187-1193.
    • (2015) Nat Genet , vol.47 , pp. 1187-1193
    • Nault, J.C.1    Datta, S.2    Imbeaud, S.3
  • 2
    • 84952067002 scopus 로고    scopus 로고
    • Adenoassociated virus type 2 and hepatocellular carcinoma?
    • Berns KI, Byrne BJ, Flotte TR, et al. Adenoassociated virus type 2 and hepatocellular carcinoma? Hum Gene Ther 2015;26:779-781.
    • (2015) Hum Gene Ther , vol.26 , pp. 779-781
    • Berns, K.I.1    Byrne, B.J.2    Flotte, T.R.3
  • 3
    • 84948649974 scopus 로고    scopus 로고
    • Adeno-associated vector toxicity - To be or not to be?
    • Buning H, Schmidt M. Adeno-associated vector toxicity - to be or not to be? Mol Ther 2015;23: 1673-1675.
    • (2015) Mol Ther , vol.23 , pp. 1673-1675
    • Buning, H.1    Schmidt, M.2
  • 4
    • 84991573957 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and direct acting antiviral treatments: Controversy after the revolution
    • Nault JC, Colombo M. Hepatocellular carcinoma and direct acting antiviral treatments: controversy after the revolution. J Hepatol 2016;65: 663-665.
    • (2016) J Hepatol , vol.65 , pp. 663-665
    • Nault, J.C.1    Colombo, M.2
  • 5
    • 85010857334 scopus 로고    scopus 로고
    • Adenoassociated virus type 2 as an oncogenic virus in human hepatocellular carcinoma
    • Nault JC, Datta S, Imbeaud S, et al. Adenoassociated virus type 2 as an oncogenic virus in human hepatocellular carcinoma. Mol Cell Oncol 2016;3:e1095271.
    • (2016) Mol Cell Oncol , vol.3 , pp. e1095271
    • Nault, J.C.1    Datta, S.2    Imbeaud, S.3
  • 6
    • 84964335825 scopus 로고    scopus 로고
    • Wild-type AAV insertions in hepatocellular carcinoma do not inform debate over genotoxicity risk of vectorized AAV
    • Nault JC, Mami I, La Bella T, et al. Wild-type AAV insertions in hepatocellular carcinoma do not inform debate over genotoxicity risk of vectorized AAV. Mol Ther 2016;24:660-661.
    • (2016) Mol Ther , vol.24 , pp. 660-661
    • Nault, J.C.1    Mami, I.2    La Bella, T.3
  • 7
    • 84962081587 scopus 로고    scopus 로고
    • AAV2 and hepatocellular carcinoma
    • Nault JC, Datta S, Imbeaud S, et al. AAV2 and hepatocellular carcinoma. Hum Gene Ther 2016; 27:211-213.
    • (2016) Hum Gene Ther , vol.27 , pp. 211-213
    • Nault, J.C.1    Datta, S.2    Imbeaud, S.3
  • 8
    • 84978237158 scopus 로고    scopus 로고
    • Adeno-associated virus 2-mediated hepatocellular carcinoma is very rare in Korean patients
    • Park KJ, Lee J, Park JH, et al. Adeno-associated virus 2-mediated hepatocellular carcinoma is very rare in Korean patients. Ann Lab Med 2016;36: 469-474.
    • (2016) Ann Lab Med , vol.36 , pp. 469-474
    • Park, K.J.1    Lee, J.2    Park, J.H.3
  • 9
    • 0001592496 scopus 로고
    • Adenovirus-associated defective virus particles
    • Atchison RW, Casto BC, Hammon WM. Adenovirus-associated defective virus particles. Science 1965;149:754-756.
