-
1
-
-
77954899030
-
Phase i study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010;28:3167-75.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
-
2
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQM, Hwu W-J, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-65.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.M.3
Hwu, W.-J.4
Topalian, S.L.5
Hwu, P.6
-
3
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu W-J, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44.
-
(2013)
N Engl J Med
, vol.369
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.-J.5
Kefford, R.6
-
4
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
-
5
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013;369:122-33.
-
(2013)
N Engl J Med
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
Postow, M.A.4
Rizvi, N.A.5
Lesokhin, A.M.6
-
6
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26.
-
(2011)
N Engl J Med
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O'Day, S.4
Weber, J.5
Garbe, C.6
-
7
-
-
84908354848
-
Antiprogrammed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
-
Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, et al. Antiprogrammed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014;384:1109-17.
-
(2014)
Lancet
, vol.384
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
-
8
-
-
84960498096
-
Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: A multicentre, phase 1b study
-
Antonia S, Goldberg SB, Balmanoukian A, Chaft JE, Sanborn RE, Gupta A, et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study. Lancet Oncol 2016;17:299-308.
-
(2016)
Lancet Oncol
, vol.17
, pp. 299-308
-
-
Antonia, S.1
Goldberg, S.B.2
Balmanoukian, A.3
Chaft, J.E.4
Sanborn, R.E.5
Gupta, A.6
-
9
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 2015;373:1627-39.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
Spigel, D.R.4
Steins, M.5
Ready, N.E.6
-
10
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 2015;372:2018-28.
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
Leighl, N.4
Balmanoukian, A.S.5
Eder, J.P.6
-
11
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): A randomised controlled trial
-
Herbst RS, Baas P, Kim D-W, Felip E, Pérez-Gracia JL, Han J-Y, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet Lond Engl 2016;387:1540-50.
-
(2016)
Lancet Lond Engl
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.-W.3
Felip, E.4
Pérez-Gracia, J.L.5
Han, J.-Y.6
-
12
-
-
84966771330
-
Targeting T cell co-receptors for cancer therapy
-
Callahan MK, Postow MA, Wolchok JD. Targeting T cell co-receptors for cancer therapy. Immunity 2016;44:1069-78.
-
(2016)
Immunity
, vol.44
, pp. 1069-1078
-
-
Callahan, M.K.1
Postow, M.A.2
Wolchok, J.D.3
-
13
-
-
84859128199
-
Colocalization of inflammatory responsewith B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
-
Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, et al. Colocalization of inflammatory responsewith B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012;4:127ra37.
-
(2012)
Sci Transl Med
, vol.4
, pp. 127ra37
-
-
Taube, J.M.1
Anders, R.A.2
Young, G.D.3
Xu, H.4
Sharma, R.5
McMiller, T.L.6
-
14
-
-
84904024273
-
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
-
Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res 2014;20: 5064-74.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5064-5074
-
-
Taube, J.M.1
Klein, A.2
Brahmer, J.R.3
Xu, H.4
Pan, X.5
Kim, J.H.6
-
15
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 252-264
-
-
Pardoll, D.M.1
-
16
-
-
84905991829
-
Abstract CT104: Antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): Correlation of tumor PD-L1 expression with outcome
-
Daud AI, Hamid O, Ribas A, Hodi FS, Hwu W-J, Kefford R, et al. Abstract CT104: antitumor activity of the anti-PD-1 monoclonal antibody MK-3475 in melanoma(MEL): correlation of tumor PD-L1 expression with outcome. Cancer Res 2014;74(19 Suppl):CT104.
-
(2014)
Cancer Res
, vol.74
, Issue.19
, pp. CT104
-
-
Daud, A.I.1
Hamid, O.2
Ribas, A.3
Hodi, F.S.4
Hwu, W.-J.5
Kefford, R.6
-
17
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria J-C, Kowanetz M, Fine GD, Hamid O, Gordon MS, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563-7.
-
(2014)
Nature
, vol.515
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.-C.2
Kowanetz, M.3
Fine, G.D.4
Hamid, O.5
Gordon, M.S.6
-
18
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJM, Robert L, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature 2014;515:568-71.
