Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: A role for bone marrow derived macrophages

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Kallis, Yiannis N ^a   Scotton, Christopher J ^b   MacKinnon, Alison C ^c   Goldin, Robert D ^a   Wright, Nicholas A ^d   Iredale, John P ^c   Chambers, Rachel C ^b   Forbes, Stuart J ^c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; COLLAGEN; PROTEINASE ACTIVATED RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CELL EXPANSION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GRAFT RECIPIENT; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; LIVER FIBROSIS; LIVER INJURY; MACROPHAGE; MICROSCOPY; MOUSE; MYOFIBROBLAST; NONHUMAN; PROTEIN DEFICIENCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE; Y CHROMOSOME;

ANALYSIS OF VARIANCE; ANIMALS; BONE MARROW TRANSPLANTATION; CARBON TETRACHLORIDE; CELL LINE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER; LIVER CIRRHOSIS; MACROPHAGES; MICE; MYOFIBROBLASTS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, PAR-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84900297546     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086241     Document Type: Article

References (32)

1. Russo FP, Alison MR, Bigger BW, Amofah E, Florou A, et al. (2006) The bone marrow functionally contributes to liver fibrosis. Gastroenterology 130: 1807-1821. (Pubitemid 43668827)
2. Baba S, Fujii H, Hirose T, Yasuchika K, Azuma H, et al. (2004) Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol 40: 255-260. (Pubitemid 38115830)
3. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, et al. (2006) Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 45: 429-438. (Pubitemid 44142115)
4. Forbes SJ, Russo FP, Rey V, Burra P, Rugge M, et al. (2004) A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 126: 955-963. (Pubitemid 38451166)
5. Duffield JS, Forbes SJ, Constandinou CM, Clay S, Partolina M, et al. (2005) Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 115: 56-65. (Pubitemid 40385505)
6. Ide M, Kuwamura M, Kotani T, Sawamoto O, Yamate J (2005) Effects of gadolinium chloride (GdCl(3)) on the appearance of macrophage populations and fibrogenesis in thioacetamide-induced rat hepatic lesions. J Comp Pathol 133: 92-102. (Pubitemid 41150166)
7. Imamura M, Ogawa T, Sasaguri Y, Chayama K, Ueno H (2005) Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats. Gastroenterology 128: 138-146. (Pubitemid 40039965)
8. Karlmark KR, Weiskirchen R, Zimmermann HW, Gassler N, Ginhoux F, et al. (2009) Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 50: 261-274.
9. Fallowfield JA, Mizuno M, Kendall TJ, Constandinou CM, Benyon RC, et al. (2007) Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol 178: 5288-5295. (Pubitemid 46595314)
10. Higashiyama R, Inagaki Y, Hong YY, Kushida M, Nakao S, et al. (2007) Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology 45: 213-222. (Pubitemid 46144381)
11. Thomas JA, Pope C, Wojtacha D, Robson AJ, Gordon-Walker TT, et al. (2011) Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Hepatology 53: 2003-2015.
12. Chambers RC, Leoni P, Blanc-Brude OP, Wembridge DE, Laurent GJ (2000) Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J Biol Chem 275: 35584-35591.
13. Cunningham MA, Rondeau E, Chen X, Coughlin SR, Holdsworth SR, et al. (2000) Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 191: 455-462.
14. Duplantier JG, Dubuisson L, Senant N, Freyburger G, Laurendeau I, et al. (2004) A role for thrombin in liver fibrosis. Gut 53: 1682-1687. (Pubitemid 39434115)
15. Kubo H, Nakayama K, Yanai M, Suzuki T, Yamaya M, et al. (2005) Anticoagulant therapy for idiopathic pulmonary fibrosis. Chest 128: 1475-1482. (Pubitemid 41324435)
16. Anstee QM, Goldin RD, Wright M, Martinelli A, Cox R, et al. (2008) Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies. J Thromb Haemost.
17. Wright M, Goldin R, Hellier S, Knapp S, Frodsham A, et al. (2003) Factor V Leiden polymorphism and the rate of fibrosis development in chronic hepatitis C virus infection. Gut 52: 1206-1210. (Pubitemid 36877437)
18. Chambers RC (2008) Procoagulant signalling mechanisms in lung inflammation and fibrosis: novel opportunities for pharmacological intervention? Br J Pharmacol 153 Suppl 1: S367-378.
19. Marra F, DeFranco R, Grappone C, Milani S, Pinzani M, et al. (1998) Expression of the thrombin receptor in human liver: up-regulation during acute and chronic injury. Hepatology 27: 462-471. (Pubitemid 28081061)
20. Gaca MD, Zhou X, Benyon RC (2002) Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors. J Hepatol 36: 362-369. (Pubitemid 34194796)
21. Colognato R, Slupsky JR, Jendrach M, Burysek L, Syrovets T, et al. (2003) Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 102: 2645-2652. (Pubitemid 37193608)
22. Fiorucci S, Antonelli E, Distrutti E, Severino B, Fiorentina R, et al. (2004) PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation. Hepatology 39: 365-375. (Pubitemid 38222177)
23. Rullier A, Senant N, Kisiel W, Bioulac-Sage P, Balabaud C, et al. (2006) Expression of protease-activated receptors and tissue factor in human liver. Virchows Arch 448: 46-51. (Pubitemid 43177414)
24. Rullier A, Gillibert-Duplantier J, Costet P, Cubel G, Haurie V, et al. (2008) Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis. Am J Physiol Gastrointest Liver Physiol 294: G226-235. (Pubitemid 351164861)
25. Luyendyk JP, Sullivan BP, Guo GL, Wang R (2010) Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice. Am J Pathol 176: 177-186.
26. Martinelli A, Knapp S, Anstee Q, Worku M, Tommasi A, et al. (2007) Effect of a thrombin receptor (protease-activated receptor 1, PAR-1) gene polymorphism in chronic hepatitis C liver fibrosis. J Gastroenterol Hepatol.
27. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Jr., Coughlin SR (1996) Role of the thrombin receptor in development and evidence for a second receptor. Nature 381: 516-519.
28. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, et al. (1998) A dual thrombin receptor system for platelet activation. Nature 394: 690-694. (Pubitemid 28389797)
29. Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, et al. (2005) Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol 166: 1353-1365. (Pubitemid 40586507)
30. Ajuebor MN, Flower RJ, Hannon R, Christie M, Bowers K, et al. (1998) Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J Leukoc Biol 63: 108-116. (Pubitemid 28070389)
31. Schaffner A, Rhyn P, Schoedon G, Schaer DJ (2005) Regulated expression of platelet factor 4 in human monocytes-role of PARs as a quantitatively important monocyte activation pathway. J Leukoc Biol 78: 202-209. (Pubitemid 40979959)
32. Chen D, Carpenter A, Abrahams J, Chambers RC, Lechler RI, et al. (2008) Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo. J Exp Med 205: 1739-1746.