    • (1965) Science , vol.149 , pp. 754-756
    • Atchison, R.W.1    Casto, B.C.2    Hammon, W.M.3
  • 10
    • 0015144322 scopus 로고
    • A seroepidemiologic study of adenovirus-associated virus infection in infants and children
    • Blacklow NR, Hoggan MD, Sereno MS, et al. A seroepidemiologic study of adenovirus-associated virus infection in infants and children. Am J Epidemiol 1971;94:359-366.
    • (1971) Am J Epidemiol , vol.94 , pp. 359-366
    • Blacklow, N.R.1    Hoggan, M.D.2    Sereno, M.S.3
  • 11
    • 0014302433 scopus 로고
    • Inhibition of adenovirus 12 oncogenicity by adeno-associated virus
    • Kirschstein RL, Smith KO, Peters EA. Inhibition of adenovirus 12 oncogenicity by adeno-associated virus. Proc Soc Exp Biol Med 1968;128:670-673.
    • (1968) Proc Soc Exp Biol Med , vol.128 , pp. 670-673
    • Kirschstein, R.L.1    Smith, K.O.2    Peters, E.A.3
  • 12
    • 0015890734 scopus 로고
    • Influence of adeno-associated satellite virus on adenovirusinduced tumours in hamsters
    • Mayor HD, Houlditch GS, Mumford DM. Influence of adeno-associated satellite virus on adenovirusinduced tumours in hamsters. Nat New Biol 1973; 241:44-46.
    • (1973) Nat New Biol , vol.241 , pp. 44-46
    • Mayor, H.D.1    Houlditch, G.S.2    Mumford, D.M.3
  • 13
    • 0019822735 scopus 로고
    • Inhibition of adenovirus oncogenicity in hamsters by adeno-associated virus DNA
    • de la Maza LM, Carter BJ. Inhibition of adenovirus oncogenicity in hamsters by adeno-associated virus DNA. J Natl Cancer Inst 1981;67:1323-1326.
    • (1981) J Natl Cancer Inst , vol.67 , pp. 1323-1326
    • De La Maza, L.M.1    Carter, B.J.2
  • 14
    • 0018848777 scopus 로고
    • Molecular structure of adeno-associated virus variant DNA
    • de la Maza LM, Carter BJ. Molecular structure of adeno-associated virus variant DNA. J Biol Chem 1980;255:3194-3203.
    • (1980) J Biol Chem , vol.255 , pp. 3194-3203
    • De La Maza, L.M.1    Carter, B.J.2
  • 15
    • 0035974901 scopus 로고    scopus 로고
    • Virus-mediated killing of cells that lack p53 activity
    • Raj K, Ogston P, Beard P. Virus-mediated killing of cells that lack p53 activity. Nature 2001;412: 914-917.
    • (2001) Nature , vol.412 , pp. 914-917
    • Raj, K.1    Ogston, P.2    Beard, P.3
  • 16
    • 0035974798 scopus 로고    scopus 로고
    • Achilles' heel of cancer?
    • Vogelstein B, Kinzler KW. Achilles' heel of cancer? Nature 2001;412:865-866.
    • (2001) Nature , vol.412 , pp. 865-866
    • Vogelstein, B.1    Kinzler, K.W.2
  • 17
    • 0015338438 scopus 로고
    • Inhibition of adenovirus transformation in vitro by AAV-1
    • Casto BC, Goodheart CR. Inhibition of adenovirus transformation in vitro by AAV-1. Proc Soc Exp Biol Med 1972;140:72-78.
    • (1972) Proc Soc Exp Biol Med , vol.140 , pp. 72-78
    • Casto, B.C.1    Goodheart, C.R.2
  • 18
    • 0016719041 scopus 로고
    • Effect of adeno-associated virus on cancer expression by herpesvirus-transformed hamster cells
    • Cukor G, Blacklow NR, Kibrick S, et al. Effect of adeno-associated virus on cancer expression by herpesvirus-transformed hamster cells. J Natl Cancer Inst 1975;55:957-959.