-
(2014)
Nature
, vol.515
, pp. 568-571
-
-
Tumeh, P.C.1
Harview, C.L.2
Yearley, J.H.3
Shintaku, I.P.4
Taylor, E.J.M.5
Robert, L.6
-
20
-
-
84958803056
-
Clinical characteristics predictive of response to pembrolizumab in advanced melanoma
-
(abstr 9031)
-
Tsai KK, Loo K, Khurana N, Algazi AP, Hwang J, Sanchez R, et al. Clinical characteristics predictive of response to pembrolizumab in advanced melanoma. J Clin Oncol 33, 2015(suppl; abstr 9031).
-
(2015)
J Clin Oncol
, vol.33
-
-
Tsai, K.K.1
Loo, K.2
Khurana, N.3
Algazi, A.P.4
Hwang, J.5
Sanchez, R.6
-
21
-
-
57849117384
-
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
-
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 2009;45:228-47.
-
(2009)
Eur J Cancer
, vol.45
, pp. 228-247
-
-
Eisenhauer, E.A.1
Therasse, P.2
Bogaerts, J.3
Schwartz, L.H.4
Sargent, D.5
Ford, R.6
-
22
-
-
84947704341
-
Long-term efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001
-
(abstr 9005)
-
Daud AI, Ribas A, Robert C, Hodi FS, Wolchok JD, Joshua AM, et al. Long-term efficacy of pembrolizumab (pembro; MK-3475) in a pooled analysis of 655 patients (pts) with advanced melanoma (MEL) enrolled in KEYNOTE-001. J Clin Oncol 33, 2015(suppl; abstr 9005).
-
(2015)
J Clin Oncol
, vol.33
-
-
Daud, A.I.1
Ribas, A.2
Robert, C.3
Hodi, F.S.4
Wolchok, J.D.5
Joshua, A.M.6
-
23
-
-
84938205998
-
Pembrolizumab versus investigator-choice chemotherapy for ipilimumabrefractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
-
Ribas A, Puzanov I, Dummer R, Schadendorf D, Hamid O, Robert C, et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumabrefractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol 2015;16:908-18.
-
(2015)
Lancet Oncol
, vol.16
, pp. 908-918
-
-
Ribas, A.1
Puzanov, I.2
Dummer, R.3
Schadendorf, D.4
Hamid, O.5
Robert, C.6
-
24
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015;372:2521-32.
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
-
25
-
-
0017153835
-
Mechanisms in the acceptance of organ grafts
-
Calne RY. Mechanisms in the acceptance of organ grafts. Br Med Bull 1976;32:107-12.
-
(1976)
Br Med Bull
, vol.32
, pp. 107-112
-
-
Calne, R.Y.1
-
26
-
-
0014661390
-
Induction of immunological tolerance by porcine liver allografts
-
Calne RY, Sells RA, Pena JR, Davis DR, Millard PR, Herbertson BM, et al. Induction of immunological tolerance by porcine liver allografts. Nature 1969;223:472-6.
-
(1969)
Nature
, vol.223
, pp. 472-476
-
-
Calne, R.Y.1
Sells, R.A.2
Pena, J.R.3
Davis, D.R.4
Millard, P.R.5
Herbertson, B.M.6
-
27
-
-
0014200984
-
Hepatic suppression of sensitization to antigen absorbed into the portal system
-
Cantor HM, Dumont AE. Hepatic suppression of sensitization to antigen absorbed into the portal system. Nature 1967;215:744-5.
-
(1967)
Nature
, vol.215
, pp. 744-745
-
-
Cantor, H.M.1
Dumont, A.E.2
-
28
-
-
0034035178
-
Immunological tolerance - The liver effect
-
Calne RY. Immunological tolerance - the liver effect. Immunol Rev 2000;174:280-2.
-
(2000)
Immunol Rev
, vol.174
, pp. 280-282
-
-
Calne, R.Y.1
-
29
-
-
0031570116
-
Apoptosis within spontaneously accepted mouse liver allografts: Evidence for deletion of cytotoxic T cells and implications for tolerance induction
-
Qian S, Lu L, Fu F, Li Y, Li W, Starzl TE, et al. Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J Immunol 1997;158:4654-61.
-
(1997)
J Immunol
, vol.158
, pp. 4654-4661
-
-
Qian, S.1
Lu, L.2
Fu, F.3
Li, Y.4
Li, W.5
Starzl, T.E.6
-
30
-
-
84886646838
-
Immune surveillance by the liver
-
Jenne CN, Kubes P. Immune surveillance by the liver. Nat Immunol 2013;14:996-1006.
