Induction of hepatocellular carcinoma by in vivo gene targeting

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 28, 2012, Pages 11264-11269

  Wang, Pei Rong ^a   Xu, Mei ^a   Toffanin, Sara ^b,c   Li, Yi ^a   Llovet, Josep M ^b,d,e   Russell, David W ^a,f  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d UNIVERSITY OF BARCELONA   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^f UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Adeno associated virus; Genotoxicity

Indexed keywords

MESSENGER RNA; MICRORNA; SMALL NUCLEOLAR RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 12; CONTROLLED STUDY; COPY NUMBER VARIATION; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; ENHANCER REGION; FEMALE; GENE; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; LIVER CELL; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RIAN GENE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; DEPENDOVIRUS; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HEPATOCYTES; HUMANS; INTRONS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MODELS, GENETIC; MUTAGENS; PHENOTYPE; PROGNOSIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MUS;

EID: 84863970005     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1117032109     Document Type: Article

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