    • (1975) J Natl Cancer Inst , vol.55 , pp. 957-959
    • Cukor, G.1    Blacklow, N.R.2    Kibrick, S.3
  • 19
    • 0019414392 scopus 로고
    • Inhibition of adenovirus-transformed cell oncogenicity by adeno-associated virus
    • Ostrove JM, Duckworth DH, Berns KI. Inhibition of adenovirus-transformed cell oncogenicity by adeno-associated virus. Virology 1981;113:521-533.
    • (1981) Virology , vol.113 , pp. 521-533
    • Ostrove, J.M.1    Duckworth, D.H.2    Berns, K.I.3
  • 20
    • 0022468197 scopus 로고
    • Effect of adeno-associated virus on transformation of NIH 3T3 cells by ras gene and on tumorigenicity of an NIH 3T3 transformed cell line
    • Katz E, Carter BJ. Effect of adeno-associated virus on transformation of NIH 3T3 cells by ras gene and on tumorigenicity of an NIH 3T3 transformed cell line. Cancer Res 1986;46:3023-3026.
    • (1986) Cancer Res , vol.46 , pp. 3023-3026
    • Katz, E.1    Carter, B.J.2
  • 21
    • 0025989127 scopus 로고
    • Inhibition of H-ras expression by the adeno-associated virus Rep78 transformation suppressor gene product
    • Hermonat PL. Inhibition of H-ras expression by the adeno-associated virus Rep78 transformation suppressor gene product. Cancer Res 1991;51: 3373-3377.
    • (1991) Cancer Res , vol.51 , pp. 3373-3377
    • Hermonat, P.L.1
  • 22
    • 0025849771 scopus 로고
    • Inhibition of cellular transformation by the adeno-associated virus rep gene
    • Khleif SN, Myers T, Carter BJ, et al. Inhibition of cellular transformation by the adeno-associated virus rep gene. Virology 1991;181:738-741.
    • (1991) Virology , vol.181 , pp. 738-741
    • Khleif, S.N.1    Myers, T.2    Carter, B.J.3
  • 23
    • 0017086796 scopus 로고
    • Antibodies to adeno-associated satellite virus and herpes simplex in sera from cancer patients and normal adults
    • Mayor HD, Drake S, Stahmann J, et al. Antibodies to adeno-associated satellite virus and herpes simplex in sera from cancer patients and normal adults. Am J Obstet Gynecol 1976;126:100-104.
    • (1976) Am J Obstet Gynecol , vol.126 , pp. 100-104
    • Mayor, H.D.1    Drake, S.2    Stahmann, J.3
  • 24
    • 0032780492 scopus 로고    scopus 로고
    • Adenoassociated virus and development of cervical neoplasia
    • Strickler HD, Viscidi R, Escoffery C, et al. Adenoassociated virus and development of cervical neoplasia. J Med Virol 1999;59:60-65.
    • (1999) J Med Virol , vol.59 , pp. 60-65
    • Strickler, H.D.1    Viscidi, R.2    Escoffery, C.3
  • 25
    • 0033823001 scopus 로고    scopus 로고
    • Evaluation of the possible protective role of adenoassociated virus type 2 infection in HPV-associated premalignant disease of the cervix
    • Odunsi KO, van Ee CC, Ganesan TS, et al. Evaluation of the possible protective role of adenoassociated virus type 2 infection in HPV-associated premalignant disease of the cervix. Gynecol Oncol 2000;78:342-345.
    • (2000) Gynecol Oncol , vol.78 , pp. 342-345
    • Odunsi, K.O.1    Van Ee, C.C.2    Ganesan, T.S.3
  • 26
    • 0035568857 scopus 로고    scopus 로고
    • Adenoassociated virus is associated with a lower risk of high-grade cervical neoplasia
    • Coker AL, Russell RB, Bond SM, et al. Adenoassociated virus is associated with a lower risk of high-grade cervical neoplasia. Exp Mol Pathol 2001;70:83-89.