-
(2013)
Nat Immunol
, vol.14
, pp. 996-1006
-
-
Jenne, C.N.1
Kubes, P.2
-
31
-
-
0034533209
-
Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
-
Limmer A, Ohl J, Kurts C, Ljunggren H-G, Reiss Y, Groettrup M, et al. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. Nat Med 2000;6:1348-54.
-
(2000)
Nat Med
, vol.6
, pp. 1348-1354
-
-
Limmer, A.1
Ohl, J.2
Kurts, C.3
Ljunggren, H.-G.4
Reiss, Y.5
Groettrup, M.6
-
32
-
-
27644481817
-
Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance
-
Limmer A, Ohl J, Wingender G, Berg M, Jüngerkes F, Schumak B, et al. Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance. Eur J Immunol 2005;35: 2970-81.
-
(2005)
Eur J Immunol
, vol.35
, pp. 2970-2981
-
-
Limmer, A.1
Ohl, J.2
Wingender, G.3
Berg, M.4
Jüngerkes, F.5
Schumak, B.6
-
33
-
-
0037270978
-
Hepatic T cells and liver tolerance
-
Crispe IN. Hepatic T cells and liver tolerance. Nat Rev Immunol 2003; 3:51-62.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 51-62
-
-
Crispe, I.N.1
-
34
-
-
2142709420
-
Passive and active mechanisms trap activated CD8+ T cells in the liver
-
John B, Crispe IN. Passive and active mechanisms trap activated CD8+ T cells in the liver. J Immunol 2004;172:5222-9.
-
(2004)
J Immunol
, vol.172
, pp. 5222-5229
-
-
John, B.1
Crispe, I.N.2
-
35
-
-
0346366993
-
Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo
-
Wang J-CE, Livingstone AM. Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo. J Immunol 2003; 171:6339-43.
-
(2003)
J Immunol
, vol.171
, pp. 6339-6343
-
-
Wang, J.-C.E.1
Livingstone, A.M.2
-
36
-
-
72549097659
-
Hepatitis C virus core protein subverts the antiviral activities of human kupffer cells
-
Tu Z, Pierce RH, Kurtis J, Kuroki Y, Crispe IN, Orloff MS. Hepatitis C virus core protein subverts the antiviral activities of human kupffer cells. Gastroenterology 2010;138:305-14.
-
(2010)
Gastroenterology
, vol.138
, pp. 305-314
-
-
Tu, Z.1
Pierce, R.H.2
Kurtis, J.3
Kuroki, Y.4
Crispe, I.N.5
Orloff, M.S.6
-
37
-
-
84964341647
-
Association of pembrolizumab with tumor response and survival among patients with advanced melanoma
-
Ribas A, Hamid O, Daud A, Hodi FS, Wolchok JD, Kefford R, et al. Association of pembrolizumab with tumor response and survival among patients with advanced melanoma. JAMA 2016;315:1600-9.
-
(2016)
JAMA
, vol.315
, pp. 1600-1609
-
-
Ribas, A.1
Hamid, O.2
Daud, A.3
Hodi, F.S.4
Wolchok, J.D.5
Kefford, R.6
-
38
-
-
85010652953
-
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
-
pii:eaaf8399
-
Davoli T, Uno H, Wooten EC, Elledge SJ. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science 2017;355:pii:eaaf8399.
-
(2017)
Science
, vol.355
-
-
Davoli, T.1
Uno, H.2
Wooten, E.C.3
Elledge, S.J.4
-
39
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015;348:124-8.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
Kvistborg, P.4
Makarov, V.5
Havel, J.J.6
-
40
-
-
84948451779
-
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
-
Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 2015;350:1084-9.
-
(2015)
Science
, vol.350
, pp. 1084-1089
-
-
Sivan, A.1
Corrales, L.2
Hubert, N.3
Williams, J.B.4
Aquino-Michaels, K.5
Earley, Z.M.6
-
41
-
-
84936953099
-
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
-
Spranger S, Bao R, Gajewski TF. Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature 2015;523:231-5.
-
(2015)
Nature
, vol.523
, pp. 231-235
-
-
Spranger, S.1
Bao, R.2
Gajewski, T.F.3
|