Coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis

Toxicological Sciences

Volumn 154, Issue 2, 2016, Pages 381-391

  Nault, Rance ^a,b   Fader, Kelly A ^a,b   Kopec, Anna K ^b   Harkema, Jack R ^b   Zacharewski, Timothy R ^a,b   Luyendyk, James P ^b  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Coagulation; Fibrosis; NAFLD; PAR 1; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYTOCHROME P450 1A1; INTERLEUKIN 6; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN ANTITHROMBIN COMPLEX; AUTACOID; COLLAGEN; CYTOKINE; POLYCHLORINATED DIBENZODIOXIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT LOSS; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER CELL DAMAGE; LIVER FIBROSIS; LIVER TOXICITY; LIVER WEIGHT; LONG TERM EXPOSURE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; ANIMAL; BLOOD; BLOOD CLOTTING; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; LIVER; LIVER CIRRHOSIS; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TOXIC HEPATITIS;

ANIMALS; BLOOD COAGULATION; CHEMICAL AND DRUG INDUCED LIVER INJURY; COLLAGEN; CYTOKINES; DISEASE MODELS, ANIMAL; INFLAMMATION MEDIATORS; LIVER; LIVER CIRRHOSIS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; NON-ALCOHOLIC FATTY LIVER DISEASE; POLYCHLORINATED DIBENZODIOXINS; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION;

EID: 85018480025     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/TOXSCI/KFW175     Document Type: Article

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