    • (2001) Exp Mol Pathol , vol.70 , pp. 83-89
    • Coker, A.L.1    Russell, R.B.2    Bond, S.M.3
  • 27
    • 0035881529 scopus 로고    scopus 로고
    • Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue
    • Meyers C, Alam S, Mane M, et al. Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue. Virology 2001;287:30-39.
    • (2001) Virology , vol.287 , pp. 30-39
    • Meyers, C.1    Alam, S.2    Mane, M.3
  • 28
    • 0033929813 scopus 로고    scopus 로고
    • Binding of the human papillomavirus type 16 E7 oncoprotein and the adeno-associated virus Rep78 major regulatory protein in vitro and in yeast and the potential for downstream effects
    • Hermonat PL, Santin AD, Zhan D. Binding of the human papillomavirus type 16 E7 oncoprotein and the adeno-associated virus Rep78 major regulatory protein in vitro and in yeast and the potential for downstream effects. J Hum Virol 2000;3: 113-124.
    • (2000) J Hum Virol , vol.3 , pp. 113-124
    • Hermonat, P.L.1    Santin, A.D.2    Zhan, D.3
  • 29
    • 0033615660 scopus 로고    scopus 로고
    • Binding of the human papillomavirus type 16 p97 promoter by the adeno-associated virus Rep78 major regulatory protein correlates with inhibition
    • Zhan D, Santin AD, Liu Y, et al. Binding of the human papillomavirus type 16 p97 promoter by the adeno-associated virus Rep78 major regulatory protein correlates with inhibition. J Biol Chem 1999;274:31619-31624.
    • (1999) J Biol Chem , vol.274 , pp. 31619-31624
    • Zhan, D.1    Santin, A.D.2    Liu, Y.3
  • 30
    • 0032145584 scopus 로고    scopus 로고
    • Inhibition/stimulation of bovine papillomavirus by adeno-associated virus is time as well as multiplicity dependent
    • Hermonat PL, Meyers C, Parham GP, et al. Inhibition/stimulation of bovine papillomavirus by adeno-associated virus is time as well as multiplicity dependent. Virology 1998;247:240-250.
    • (1998) Virology , vol.247 , pp. 240-250
    • Hermonat, P.L.1    Meyers, C.2    Parham, G.P.3
  • 31
    • 0031239899 scopus 로고    scopus 로고
    • Adenoassociated virus Rep78 inhibits oncogenic transformation of primary human keratinocytes by a human papillomavirus type 16-ras chimeric
    • Hermonat PL, Plott RT, Santin AD, et al. Adenoassociated virus Rep78 inhibits oncogenic transformation of primary human keratinocytes by a human papillomavirus type 16-ras chimeric. Gynecol Oncol 1997;66:487-494.
    • (1997) Gynecol Oncol , vol.66 , pp. 487-494
    • Hermonat, P.L.1    Plott, R.T.2    Santin, A.D.3
  • 32
    • 0028230609 scopus 로고
    • Adeno-associated virus inhibits human papillomavirus type 16: A viral interaction implicated in cervical cancer
    • Hermonat PL. Adeno-associated virus inhibits human papillomavirus type 16: a viral interaction implicated in cervical cancer. Cancer Res 1994;54: 2278-2281.
    • (1994) Cancer Res , vol.54 , pp. 2278-2281
    • Hermonat, P.L.1
  • 33
    • 0026735650 scopus 로고
    • Inhibition of bovine papillomavirus plasmid DNA replication by adeno-associated virus
    • Hermonat PL. Inhibition of bovine papillomavirus plasmid DNA replication by adeno-associated virus. Virology 1992;189:329-333.
    • (1992) Virology , vol.189 , pp. 329-333
    • Hermonat, P.L.1
  • 34
    • 0024422237 scopus 로고
    • The adeno-associated virus Rep78 gene inhibits cellular transformation induced by bovine papillomavirus
    • Hermonat PL. The adeno-associated virus Rep78 gene inhibits cellular transformation induced by bovine papillomavirus. Virology 1989;172:253-261.
    • (1989) Virology , vol.172 , pp. 253-261
    • Hermonat, P.L.1
  • 35
    • 67349090624 scopus 로고    scopus 로고
    • Adeno-associated virus Rep78 protein inhibits Hepatitis B virus replication through regulation of the HBV core promoter
    • Liu T, Cong M, Wang P, et al. Adeno-associated virus Rep78 protein inhibits Hepatitis B virus replication through regulation of the HBV core promoter. Biochem Biophys Res Commun 2009; 385:106-111.
    • (2009) Biochem Biophys Res Commun , vol.385 , pp. 106-111
    • Liu, T.1    Cong, M.2    Wang, P.3
  • 36
    • 0032199766 scopus 로고    scopus 로고
    • Involvement of protein-DNA interaction in adeno-associated virus Rep78-mediated inhibition of HIV-1
    • Kokorina NA, Santin AD, Li C, et al. Involvement of protein-DNA interaction in adeno-associated virus Rep78-mediated inhibition of HIV-1. J Hum Virol 1998;1:441-450.
    • (1998) J Hum Virol , vol.1 , pp. 441-450
    • Kokorina, N.A.1    Santin, A.D.2    Li, C.3
  • 37
    • 0028099692 scopus 로고
    • The regulatory rep protein of adeno-associated virus binds to sequences within the c-H-ras promoter
    • Batchu RB, Kotin RM, Hermonat PL. The regulatory rep protein of adeno-associated virus binds to sequences within the c-H-ras promoter. Cancer Lett 1994;86:23-31.
    • (1994) Cancer Lett , vol.86 , pp. 23-31
    • Batchu, R.B.1    Kotin, R.M.2    Hermonat, P.L.3
  • 38
    • 0028356554 scopus 로고
    • Down-regulation of the human c-fos and c-myc proto-oncogene promoters by adenoassociated virus Rep78
    • Hermonat PL. Down-regulation of the human c-fos and c-myc proto-oncogene promoters by adenoassociated virus Rep78. Cancer Lett 1994;81: 129-136.
    • (1994) Cancer Lett , vol.81 , pp. 129-136
    • Hermonat, P.L.1
  • 40
    • 0025721086 scopus 로고
    • Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter
    • Kotin RM, Menninger JC, Ward DC, et al. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics 1991;10:831-834.
    • (1991) Genomics , vol.10 , pp. 831-834
    • Kotin, R.M.1    Menninger, J.C.2    Ward, D.C.3
  • 41
    • 0026070440 scopus 로고
    • Targeted integration of adeno-associated virus (AAV) into human chromosome 19
    • Samulski RJ, Zhu X, Xiao X, et al. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J 1991;10:3941-3950.
    • (1991) EMBO J , vol.10 , pp. 3941-3950
    • Samulski, R.J.1    Zhu, X.2    Xiao, X.3
  • 42
    • 0027092001 scopus 로고
    • Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination
    • Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J 1992;11: 5071-5078.
    • (1992) EMBO J , vol.11 , pp. 5071-5078
    • Kotin, R.M.1    Linden, R.M.2    Berns, K.I.3
  • 43
    • 0030850930 scopus 로고    scopus 로고
    • Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells
    • Ponnazhagan S, Erikson D, Kearns WG, et al. Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells. Hum Gene Ther 1997;8:275-284.
    • (1997) Hum Gene Ther , vol.8 , pp. 275-284
    • Ponnazhagan, S.1    Erikson, D.2    Kearns, W.G.3
  • 44
    • 0029836472 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line
    • Kearns WG, Afione SA, Fulmer SB, et al. Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. Gene Ther 1996;3:748-755.
    • (1996) Gene Ther , vol.3 , pp. 748-755
    • Kearns, W.G.1    Afione, S.A.2    Fulmer, S.B.3
  • 45
    • 0030827586 scopus 로고    scopus 로고
    • Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro
    • Yang CC, Xiao X, Zhu X, et al. Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro. J Virol 1997;71: 9231-9247.
    • (1997) J Virol , vol.71 , pp. 9231-9247
    • Yang, C.C.1    Xiao, X.2    Zhu, X.3
  • 46
    • 0037333815 scopus 로고    scopus 로고
    • Genetic fate of recombinant adeno-associated virus vector genomes in muscle
    • Schnepp BC, Clark KR, Klemanski DL, et al. Genetic fate of recombinant adeno-associated virus vector genomes in muscle. J Virol 2003;77:3495-3504.
    • (2003) J Virol , vol.77 , pp. 3495-3504
    • Schnepp, B.C.1    Clark, K.R.2    Klemanski, D.L.3
  • 47
    • 0037604791 scopus 로고    scopus 로고
    • Pathways of removal of free DNA vector ends in normal and DNAPKcs-deficient SCID mouse hepatocytes transduced with rAAV vectors
    • Nakai H, Storm TA, Fuess S, et al. Pathways of removal of free DNA vector ends in normal and DNAPKcs-deficient SCID mouse hepatocytes transduced with rAAV vectors. Hum Gene Ther 2003;14:871-881.
    • (2003) Hum Gene Ther , vol.14 , pp. 871-881
    • Nakai, H.1    Storm, T.A.2    Fuess, S.3
  • 48
    • 0034830365 scopus 로고    scopus 로고
    • Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors
    • Donsante A, Vogler C, Muzyczka N, et al. Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Ther 2001;8: 1343-1346.
    • (2001) Gene Ther , vol.8 , pp. 1343-1346
    • Donsante, A.1    Vogler, C.2    Muzyczka, N.3
  • 49
    • 34547610960 scopus 로고    scopus 로고
    • AAV vector integration sites in mouse hepatocellular carcinoma
    • Donsante A, Miller DG, Li Y, et al. AAV vector integration sites in mouse hepatocellular carcinoma. Science 2007;317:477.
    • (2007) Science , vol.317 , pp. 477
    • Donsante, A.1    Miller, D.G.2    Li, Y.3
  • 50
    • 84863970005 scopus 로고    scopus 로고
    • Induction of hepatocellular carcinoma by in vivo gene targeting
    • Wang PR, Xu M, Toffanin S, et al. Induction of hepatocellular carcinoma by in vivo gene targeting. Proc Natl Acad Sci U S A 2012;109:11264-11269.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 11264-11269
    • Wang, P.R.1    Xu, M.2    Toffanin, S.3
  • 51
    • 84877865566 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction
    • Zhong L, Malani N, Li M, et al. Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction. Hum Gene Ther 2013;24:520-525.
    • (2013) Hum Gene Ther , vol.24 , pp. 520-525
    • Zhong, L.1    Malani, N.2    Li, M.3
  • 52
    • 84922152390 scopus 로고    scopus 로고
    • Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy
    • Chandler RJ, LaFave MC, Varshney GK, et al. Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy. J Clin Invest 2015;125:870-880.
    • (2015) J Clin Invest , vol.125 , pp. 870-880
    • Chandler, R.J.1    LaFave, M.C.2    Varshney, G.K.3
  • 53
    • 84869087881 scopus 로고    scopus 로고
    • Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity
    • Rosas LE, Grieves JL, Zaraspe K, et al. Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity. Mol Ther 2012;20:2098-2110.
    • (2012) Mol Ther , vol.20 , pp. 2098-2110
    • Rosas, L.E.1    Grieves, J.L.2    Zaraspe, K.3
  • 54
    • 84880237366 scopus 로고    scopus 로고
    • No tumour-initiating risk associated with scAAV transduction in newborn rat liver
    • Gauttier V, Pichard V, Aubert D, et al. No tumour-initiating risk associated with scAAV transduction in newborn rat liver. Gene Ther 2013;20:779-784.
    • (2013) Gene Ther , vol.20 , pp. 779-784
    • Gauttier, V.1    Pichard, V.2    Aubert, D.3
  • 55
    • 22644433751 scopus 로고    scopus 로고
    • No evidence for tumorigenesis of AAV vectors in a large-scale study in mice
    • Bell P, Wang L, Lebherz C, et al. No evidence for tumorigenesis of AAV vectors in a large-scale study in mice. Mol Ther 2005;12:299-306.
    • (2005) Mol Ther , vol.12 , pp. 299-306
    • Bell, P.1    Wang, L.2    Lebherz, C.3
  • 56
    • 79953088521 scopus 로고    scopus 로고
    • Assessing the potential for AAV vector genotoxicity in a murine model
    • Li H, Malani N, Hamilton SR, et al. Assessing the potential for AAV vector genotoxicity in a murine model. Blood 2011;117:3311-3319.
    • (2011) Blood , vol.117 , pp. 3311-3319
    • Li, H.1    Malani, N.2    Hamilton, S.R.3
  • 57
    • 59649122961 scopus 로고    scopus 로고
    • Longterm correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy
    • Niemeyer GP, Herzog RW, Mount J, et al. Longterm correction of inhibitor-prone hemophilia B dogs treated with liver-directed AAV2-mediated factor IX gene therapy. Blood 2009;113:797-806.
    • (2009) Blood , vol.113 , pp. 797-806
    • Niemeyer, G.P.1    Herzog, R.W.2    Mount, J.3
  • 58
    • 84880289352 scopus 로고    scopus 로고
    • A largely random AAV integration profile after LPLD gene therapy
    • Kaeppel C, Beattie SG, Fronza R, et al. A largely random AAV integration profile after LPLD gene therapy. Nat Med 2013;19:889-891.
    • (2013) Nat Med , vol.19 , pp. 889-891
    • Kaeppel, C.1    Beattie, S.G.2    Fronza, R.3
  • 59
    • 84962744063 scopus 로고    scopus 로고
    • Recombinant AAV integration is not associated with hepatic genotoxicity in nonhuman primates and patients
    • Gil-Farina I, Fronza R, Kaeppel C, et al. Recombinant AAV integration is not associated with hepatic genotoxicity in nonhuman primates and patients. Mol Ther 2016;24:1100-1105.
    • (2016) Mol Ther , vol.24 , pp. 1100-1105
    • Gil-Farina, I.1    Fronza, R.2    Kaeppel, C.3
  • 60
    • 84869009433 scopus 로고    scopus 로고
    • RAAVmediated tumorigenesis: Still unresolved after an AAV assault
    • Valdmanis PN, Lisowski L, Kay MA. rAAVmediated tumorigenesis: still unresolved after an AAV assault. Mol Ther 2012;20:2014-2017.
    • (2012) Mol Ther , vol.20 , pp. 2014-2017
    • Valdmanis, P.N.1    Lisowski, L.2    Kay, M.A.3
  • 61
    • 84942941923 scopus 로고    scopus 로고
    • Adeno-associated virus finds its disease
    • Russell DW, Grompe M. Adeno-associated virus finds its disease. Nat Genet 2015;47:1104-1105.
    • (2015) Nat Genet , vol.47 , pp. 1104-1105
    • Russell, D.W.1    Grompe, M.2
  • 62
    • 84862767242 scopus 로고    scopus 로고
    • Gene therapy: Progress in childhood disease
    • Ginn SL, Alexander IE. Gene therapy: progress in childhood disease. J Paediatr Child Health 2012; 48:466-471.
    • (2012) J Paediatr Child Health , vol.48 , pp. 466-471
    • Ginn, S.L.1    Alexander, I.E.2
  • 63
    • 0030752558 scopus 로고    scopus 로고
    • Adenoassociated virus Rep proteins target DNA sequences to a unique locus in the human genome
    • Surosky RT, Urabe M, Godwin SG, et al. Adenoassociated virus Rep proteins target DNA sequences to a unique locus in the human genome. J Virol 1997;71:7951-7959.
    • (1997) J Virol , vol.71 , pp. 7951-7959
    • Surosky, R.T.1    Urabe, M.2    Godwin, S.G.3
  • 64
    • 0036559620 scopus 로고    scopus 로고
    • Second generation adeno-associated virus type 2-based gene therapy systems with the potential for preferential integration into AAVS1
    • Owens RA. Second generation adeno-associated virus type 2-based gene therapy systems with the potential for preferential integration into AAVS1. Curr Gene Ther 2002;2:145-159.
    • (2002) Curr Gene Ther , vol.2 , pp. 145-159
    • Owens, R.A.1
  • 65
    • 0042532722 scopus 로고    scopus 로고
    • Analysis of site-specific transgene integration following cotransduction with recombinant adenoassociated virus and a rep encoding plasmid
    • Huttner NA, Girod A, Schnittger S, et al. Analysis of site-specific transgene integration following cotransduction with recombinant adenoassociated virus and a rep encoding plasmid. J Gene Med 2003;5:120-129.
    • (2003) J Gene Med , vol.5 , pp. 120-129
    • Huttner, N.A.1    Girod, A.2    Schnittger, S.3
  • 66
    • 53649109805 scopus 로고    scopus 로고
    • Sitespecific, Rep-mediated integration of the intact beta-globin locus in the human erythroleukaemic cell line K562
    • Howden SE, Voullaire L, Wardan H, et al. Sitespecific, Rep-mediated integration of the intact beta-globin locus in the human erythroleukaemic cell line K562. Gene Ther 2008;15:1372-1383.
    • (2008) Gene Ther , vol.15 , pp. 1372-1383
    • Howden, S.E.1    Voullaire, L.2    Wardan, H.3
  • 67
    • 70350306544 scopus 로고    scopus 로고
    • Adeno-associated virus site-specific integration is mediated by proteins of the nonhomologous end-joining pathway
    • Daya S, Cortez N, Berns KI. Adeno-associated virus site-specific integration is mediated by proteins of the nonhomologous end-joining pathway. J Virol 2009;83:11655-11664.
    • (2009) J Virol , vol.83 , pp. 11655-11664
    • Daya, S.1    Cortez, N.2    Berns, K.I.3
  • 68
    • 84955240212 scopus 로고    scopus 로고
    • Adeno-associated virus: The naturally occurring virus versus the recombinant vector
    • Srivastava A. Adeno-associated virus: the naturally occurring virus versus the recombinant vector. Hum Gene Ther 2016;27:1-6.
    • (2016) Hum Gene Ther , vol.27 , pp. 1-6
    • Srivastava, A.1
  • 69
    • 84985993659 scopus 로고    scopus 로고
    • In vivo tissue-tropism of adenoassociated viral vectors
    • Srivastava A. In vivo tissue-tropism of adenoassociated viral vectors. Curr Opin Virol 2016;21: 75-80.
    • (2016) Curr Opin Virol , vol.21 , pp. 75-80
    • Srivastava, A.1
  • 70
    • 84983446228 scopus 로고    scopus 로고
    • Development of optimized AAV serotype vectors for high-efficiency transduction at further reduced doses
    • Ling C, Li B, Ma W, et al. Development of optimized AAV serotype vectors for high-efficiency transduction at further reduced doses. Hum Gene Ther Methods 2016;27:143-149.
    • (2016) Hum Gene Ther Methods , vol.27 , pp. 143-149
    • Ling, C.1    Li, B.2    Ma, W.3


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